The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience

Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality ar...
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Autor*in:	Arianna Di Molfetta [verfasserIn] Fabrizio Gandolfo [verfasserIn] Sergio Filippelli [verfasserIn] Gianluigi Perri [verfasserIn] Luca Di Chiara [verfasserIn] Roberta Iacobelli [verfasserIn] Rachele Adorisio [verfasserIn] Isabella Favia [verfasserIn] Alessandra Rizza [verfasserIn] Giuseppina Testa [verfasserIn] Matteo Di Nardo [verfasserIn] Antonio Amodeo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Pediatric heart failure Berlin Heart Pediatric VAD Low weight LVAD Survival on pediatric LVAD

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 7(2016)
Übergeordnetes Werk:	volume:7 ; year:2016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2016.00614

Katalog-ID:	DOAJ009168087

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520			\|a Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality are smallest patients namely the ones implanted in the first year of life or with a lower body surface area. This work aims at retrospective reviewing a single centre experience in using BHE in children with a body weight under 10kg. Methods: Data of all pediatric patients under 10kg undergoing BHE implantation in our institution from March 2002 to March 2016 were retrospectively reviewed Results: Of the 30 patients enrolled in the study, 53% were male, 87% were affected by a dilated cardiomyopathy with an average weight and age at the implantation of 6.75±2.16Kg and 11.57±10.12 months, respectively. Three patients (10%) required a BIVAD implantation. After the implantation, 7 patients (23%) required re-intervention for bleeding and 9 patients (30%) experienced BHE cannulas infection. A total of 56 BHE pump were changed for thrombus formation (1.86 BHE pump for patient). The average duration of VAD support was 132.8±94.4 days. Twenty patients (67%) were successfully transplanted and 10 patients (33%) died: 7 for major neurological complication and 3 for sepsis. Conclusion: Mechanical support in smaller children with end stage heart failure is an effective strategy for bridging patients to HTx. The need for BIVAD was relegated, in the last years, only to restrictive cardiomiopathy. Further efforts are required in small infants to improve anticoagulation strategy to reduce neurological events and BHE pump changes.
650		4	\|a Pediatric heart failure
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650		4	\|a Pediatric VAD
650		4	\|a Low weight LVAD
650		4	\|a Survival on pediatric LVAD
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allfields	10.3389/fphys.2016.00614 doi (DE-627)DOAJ009168087 (DE-599)DOAJcfaa79c6e0004ee6afbd865a29d1dbda DE-627 ger DE-627 rakwb eng QP1-981 Arianna Di Molfetta verfasserin aut The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality are smallest patients namely the ones implanted in the first year of life or with a lower body surface area. This work aims at retrospective reviewing a single centre experience in using BHE in children with a body weight under 10kg. Methods: Data of all pediatric patients under 10kg undergoing BHE implantation in our institution from March 2002 to March 2016 were retrospectively reviewed Results: Of the 30 patients enrolled in the study, 53% were male, 87% were affected by a dilated cardiomyopathy with an average weight and age at the implantation of 6.75±2.16Kg and 11.57±10.12 months, respectively. Three patients (10%) required a BIVAD implantation. After the implantation, 7 patients (23%) required re-intervention for bleeding and 9 patients (30%) experienced BHE cannulas infection. A total of 56 BHE pump were changed for thrombus formation (1.86 BHE pump for patient). The average duration of VAD support was 132.8±94.4 days. Twenty patients (67%) were successfully transplanted and 10 patients (33%) died: 7 for major neurological complication and 3 for sepsis. Conclusion: Mechanical support in smaller children with end stage heart failure is an effective strategy for bridging patients to HTx. The need for BIVAD was relegated, in the last years, only to restrictive cardiomiopathy. Further efforts are required in small infants to improve anticoagulation strategy to reduce neurological events and BHE pump changes. Pediatric heart failure Berlin Heart Pediatric VAD Low weight LVAD Survival on pediatric LVAD Physiology Fabrizio Gandolfo verfasserin aut Sergio Filippelli verfasserin aut Gianluigi Perri verfasserin aut Luca Di Chiara verfasserin aut Roberta Iacobelli verfasserin aut Rachele Adorisio verfasserin aut Isabella Favia verfasserin aut Alessandra Rizza verfasserin aut Giuseppina Testa verfasserin aut Matteo Di Nardo verfasserin aut Antonio Amodeo verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 7(2016) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:7 year:2016 https://doi.org/10.3389/fphys.2016.00614 kostenfrei https://doaj.org/article/cfaa79c6e0004ee6afbd865a29d1dbda kostenfrei http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00614/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016
spelling	10.3389/fphys.2016.00614 doi (DE-627)DOAJ009168087 (DE-599)DOAJcfaa79c6e0004ee6afbd865a29d1dbda DE-627 ger DE-627 rakwb eng QP1-981 Arianna Di Molfetta verfasserin aut The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality are smallest patients namely the ones implanted in the first year of life or with a lower body surface area. This work aims at retrospective reviewing a single centre experience in using BHE in children with a body weight under 10kg. Methods: Data of all pediatric patients under 10kg undergoing BHE implantation in our institution from March 2002 to March 2016 were retrospectively reviewed Results: Of the 30 patients enrolled in the study, 53% were male, 87% were affected by a dilated cardiomyopathy with an average weight and age at the implantation of 6.75±2.16Kg and 11.57±10.12 months, respectively. Three patients (10%) required a BIVAD implantation. After the implantation, 7 patients (23%) required re-intervention for bleeding and 9 patients (30%) experienced BHE cannulas infection. A total of 56 BHE pump were changed for thrombus formation (1.86 BHE pump for patient). The average duration of VAD support was 132.8±94.4 days. Twenty patients (67%) were successfully transplanted and 10 patients (33%) died: 7 for major neurological complication and 3 for sepsis. Conclusion: Mechanical support in smaller children with end stage heart failure is an effective strategy for bridging patients to HTx. The need for BIVAD was relegated, in the last years, only to restrictive cardiomiopathy. Further efforts are required in small infants to improve anticoagulation strategy to reduce neurological events and BHE pump changes. Pediatric heart failure Berlin Heart Pediatric VAD Low weight LVAD Survival on pediatric LVAD Physiology Fabrizio Gandolfo verfasserin aut Sergio Filippelli verfasserin aut Gianluigi Perri verfasserin aut Luca Di Chiara verfasserin aut Roberta Iacobelli verfasserin aut Rachele Adorisio verfasserin aut Isabella Favia verfasserin aut Alessandra Rizza verfasserin aut Giuseppina Testa verfasserin aut Matteo Di Nardo verfasserin aut Antonio Amodeo verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 7(2016) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:7 year:2016 https://doi.org/10.3389/fphys.2016.00614 kostenfrei https://doaj.org/article/cfaa79c6e0004ee6afbd865a29d1dbda kostenfrei http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00614/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016
allfields_unstemmed	10.3389/fphys.2016.00614 doi (DE-627)DOAJ009168087 (DE-599)DOAJcfaa79c6e0004ee6afbd865a29d1dbda DE-627 ger DE-627 rakwb eng QP1-981 Arianna Di Molfetta verfasserin aut The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality are smallest patients namely the ones implanted in the first year of life or with a lower body surface area. This work aims at retrospective reviewing a single centre experience in using BHE in children with a body weight under 10kg. Methods: Data of all pediatric patients under 10kg undergoing BHE implantation in our institution from March 2002 to March 2016 were retrospectively reviewed Results: Of the 30 patients enrolled in the study, 53% were male, 87% were affected by a dilated cardiomyopathy with an average weight and age at the implantation of 6.75±2.16Kg and 11.57±10.12 months, respectively. Three patients (10%) required a BIVAD implantation. After the implantation, 7 patients (23%) required re-intervention for bleeding and 9 patients (30%) experienced BHE cannulas infection. A total of 56 BHE pump were changed for thrombus formation (1.86 BHE pump for patient). The average duration of VAD support was 132.8±94.4 days. Twenty patients (67%) were successfully transplanted and 10 patients (33%) died: 7 for major neurological complication and 3 for sepsis. Conclusion: Mechanical support in smaller children with end stage heart failure is an effective strategy for bridging patients to HTx. The need for BIVAD was relegated, in the last years, only to restrictive cardiomiopathy. Further efforts are required in small infants to improve anticoagulation strategy to reduce neurological events and BHE pump changes. Pediatric heart failure Berlin Heart Pediatric VAD Low weight LVAD Survival on pediatric LVAD Physiology Fabrizio Gandolfo verfasserin aut Sergio Filippelli verfasserin aut Gianluigi Perri verfasserin aut Luca Di Chiara verfasserin aut Roberta Iacobelli verfasserin aut Rachele Adorisio verfasserin aut Isabella Favia verfasserin aut Alessandra Rizza verfasserin aut Giuseppina Testa verfasserin aut Matteo Di Nardo verfasserin aut Antonio Amodeo verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 7(2016) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:7 year:2016 https://doi.org/10.3389/fphys.2016.00614 kostenfrei https://doaj.org/article/cfaa79c6e0004ee6afbd865a29d1dbda kostenfrei http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00614/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016
allfieldsGer	10.3389/fphys.2016.00614 doi (DE-627)DOAJ009168087 (DE-599)DOAJcfaa79c6e0004ee6afbd865a29d1dbda DE-627 ger DE-627 rakwb eng QP1-981 Arianna Di Molfetta verfasserin aut The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality are smallest patients namely the ones implanted in the first year of life or with a lower body surface area. This work aims at retrospective reviewing a single centre experience in using BHE in children with a body weight under 10kg. Methods: Data of all pediatric patients under 10kg undergoing BHE implantation in our institution from March 2002 to March 2016 were retrospectively reviewed Results: Of the 30 patients enrolled in the study, 53% were male, 87% were affected by a dilated cardiomyopathy with an average weight and age at the implantation of 6.75±2.16Kg and 11.57±10.12 months, respectively. Three patients (10%) required a BIVAD implantation. After the implantation, 7 patients (23%) required re-intervention for bleeding and 9 patients (30%) experienced BHE cannulas infection. A total of 56 BHE pump were changed for thrombus formation (1.86 BHE pump for patient). The average duration of VAD support was 132.8±94.4 days. Twenty patients (67%) were successfully transplanted and 10 patients (33%) died: 7 for major neurological complication and 3 for sepsis. Conclusion: Mechanical support in smaller children with end stage heart failure is an effective strategy for bridging patients to HTx. The need for BIVAD was relegated, in the last years, only to restrictive cardiomiopathy. Further efforts are required in small infants to improve anticoagulation strategy to reduce neurological events and BHE pump changes. Pediatric heart failure Berlin Heart Pediatric VAD Low weight LVAD Survival on pediatric LVAD Physiology Fabrizio Gandolfo verfasserin aut Sergio Filippelli verfasserin aut Gianluigi Perri verfasserin aut Luca Di Chiara verfasserin aut Roberta Iacobelli verfasserin aut Rachele Adorisio verfasserin aut Isabella Favia verfasserin aut Alessandra Rizza verfasserin aut Giuseppina Testa verfasserin aut Matteo Di Nardo verfasserin aut Antonio Amodeo verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 7(2016) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:7 year:2016 https://doi.org/10.3389/fphys.2016.00614 kostenfrei https://doaj.org/article/cfaa79c6e0004ee6afbd865a29d1dbda kostenfrei http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00614/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016
allfieldsSound	10.3389/fphys.2016.00614 doi (DE-627)DOAJ009168087 (DE-599)DOAJcfaa79c6e0004ee6afbd865a29d1dbda DE-627 ger DE-627 rakwb eng QP1-981 Arianna Di Molfetta verfasserin aut The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality are smallest patients namely the ones implanted in the first year of life or with a lower body surface area. This work aims at retrospective reviewing a single centre experience in using BHE in children with a body weight under 10kg. Methods: Data of all pediatric patients under 10kg undergoing BHE implantation in our institution from March 2002 to March 2016 were retrospectively reviewed Results: Of the 30 patients enrolled in the study, 53% were male, 87% were affected by a dilated cardiomyopathy with an average weight and age at the implantation of 6.75±2.16Kg and 11.57±10.12 months, respectively. Three patients (10%) required a BIVAD implantation. After the implantation, 7 patients (23%) required re-intervention for bleeding and 9 patients (30%) experienced BHE cannulas infection. A total of 56 BHE pump were changed for thrombus formation (1.86 BHE pump for patient). The average duration of VAD support was 132.8±94.4 days. Twenty patients (67%) were successfully transplanted and 10 patients (33%) died: 7 for major neurological complication and 3 for sepsis. Conclusion: Mechanical support in smaller children with end stage heart failure is an effective strategy for bridging patients to HTx. The need for BIVAD was relegated, in the last years, only to restrictive cardiomiopathy. Further efforts are required in small infants to improve anticoagulation strategy to reduce neurological events and BHE pump changes. Pediatric heart failure Berlin Heart Pediatric VAD Low weight LVAD Survival on pediatric LVAD Physiology Fabrizio Gandolfo verfasserin aut Sergio Filippelli verfasserin aut Gianluigi Perri verfasserin aut Luca Di Chiara verfasserin aut Roberta Iacobelli verfasserin aut Rachele Adorisio verfasserin aut Isabella Favia verfasserin aut Alessandra Rizza verfasserin aut Giuseppina Testa verfasserin aut Matteo Di Nardo verfasserin aut Antonio Amodeo verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 7(2016) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:7 year:2016 https://doi.org/10.3389/fphys.2016.00614 kostenfrei https://doaj.org/article/cfaa79c6e0004ee6afbd865a29d1dbda kostenfrei http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00614/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016
language	English
source	In Frontiers in Physiology 7(2016) volume:7 year:2016
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authorswithroles_txt_mv	Arianna Di Molfetta @@aut@@ Fabrizio Gandolfo @@aut@@ Sergio Filippelli @@aut@@ Gianluigi Perri @@aut@@ Luca Di Chiara @@aut@@ Roberta Iacobelli @@aut@@ Rachele Adorisio @@aut@@ Isabella Favia @@aut@@ Alessandra Rizza @@aut@@ Giuseppina Testa @@aut@@ Matteo Di Nardo @@aut@@ Antonio Amodeo @@aut@@
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author	Arianna Di Molfetta
spellingShingle	Arianna Di Molfetta misc QP1-981 misc Pediatric heart failure misc Berlin Heart misc Pediatric VAD misc Low weight LVAD misc Survival on pediatric LVAD misc Physiology The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience
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topic_title	QP1-981 The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience Pediatric heart failure Berlin Heart Pediatric VAD Low weight LVAD Survival on pediatric LVAD
topic	misc QP1-981 misc Pediatric heart failure misc Berlin Heart misc Pediatric VAD misc Low weight LVAD misc Survival on pediatric LVAD misc Physiology
topic_unstemmed	misc QP1-981 misc Pediatric heart failure misc Berlin Heart misc Pediatric VAD misc Low weight LVAD misc Survival on pediatric LVAD misc Physiology
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title	The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience
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title_sort	use of berlin heart excor vad in children less than 10kg: a single center experience
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title_auth	The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience
abstract	Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality are smallest patients namely the ones implanted in the first year of life or with a lower body surface area. This work aims at retrospective reviewing a single centre experience in using BHE in children with a body weight under 10kg. Methods: Data of all pediatric patients under 10kg undergoing BHE implantation in our institution from March 2002 to March 2016 were retrospectively reviewed Results: Of the 30 patients enrolled in the study, 53% were male, 87% were affected by a dilated cardiomyopathy with an average weight and age at the implantation of 6.75±2.16Kg and 11.57±10.12 months, respectively. Three patients (10%) required a BIVAD implantation. After the implantation, 7 patients (23%) required re-intervention for bleeding and 9 patients (30%) experienced BHE cannulas infection. A total of 56 BHE pump were changed for thrombus formation (1.86 BHE pump for patient). The average duration of VAD support was 132.8±94.4 days. Twenty patients (67%) were successfully transplanted and 10 patients (33%) died: 7 for major neurological complication and 3 for sepsis. Conclusion: Mechanical support in smaller children with end stage heart failure is an effective strategy for bridging patients to HTx. The need for BIVAD was relegated, in the last years, only to restrictive cardiomiopathy. Further efforts are required in small infants to improve anticoagulation strategy to reduce neurological events and BHE pump changes.
abstractGer	Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality are smallest patients namely the ones implanted in the first year of life or with a lower body surface area. This work aims at retrospective reviewing a single centre experience in using BHE in children with a body weight under 10kg. Methods: Data of all pediatric patients under 10kg undergoing BHE implantation in our institution from March 2002 to March 2016 were retrospectively reviewed Results: Of the 30 patients enrolled in the study, 53% were male, 87% were affected by a dilated cardiomyopathy with an average weight and age at the implantation of 6.75±2.16Kg and 11.57±10.12 months, respectively. Three patients (10%) required a BIVAD implantation. After the implantation, 7 patients (23%) required re-intervention for bleeding and 9 patients (30%) experienced BHE cannulas infection. A total of 56 BHE pump were changed for thrombus formation (1.86 BHE pump for patient). The average duration of VAD support was 132.8±94.4 days. Twenty patients (67%) were successfully transplanted and 10 patients (33%) died: 7 for major neurological complication and 3 for sepsis. Conclusion: Mechanical support in smaller children with end stage heart failure is an effective strategy for bridging patients to HTx. The need for BIVAD was relegated, in the last years, only to restrictive cardiomiopathy. Further efforts are required in small infants to improve anticoagulation strategy to reduce neurological events and BHE pump changes.
abstract_unstemmed	Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality are smallest patients namely the ones implanted in the first year of life or with a lower body surface area. This work aims at retrospective reviewing a single centre experience in using BHE in children with a body weight under 10kg. Methods: Data of all pediatric patients under 10kg undergoing BHE implantation in our institution from March 2002 to March 2016 were retrospectively reviewed Results: Of the 30 patients enrolled in the study, 53% were male, 87% were affected by a dilated cardiomyopathy with an average weight and age at the implantation of 6.75±2.16Kg and 11.57±10.12 months, respectively. Three patients (10%) required a BIVAD implantation. After the implantation, 7 patients (23%) required re-intervention for bleeding and 9 patients (30%) experienced BHE cannulas infection. A total of 56 BHE pump were changed for thrombus formation (1.86 BHE pump for patient). The average duration of VAD support was 132.8±94.4 days. Twenty patients (67%) were successfully transplanted and 10 patients (33%) died: 7 for major neurological complication and 3 for sepsis. Conclusion: Mechanical support in smaller children with end stage heart failure is an effective strategy for bridging patients to HTx. The need for BIVAD was relegated, in the last years, only to restrictive cardiomiopathy. Further efforts are required in small infants to improve anticoagulation strategy to reduce neurological events and BHE pump changes.
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title_short	The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience
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Particularly demanding in terms of morbidity and mortality are smallest patients namely the ones implanted in the first year of life or with a lower body surface area. This work aims at retrospective reviewing a single centre experience in using BHE in children with a body weight under 10kg. Methods: Data of all pediatric patients under 10kg undergoing BHE implantation in our institution from March 2002 to March 2016 were retrospectively reviewed Results: Of the 30 patients enrolled in the study, 53% were male, 87% were affected by a dilated cardiomyopathy with an average weight and age at the implantation of 6.75±2.16Kg and 11.57±10.12 months, respectively. Three patients (10%) required a BIVAD implantation. After the implantation, 7 patients (23%) required re-intervention for bleeding and 9 patients (30%) experienced BHE cannulas infection. A total of 56 BHE pump were changed for thrombus formation (1.86 BHE pump for patient). The average duration of VAD support was 132.8±94.4 days. Twenty patients (67%) were successfully transplanted and 10 patients (33%) died: 7 for major neurological complication and 3 for sepsis. Conclusion: Mechanical support in smaller children with end stage heart failure is an effective strategy for bridging patients to HTx. The need for BIVAD was relegated, in the last years, only to restrictive cardiomiopathy. 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The use of Berlin Heart EXCOR VAD in children less than 10kg: a single center experience

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