Mutans streptococci genetic strains in children with severe early childhood caries: follow-up study at one-year post-dental rehabilitation therapy
Background: Genotypic strains of cariogenic mutans streptococci (MS) may vary in important virulence properties. In previous published studies, we identified 39 MS strains from pediatric patients undergoing full-mouth dental rehabilitation, including the removal and/or repair of carious lesions and...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Elizabeth A. Palmer [verfasserIn] Alex Vo [verfasserIn] Shelby B. Hiles [verfasserIn] Patricia Peirano [verfasserIn] Samyia Chaudhry [verfasserIn] Amy Trevor [verfasserIn] Iraj Kasimi [verfasserIn] Jill Pollard [verfasserIn] Christopher Kyles [verfasserIn] Michael Leo [verfasserIn] Beth Wilmot [verfasserIn] John Engle [verfasserIn] John Peterson [verfasserIn] Tom Maier [verfasserIn] Curtis A. Machida [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Oral Microbiology - Taylor & Francis Group, 2010, 4(2012), 0, Seite 11 |
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| Übergeordnetes Werk: |
volume:4 ; year:2012 ; number:0 ; pages:11 |
| Links: |
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| DOI / URN: |
10.3402/jom.v4i0.19530 |
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| 520 | |a Background: Genotypic strains of cariogenic mutans streptococci (MS) may vary in important virulence properties. In previous published studies, we identified 39 MS strains from pediatric patients undergoing full-mouth dental rehabilitation, including the removal and/or repair of carious lesions and application of antimicrobial rinse and fluoride varnish. Objectives: The objectives of this current 1-year follow-up study are to assess the variability of MS strains that occur at 1-year post-rehabilitation and characterize the xylitol-resistance properties of MS strains that predominate. Methods: Plaque from five children with severe early childhood caries was collected 1-year post-rehabilitation. MS isolates were subjected to arbitrarily primed-polymerase chain reaction (AP-PCR) for identification of genetic strains and in vitro xylitol-inhibition experiments. To more precisely define strain distributions within each patient, we isolated large numbers of isolates per patient. Results: MS strains diminished from several strains pre-rehabilitation, to one dominant strain at 1-year post-rehabilitation, with several new emergent strains. The majority of the clinical MS strains, as well as the Streptococcus mutans laboratory strains ATCC 25175 and 35668, were predicted to undergo 50% inhibition with 2.48–5.58% xylitol, with some clinical MS strains being significantly more resistant in vitro. Conclusions: Our follow-up study using patients from the original cohort demonstrates that specific MS strains are dominant at 1-year post-dental rehabilitation. Most of the clinical MS strains are similar in xylitol resistance to the attenuated S. mutans ATCC control strains, with some strains being more resistant to xylitol in vitro. | ||
| 650 | 4 | |a mutans streptococci | |
| 650 | 4 | |a distribution of genotypic MS strains | |
| 650 | 4 | |a Streptococcus mutans | |
| 650 | 4 | |a oral streptococci | |
| 650 | 4 | |a severe early childhood caries | |
| 650 | 4 | |a full-mouth dental rehabilitation therapy | |
| 653 | 0 | |a Infectious and parasitic diseases | |
| 653 | 0 | |a Microbiology | |
| 700 | 0 | |a Alex Vo |e verfasserin |4 aut | |
| 700 | 0 | |a Shelby B. Hiles |e verfasserin |4 aut | |
| 700 | 0 | |a Patricia Peirano |e verfasserin |4 aut | |
| 700 | 0 | |a Samyia Chaudhry |e verfasserin |4 aut | |
| 700 | 0 | |a Amy Trevor |e verfasserin |4 aut | |
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| 700 | 0 | |a Jill Pollard |e verfasserin |4 aut | |
| 700 | 0 | |a Christopher Kyles |e verfasserin |4 aut | |
| 700 | 0 | |a Michael Leo |e verfasserin |4 aut | |
| 700 | 0 | |a Beth Wilmot |e verfasserin |4 aut | |
| 700 | 0 | |a John Engle |e verfasserin |4 aut | |
| 700 | 0 | |a John Peterson |e verfasserin |4 aut | |
| 700 | 0 | |a Tom Maier |e verfasserin |4 aut | |
| 700 | 0 | |a Curtis A. Machida |e verfasserin |4 aut | |
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10.3402/jom.v4i0.19530 doi (DE-627)DOAJ00929001X (DE-599)DOAJa011740cb07541908f39c20da8b3723b DE-627 ger DE-627 rakwb eng RC109-216 QR1-502 Elizabeth A. Palmer verfasserin aut Mutans streptococci genetic strains in children with severe early childhood caries: follow-up study at one-year post-dental rehabilitation therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Genotypic strains of cariogenic mutans streptococci (MS) may vary in important virulence properties. In previous published studies, we identified 39 MS strains from pediatric patients undergoing full-mouth dental rehabilitation, including the removal and/or repair of carious lesions and application of antimicrobial rinse and fluoride varnish. Objectives: The objectives of this current 1-year follow-up study are to assess the variability of MS strains that occur at 1-year post-rehabilitation and characterize the xylitol-resistance properties of MS strains that predominate. Methods: Plaque from five children with severe early childhood caries was collected 1-year post-rehabilitation. MS isolates were subjected to arbitrarily primed-polymerase chain reaction (AP-PCR) for identification of genetic strains and in vitro xylitol-inhibition experiments. To more precisely define strain distributions within each patient, we isolated large numbers of isolates per patient. Results: MS strains diminished from several strains pre-rehabilitation, to one dominant strain at 1-year post-rehabilitation, with several new emergent strains. The majority of the clinical MS strains, as well as the Streptococcus mutans laboratory strains ATCC 25175 and 35668, were predicted to undergo 50% inhibition with 2.48–5.58% xylitol, with some clinical MS strains being significantly more resistant in vitro. Conclusions: Our follow-up study using patients from the original cohort demonstrates that specific MS strains are dominant at 1-year post-dental rehabilitation. Most of the clinical MS strains are similar in xylitol resistance to the attenuated S. mutans ATCC control strains, with some strains being more resistant to xylitol in vitro. mutans streptococci distribution of genotypic MS strains Streptococcus mutans oral streptococci severe early childhood caries full-mouth dental rehabilitation therapy Infectious and parasitic diseases Microbiology Alex Vo verfasserin aut Shelby B. Hiles verfasserin aut Patricia Peirano verfasserin aut Samyia Chaudhry verfasserin aut Amy Trevor verfasserin aut Iraj Kasimi verfasserin aut Jill Pollard verfasserin aut Christopher Kyles verfasserin aut Michael Leo verfasserin aut Beth Wilmot verfasserin aut John Engle verfasserin aut John Peterson verfasserin aut Tom Maier verfasserin aut Curtis A. Machida verfasserin aut In Journal of Oral Microbiology Taylor & Francis Group, 2010 4(2012), 0, Seite 11 (DE-627)612653889 (DE-600)2523919-3 20002297 nnns volume:4 year:2012 number:0 pages:11 https://doi.org/10.3402/jom.v4i0.19530 kostenfrei https://doaj.org/article/a011740cb07541908f39c20da8b3723b kostenfrei http://www.journaloforalmicrobiology.net/index.php/jom/article/view/19530/25105 kostenfrei https://doaj.org/toc/2000-2297 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2012 0 11 |
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10.3402/jom.v4i0.19530 doi (DE-627)DOAJ00929001X (DE-599)DOAJa011740cb07541908f39c20da8b3723b DE-627 ger DE-627 rakwb eng RC109-216 QR1-502 Elizabeth A. Palmer verfasserin aut Mutans streptococci genetic strains in children with severe early childhood caries: follow-up study at one-year post-dental rehabilitation therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Genotypic strains of cariogenic mutans streptococci (MS) may vary in important virulence properties. In previous published studies, we identified 39 MS strains from pediatric patients undergoing full-mouth dental rehabilitation, including the removal and/or repair of carious lesions and application of antimicrobial rinse and fluoride varnish. Objectives: The objectives of this current 1-year follow-up study are to assess the variability of MS strains that occur at 1-year post-rehabilitation and characterize the xylitol-resistance properties of MS strains that predominate. Methods: Plaque from five children with severe early childhood caries was collected 1-year post-rehabilitation. MS isolates were subjected to arbitrarily primed-polymerase chain reaction (AP-PCR) for identification of genetic strains and in vitro xylitol-inhibition experiments. To more precisely define strain distributions within each patient, we isolated large numbers of isolates per patient. Results: MS strains diminished from several strains pre-rehabilitation, to one dominant strain at 1-year post-rehabilitation, with several new emergent strains. The majority of the clinical MS strains, as well as the Streptococcus mutans laboratory strains ATCC 25175 and 35668, were predicted to undergo 50% inhibition with 2.48–5.58% xylitol, with some clinical MS strains being significantly more resistant in vitro. Conclusions: Our follow-up study using patients from the original cohort demonstrates that specific MS strains are dominant at 1-year post-dental rehabilitation. Most of the clinical MS strains are similar in xylitol resistance to the attenuated S. mutans ATCC control strains, with some strains being more resistant to xylitol in vitro. mutans streptococci distribution of genotypic MS strains Streptococcus mutans oral streptococci severe early childhood caries full-mouth dental rehabilitation therapy Infectious and parasitic diseases Microbiology Alex Vo verfasserin aut Shelby B. Hiles verfasserin aut Patricia Peirano verfasserin aut Samyia Chaudhry verfasserin aut Amy Trevor verfasserin aut Iraj Kasimi verfasserin aut Jill Pollard verfasserin aut Christopher Kyles verfasserin aut Michael Leo verfasserin aut Beth Wilmot verfasserin aut John Engle verfasserin aut John Peterson verfasserin aut Tom Maier verfasserin aut Curtis A. Machida verfasserin aut In Journal of Oral Microbiology Taylor & Francis Group, 2010 4(2012), 0, Seite 11 (DE-627)612653889 (DE-600)2523919-3 20002297 nnns volume:4 year:2012 number:0 pages:11 https://doi.org/10.3402/jom.v4i0.19530 kostenfrei https://doaj.org/article/a011740cb07541908f39c20da8b3723b kostenfrei http://www.journaloforalmicrobiology.net/index.php/jom/article/view/19530/25105 kostenfrei https://doaj.org/toc/2000-2297 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2012 0 11 |
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10.3402/jom.v4i0.19530 doi (DE-627)DOAJ00929001X (DE-599)DOAJa011740cb07541908f39c20da8b3723b DE-627 ger DE-627 rakwb eng RC109-216 QR1-502 Elizabeth A. Palmer verfasserin aut Mutans streptococci genetic strains in children with severe early childhood caries: follow-up study at one-year post-dental rehabilitation therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Genotypic strains of cariogenic mutans streptococci (MS) may vary in important virulence properties. In previous published studies, we identified 39 MS strains from pediatric patients undergoing full-mouth dental rehabilitation, including the removal and/or repair of carious lesions and application of antimicrobial rinse and fluoride varnish. Objectives: The objectives of this current 1-year follow-up study are to assess the variability of MS strains that occur at 1-year post-rehabilitation and characterize the xylitol-resistance properties of MS strains that predominate. Methods: Plaque from five children with severe early childhood caries was collected 1-year post-rehabilitation. MS isolates were subjected to arbitrarily primed-polymerase chain reaction (AP-PCR) for identification of genetic strains and in vitro xylitol-inhibition experiments. To more precisely define strain distributions within each patient, we isolated large numbers of isolates per patient. Results: MS strains diminished from several strains pre-rehabilitation, to one dominant strain at 1-year post-rehabilitation, with several new emergent strains. The majority of the clinical MS strains, as well as the Streptococcus mutans laboratory strains ATCC 25175 and 35668, were predicted to undergo 50% inhibition with 2.48–5.58% xylitol, with some clinical MS strains being significantly more resistant in vitro. Conclusions: Our follow-up study using patients from the original cohort demonstrates that specific MS strains are dominant at 1-year post-dental rehabilitation. Most of the clinical MS strains are similar in xylitol resistance to the attenuated S. mutans ATCC control strains, with some strains being more resistant to xylitol in vitro. mutans streptococci distribution of genotypic MS strains Streptococcus mutans oral streptococci severe early childhood caries full-mouth dental rehabilitation therapy Infectious and parasitic diseases Microbiology Alex Vo verfasserin aut Shelby B. Hiles verfasserin aut Patricia Peirano verfasserin aut Samyia Chaudhry verfasserin aut Amy Trevor verfasserin aut Iraj Kasimi verfasserin aut Jill Pollard verfasserin aut Christopher Kyles verfasserin aut Michael Leo verfasserin aut Beth Wilmot verfasserin aut John Engle verfasserin aut John Peterson verfasserin aut Tom Maier verfasserin aut Curtis A. Machida verfasserin aut In Journal of Oral Microbiology Taylor & Francis Group, 2010 4(2012), 0, Seite 11 (DE-627)612653889 (DE-600)2523919-3 20002297 nnns volume:4 year:2012 number:0 pages:11 https://doi.org/10.3402/jom.v4i0.19530 kostenfrei https://doaj.org/article/a011740cb07541908f39c20da8b3723b kostenfrei http://www.journaloforalmicrobiology.net/index.php/jom/article/view/19530/25105 kostenfrei https://doaj.org/toc/2000-2297 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2012 0 11 |
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10.3402/jom.v4i0.19530 doi (DE-627)DOAJ00929001X (DE-599)DOAJa011740cb07541908f39c20da8b3723b DE-627 ger DE-627 rakwb eng RC109-216 QR1-502 Elizabeth A. Palmer verfasserin aut Mutans streptococci genetic strains in children with severe early childhood caries: follow-up study at one-year post-dental rehabilitation therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Genotypic strains of cariogenic mutans streptococci (MS) may vary in important virulence properties. In previous published studies, we identified 39 MS strains from pediatric patients undergoing full-mouth dental rehabilitation, including the removal and/or repair of carious lesions and application of antimicrobial rinse and fluoride varnish. Objectives: The objectives of this current 1-year follow-up study are to assess the variability of MS strains that occur at 1-year post-rehabilitation and characterize the xylitol-resistance properties of MS strains that predominate. Methods: Plaque from five children with severe early childhood caries was collected 1-year post-rehabilitation. MS isolates were subjected to arbitrarily primed-polymerase chain reaction (AP-PCR) for identification of genetic strains and in vitro xylitol-inhibition experiments. To more precisely define strain distributions within each patient, we isolated large numbers of isolates per patient. Results: MS strains diminished from several strains pre-rehabilitation, to one dominant strain at 1-year post-rehabilitation, with several new emergent strains. The majority of the clinical MS strains, as well as the Streptococcus mutans laboratory strains ATCC 25175 and 35668, were predicted to undergo 50% inhibition with 2.48–5.58% xylitol, with some clinical MS strains being significantly more resistant in vitro. Conclusions: Our follow-up study using patients from the original cohort demonstrates that specific MS strains are dominant at 1-year post-dental rehabilitation. Most of the clinical MS strains are similar in xylitol resistance to the attenuated S. mutans ATCC control strains, with some strains being more resistant to xylitol in vitro. mutans streptococci distribution of genotypic MS strains Streptococcus mutans oral streptococci severe early childhood caries full-mouth dental rehabilitation therapy Infectious and parasitic diseases Microbiology Alex Vo verfasserin aut Shelby B. Hiles verfasserin aut Patricia Peirano verfasserin aut Samyia Chaudhry verfasserin aut Amy Trevor verfasserin aut Iraj Kasimi verfasserin aut Jill Pollard verfasserin aut Christopher Kyles verfasserin aut Michael Leo verfasserin aut Beth Wilmot verfasserin aut John Engle verfasserin aut John Peterson verfasserin aut Tom Maier verfasserin aut Curtis A. Machida verfasserin aut In Journal of Oral Microbiology Taylor & Francis Group, 2010 4(2012), 0, Seite 11 (DE-627)612653889 (DE-600)2523919-3 20002297 nnns volume:4 year:2012 number:0 pages:11 https://doi.org/10.3402/jom.v4i0.19530 kostenfrei https://doaj.org/article/a011740cb07541908f39c20da8b3723b kostenfrei http://www.journaloforalmicrobiology.net/index.php/jom/article/view/19530/25105 kostenfrei https://doaj.org/toc/2000-2297 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2012 0 11 |
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10.3402/jom.v4i0.19530 doi (DE-627)DOAJ00929001X (DE-599)DOAJa011740cb07541908f39c20da8b3723b DE-627 ger DE-627 rakwb eng RC109-216 QR1-502 Elizabeth A. Palmer verfasserin aut Mutans streptococci genetic strains in children with severe early childhood caries: follow-up study at one-year post-dental rehabilitation therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Genotypic strains of cariogenic mutans streptococci (MS) may vary in important virulence properties. In previous published studies, we identified 39 MS strains from pediatric patients undergoing full-mouth dental rehabilitation, including the removal and/or repair of carious lesions and application of antimicrobial rinse and fluoride varnish. Objectives: The objectives of this current 1-year follow-up study are to assess the variability of MS strains that occur at 1-year post-rehabilitation and characterize the xylitol-resistance properties of MS strains that predominate. Methods: Plaque from five children with severe early childhood caries was collected 1-year post-rehabilitation. MS isolates were subjected to arbitrarily primed-polymerase chain reaction (AP-PCR) for identification of genetic strains and in vitro xylitol-inhibition experiments. To more precisely define strain distributions within each patient, we isolated large numbers of isolates per patient. Results: MS strains diminished from several strains pre-rehabilitation, to one dominant strain at 1-year post-rehabilitation, with several new emergent strains. The majority of the clinical MS strains, as well as the Streptococcus mutans laboratory strains ATCC 25175 and 35668, were predicted to undergo 50% inhibition with 2.48–5.58% xylitol, with some clinical MS strains being significantly more resistant in vitro. Conclusions: Our follow-up study using patients from the original cohort demonstrates that specific MS strains are dominant at 1-year post-dental rehabilitation. Most of the clinical MS strains are similar in xylitol resistance to the attenuated S. mutans ATCC control strains, with some strains being more resistant to xylitol in vitro. mutans streptococci distribution of genotypic MS strains Streptococcus mutans oral streptococci severe early childhood caries full-mouth dental rehabilitation therapy Infectious and parasitic diseases Microbiology Alex Vo verfasserin aut Shelby B. Hiles verfasserin aut Patricia Peirano verfasserin aut Samyia Chaudhry verfasserin aut Amy Trevor verfasserin aut Iraj Kasimi verfasserin aut Jill Pollard verfasserin aut Christopher Kyles verfasserin aut Michael Leo verfasserin aut Beth Wilmot verfasserin aut John Engle verfasserin aut John Peterson verfasserin aut Tom Maier verfasserin aut Curtis A. Machida verfasserin aut In Journal of Oral Microbiology Taylor & Francis Group, 2010 4(2012), 0, Seite 11 (DE-627)612653889 (DE-600)2523919-3 20002297 nnns volume:4 year:2012 number:0 pages:11 https://doi.org/10.3402/jom.v4i0.19530 kostenfrei https://doaj.org/article/a011740cb07541908f39c20da8b3723b kostenfrei http://www.journaloforalmicrobiology.net/index.php/jom/article/view/19530/25105 kostenfrei https://doaj.org/toc/2000-2297 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2012 0 11 |
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Elizabeth A. Palmer @@aut@@ Alex Vo @@aut@@ Shelby B. Hiles @@aut@@ Patricia Peirano @@aut@@ Samyia Chaudhry @@aut@@ Amy Trevor @@aut@@ Iraj Kasimi @@aut@@ Jill Pollard @@aut@@ Christopher Kyles @@aut@@ Michael Leo @@aut@@ Beth Wilmot @@aut@@ John Engle @@aut@@ John Peterson @@aut@@ Tom Maier @@aut@@ Curtis A. Machida @@aut@@ |
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RC109-216 QR1-502 Mutans streptococci genetic strains in children with severe early childhood caries: follow-up study at one-year post-dental rehabilitation therapy mutans streptococci distribution of genotypic MS strains Streptococcus mutans oral streptococci severe early childhood caries full-mouth dental rehabilitation therapy |
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mutans streptococci genetic strains in children with severe early childhood caries: follow-up study at one-year post-dental rehabilitation therapy |
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Mutans streptococci genetic strains in children with severe early childhood caries: follow-up study at one-year post-dental rehabilitation therapy |
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Background: Genotypic strains of cariogenic mutans streptococci (MS) may vary in important virulence properties. In previous published studies, we identified 39 MS strains from pediatric patients undergoing full-mouth dental rehabilitation, including the removal and/or repair of carious lesions and application of antimicrobial rinse and fluoride varnish. Objectives: The objectives of this current 1-year follow-up study are to assess the variability of MS strains that occur at 1-year post-rehabilitation and characterize the xylitol-resistance properties of MS strains that predominate. Methods: Plaque from five children with severe early childhood caries was collected 1-year post-rehabilitation. MS isolates were subjected to arbitrarily primed-polymerase chain reaction (AP-PCR) for identification of genetic strains and in vitro xylitol-inhibition experiments. To more precisely define strain distributions within each patient, we isolated large numbers of isolates per patient. Results: MS strains diminished from several strains pre-rehabilitation, to one dominant strain at 1-year post-rehabilitation, with several new emergent strains. The majority of the clinical MS strains, as well as the Streptococcus mutans laboratory strains ATCC 25175 and 35668, were predicted to undergo 50% inhibition with 2.48–5.58% xylitol, with some clinical MS strains being significantly more resistant in vitro. Conclusions: Our follow-up study using patients from the original cohort demonstrates that specific MS strains are dominant at 1-year post-dental rehabilitation. Most of the clinical MS strains are similar in xylitol resistance to the attenuated S. mutans ATCC control strains, with some strains being more resistant to xylitol in vitro. |
| abstractGer |
Background: Genotypic strains of cariogenic mutans streptococci (MS) may vary in important virulence properties. In previous published studies, we identified 39 MS strains from pediatric patients undergoing full-mouth dental rehabilitation, including the removal and/or repair of carious lesions and application of antimicrobial rinse and fluoride varnish. Objectives: The objectives of this current 1-year follow-up study are to assess the variability of MS strains that occur at 1-year post-rehabilitation and characterize the xylitol-resistance properties of MS strains that predominate. Methods: Plaque from five children with severe early childhood caries was collected 1-year post-rehabilitation. MS isolates were subjected to arbitrarily primed-polymerase chain reaction (AP-PCR) for identification of genetic strains and in vitro xylitol-inhibition experiments. To more precisely define strain distributions within each patient, we isolated large numbers of isolates per patient. Results: MS strains diminished from several strains pre-rehabilitation, to one dominant strain at 1-year post-rehabilitation, with several new emergent strains. The majority of the clinical MS strains, as well as the Streptococcus mutans laboratory strains ATCC 25175 and 35668, were predicted to undergo 50% inhibition with 2.48–5.58% xylitol, with some clinical MS strains being significantly more resistant in vitro. Conclusions: Our follow-up study using patients from the original cohort demonstrates that specific MS strains are dominant at 1-year post-dental rehabilitation. Most of the clinical MS strains are similar in xylitol resistance to the attenuated S. mutans ATCC control strains, with some strains being more resistant to xylitol in vitro. |
| abstract_unstemmed |
Background: Genotypic strains of cariogenic mutans streptococci (MS) may vary in important virulence properties. In previous published studies, we identified 39 MS strains from pediatric patients undergoing full-mouth dental rehabilitation, including the removal and/or repair of carious lesions and application of antimicrobial rinse and fluoride varnish. Objectives: The objectives of this current 1-year follow-up study are to assess the variability of MS strains that occur at 1-year post-rehabilitation and characterize the xylitol-resistance properties of MS strains that predominate. Methods: Plaque from five children with severe early childhood caries was collected 1-year post-rehabilitation. MS isolates were subjected to arbitrarily primed-polymerase chain reaction (AP-PCR) for identification of genetic strains and in vitro xylitol-inhibition experiments. To more precisely define strain distributions within each patient, we isolated large numbers of isolates per patient. Results: MS strains diminished from several strains pre-rehabilitation, to one dominant strain at 1-year post-rehabilitation, with several new emergent strains. The majority of the clinical MS strains, as well as the Streptococcus mutans laboratory strains ATCC 25175 and 35668, were predicted to undergo 50% inhibition with 2.48–5.58% xylitol, with some clinical MS strains being significantly more resistant in vitro. Conclusions: Our follow-up study using patients from the original cohort demonstrates that specific MS strains are dominant at 1-year post-dental rehabilitation. Most of the clinical MS strains are similar in xylitol resistance to the attenuated S. mutans ATCC control strains, with some strains being more resistant to xylitol in vitro. |
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