Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias

Background: Angiodysplasias are one of the most frequent causes of gastrointestinal bleeding. Pharmacological options, such as octreotide Long-Acting Release (LAR), do not yet have a defined role and are currently used for patients who are not candidates for or are refractory to endoscopic treatment...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Paulo Salgueiro [verfasserIn] Ricardo Marcos-Pinto [verfasserIn] Rodrigo Liberal [verfasserIn] Paula Lago [verfasserIn] Ricardo Magalhães [verfasserIn] Maria Magalhães [verfasserIn] José Ferreira [verfasserIn] Isabel Pedroto [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Octreotide Long-Acting Release Angiodysplasias Gastrointestinal bleeding

Übergeordnetes Werk:	In: GE: Portuguese Journal of Gastroenterology - Karger Publishers, 2016, 21(2014), 5, Seite 176-183
Übergeordnetes Werk:	volume:21 ; year:2014 ; number:5 ; pages:176-183

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jpg.2014.05.001

Katalog-ID:	DOAJ009118934

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520			\|a Background: Angiodysplasias are one of the most frequent causes of gastrointestinal bleeding. Pharmacological options, such as octreotide Long-Acting Release (LAR), do not yet have a defined role and are currently used for patients who are not candidates for or are refractory to endoscopic treatment. Aims: (1) To evaluate the efficacy of octreotide LAR by considering transfusion requirements (units of packed erythrocytes (UPE)/month) and number of hospitalizations/month before and during therapy; (2) to verify whether the characteristics of patients and/or concurrent medication influenced response to therapy; and (3) to evaluate the safety of therapy by registering adverse effects. Methods: A retrospective cohort of 16 patients with angiodysplasias treated with octreotide LAR was reviewed. Results: (1) There was a significant decrease (follow up before vs. follow up during) in the median number of UPE/month (1.84 vs. 0.42, p = 0.008) and the number of admissions/month (0.21 vs. 0.00, p = 0.015). (2) Of the characteristics analyzed, only the presence of aortic stenosis (vs. other comorbidities) positively influenced the response to therapy in relation to the variation in transfusion requirements (−2.39 UPE/month vs. −0.61 UPE/month; p = 0.009). (3) Adverse effects: splenic infarction (1 patient) and gallstones (1 patient). Conclusions: Octreotide LAR is effective as prophylaxis for gastrointestinal bleeding angiodysplasia by decreasing transfusion requirements and the need for hospitalizations. Patients with aortic stenosis were those who most benefited from the therapy. A dose of 20 mg/month did not prove more effective than a dose of 10 mg/month.
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650		4	\|a Gastrointestinal bleeding
653		0	\|a Diseases of the digestive system. Gastroenterology
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700	0		\|a Isabel Pedroto \|e verfasserin \|4 aut
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allfields	10.1016/j.jpg.2014.05.001 doi (DE-627)DOAJ009118934 (DE-599)DOAJcc179bb8accd41738162215844710c6e DE-627 ger DE-627 rakwb eng RC799-869 Paulo Salgueiro verfasserin aut Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Angiodysplasias are one of the most frequent causes of gastrointestinal bleeding. Pharmacological options, such as octreotide Long-Acting Release (LAR), do not yet have a defined role and are currently used for patients who are not candidates for or are refractory to endoscopic treatment. Aims: (1) To evaluate the efficacy of octreotide LAR by considering transfusion requirements (units of packed erythrocytes (UPE)/month) and number of hospitalizations/month before and during therapy; (2) to verify whether the characteristics of patients and/or concurrent medication influenced response to therapy; and (3) to evaluate the safety of therapy by registering adverse effects. Methods: A retrospective cohort of 16 patients with angiodysplasias treated with octreotide LAR was reviewed. Results: (1) There was a significant decrease (follow up before vs. follow up during) in the median number of UPE/month (1.84 vs. 0.42, p = 0.008) and the number of admissions/month (0.21 vs. 0.00, p = 0.015). (2) Of the characteristics analyzed, only the presence of aortic stenosis (vs. other comorbidities) positively influenced the response to therapy in relation to the variation in transfusion requirements (−2.39 UPE/month vs. −0.61 UPE/month; p = 0.009). (3) Adverse effects: splenic infarction (1 patient) and gallstones (1 patient). Conclusions: Octreotide LAR is effective as prophylaxis for gastrointestinal bleeding angiodysplasia by decreasing transfusion requirements and the need for hospitalizations. Patients with aortic stenosis were those who most benefited from the therapy. A dose of 20 mg/month did not prove more effective than a dose of 10 mg/month. Octreotide Long-Acting Release Angiodysplasias Gastrointestinal bleeding Diseases of the digestive system. Gastroenterology Ricardo Marcos-Pinto verfasserin aut Rodrigo Liberal verfasserin aut Paula Lago verfasserin aut Ricardo Magalhães verfasserin aut Maria Magalhães verfasserin aut José Ferreira verfasserin aut Isabel Pedroto verfasserin aut In GE: Portuguese Journal of Gastroenterology Karger Publishers, 2016 21(2014), 5, Seite 176-183 (DE-627)835893308 (DE-600)2835774-7 23871954 nnns volume:21 year:2014 number:5 pages:176-183 https://doi.org/10.1016/j.jpg.2014.05.001 kostenfrei https://doaj.org/article/cc179bb8accd41738162215844710c6e kostenfrei http://www.sciencedirect.com/science/article/pii/S0872817814000629 kostenfrei https://doaj.org/toc/2341-4545 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2014 5 176-183
spelling	10.1016/j.jpg.2014.05.001 doi (DE-627)DOAJ009118934 (DE-599)DOAJcc179bb8accd41738162215844710c6e DE-627 ger DE-627 rakwb eng RC799-869 Paulo Salgueiro verfasserin aut Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Angiodysplasias are one of the most frequent causes of gastrointestinal bleeding. Pharmacological options, such as octreotide Long-Acting Release (LAR), do not yet have a defined role and are currently used for patients who are not candidates for or are refractory to endoscopic treatment. Aims: (1) To evaluate the efficacy of octreotide LAR by considering transfusion requirements (units of packed erythrocytes (UPE)/month) and number of hospitalizations/month before and during therapy; (2) to verify whether the characteristics of patients and/or concurrent medication influenced response to therapy; and (3) to evaluate the safety of therapy by registering adverse effects. Methods: A retrospective cohort of 16 patients with angiodysplasias treated with octreotide LAR was reviewed. Results: (1) There was a significant decrease (follow up before vs. follow up during) in the median number of UPE/month (1.84 vs. 0.42, p = 0.008) and the number of admissions/month (0.21 vs. 0.00, p = 0.015). (2) Of the characteristics analyzed, only the presence of aortic stenosis (vs. other comorbidities) positively influenced the response to therapy in relation to the variation in transfusion requirements (−2.39 UPE/month vs. −0.61 UPE/month; p = 0.009). (3) Adverse effects: splenic infarction (1 patient) and gallstones (1 patient). Conclusions: Octreotide LAR is effective as prophylaxis for gastrointestinal bleeding angiodysplasia by decreasing transfusion requirements and the need for hospitalizations. Patients with aortic stenosis were those who most benefited from the therapy. A dose of 20 mg/month did not prove more effective than a dose of 10 mg/month. Octreotide Long-Acting Release Angiodysplasias Gastrointestinal bleeding Diseases of the digestive system. Gastroenterology Ricardo Marcos-Pinto verfasserin aut Rodrigo Liberal verfasserin aut Paula Lago verfasserin aut Ricardo Magalhães verfasserin aut Maria Magalhães verfasserin aut José Ferreira verfasserin aut Isabel Pedroto verfasserin aut In GE: Portuguese Journal of Gastroenterology Karger Publishers, 2016 21(2014), 5, Seite 176-183 (DE-627)835893308 (DE-600)2835774-7 23871954 nnns volume:21 year:2014 number:5 pages:176-183 https://doi.org/10.1016/j.jpg.2014.05.001 kostenfrei https://doaj.org/article/cc179bb8accd41738162215844710c6e kostenfrei http://www.sciencedirect.com/science/article/pii/S0872817814000629 kostenfrei https://doaj.org/toc/2341-4545 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2014 5 176-183
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allfieldsGer	10.1016/j.jpg.2014.05.001 doi (DE-627)DOAJ009118934 (DE-599)DOAJcc179bb8accd41738162215844710c6e DE-627 ger DE-627 rakwb eng RC799-869 Paulo Salgueiro verfasserin aut Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Angiodysplasias are one of the most frequent causes of gastrointestinal bleeding. Pharmacological options, such as octreotide Long-Acting Release (LAR), do not yet have a defined role and are currently used for patients who are not candidates for or are refractory to endoscopic treatment. Aims: (1) To evaluate the efficacy of octreotide LAR by considering transfusion requirements (units of packed erythrocytes (UPE)/month) and number of hospitalizations/month before and during therapy; (2) to verify whether the characteristics of patients and/or concurrent medication influenced response to therapy; and (3) to evaluate the safety of therapy by registering adverse effects. Methods: A retrospective cohort of 16 patients with angiodysplasias treated with octreotide LAR was reviewed. Results: (1) There was a significant decrease (follow up before vs. follow up during) in the median number of UPE/month (1.84 vs. 0.42, p = 0.008) and the number of admissions/month (0.21 vs. 0.00, p = 0.015). (2) Of the characteristics analyzed, only the presence of aortic stenosis (vs. other comorbidities) positively influenced the response to therapy in relation to the variation in transfusion requirements (−2.39 UPE/month vs. −0.61 UPE/month; p = 0.009). (3) Adverse effects: splenic infarction (1 patient) and gallstones (1 patient). Conclusions: Octreotide LAR is effective as prophylaxis for gastrointestinal bleeding angiodysplasia by decreasing transfusion requirements and the need for hospitalizations. Patients with aortic stenosis were those who most benefited from the therapy. A dose of 20 mg/month did not prove more effective than a dose of 10 mg/month. Octreotide Long-Acting Release Angiodysplasias Gastrointestinal bleeding Diseases of the digestive system. Gastroenterology Ricardo Marcos-Pinto verfasserin aut Rodrigo Liberal verfasserin aut Paula Lago verfasserin aut Ricardo Magalhães verfasserin aut Maria Magalhães verfasserin aut José Ferreira verfasserin aut Isabel Pedroto verfasserin aut In GE: Portuguese Journal of Gastroenterology Karger Publishers, 2016 21(2014), 5, Seite 176-183 (DE-627)835893308 (DE-600)2835774-7 23871954 nnns volume:21 year:2014 number:5 pages:176-183 https://doi.org/10.1016/j.jpg.2014.05.001 kostenfrei https://doaj.org/article/cc179bb8accd41738162215844710c6e kostenfrei http://www.sciencedirect.com/science/article/pii/S0872817814000629 kostenfrei https://doaj.org/toc/2341-4545 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2014 5 176-183
allfieldsSound	10.1016/j.jpg.2014.05.001 doi (DE-627)DOAJ009118934 (DE-599)DOAJcc179bb8accd41738162215844710c6e DE-627 ger DE-627 rakwb eng RC799-869 Paulo Salgueiro verfasserin aut Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Angiodysplasias are one of the most frequent causes of gastrointestinal bleeding. Pharmacological options, such as octreotide Long-Acting Release (LAR), do not yet have a defined role and are currently used for patients who are not candidates for or are refractory to endoscopic treatment. Aims: (1) To evaluate the efficacy of octreotide LAR by considering transfusion requirements (units of packed erythrocytes (UPE)/month) and number of hospitalizations/month before and during therapy; (2) to verify whether the characteristics of patients and/or concurrent medication influenced response to therapy; and (3) to evaluate the safety of therapy by registering adverse effects. Methods: A retrospective cohort of 16 patients with angiodysplasias treated with octreotide LAR was reviewed. Results: (1) There was a significant decrease (follow up before vs. follow up during) in the median number of UPE/month (1.84 vs. 0.42, p = 0.008) and the number of admissions/month (0.21 vs. 0.00, p = 0.015). (2) Of the characteristics analyzed, only the presence of aortic stenosis (vs. other comorbidities) positively influenced the response to therapy in relation to the variation in transfusion requirements (−2.39 UPE/month vs. −0.61 UPE/month; p = 0.009). (3) Adverse effects: splenic infarction (1 patient) and gallstones (1 patient). Conclusions: Octreotide LAR is effective as prophylaxis for gastrointestinal bleeding angiodysplasia by decreasing transfusion requirements and the need for hospitalizations. Patients with aortic stenosis were those who most benefited from the therapy. A dose of 20 mg/month did not prove more effective than a dose of 10 mg/month. Octreotide Long-Acting Release Angiodysplasias Gastrointestinal bleeding Diseases of the digestive system. Gastroenterology Ricardo Marcos-Pinto verfasserin aut Rodrigo Liberal verfasserin aut Paula Lago verfasserin aut Ricardo Magalhães verfasserin aut Maria Magalhães verfasserin aut José Ferreira verfasserin aut Isabel Pedroto verfasserin aut In GE: Portuguese Journal of Gastroenterology Karger Publishers, 2016 21(2014), 5, Seite 176-183 (DE-627)835893308 (DE-600)2835774-7 23871954 nnns volume:21 year:2014 number:5 pages:176-183 https://doi.org/10.1016/j.jpg.2014.05.001 kostenfrei https://doaj.org/article/cc179bb8accd41738162215844710c6e kostenfrei http://www.sciencedirect.com/science/article/pii/S0872817814000629 kostenfrei https://doaj.org/toc/2341-4545 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2014 5 176-183
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authorswithroles_txt_mv	Paulo Salgueiro @@aut@@ Ricardo Marcos-Pinto @@aut@@ Rodrigo Liberal @@aut@@ Paula Lago @@aut@@ Ricardo Magalhães @@aut@@ Maria Magalhães @@aut@@ José Ferreira @@aut@@ Isabel Pedroto @@aut@@
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(2) Of the characteristics analyzed, only the presence of aortic stenosis (vs. other comorbidities) positively influenced the response to therapy in relation to the variation in transfusion requirements (−2.39 UPE/month vs. −0.61 UPE/month; p = 0.009). (3) Adverse effects: splenic infarction (1 patient) and gallstones (1 patient). Conclusions: Octreotide LAR is effective as prophylaxis for gastrointestinal bleeding angiodysplasia by decreasing transfusion requirements and the need for hospitalizations. Patients with aortic stenosis were those who most benefited from the therapy. 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callnumber-first	R - Medicine
author	Paulo Salgueiro
spellingShingle	Paulo Salgueiro misc RC799-869 misc Octreotide Long-Acting Release misc Angiodysplasias misc Gastrointestinal bleeding misc Diseases of the digestive system. Gastroenterology Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias
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topic_title	RC799-869 Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias Octreotide Long-Acting Release Angiodysplasias Gastrointestinal bleeding
topic	misc RC799-869 misc Octreotide Long-Acting Release misc Angiodysplasias misc Gastrointestinal bleeding misc Diseases of the digestive system. Gastroenterology
topic_unstemmed	misc RC799-869 misc Octreotide Long-Acting Release misc Angiodysplasias misc Gastrointestinal bleeding misc Diseases of the digestive system. Gastroenterology
topic_browse	misc RC799-869 misc Octreotide Long-Acting Release misc Angiodysplasias misc Gastrointestinal bleeding misc Diseases of the digestive system. Gastroenterology
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title	Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias
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title_full	Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias
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author_browse	Paulo Salgueiro Ricardo Marcos-Pinto Rodrigo Liberal Paula Lago Ricardo Magalhães Maria Magalhães José Ferreira Isabel Pedroto
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title_sort	octreotide long-acting release is effective in preventing gastrointestinal bleeding due to angiodysplasias
callnumber	RC799-869
title_auth	Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias
abstract	Background: Angiodysplasias are one of the most frequent causes of gastrointestinal bleeding. Pharmacological options, such as octreotide Long-Acting Release (LAR), do not yet have a defined role and are currently used for patients who are not candidates for or are refractory to endoscopic treatment. Aims: (1) To evaluate the efficacy of octreotide LAR by considering transfusion requirements (units of packed erythrocytes (UPE)/month) and number of hospitalizations/month before and during therapy; (2) to verify whether the characteristics of patients and/or concurrent medication influenced response to therapy; and (3) to evaluate the safety of therapy by registering adverse effects. Methods: A retrospective cohort of 16 patients with angiodysplasias treated with octreotide LAR was reviewed. Results: (1) There was a significant decrease (follow up before vs. follow up during) in the median number of UPE/month (1.84 vs. 0.42, p = 0.008) and the number of admissions/month (0.21 vs. 0.00, p = 0.015). (2) Of the characteristics analyzed, only the presence of aortic stenosis (vs. other comorbidities) positively influenced the response to therapy in relation to the variation in transfusion requirements (−2.39 UPE/month vs. −0.61 UPE/month; p = 0.009). (3) Adverse effects: splenic infarction (1 patient) and gallstones (1 patient). Conclusions: Octreotide LAR is effective as prophylaxis for gastrointestinal bleeding angiodysplasia by decreasing transfusion requirements and the need for hospitalizations. Patients with aortic stenosis were those who most benefited from the therapy. A dose of 20 mg/month did not prove more effective than a dose of 10 mg/month.
abstractGer	Background: Angiodysplasias are one of the most frequent causes of gastrointestinal bleeding. Pharmacological options, such as octreotide Long-Acting Release (LAR), do not yet have a defined role and are currently used for patients who are not candidates for or are refractory to endoscopic treatment. Aims: (1) To evaluate the efficacy of octreotide LAR by considering transfusion requirements (units of packed erythrocytes (UPE)/month) and number of hospitalizations/month before and during therapy; (2) to verify whether the characteristics of patients and/or concurrent medication influenced response to therapy; and (3) to evaluate the safety of therapy by registering adverse effects. Methods: A retrospective cohort of 16 patients with angiodysplasias treated with octreotide LAR was reviewed. Results: (1) There was a significant decrease (follow up before vs. follow up during) in the median number of UPE/month (1.84 vs. 0.42, p = 0.008) and the number of admissions/month (0.21 vs. 0.00, p = 0.015). (2) Of the characteristics analyzed, only the presence of aortic stenosis (vs. other comorbidities) positively influenced the response to therapy in relation to the variation in transfusion requirements (−2.39 UPE/month vs. −0.61 UPE/month; p = 0.009). (3) Adverse effects: splenic infarction (1 patient) and gallstones (1 patient). Conclusions: Octreotide LAR is effective as prophylaxis for gastrointestinal bleeding angiodysplasia by decreasing transfusion requirements and the need for hospitalizations. Patients with aortic stenosis were those who most benefited from the therapy. A dose of 20 mg/month did not prove more effective than a dose of 10 mg/month.
abstract_unstemmed	Background: Angiodysplasias are one of the most frequent causes of gastrointestinal bleeding. Pharmacological options, such as octreotide Long-Acting Release (LAR), do not yet have a defined role and are currently used for patients who are not candidates for or are refractory to endoscopic treatment. Aims: (1) To evaluate the efficacy of octreotide LAR by considering transfusion requirements (units of packed erythrocytes (UPE)/month) and number of hospitalizations/month before and during therapy; (2) to verify whether the characteristics of patients and/or concurrent medication influenced response to therapy; and (3) to evaluate the safety of therapy by registering adverse effects. Methods: A retrospective cohort of 16 patients with angiodysplasias treated with octreotide LAR was reviewed. Results: (1) There was a significant decrease (follow up before vs. follow up during) in the median number of UPE/month (1.84 vs. 0.42, p = 0.008) and the number of admissions/month (0.21 vs. 0.00, p = 0.015). (2) Of the characteristics analyzed, only the presence of aortic stenosis (vs. other comorbidities) positively influenced the response to therapy in relation to the variation in transfusion requirements (−2.39 UPE/month vs. −0.61 UPE/month; p = 0.009). (3) Adverse effects: splenic infarction (1 patient) and gallstones (1 patient). Conclusions: Octreotide LAR is effective as prophylaxis for gastrointestinal bleeding angiodysplasia by decreasing transfusion requirements and the need for hospitalizations. Patients with aortic stenosis were those who most benefited from the therapy. A dose of 20 mg/month did not prove more effective than a dose of 10 mg/month.
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title_short	Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias
url	https://doi.org/10.1016/j.jpg.2014.05.001 https://doaj.org/article/cc179bb8accd41738162215844710c6e http://www.sciencedirect.com/science/article/pii/S0872817814000629 https://doaj.org/toc/2341-4545
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author2	Ricardo Marcos-Pinto Rodrigo Liberal Paula Lago Ricardo Magalhães Maria Magalhães José Ferreira Isabel Pedroto
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(2) Of the characteristics analyzed, only the presence of aortic stenosis (vs. other comorbidities) positively influenced the response to therapy in relation to the variation in transfusion requirements (−2.39 UPE/month vs. −0.61 UPE/month; p = 0.009). (3) Adverse effects: splenic infarction (1 patient) and gallstones (1 patient). Conclusions: Octreotide LAR is effective as prophylaxis for gastrointestinal bleeding angiodysplasia by decreasing transfusion requirements and the need for hospitalizations. Patients with aortic stenosis were those who most benefited from the therapy. 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Octreotide Long-Acting Release is effective in preventing gastrointestinal bleeding due to angiodysplasias

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