Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study

Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but availabl...
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Autor*in:	Artur Reginia [verfasserIn] Jerzy Samochowiec [verfasserIn] Marcin Jabłoński [verfasserIn] Ewa Ferensztajn-Rochowiak [verfasserIn] Janusz K. Rybakowski [verfasserIn] Arkadiusz Telesiński [verfasserIn] Maciej Tarnowski [verfasserIn] Błażej Misiak [verfasserIn] Mariusz Z. Ratajczak [verfasserIn] Jolanta Kucharska-Mazur [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	stem cells VSEL bipolar disorder

Übergeordnetes Werk:	In: Brain Sciences - MDPI AG, 2012, 10(2020), 7, p 408
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:7, p 408

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/brainsci10070408

Katalog-ID:	DOAJ009212485

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allfieldsGer	10.3390/brainsci10070408 doi (DE-627)DOAJ009212485 (DE-599)DOAJ16a31e4f65f84271992455f89437d5ea DE-627 ger DE-627 rakwb eng RC321-571 Artur Reginia verfasserin aut Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder. stem cells VSEL bipolar disorder Neurosciences. Biological psychiatry. Neuropsychiatry Jerzy Samochowiec verfasserin aut Marcin Jabłoński verfasserin aut Ewa Ferensztajn-Rochowiak verfasserin aut Janusz K. Rybakowski verfasserin aut Arkadiusz Telesiński verfasserin aut Maciej Tarnowski verfasserin aut Błażej Misiak verfasserin aut Mariusz Z. Ratajczak verfasserin aut Jolanta Kucharska-Mazur verfasserin aut In Brain Sciences MDPI AG, 2012 10(2020), 7, p 408 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:10 year:2020 number:7, p 408 https://doi.org/10.3390/brainsci10070408 kostenfrei https://doaj.org/article/16a31e4f65f84271992455f89437d5ea kostenfrei https://www.mdpi.com/2076-3425/10/7/408 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 7, p 408
allfieldsSound	10.3390/brainsci10070408 doi (DE-627)DOAJ009212485 (DE-599)DOAJ16a31e4f65f84271992455f89437d5ea DE-627 ger DE-627 rakwb eng RC321-571 Artur Reginia verfasserin aut Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder. stem cells VSEL bipolar disorder Neurosciences. Biological psychiatry. Neuropsychiatry Jerzy Samochowiec verfasserin aut Marcin Jabłoński verfasserin aut Ewa Ferensztajn-Rochowiak verfasserin aut Janusz K. Rybakowski verfasserin aut Arkadiusz Telesiński verfasserin aut Maciej Tarnowski verfasserin aut Błażej Misiak verfasserin aut Mariusz Z. Ratajczak verfasserin aut Jolanta Kucharska-Mazur verfasserin aut In Brain Sciences MDPI AG, 2012 10(2020), 7, p 408 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:10 year:2020 number:7, p 408 https://doi.org/10.3390/brainsci10070408 kostenfrei https://doaj.org/article/16a31e4f65f84271992455f89437d5ea kostenfrei https://www.mdpi.com/2076-3425/10/7/408 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 7, p 408
language	English
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sourceStr	In Brain Sciences 10(2020), 7, p 408 volume:10 year:2020 number:7, p 408
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authorswithroles_txt_mv	Artur Reginia @@aut@@ Jerzy Samochowiec @@aut@@ Marcin Jabłoński @@aut@@ Ewa Ferensztajn-Rochowiak @@aut@@ Janusz K. Rybakowski @@aut@@ Arkadiusz Telesiński @@aut@@ Maciej Tarnowski @@aut@@ Błażej Misiak @@aut@@ Mariusz Z. Ratajczak @@aut@@ Jolanta Kucharska-Mazur @@aut@@
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callnumber-first	R - Medicine
author	Artur Reginia
spellingShingle	Artur Reginia misc RC321-571 misc stem cells misc VSEL misc bipolar disorder misc Neurosciences. Biological psychiatry. Neuropsychiatry Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study
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topic_title	RC321-571 Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study stem cells VSEL bipolar disorder
topic	misc RC321-571 misc stem cells misc VSEL misc bipolar disorder misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc stem cells misc VSEL misc bipolar disorder misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study
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author_browse	Artur Reginia Jerzy Samochowiec Marcin Jabłoński Ewa Ferensztajn-Rochowiak Janusz K. Rybakowski Arkadiusz Telesiński Maciej Tarnowski Błażej Misiak Mariusz Z. Ratajczak Jolanta Kucharska-Mazur
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title_sort	markers of regenerative processes in patients with bipolar disorder: a case-control study
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title_auth	Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study
abstract	Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder.
abstractGer	Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder.
abstract_unstemmed	Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder.
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title_short	Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study
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up_date	2024-07-03T22:33:55.801Z
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