Histamine and neuroinflammation: insights from mouse experimental autoimmune encephalomyelitis

Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the CNS whose pathogenesis remains largely unknown, and available therapies are rarely successful in reversing neurological deficits or stopping disease progression. Ongoing studies on MS and the widely used murine model...
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Gespeichert in:

Autor*in:	Maria Beatrice ePassani [verfasserIn] Clara eBallerini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Autoimmune Diseases Multiple Sclerosis H1 receptor H2 receptor H3 receptor H4 receptor

Übergeordnetes Werk:	In: Frontiers in Systems Neuroscience - Frontiers Media S.A., 2008, 6(2012)
Übergeordnetes Werk:	volume:6 ; year:2012

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnsys.2012.00032

Katalog-ID:	DOAJ009093354

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allfieldsSound	10.3389/fnsys.2012.00032 doi (DE-627)DOAJ009093354 (DE-599)DOAJ46d43ff8cbb648ee8f016e9fcbeb6e7f DE-627 ger DE-627 rakwb eng RC321-571 Maria Beatrice ePassani verfasserin aut Histamine and neuroinflammation: insights from mouse experimental autoimmune encephalomyelitis 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the CNS whose pathogenesis remains largely unknown, and available therapies are rarely successful in reversing neurological deficits or stopping disease progression. Ongoing studies on MS and the widely used murine model experimental autoimmune encephalomyelitis (EAE) are trying to dissect out the many components of this complex and heterogeneous neurodegenerative disease in the hope of providing a mechanism-based characterization of MS that will afford successful strategies to limit and repair the neuronal damage. Recently, histamine has been postulated to have a key regulatory role in EAE and in MS pathogenesis. Histamine is a mediator of inflammation and immune responses, it explicates its many actions through four G protein-coupled receptors (H1,2,3,4R) that signal through distinct intracellular pathways and have different therapeutic potentials as they vary in expression, distribution of isoforms, signaling properties and function. Immune cells involved in MS/EAE, including dendritic cells and T lymphocytes, express H1R, H2R and H4R, and histamine may have varying and counteracting effects on a particular cell type depending on the receptor subtypes being activated. Here, we review evidence of the complex and controversial role of histamine in MS/EAE pathogenesis and evaluate the therapeutic potential of histaminergic ligands to treat autoimmune diseases. Autoimmune Diseases Multiple Sclerosis H1 receptor H2 receptor H3 receptor H4 receptor Neurosciences. Biological psychiatry. Neuropsychiatry Clara eBallerini verfasserin aut In Frontiers in Systems Neuroscience Frontiers Media S.A., 2008 6(2012) (DE-627)579826740 (DE-600)2453005-0 16625137 nnns volume:6 year:2012 https://doi.org/10.3389/fnsys.2012.00032 kostenfrei https://doaj.org/article/46d43ff8cbb648ee8f016e9fcbeb6e7f kostenfrei http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00032/full kostenfrei https://doaj.org/toc/1662-5137 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2012
language	English
source	In Frontiers in Systems Neuroscience 6(2012) volume:6 year:2012
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topic_facet	Autoimmune Diseases Multiple Sclerosis H1 receptor H2 receptor H3 receptor H4 receptor Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Systems Neuroscience
authorswithroles_txt_mv	Maria Beatrice ePassani @@aut@@ Clara eBallerini @@aut@@
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callnumber-first	R - Medicine
author	Maria Beatrice ePassani
spellingShingle	Maria Beatrice ePassani misc RC321-571 misc Autoimmune Diseases misc Multiple Sclerosis misc H1 receptor misc H2 receptor misc H3 receptor misc H4 receptor misc Neurosciences. Biological psychiatry. Neuropsychiatry Histamine and neuroinflammation: insights from mouse experimental autoimmune encephalomyelitis
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topic_title	RC321-571 Histamine and neuroinflammation: insights from mouse experimental autoimmune encephalomyelitis Autoimmune Diseases Multiple Sclerosis H1 receptor H2 receptor H3 receptor H4 receptor
topic	misc RC321-571 misc Autoimmune Diseases misc Multiple Sclerosis misc H1 receptor misc H2 receptor misc H3 receptor misc H4 receptor misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Histamine and neuroinflammation: insights from mouse experimental autoimmune encephalomyelitis
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title_full	Histamine and neuroinflammation: insights from mouse experimental autoimmune encephalomyelitis
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title_sort	histamine and neuroinflammation: insights from mouse experimental autoimmune encephalomyelitis
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title_auth	Histamine and neuroinflammation: insights from mouse experimental autoimmune encephalomyelitis
abstract	Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the CNS whose pathogenesis remains largely unknown, and available therapies are rarely successful in reversing neurological deficits or stopping disease progression. Ongoing studies on MS and the widely used murine model experimental autoimmune encephalomyelitis (EAE) are trying to dissect out the many components of this complex and heterogeneous neurodegenerative disease in the hope of providing a mechanism-based characterization of MS that will afford successful strategies to limit and repair the neuronal damage. Recently, histamine has been postulated to have a key regulatory role in EAE and in MS pathogenesis. Histamine is a mediator of inflammation and immune responses, it explicates its many actions through four G protein-coupled receptors (H1,2,3,4R) that signal through distinct intracellular pathways and have different therapeutic potentials as they vary in expression, distribution of isoforms, signaling properties and function. Immune cells involved in MS/EAE, including dendritic cells and T lymphocytes, express H1R, H2R and H4R, and histamine may have varying and counteracting effects on a particular cell type depending on the receptor subtypes being activated. Here, we review evidence of the complex and controversial role of histamine in MS/EAE pathogenesis and evaluate the therapeutic potential of histaminergic ligands to treat autoimmune diseases.
abstractGer	Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the CNS whose pathogenesis remains largely unknown, and available therapies are rarely successful in reversing neurological deficits or stopping disease progression. Ongoing studies on MS and the widely used murine model experimental autoimmune encephalomyelitis (EAE) are trying to dissect out the many components of this complex and heterogeneous neurodegenerative disease in the hope of providing a mechanism-based characterization of MS that will afford successful strategies to limit and repair the neuronal damage. Recently, histamine has been postulated to have a key regulatory role in EAE and in MS pathogenesis. Histamine is a mediator of inflammation and immune responses, it explicates its many actions through four G protein-coupled receptors (H1,2,3,4R) that signal through distinct intracellular pathways and have different therapeutic potentials as they vary in expression, distribution of isoforms, signaling properties and function. Immune cells involved in MS/EAE, including dendritic cells and T lymphocytes, express H1R, H2R and H4R, and histamine may have varying and counteracting effects on a particular cell type depending on the receptor subtypes being activated. Here, we review evidence of the complex and controversial role of histamine in MS/EAE pathogenesis and evaluate the therapeutic potential of histaminergic ligands to treat autoimmune diseases.
abstract_unstemmed	Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the CNS whose pathogenesis remains largely unknown, and available therapies are rarely successful in reversing neurological deficits or stopping disease progression. Ongoing studies on MS and the widely used murine model experimental autoimmune encephalomyelitis (EAE) are trying to dissect out the many components of this complex and heterogeneous neurodegenerative disease in the hope of providing a mechanism-based characterization of MS that will afford successful strategies to limit and repair the neuronal damage. Recently, histamine has been postulated to have a key regulatory role in EAE and in MS pathogenesis. Histamine is a mediator of inflammation and immune responses, it explicates its many actions through four G protein-coupled receptors (H1,2,3,4R) that signal through distinct intracellular pathways and have different therapeutic potentials as they vary in expression, distribution of isoforms, signaling properties and function. Immune cells involved in MS/EAE, including dendritic cells and T lymphocytes, express H1R, H2R and H4R, and histamine may have varying and counteracting effects on a particular cell type depending on the receptor subtypes being activated. Here, we review evidence of the complex and controversial role of histamine in MS/EAE pathogenesis and evaluate the therapeutic potential of histaminergic ligands to treat autoimmune diseases.
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title_short	Histamine and neuroinflammation: insights from mouse experimental autoimmune encephalomyelitis
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