The Contribution of the Immune System in Bone Metastasis Pathogenesis

Bone metastasis is associated with significant morbidity for cancer patients and results in a reduced quality of life. The bone marrow is a fertile soil containing a complex composition of immune cells that may actually provide an immune-privileged niche for disseminated tumor cells to colonize and...
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Gespeichert in:

Autor*in:	Lisha Xiang [verfasserIn] Daniele M. Gilkes [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	bone metastasis immune system immunotherapy

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 20(2019), 4, p 999
Übergeordnetes Werk:	volume:20 ; year:2019 ; number:4, p 999

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms20040999

Katalog-ID:	DOAJ009203079

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spelling	10.3390/ijms20040999 doi (DE-627)DOAJ009203079 (DE-599)DOAJ1758fa3325e7471ba9ece08f21a1b8b8 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Lisha Xiang verfasserin aut The Contribution of the Immune System in Bone Metastasis Pathogenesis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bone metastasis is associated with significant morbidity for cancer patients and results in a reduced quality of life. The bone marrow is a fertile soil containing a complex composition of immune cells that may actually provide an immune-privileged niche for disseminated tumor cells to colonize and proliferate. In this unique immune milieu, multiple immune cells including T cells, natural killer cells, macrophages, dendritic cells, myeloid-derived suppressor cells, and neutrophils are involved in the process of bone metastasis. In this review, we will discuss the crosstalk between immune cells in bone microenvironment and their involvement with cancer cell metastasis to the bone. Furthermore, we will highlight the anti-tumoral and pro-tumoral function of each immune cell type that contributes to bone metastasis. We will end with a discussion of current therapeutic strategies aimed at sensitizing immune cells. bone metastasis immune system immunotherapy Biology (General) Chemistry Daniele M. Gilkes verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 4, p 999 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:4, p 999 https://doi.org/10.3390/ijms20040999 kostenfrei https://doaj.org/article/1758fa3325e7471ba9ece08f21a1b8b8 kostenfrei https://www.mdpi.com/1422-0067/20/4/999 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 4, p 999
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allfieldsSound	10.3390/ijms20040999 doi (DE-627)DOAJ009203079 (DE-599)DOAJ1758fa3325e7471ba9ece08f21a1b8b8 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Lisha Xiang verfasserin aut The Contribution of the Immune System in Bone Metastasis Pathogenesis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bone metastasis is associated with significant morbidity for cancer patients and results in a reduced quality of life. The bone marrow is a fertile soil containing a complex composition of immune cells that may actually provide an immune-privileged niche for disseminated tumor cells to colonize and proliferate. In this unique immune milieu, multiple immune cells including T cells, natural killer cells, macrophages, dendritic cells, myeloid-derived suppressor cells, and neutrophils are involved in the process of bone metastasis. In this review, we will discuss the crosstalk between immune cells in bone microenvironment and their involvement with cancer cell metastasis to the bone. Furthermore, we will highlight the anti-tumoral and pro-tumoral function of each immune cell type that contributes to bone metastasis. We will end with a discussion of current therapeutic strategies aimed at sensitizing immune cells. bone metastasis immune system immunotherapy Biology (General) Chemistry Daniele M. Gilkes verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 4, p 999 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:4, p 999 https://doi.org/10.3390/ijms20040999 kostenfrei https://doaj.org/article/1758fa3325e7471ba9ece08f21a1b8b8 kostenfrei https://www.mdpi.com/1422-0067/20/4/999 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 4, p 999
language	English
source	In International Journal of Molecular Sciences 20(2019), 4, p 999 volume:20 year:2019 number:4, p 999
sourceStr	In International Journal of Molecular Sciences 20(2019), 4, p 999 volume:20 year:2019 number:4, p 999
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topic_facet	bone metastasis immune system immunotherapy Biology (General) Chemistry
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callnumber-first	Q - Science
author	Lisha Xiang
spellingShingle	Lisha Xiang misc QH301-705.5 misc QD1-999 misc bone metastasis misc immune system misc immunotherapy misc Biology (General) misc Chemistry The Contribution of the Immune System in Bone Metastasis Pathogenesis
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topic_title	QH301-705.5 QD1-999 The Contribution of the Immune System in Bone Metastasis Pathogenesis bone metastasis immune system immunotherapy
topic	misc QH301-705.5 misc QD1-999 misc bone metastasis misc immune system misc immunotherapy misc Biology (General) misc Chemistry
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title	The Contribution of the Immune System in Bone Metastasis Pathogenesis
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title_auth	The Contribution of the Immune System in Bone Metastasis Pathogenesis
abstract	Bone metastasis is associated with significant morbidity for cancer patients and results in a reduced quality of life. The bone marrow is a fertile soil containing a complex composition of immune cells that may actually provide an immune-privileged niche for disseminated tumor cells to colonize and proliferate. In this unique immune milieu, multiple immune cells including T cells, natural killer cells, macrophages, dendritic cells, myeloid-derived suppressor cells, and neutrophils are involved in the process of bone metastasis. In this review, we will discuss the crosstalk between immune cells in bone microenvironment and their involvement with cancer cell metastasis to the bone. Furthermore, we will highlight the anti-tumoral and pro-tumoral function of each immune cell type that contributes to bone metastasis. We will end with a discussion of current therapeutic strategies aimed at sensitizing immune cells.
abstractGer	Bone metastasis is associated with significant morbidity for cancer patients and results in a reduced quality of life. The bone marrow is a fertile soil containing a complex composition of immune cells that may actually provide an immune-privileged niche for disseminated tumor cells to colonize and proliferate. In this unique immune milieu, multiple immune cells including T cells, natural killer cells, macrophages, dendritic cells, myeloid-derived suppressor cells, and neutrophils are involved in the process of bone metastasis. In this review, we will discuss the crosstalk between immune cells in bone microenvironment and their involvement with cancer cell metastasis to the bone. Furthermore, we will highlight the anti-tumoral and pro-tumoral function of each immune cell type that contributes to bone metastasis. We will end with a discussion of current therapeutic strategies aimed at sensitizing immune cells.
abstract_unstemmed	Bone metastasis is associated with significant morbidity for cancer patients and results in a reduced quality of life. The bone marrow is a fertile soil containing a complex composition of immune cells that may actually provide an immune-privileged niche for disseminated tumor cells to colonize and proliferate. In this unique immune milieu, multiple immune cells including T cells, natural killer cells, macrophages, dendritic cells, myeloid-derived suppressor cells, and neutrophils are involved in the process of bone metastasis. In this review, we will discuss the crosstalk between immune cells in bone microenvironment and their involvement with cancer cell metastasis to the bone. Furthermore, we will highlight the anti-tumoral and pro-tumoral function of each immune cell type that contributes to bone metastasis. We will end with a discussion of current therapeutic strategies aimed at sensitizing immune cells.
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title_short	The Contribution of the Immune System in Bone Metastasis Pathogenesis
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