Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells

Etoposide (ETO) is a cytotoxic drug that exerts its effect by increasing reactive oxygen species (ROS) production. Although ETO is widely used, fast metabolism, poor solubility, systemic toxicity, and multi-drug resistance induction all limit its administration dosage and its therapeutic efficiency....
Ausführliche Beschreibung

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Autor*in:	Silvana Alfei [verfasserIn] Barbara Marengo [verfasserIn] Cinzia Domenicotti [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	etoposide lab-made biodegradable dendrimer nanoparticle formulation improved solubility neuroblastoma cells synergistic action protracted release

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 9(2020), 1, p 50
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:1, p 50

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox9010050

Katalog-ID:	DOAJ009429441

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language	English
source	In Antioxidants 9(2020), 1, p 50 volume:9 year:2020 number:1, p 50
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institution	findex.gbv.de
topic_facet	etoposide lab-made biodegradable dendrimer nanoparticle formulation improved solubility neuroblastoma cells synergistic action protracted release Therapeutics. Pharmacology
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container_title	Antioxidants
authorswithroles_txt_mv	Silvana Alfei @@aut@@ Barbara Marengo @@aut@@ Cinzia Domenicotti @@aut@@
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callnumber-first	R - Medicine
author	Silvana Alfei
spellingShingle	Silvana Alfei misc RM1-950 misc etoposide misc lab-made biodegradable dendrimer misc nanoparticle formulation misc improved solubility misc neuroblastoma cells misc synergistic action misc protracted release misc Therapeutics. Pharmacology Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells
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topic_title	RM1-950 Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells etoposide lab-made biodegradable dendrimer nanoparticle formulation improved solubility neuroblastoma cells synergistic action protracted release
topic	misc RM1-950 misc etoposide misc lab-made biodegradable dendrimer misc nanoparticle formulation misc improved solubility misc neuroblastoma cells misc synergistic action misc protracted release misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc etoposide misc lab-made biodegradable dendrimer misc nanoparticle formulation misc improved solubility misc neuroblastoma cells misc synergistic action misc protracted release misc Therapeutics. Pharmacology
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title	Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells
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title_full	Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells
author_sort	Silvana Alfei
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author_browse	Silvana Alfei Barbara Marengo Cinzia Domenicotti
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title_sort	polyester-based dendrimer nanoparticles combined with etoposide have an improved cytotoxic and pro-oxidant effect on human neuroblastoma cells
callnumber	RM1-950
title_auth	Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells
abstract	Etoposide (ETO) is a cytotoxic drug that exerts its effect by increasing reactive oxygen species (ROS) production. Although ETO is widely used, fast metabolism, poor solubility, systemic toxicity, and multi-drug resistance induction all limit its administration dosage and its therapeutic efficiency. In order to address these issues, a biodegradable dendrimer was prepared for entrapping and protecting ETO and for enhancing its solubility and effectiveness. The achieved dendrimer complex with ETO (CPX <b<5</b<) showed the typical properties of a well-functioning delivery system, i.e., nanospherical morphology (70 nm), optimal Z-potential (−45 mV), good drug loading (37%), very satisfying entrapment efficiency (53%), and a remarkably improved solubility in biocompatible solvents. In regards to its cytotoxic activity, CPX <b<5</b< was tested on neuroblastoma (NB) cells with very promising results. In fact, the dendrimer scaffold and ETO are able to exert per se a cytotoxic and pro-oxidant activity on human NB cells. When CPX <b<5</b< is combined with ETO, it shows a synergistic action, slowly releasing the drug over time and significantly improving and protracting bioactivity. On the basis of these findings, the prepared ETO reservoir represents a novel biodegradable and promising device for the delivery of ETO into NB cells.
abstractGer	Etoposide (ETO) is a cytotoxic drug that exerts its effect by increasing reactive oxygen species (ROS) production. Although ETO is widely used, fast metabolism, poor solubility, systemic toxicity, and multi-drug resistance induction all limit its administration dosage and its therapeutic efficiency. In order to address these issues, a biodegradable dendrimer was prepared for entrapping and protecting ETO and for enhancing its solubility and effectiveness. The achieved dendrimer complex with ETO (CPX <b<5</b<) showed the typical properties of a well-functioning delivery system, i.e., nanospherical morphology (70 nm), optimal Z-potential (−45 mV), good drug loading (37%), very satisfying entrapment efficiency (53%), and a remarkably improved solubility in biocompatible solvents. In regards to its cytotoxic activity, CPX <b<5</b< was tested on neuroblastoma (NB) cells with very promising results. In fact, the dendrimer scaffold and ETO are able to exert per se a cytotoxic and pro-oxidant activity on human NB cells. When CPX <b<5</b< is combined with ETO, it shows a synergistic action, slowly releasing the drug over time and significantly improving and protracting bioactivity. On the basis of these findings, the prepared ETO reservoir represents a novel biodegradable and promising device for the delivery of ETO into NB cells.
abstract_unstemmed	Etoposide (ETO) is a cytotoxic drug that exerts its effect by increasing reactive oxygen species (ROS) production. Although ETO is widely used, fast metabolism, poor solubility, systemic toxicity, and multi-drug resistance induction all limit its administration dosage and its therapeutic efficiency. In order to address these issues, a biodegradable dendrimer was prepared for entrapping and protecting ETO and for enhancing its solubility and effectiveness. The achieved dendrimer complex with ETO (CPX <b<5</b<) showed the typical properties of a well-functioning delivery system, i.e., nanospherical morphology (70 nm), optimal Z-potential (−45 mV), good drug loading (37%), very satisfying entrapment efficiency (53%), and a remarkably improved solubility in biocompatible solvents. In regards to its cytotoxic activity, CPX <b<5</b< was tested on neuroblastoma (NB) cells with very promising results. In fact, the dendrimer scaffold and ETO are able to exert per se a cytotoxic and pro-oxidant activity on human NB cells. When CPX <b<5</b< is combined with ETO, it shows a synergistic action, slowly releasing the drug over time and significantly improving and protracting bioactivity. On the basis of these findings, the prepared ETO reservoir represents a novel biodegradable and promising device for the delivery of ETO into NB cells.
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title_short	Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells
url	https://doi.org/10.3390/antiox9010050 https://doaj.org/article/8a26c2a12f6c4d698bae33af30c66245 https://www.mdpi.com/2076-3921/9/1/50 https://doaj.org/toc/2076-3921
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Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells

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