Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model

Rong-zi Li,1 Xiao-Wen Ding,1 Thangiah Geetha,1 Layla Al-Nakkash,2 Tom L Broderick,2 Jeganathan Ramesh Babu1 1Department of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA; 2Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USACorrespondence: Jeganathan Ramesh BabuDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USATel +1 334 844 3840 Fax +1 334 844 3268Email jeganrbauburn.eduPurpose: Diabetes mellitus (DM)-induced brain damage is characterized by cellular, molecular and functional changes. The mechanisms include oxidative stress, neuroinflammation, reduction of neurotrophic factors, insulin resistance, excessive amyloid beta (Aβ) deposition and Tau phosphorylation. Both antidiabetic and neuroprotective effects of the phytoestrogen genistein have been reported. However, the beneficial effect of genistein in brain of the ob/ob mouse model of severe obesity and diabetes remains to be determined.Methods: In this study, female ob/ob mice and lean control mice were fed with either a standard diet or a diet containing genistein (600mg/kg) for a period of 4 weeks. Body weight was monitored weekly. Blood was collected for the measurement of glucose, insulin and common cytokines. Mice brains were isolated for Western immunoblotting analyses.Results: Treatment with genistein reduced weight gain of ob/ob mice and decreased hyperglycemia compared to ob/ob mice fed the standard diet. The main findings show that genistein treatment increased insulin sensitivity and the expression levels of the neurotrophic factors nerve growth factor (NGF) and brain-derived neurotrophic factors (BDNF). In these mice, genistein also reduced Aβ deposition and the level of hyper-phosphorylated Tau protein.Conclusion: The results of our study indicate the beneficial effects of genistein in the obese diabetic mouse brain, including improving brain insulin signaling, increasing neurotrophic support, and alleviating Alzheimer’s disease-related pathology.Keywords: isoflavones, leptin-deficient mice, brain injury, insulin signaling, amyloid beta Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Li R [verfasserIn] Ding XW [verfasserIn] Geetha T [verfasserIn] Al-Nakkash L [verfasserIn] Broderick TL [verfasserIn] Babu JR [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	isoflavones leptin deficiency mice brain injury insulin signaling amyloid beta.

Übergeordnetes Werk:	In: Drug Design, Development and Therapy - Dove Medical Press, 2008, (2020), Seite 3325-3336
Übergeordnetes Werk:	year:2020 ; pages:3325-3336

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ009144102

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allfields	(DE-627)DOAJ009144102 (DE-599)DOAJ4001f16ec4ce4c06aa51af58d1261090 DE-627 ger DE-627 rakwb eng RM1-950 Li R verfasserin aut Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rong-zi Li,1 Xiao-Wen Ding,1 Thangiah Geetha,1 Layla Al-Nakkash,2 Tom L Broderick,2 Jeganathan Ramesh Babu1 1Department of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA; 2Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USACorrespondence: Jeganathan Ramesh BabuDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USATel +1 334 844 3840 Fax +1 334 844 3268Email jeganrbauburn.eduPurpose: Diabetes mellitus (DM)-induced brain damage is characterized by cellular, molecular and functional changes. The mechanisms include oxidative stress, neuroinflammation, reduction of neurotrophic factors, insulin resistance, excessive amyloid beta (Aβ) deposition and Tau phosphorylation. Both antidiabetic and neuroprotective effects of the phytoestrogen genistein have been reported. However, the beneficial effect of genistein in brain of the ob/ob mouse model of severe obesity and diabetes remains to be determined.Methods: In this study, female ob/ob mice and lean control mice were fed with either a standard diet or a diet containing genistein (600mg/kg) for a period of 4 weeks. Body weight was monitored weekly. Blood was collected for the measurement of glucose, insulin and common cytokines. Mice brains were isolated for Western immunoblotting analyses.Results: Treatment with genistein reduced weight gain of ob/ob mice and decreased hyperglycemia compared to ob/ob mice fed the standard diet. The main findings show that genistein treatment increased insulin sensitivity and the expression levels of the neurotrophic factors nerve growth factor (NGF) and brain-derived neurotrophic factors (BDNF). In these mice, genistein also reduced Aβ deposition and the level of hyper-phosphorylated Tau protein.Conclusion: The results of our study indicate the beneficial effects of genistein in the obese diabetic mouse brain, including improving brain insulin signaling, increasing neurotrophic support, and alleviating Alzheimer’s disease-related pathology.Keywords: isoflavones, leptin-deficient mice, brain injury, insulin signaling, amyloid beta isoflavones leptin deficiency mice brain injury insulin signaling amyloid beta. Therapeutics. Pharmacology Ding XW verfasserin aut Geetha T verfasserin aut Al-Nakkash L verfasserin aut Broderick TL verfasserin aut Babu JR verfasserin aut In Drug Design, Development and Therapy Dove Medical Press, 2008 (2020), Seite 3325-3336 (DE-627)578533138 (DE-600)2451346-5 11778881 nnns year:2020 pages:3325-3336 https://doaj.org/article/4001f16ec4ce4c06aa51af58d1261090 kostenfrei https://www.dovepress.com/beneficial-effect-of-genistein-on-diabetes-induced-brain-damage-in-the-peer-reviewed-article-DDDT kostenfrei https://doaj.org/toc/1177-8881 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 3325-3336
spelling	(DE-627)DOAJ009144102 (DE-599)DOAJ4001f16ec4ce4c06aa51af58d1261090 DE-627 ger DE-627 rakwb eng RM1-950 Li R verfasserin aut Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rong-zi Li,1 Xiao-Wen Ding,1 Thangiah Geetha,1 Layla Al-Nakkash,2 Tom L Broderick,2 Jeganathan Ramesh Babu1 1Department of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA; 2Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USACorrespondence: Jeganathan Ramesh BabuDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USATel +1 334 844 3840 Fax +1 334 844 3268Email jeganrbauburn.eduPurpose: Diabetes mellitus (DM)-induced brain damage is characterized by cellular, molecular and functional changes. The mechanisms include oxidative stress, neuroinflammation, reduction of neurotrophic factors, insulin resistance, excessive amyloid beta (Aβ) deposition and Tau phosphorylation. Both antidiabetic and neuroprotective effects of the phytoestrogen genistein have been reported. However, the beneficial effect of genistein in brain of the ob/ob mouse model of severe obesity and diabetes remains to be determined.Methods: In this study, female ob/ob mice and lean control mice were fed with either a standard diet or a diet containing genistein (600mg/kg) for a period of 4 weeks. Body weight was monitored weekly. Blood was collected for the measurement of glucose, insulin and common cytokines. Mice brains were isolated for Western immunoblotting analyses.Results: Treatment with genistein reduced weight gain of ob/ob mice and decreased hyperglycemia compared to ob/ob mice fed the standard diet. The main findings show that genistein treatment increased insulin sensitivity and the expression levels of the neurotrophic factors nerve growth factor (NGF) and brain-derived neurotrophic factors (BDNF). In these mice, genistein also reduced Aβ deposition and the level of hyper-phosphorylated Tau protein.Conclusion: The results of our study indicate the beneficial effects of genistein in the obese diabetic mouse brain, including improving brain insulin signaling, increasing neurotrophic support, and alleviating Alzheimer’s disease-related pathology.Keywords: isoflavones, leptin-deficient mice, brain injury, insulin signaling, amyloid beta isoflavones leptin deficiency mice brain injury insulin signaling amyloid beta. Therapeutics. Pharmacology Ding XW verfasserin aut Geetha T verfasserin aut Al-Nakkash L verfasserin aut Broderick TL verfasserin aut Babu JR verfasserin aut In Drug Design, Development and Therapy Dove Medical Press, 2008 (2020), Seite 3325-3336 (DE-627)578533138 (DE-600)2451346-5 11778881 nnns year:2020 pages:3325-3336 https://doaj.org/article/4001f16ec4ce4c06aa51af58d1261090 kostenfrei https://www.dovepress.com/beneficial-effect-of-genistein-on-diabetes-induced-brain-damage-in-the-peer-reviewed-article-DDDT kostenfrei https://doaj.org/toc/1177-8881 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 3325-3336
allfields_unstemmed	(DE-627)DOAJ009144102 (DE-599)DOAJ4001f16ec4ce4c06aa51af58d1261090 DE-627 ger DE-627 rakwb eng RM1-950 Li R verfasserin aut Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rong-zi Li,1 Xiao-Wen Ding,1 Thangiah Geetha,1 Layla Al-Nakkash,2 Tom L Broderick,2 Jeganathan Ramesh Babu1 1Department of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA; 2Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USACorrespondence: Jeganathan Ramesh BabuDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USATel +1 334 844 3840 Fax +1 334 844 3268Email jeganrbauburn.eduPurpose: Diabetes mellitus (DM)-induced brain damage is characterized by cellular, molecular and functional changes. The mechanisms include oxidative stress, neuroinflammation, reduction of neurotrophic factors, insulin resistance, excessive amyloid beta (Aβ) deposition and Tau phosphorylation. Both antidiabetic and neuroprotective effects of the phytoestrogen genistein have been reported. However, the beneficial effect of genistein in brain of the ob/ob mouse model of severe obesity and diabetes remains to be determined.Methods: In this study, female ob/ob mice and lean control mice were fed with either a standard diet or a diet containing genistein (600mg/kg) for a period of 4 weeks. Body weight was monitored weekly. Blood was collected for the measurement of glucose, insulin and common cytokines. Mice brains were isolated for Western immunoblotting analyses.Results: Treatment with genistein reduced weight gain of ob/ob mice and decreased hyperglycemia compared to ob/ob mice fed the standard diet. The main findings show that genistein treatment increased insulin sensitivity and the expression levels of the neurotrophic factors nerve growth factor (NGF) and brain-derived neurotrophic factors (BDNF). In these mice, genistein also reduced Aβ deposition and the level of hyper-phosphorylated Tau protein.Conclusion: The results of our study indicate the beneficial effects of genistein in the obese diabetic mouse brain, including improving brain insulin signaling, increasing neurotrophic support, and alleviating Alzheimer’s disease-related pathology.Keywords: isoflavones, leptin-deficient mice, brain injury, insulin signaling, amyloid beta isoflavones leptin deficiency mice brain injury insulin signaling amyloid beta. Therapeutics. Pharmacology Ding XW verfasserin aut Geetha T verfasserin aut Al-Nakkash L verfasserin aut Broderick TL verfasserin aut Babu JR verfasserin aut In Drug Design, Development and Therapy Dove Medical Press, 2008 (2020), Seite 3325-3336 (DE-627)578533138 (DE-600)2451346-5 11778881 nnns year:2020 pages:3325-3336 https://doaj.org/article/4001f16ec4ce4c06aa51af58d1261090 kostenfrei https://www.dovepress.com/beneficial-effect-of-genistein-on-diabetes-induced-brain-damage-in-the-peer-reviewed-article-DDDT kostenfrei https://doaj.org/toc/1177-8881 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 3325-3336
allfieldsGer	(DE-627)DOAJ009144102 (DE-599)DOAJ4001f16ec4ce4c06aa51af58d1261090 DE-627 ger DE-627 rakwb eng RM1-950 Li R verfasserin aut Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rong-zi Li,1 Xiao-Wen Ding,1 Thangiah Geetha,1 Layla Al-Nakkash,2 Tom L Broderick,2 Jeganathan Ramesh Babu1 1Department of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA; 2Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USACorrespondence: Jeganathan Ramesh BabuDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USATel +1 334 844 3840 Fax +1 334 844 3268Email jeganrbauburn.eduPurpose: Diabetes mellitus (DM)-induced brain damage is characterized by cellular, molecular and functional changes. The mechanisms include oxidative stress, neuroinflammation, reduction of neurotrophic factors, insulin resistance, excessive amyloid beta (Aβ) deposition and Tau phosphorylation. Both antidiabetic and neuroprotective effects of the phytoestrogen genistein have been reported. However, the beneficial effect of genistein in brain of the ob/ob mouse model of severe obesity and diabetes remains to be determined.Methods: In this study, female ob/ob mice and lean control mice were fed with either a standard diet or a diet containing genistein (600mg/kg) for a period of 4 weeks. Body weight was monitored weekly. Blood was collected for the measurement of glucose, insulin and common cytokines. Mice brains were isolated for Western immunoblotting analyses.Results: Treatment with genistein reduced weight gain of ob/ob mice and decreased hyperglycemia compared to ob/ob mice fed the standard diet. The main findings show that genistein treatment increased insulin sensitivity and the expression levels of the neurotrophic factors nerve growth factor (NGF) and brain-derived neurotrophic factors (BDNF). In these mice, genistein also reduced Aβ deposition and the level of hyper-phosphorylated Tau protein.Conclusion: The results of our study indicate the beneficial effects of genistein in the obese diabetic mouse brain, including improving brain insulin signaling, increasing neurotrophic support, and alleviating Alzheimer’s disease-related pathology.Keywords: isoflavones, leptin-deficient mice, brain injury, insulin signaling, amyloid beta isoflavones leptin deficiency mice brain injury insulin signaling amyloid beta. Therapeutics. Pharmacology Ding XW verfasserin aut Geetha T verfasserin aut Al-Nakkash L verfasserin aut Broderick TL verfasserin aut Babu JR verfasserin aut In Drug Design, Development and Therapy Dove Medical Press, 2008 (2020), Seite 3325-3336 (DE-627)578533138 (DE-600)2451346-5 11778881 nnns year:2020 pages:3325-3336 https://doaj.org/article/4001f16ec4ce4c06aa51af58d1261090 kostenfrei https://www.dovepress.com/beneficial-effect-of-genistein-on-diabetes-induced-brain-damage-in-the-peer-reviewed-article-DDDT kostenfrei https://doaj.org/toc/1177-8881 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 3325-3336
allfieldsSound	(DE-627)DOAJ009144102 (DE-599)DOAJ4001f16ec4ce4c06aa51af58d1261090 DE-627 ger DE-627 rakwb eng RM1-950 Li R verfasserin aut Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rong-zi Li,1 Xiao-Wen Ding,1 Thangiah Geetha,1 Layla Al-Nakkash,2 Tom L Broderick,2 Jeganathan Ramesh Babu1 1Department of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA; 2Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USACorrespondence: Jeganathan Ramesh BabuDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USATel +1 334 844 3840 Fax +1 334 844 3268Email jeganrbauburn.eduPurpose: Diabetes mellitus (DM)-induced brain damage is characterized by cellular, molecular and functional changes. The mechanisms include oxidative stress, neuroinflammation, reduction of neurotrophic factors, insulin resistance, excessive amyloid beta (Aβ) deposition and Tau phosphorylation. Both antidiabetic and neuroprotective effects of the phytoestrogen genistein have been reported. However, the beneficial effect of genistein in brain of the ob/ob mouse model of severe obesity and diabetes remains to be determined.Methods: In this study, female ob/ob mice and lean control mice were fed with either a standard diet or a diet containing genistein (600mg/kg) for a period of 4 weeks. Body weight was monitored weekly. Blood was collected for the measurement of glucose, insulin and common cytokines. Mice brains were isolated for Western immunoblotting analyses.Results: Treatment with genistein reduced weight gain of ob/ob mice and decreased hyperglycemia compared to ob/ob mice fed the standard diet. The main findings show that genistein treatment increased insulin sensitivity and the expression levels of the neurotrophic factors nerve growth factor (NGF) and brain-derived neurotrophic factors (BDNF). In these mice, genistein also reduced Aβ deposition and the level of hyper-phosphorylated Tau protein.Conclusion: The results of our study indicate the beneficial effects of genistein in the obese diabetic mouse brain, including improving brain insulin signaling, increasing neurotrophic support, and alleviating Alzheimer’s disease-related pathology.Keywords: isoflavones, leptin-deficient mice, brain injury, insulin signaling, amyloid beta isoflavones leptin deficiency mice brain injury insulin signaling amyloid beta. Therapeutics. Pharmacology Ding XW verfasserin aut Geetha T verfasserin aut Al-Nakkash L verfasserin aut Broderick TL verfasserin aut Babu JR verfasserin aut In Drug Design, Development and Therapy Dove Medical Press, 2008 (2020), Seite 3325-3336 (DE-627)578533138 (DE-600)2451346-5 11778881 nnns year:2020 pages:3325-3336 https://doaj.org/article/4001f16ec4ce4c06aa51af58d1261090 kostenfrei https://www.dovepress.com/beneficial-effect-of-genistein-on-diabetes-induced-brain-damage-in-the-peer-reviewed-article-DDDT kostenfrei https://doaj.org/toc/1177-8881 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 3325-3336
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author	Li R
spellingShingle	Li R misc RM1-950 misc isoflavones misc leptin deficiency mice misc brain injury misc insulin signaling misc amyloid beta. misc Therapeutics. Pharmacology Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model
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topic_title	RM1-950 Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model isoflavones leptin deficiency mice brain injury insulin signaling amyloid beta
topic	misc RM1-950 misc isoflavones misc leptin deficiency mice misc brain injury misc insulin signaling misc amyloid beta. misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc isoflavones misc leptin deficiency mice misc brain injury misc insulin signaling misc amyloid beta. misc Therapeutics. Pharmacology
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title	Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model
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title_full	Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model
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author_browse	Li R Ding XW Geetha T Al-Nakkash L Broderick TL Babu JR
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title_sort	beneficial effect of genistein on diabetes-induced brain damage in the ob/ob mouse model
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title_auth	Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model
abstract	Rong-zi Li,1 Xiao-Wen Ding,1 Thangiah Geetha,1 Layla Al-Nakkash,2 Tom L Broderick,2 Jeganathan Ramesh Babu1 1Department of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA; 2Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USACorrespondence: Jeganathan Ramesh BabuDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USATel +1 334 844 3840 Fax +1 334 844 3268Email jeganrbauburn.eduPurpose: Diabetes mellitus (DM)-induced brain damage is characterized by cellular, molecular and functional changes. The mechanisms include oxidative stress, neuroinflammation, reduction of neurotrophic factors, insulin resistance, excessive amyloid beta (Aβ) deposition and Tau phosphorylation. Both antidiabetic and neuroprotective effects of the phytoestrogen genistein have been reported. However, the beneficial effect of genistein in brain of the ob/ob mouse model of severe obesity and diabetes remains to be determined.Methods: In this study, female ob/ob mice and lean control mice were fed with either a standard diet or a diet containing genistein (600mg/kg) for a period of 4 weeks. Body weight was monitored weekly. Blood was collected for the measurement of glucose, insulin and common cytokines. Mice brains were isolated for Western immunoblotting analyses.Results: Treatment with genistein reduced weight gain of ob/ob mice and decreased hyperglycemia compared to ob/ob mice fed the standard diet. The main findings show that genistein treatment increased insulin sensitivity and the expression levels of the neurotrophic factors nerve growth factor (NGF) and brain-derived neurotrophic factors (BDNF). In these mice, genistein also reduced Aβ deposition and the level of hyper-phosphorylated Tau protein.Conclusion: The results of our study indicate the beneficial effects of genistein in the obese diabetic mouse brain, including improving brain insulin signaling, increasing neurotrophic support, and alleviating Alzheimer’s disease-related pathology.Keywords: isoflavones, leptin-deficient mice, brain injury, insulin signaling, amyloid beta
abstractGer	Rong-zi Li,1 Xiao-Wen Ding,1 Thangiah Geetha,1 Layla Al-Nakkash,2 Tom L Broderick,2 Jeganathan Ramesh Babu1 1Department of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA; 2Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USACorrespondence: Jeganathan Ramesh BabuDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USATel +1 334 844 3840 Fax +1 334 844 3268Email jeganrbauburn.eduPurpose: Diabetes mellitus (DM)-induced brain damage is characterized by cellular, molecular and functional changes. The mechanisms include oxidative stress, neuroinflammation, reduction of neurotrophic factors, insulin resistance, excessive amyloid beta (Aβ) deposition and Tau phosphorylation. Both antidiabetic and neuroprotective effects of the phytoestrogen genistein have been reported. However, the beneficial effect of genistein in brain of the ob/ob mouse model of severe obesity and diabetes remains to be determined.Methods: In this study, female ob/ob mice and lean control mice were fed with either a standard diet or a diet containing genistein (600mg/kg) for a period of 4 weeks. Body weight was monitored weekly. Blood was collected for the measurement of glucose, insulin and common cytokines. Mice brains were isolated for Western immunoblotting analyses.Results: Treatment with genistein reduced weight gain of ob/ob mice and decreased hyperglycemia compared to ob/ob mice fed the standard diet. The main findings show that genistein treatment increased insulin sensitivity and the expression levels of the neurotrophic factors nerve growth factor (NGF) and brain-derived neurotrophic factors (BDNF). In these mice, genistein also reduced Aβ deposition and the level of hyper-phosphorylated Tau protein.Conclusion: The results of our study indicate the beneficial effects of genistein in the obese diabetic mouse brain, including improving brain insulin signaling, increasing neurotrophic support, and alleviating Alzheimer’s disease-related pathology.Keywords: isoflavones, leptin-deficient mice, brain injury, insulin signaling, amyloid beta
abstract_unstemmed	Rong-zi Li,1 Xiao-Wen Ding,1 Thangiah Geetha,1 Layla Al-Nakkash,2 Tom L Broderick,2 Jeganathan Ramesh Babu1 1Department of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA; 2Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USACorrespondence: Jeganathan Ramesh BabuDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USATel +1 334 844 3840 Fax +1 334 844 3268Email jeganrbauburn.eduPurpose: Diabetes mellitus (DM)-induced brain damage is characterized by cellular, molecular and functional changes. The mechanisms include oxidative stress, neuroinflammation, reduction of neurotrophic factors, insulin resistance, excessive amyloid beta (Aβ) deposition and Tau phosphorylation. Both antidiabetic and neuroprotective effects of the phytoestrogen genistein have been reported. However, the beneficial effect of genistein in brain of the ob/ob mouse model of severe obesity and diabetes remains to be determined.Methods: In this study, female ob/ob mice and lean control mice were fed with either a standard diet or a diet containing genistein (600mg/kg) for a period of 4 weeks. Body weight was monitored weekly. Blood was collected for the measurement of glucose, insulin and common cytokines. Mice brains were isolated for Western immunoblotting analyses.Results: Treatment with genistein reduced weight gain of ob/ob mice and decreased hyperglycemia compared to ob/ob mice fed the standard diet. The main findings show that genistein treatment increased insulin sensitivity and the expression levels of the neurotrophic factors nerve growth factor (NGF) and brain-derived neurotrophic factors (BDNF). In these mice, genistein also reduced Aβ deposition and the level of hyper-phosphorylated Tau protein.Conclusion: The results of our study indicate the beneficial effects of genistein in the obese diabetic mouse brain, including improving brain insulin signaling, increasing neurotrophic support, and alleviating Alzheimer’s disease-related pathology.Keywords: isoflavones, leptin-deficient mice, brain injury, insulin signaling, amyloid beta
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title_short	Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model
url	https://doaj.org/article/4001f16ec4ce4c06aa51af58d1261090 https://www.dovepress.com/beneficial-effect-of-genistein-on-diabetes-induced-brain-damage-in-the-peer-reviewed-article-DDDT https://doaj.org/toc/1177-8881
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