Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection.

Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy.We prospectively screened 24,430 subjec...
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Autor*in:	Jintanat Ananworanich [verfasserIn] Alexandra Schuetz [verfasserIn] Claire Vandergeeten [verfasserIn] Irini Sereti [verfasserIn] Mark de Souza [verfasserIn] Rungsun Rerknimitr [verfasserIn] Robin Dewar [verfasserIn] Mary Marovich [verfasserIn] Frits van Griensven [verfasserIn] Rafick Sekaly [verfasserIn] Suteeraporn Pinyakorn [verfasserIn] Nittaya Phanuphak [verfasserIn] Rapee Trichavaroj [verfasserIn] Wiriya Rutvisuttinunt [verfasserIn] Nitiya Chomchey [verfasserIn] Robert Paris [verfasserIn] Sheila Peel [verfasserIn] Victor Valcour [verfasserIn] Frank Maldarelli [verfasserIn] Nicolas Chomont [verfasserIn] Nelson Michael [verfasserIn] Praphan Phanuphak [verfasserIn] Jerome H Kim [verfasserIn] RV254/SEARCH 010 Study Group [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 7(2012), 3, p e33948
Übergeordnetes Werk:	volume:7 ; year:2012 ; number:3, p e33948

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0033948

Katalog-ID:	DOAJ009498281

Internformat


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245	1	0	\|a Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection.
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520			\|a Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy.We prospectively screened 24,430 subjects in Bangkok and identified 40 AHI individuals. Thirty Thais were enrolled (8 Fiebig I, 5 Fiebig II, 15 Fiebig III, 2 Fiebig IV) of whom 15 completed 24 weeks of megaHAART (tenofovir/emtricitabine/efavirenz/raltegravir/maraviroc). Sigmoid biopsies were completed in 24/30 at baseline and 13/15 at week 24. At baseline, the median age was 29 years and 83% were MSM. Most were symptomatic (87%), and were infected with R5-tropic (77%) CRF01_AE (70%). Median CD4 was 406 cells/mm(3). HIV RNA was 5.5 log(10) copies/ml. Median total blood HIV DNA was higher in Fiebig III (550 copy/10(6) PBMC) vs. Fiebig I (8 copy/10(6) PBMC) (p = 0.01) while the median %CD4+CCR5+ gut T cells was lower in Fiebig III (19%) vs. Fiebig I (59%) (p = 0.0008). After 24 weeks of megaHAART, HIV RNA levels of <50 copies were achieved in 14/15 in blood and 13/13 in gut. Total blood HIV DNA at week 0 predicted reservoir size at week 24 (p<0.001). Total HIV DNA declined significantly and was undetectable in 3 of 15 in blood and 3 of 7 in gut. Frequency of CD4+CCR5+ gut T cells increased from 41% at baseline to 64% at week 24 (p<0.050); subjects with less than 40% at baseline had a significant increase in CD4+CCR5+ T cells from baseline to week 24 (14% vs. 71%, p = 0.02).Gut T cell depletion and HIV reservoir seeding increases with progression of AHI. MegaHAART was associated with immune restoration and reduced reservoir size. Our findings could inform research on strategies to achieve HIV drug-free remission.
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700	0		\|a Mark de Souza \|e verfasserin \|4 aut
700	0		\|a Rungsun Rerknimitr \|e verfasserin \|4 aut
700	0		\|a Robin Dewar \|e verfasserin \|4 aut
700	0		\|a Mary Marovich \|e verfasserin \|4 aut
700	0		\|a Frits van Griensven \|e verfasserin \|4 aut
700	0		\|a Rafick Sekaly \|e verfasserin \|4 aut
700	0		\|a Suteeraporn Pinyakorn \|e verfasserin \|4 aut
700	0		\|a Nittaya Phanuphak \|e verfasserin \|4 aut
700	0		\|a Rapee Trichavaroj \|e verfasserin \|4 aut
700	0		\|a Wiriya Rutvisuttinunt \|e verfasserin \|4 aut
700	0		\|a Nitiya Chomchey \|e verfasserin \|4 aut
700	0		\|a Robert Paris \|e verfasserin \|4 aut
700	0		\|a Sheila Peel \|e verfasserin \|4 aut
700	0		\|a Victor Valcour \|e verfasserin \|4 aut
700	0		\|a Frank Maldarelli \|e verfasserin \|4 aut
700	0		\|a Nicolas Chomont \|e verfasserin \|4 aut
700	0		\|a Nelson Michael \|e verfasserin \|4 aut
700	0		\|a Praphan Phanuphak \|e verfasserin \|4 aut
700	0		\|a Jerome H Kim \|e verfasserin \|4 aut
700	0		\|a RV254/SEARCH 010 Study Group \|e verfasserin \|4 aut
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912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_34
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
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912			\|a GBV_ILN_151
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912			\|a GBV_ILN_235
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2061
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912			\|a GBV_ILN_2113
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912			\|a GBV_ILN_4125
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912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
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Indexfelder

author_variant	j a ja a s as c v cv i s is m d s mds r r rr r d rd m m mm f v g fvg r s rs s p sp n p np r t rt w r wr n c nc r p rp s p sp v v vv f m fm n c nc n m nm p p pp j h k jhk r s g rsg
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publishDate	2012
allfields	10.1371/journal.pone.0033948 doi (DE-627)DOAJ009498281 (DE-599)DOAJc49702a6e259441ea7e70755a0451c1e DE-627 ger DE-627 rakwb eng Jintanat Ananworanich verfasserin aut Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy.We prospectively screened 24,430 subjects in Bangkok and identified 40 AHI individuals. Thirty Thais were enrolled (8 Fiebig I, 5 Fiebig II, 15 Fiebig III, 2 Fiebig IV) of whom 15 completed 24 weeks of megaHAART (tenofovir/emtricitabine/efavirenz/raltegravir/maraviroc). Sigmoid biopsies were completed in 24/30 at baseline and 13/15 at week 24. At baseline, the median age was 29 years and 83% were MSM. Most were symptomatic (87%), and were infected with R5-tropic (77%) CRF01_AE (70%). Median CD4 was 406 cells/mm(3). HIV RNA was 5.5 log(10) copies/ml. Median total blood HIV DNA was higher in Fiebig III (550 copy/10(6) PBMC) vs. Fiebig I (8 copy/10(6) PBMC) (p = 0.01) while the median %CD4+CCR5+ gut T cells was lower in Fiebig III (19%) vs. Fiebig I (59%) (p = 0.0008). After 24 weeks of megaHAART, HIV RNA levels of <50 copies were achieved in 14/15 in blood and 13/13 in gut. Total blood HIV DNA at week 0 predicted reservoir size at week 24 (p<0.001). Total HIV DNA declined significantly and was undetectable in 3 of 15 in blood and 3 of 7 in gut. Frequency of CD4+CCR5+ gut T cells increased from 41% at baseline to 64% at week 24 (p<0.050); subjects with less than 40% at baseline had a significant increase in CD4+CCR5+ T cells from baseline to week 24 (14% vs. 71%, p = 0.02).Gut T cell depletion and HIV reservoir seeding increases with progression of AHI. MegaHAART was associated with immune restoration and reduced reservoir size. Our findings could inform research on strategies to achieve HIV drug-free remission. Medicine R Science Q Alexandra Schuetz verfasserin aut Claire Vandergeeten verfasserin aut Irini Sereti verfasserin aut Mark de Souza verfasserin aut Rungsun Rerknimitr verfasserin aut Robin Dewar verfasserin aut Mary Marovich verfasserin aut Frits van Griensven verfasserin aut Rafick Sekaly verfasserin aut Suteeraporn Pinyakorn verfasserin aut Nittaya Phanuphak verfasserin aut Rapee Trichavaroj verfasserin aut Wiriya Rutvisuttinunt verfasserin aut Nitiya Chomchey verfasserin aut Robert Paris verfasserin aut Sheila Peel verfasserin aut Victor Valcour verfasserin aut Frank Maldarelli verfasserin aut Nicolas Chomont verfasserin aut Nelson Michael verfasserin aut Praphan Phanuphak verfasserin aut Jerome H Kim verfasserin aut RV254/SEARCH 010 Study Group verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 7(2012), 3, p e33948 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:7 year:2012 number:3, p e33948 https://doi.org/10.1371/journal.pone.0033948 kostenfrei https://doaj.org/article/c49702a6e259441ea7e70755a0451c1e kostenfrei http://europepmc.org/articles/PMC3316511?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 3, p e33948
spelling	10.1371/journal.pone.0033948 doi (DE-627)DOAJ009498281 (DE-599)DOAJc49702a6e259441ea7e70755a0451c1e DE-627 ger DE-627 rakwb eng Jintanat Ananworanich verfasserin aut Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy.We prospectively screened 24,430 subjects in Bangkok and identified 40 AHI individuals. Thirty Thais were enrolled (8 Fiebig I, 5 Fiebig II, 15 Fiebig III, 2 Fiebig IV) of whom 15 completed 24 weeks of megaHAART (tenofovir/emtricitabine/efavirenz/raltegravir/maraviroc). Sigmoid biopsies were completed in 24/30 at baseline and 13/15 at week 24. At baseline, the median age was 29 years and 83% were MSM. Most were symptomatic (87%), and were infected with R5-tropic (77%) CRF01_AE (70%). Median CD4 was 406 cells/mm(3). HIV RNA was 5.5 log(10) copies/ml. Median total blood HIV DNA was higher in Fiebig III (550 copy/10(6) PBMC) vs. Fiebig I (8 copy/10(6) PBMC) (p = 0.01) while the median %CD4+CCR5+ gut T cells was lower in Fiebig III (19%) vs. Fiebig I (59%) (p = 0.0008). After 24 weeks of megaHAART, HIV RNA levels of <50 copies were achieved in 14/15 in blood and 13/13 in gut. Total blood HIV DNA at week 0 predicted reservoir size at week 24 (p<0.001). Total HIV DNA declined significantly and was undetectable in 3 of 15 in blood and 3 of 7 in gut. Frequency of CD4+CCR5+ gut T cells increased from 41% at baseline to 64% at week 24 (p<0.050); subjects with less than 40% at baseline had a significant increase in CD4+CCR5+ T cells from baseline to week 24 (14% vs. 71%, p = 0.02).Gut T cell depletion and HIV reservoir seeding increases with progression of AHI. MegaHAART was associated with immune restoration and reduced reservoir size. Our findings could inform research on strategies to achieve HIV drug-free remission. Medicine R Science Q Alexandra Schuetz verfasserin aut Claire Vandergeeten verfasserin aut Irini Sereti verfasserin aut Mark de Souza verfasserin aut Rungsun Rerknimitr verfasserin aut Robin Dewar verfasserin aut Mary Marovich verfasserin aut Frits van Griensven verfasserin aut Rafick Sekaly verfasserin aut Suteeraporn Pinyakorn verfasserin aut Nittaya Phanuphak verfasserin aut Rapee Trichavaroj verfasserin aut Wiriya Rutvisuttinunt verfasserin aut Nitiya Chomchey verfasserin aut Robert Paris verfasserin aut Sheila Peel verfasserin aut Victor Valcour verfasserin aut Frank Maldarelli verfasserin aut Nicolas Chomont verfasserin aut Nelson Michael verfasserin aut Praphan Phanuphak verfasserin aut Jerome H Kim verfasserin aut RV254/SEARCH 010 Study Group verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 7(2012), 3, p e33948 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:7 year:2012 number:3, p e33948 https://doi.org/10.1371/journal.pone.0033948 kostenfrei https://doaj.org/article/c49702a6e259441ea7e70755a0451c1e kostenfrei http://europepmc.org/articles/PMC3316511?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 3, p e33948
allfields_unstemmed	10.1371/journal.pone.0033948 doi (DE-627)DOAJ009498281 (DE-599)DOAJc49702a6e259441ea7e70755a0451c1e DE-627 ger DE-627 rakwb eng Jintanat Ananworanich verfasserin aut Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy.We prospectively screened 24,430 subjects in Bangkok and identified 40 AHI individuals. Thirty Thais were enrolled (8 Fiebig I, 5 Fiebig II, 15 Fiebig III, 2 Fiebig IV) of whom 15 completed 24 weeks of megaHAART (tenofovir/emtricitabine/efavirenz/raltegravir/maraviroc). Sigmoid biopsies were completed in 24/30 at baseline and 13/15 at week 24. At baseline, the median age was 29 years and 83% were MSM. Most were symptomatic (87%), and were infected with R5-tropic (77%) CRF01_AE (70%). Median CD4 was 406 cells/mm(3). HIV RNA was 5.5 log(10) copies/ml. Median total blood HIV DNA was higher in Fiebig III (550 copy/10(6) PBMC) vs. Fiebig I (8 copy/10(6) PBMC) (p = 0.01) while the median %CD4+CCR5+ gut T cells was lower in Fiebig III (19%) vs. Fiebig I (59%) (p = 0.0008). After 24 weeks of megaHAART, HIV RNA levels of <50 copies were achieved in 14/15 in blood and 13/13 in gut. Total blood HIV DNA at week 0 predicted reservoir size at week 24 (p<0.001). Total HIV DNA declined significantly and was undetectable in 3 of 15 in blood and 3 of 7 in gut. Frequency of CD4+CCR5+ gut T cells increased from 41% at baseline to 64% at week 24 (p<0.050); subjects with less than 40% at baseline had a significant increase in CD4+CCR5+ T cells from baseline to week 24 (14% vs. 71%, p = 0.02).Gut T cell depletion and HIV reservoir seeding increases with progression of AHI. MegaHAART was associated with immune restoration and reduced reservoir size. Our findings could inform research on strategies to achieve HIV drug-free remission. Medicine R Science Q Alexandra Schuetz verfasserin aut Claire Vandergeeten verfasserin aut Irini Sereti verfasserin aut Mark de Souza verfasserin aut Rungsun Rerknimitr verfasserin aut Robin Dewar verfasserin aut Mary Marovich verfasserin aut Frits van Griensven verfasserin aut Rafick Sekaly verfasserin aut Suteeraporn Pinyakorn verfasserin aut Nittaya Phanuphak verfasserin aut Rapee Trichavaroj verfasserin aut Wiriya Rutvisuttinunt verfasserin aut Nitiya Chomchey verfasserin aut Robert Paris verfasserin aut Sheila Peel verfasserin aut Victor Valcour verfasserin aut Frank Maldarelli verfasserin aut Nicolas Chomont verfasserin aut Nelson Michael verfasserin aut Praphan Phanuphak verfasserin aut Jerome H Kim verfasserin aut RV254/SEARCH 010 Study Group verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 7(2012), 3, p e33948 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:7 year:2012 number:3, p e33948 https://doi.org/10.1371/journal.pone.0033948 kostenfrei https://doaj.org/article/c49702a6e259441ea7e70755a0451c1e kostenfrei http://europepmc.org/articles/PMC3316511?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 3, p e33948
allfieldsGer	10.1371/journal.pone.0033948 doi (DE-627)DOAJ009498281 (DE-599)DOAJc49702a6e259441ea7e70755a0451c1e DE-627 ger DE-627 rakwb eng Jintanat Ananworanich verfasserin aut Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy.We prospectively screened 24,430 subjects in Bangkok and identified 40 AHI individuals. Thirty Thais were enrolled (8 Fiebig I, 5 Fiebig II, 15 Fiebig III, 2 Fiebig IV) of whom 15 completed 24 weeks of megaHAART (tenofovir/emtricitabine/efavirenz/raltegravir/maraviroc). Sigmoid biopsies were completed in 24/30 at baseline and 13/15 at week 24. At baseline, the median age was 29 years and 83% were MSM. Most were symptomatic (87%), and were infected with R5-tropic (77%) CRF01_AE (70%). Median CD4 was 406 cells/mm(3). HIV RNA was 5.5 log(10) copies/ml. Median total blood HIV DNA was higher in Fiebig III (550 copy/10(6) PBMC) vs. Fiebig I (8 copy/10(6) PBMC) (p = 0.01) while the median %CD4+CCR5+ gut T cells was lower in Fiebig III (19%) vs. Fiebig I (59%) (p = 0.0008). After 24 weeks of megaHAART, HIV RNA levels of <50 copies were achieved in 14/15 in blood and 13/13 in gut. Total blood HIV DNA at week 0 predicted reservoir size at week 24 (p<0.001). Total HIV DNA declined significantly and was undetectable in 3 of 15 in blood and 3 of 7 in gut. Frequency of CD4+CCR5+ gut T cells increased from 41% at baseline to 64% at week 24 (p<0.050); subjects with less than 40% at baseline had a significant increase in CD4+CCR5+ T cells from baseline to week 24 (14% vs. 71%, p = 0.02).Gut T cell depletion and HIV reservoir seeding increases with progression of AHI. MegaHAART was associated with immune restoration and reduced reservoir size. Our findings could inform research on strategies to achieve HIV drug-free remission. Medicine R Science Q Alexandra Schuetz verfasserin aut Claire Vandergeeten verfasserin aut Irini Sereti verfasserin aut Mark de Souza verfasserin aut Rungsun Rerknimitr verfasserin aut Robin Dewar verfasserin aut Mary Marovich verfasserin aut Frits van Griensven verfasserin aut Rafick Sekaly verfasserin aut Suteeraporn Pinyakorn verfasserin aut Nittaya Phanuphak verfasserin aut Rapee Trichavaroj verfasserin aut Wiriya Rutvisuttinunt verfasserin aut Nitiya Chomchey verfasserin aut Robert Paris verfasserin aut Sheila Peel verfasserin aut Victor Valcour verfasserin aut Frank Maldarelli verfasserin aut Nicolas Chomont verfasserin aut Nelson Michael verfasserin aut Praphan Phanuphak verfasserin aut Jerome H Kim verfasserin aut RV254/SEARCH 010 Study Group verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 7(2012), 3, p e33948 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:7 year:2012 number:3, p e33948 https://doi.org/10.1371/journal.pone.0033948 kostenfrei https://doaj.org/article/c49702a6e259441ea7e70755a0451c1e kostenfrei http://europepmc.org/articles/PMC3316511?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 3, p e33948
allfieldsSound	10.1371/journal.pone.0033948 doi (DE-627)DOAJ009498281 (DE-599)DOAJc49702a6e259441ea7e70755a0451c1e DE-627 ger DE-627 rakwb eng Jintanat Ananworanich verfasserin aut Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy.We prospectively screened 24,430 subjects in Bangkok and identified 40 AHI individuals. Thirty Thais were enrolled (8 Fiebig I, 5 Fiebig II, 15 Fiebig III, 2 Fiebig IV) of whom 15 completed 24 weeks of megaHAART (tenofovir/emtricitabine/efavirenz/raltegravir/maraviroc). Sigmoid biopsies were completed in 24/30 at baseline and 13/15 at week 24. At baseline, the median age was 29 years and 83% were MSM. Most were symptomatic (87%), and were infected with R5-tropic (77%) CRF01_AE (70%). Median CD4 was 406 cells/mm(3). HIV RNA was 5.5 log(10) copies/ml. Median total blood HIV DNA was higher in Fiebig III (550 copy/10(6) PBMC) vs. Fiebig I (8 copy/10(6) PBMC) (p = 0.01) while the median %CD4+CCR5+ gut T cells was lower in Fiebig III (19%) vs. Fiebig I (59%) (p = 0.0008). After 24 weeks of megaHAART, HIV RNA levels of <50 copies were achieved in 14/15 in blood and 13/13 in gut. Total blood HIV DNA at week 0 predicted reservoir size at week 24 (p<0.001). Total HIV DNA declined significantly and was undetectable in 3 of 15 in blood and 3 of 7 in gut. Frequency of CD4+CCR5+ gut T cells increased from 41% at baseline to 64% at week 24 (p<0.050); subjects with less than 40% at baseline had a significant increase in CD4+CCR5+ T cells from baseline to week 24 (14% vs. 71%, p = 0.02).Gut T cell depletion and HIV reservoir seeding increases with progression of AHI. MegaHAART was associated with immune restoration and reduced reservoir size. Our findings could inform research on strategies to achieve HIV drug-free remission. Medicine R Science Q Alexandra Schuetz verfasserin aut Claire Vandergeeten verfasserin aut Irini Sereti verfasserin aut Mark de Souza verfasserin aut Rungsun Rerknimitr verfasserin aut Robin Dewar verfasserin aut Mary Marovich verfasserin aut Frits van Griensven verfasserin aut Rafick Sekaly verfasserin aut Suteeraporn Pinyakorn verfasserin aut Nittaya Phanuphak verfasserin aut Rapee Trichavaroj verfasserin aut Wiriya Rutvisuttinunt verfasserin aut Nitiya Chomchey verfasserin aut Robert Paris verfasserin aut Sheila Peel verfasserin aut Victor Valcour verfasserin aut Frank Maldarelli verfasserin aut Nicolas Chomont verfasserin aut Nelson Michael verfasserin aut Praphan Phanuphak verfasserin aut Jerome H Kim verfasserin aut RV254/SEARCH 010 Study Group verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 7(2012), 3, p e33948 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:7 year:2012 number:3, p e33948 https://doi.org/10.1371/journal.pone.0033948 kostenfrei https://doaj.org/article/c49702a6e259441ea7e70755a0451c1e kostenfrei http://europepmc.org/articles/PMC3316511?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 3, p e33948
language	English
source	In PLoS ONE 7(2012), 3, p e33948 volume:7 year:2012 number:3, p e33948
sourceStr	In PLoS ONE 7(2012), 3, p e33948 volume:7 year:2012 number:3, p e33948
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authorswithroles_txt_mv	Jintanat Ananworanich @@aut@@ Alexandra Schuetz @@aut@@ Claire Vandergeeten @@aut@@ Irini Sereti @@aut@@ Mark de Souza @@aut@@ Rungsun Rerknimitr @@aut@@ Robin Dewar @@aut@@ Mary Marovich @@aut@@ Frits van Griensven @@aut@@ Rafick Sekaly @@aut@@ Suteeraporn Pinyakorn @@aut@@ Nittaya Phanuphak @@aut@@ Rapee Trichavaroj @@aut@@ Wiriya Rutvisuttinunt @@aut@@ Nitiya Chomchey @@aut@@ Robert Paris @@aut@@ Sheila Peel @@aut@@ Victor Valcour @@aut@@ Frank Maldarelli @@aut@@ Nicolas Chomont @@aut@@ Nelson Michael @@aut@@ Praphan Phanuphak @@aut@@ Jerome H Kim @@aut@@ RV254/SEARCH 010 Study Group @@aut@@
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author	Jintanat Ananworanich
spellingShingle	Jintanat Ananworanich misc Medicine misc R misc Science misc Q Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection.
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topic_title	Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection
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title	Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection.
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title_full	Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection
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author_browse	Jintanat Ananworanich Alexandra Schuetz Claire Vandergeeten Irini Sereti Mark de Souza Rungsun Rerknimitr Robin Dewar Mary Marovich Frits van Griensven Rafick Sekaly Suteeraporn Pinyakorn Nittaya Phanuphak Rapee Trichavaroj Wiriya Rutvisuttinunt Nitiya Chomchey Robert Paris Sheila Peel Victor Valcour Frank Maldarelli Nicolas Chomont Nelson Michael Praphan Phanuphak Jerome H Kim RV254/SEARCH 010 Study Group
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title_sort	impact of multi-targeted antiretroviral treatment on gut t cell depletion and hiv reservoir seeding during acute hiv infection
title_auth	Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection.
abstract	Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy.We prospectively screened 24,430 subjects in Bangkok and identified 40 AHI individuals. Thirty Thais were enrolled (8 Fiebig I, 5 Fiebig II, 15 Fiebig III, 2 Fiebig IV) of whom 15 completed 24 weeks of megaHAART (tenofovir/emtricitabine/efavirenz/raltegravir/maraviroc). Sigmoid biopsies were completed in 24/30 at baseline and 13/15 at week 24. At baseline, the median age was 29 years and 83% were MSM. Most were symptomatic (87%), and were infected with R5-tropic (77%) CRF01_AE (70%). Median CD4 was 406 cells/mm(3). HIV RNA was 5.5 log(10) copies/ml. Median total blood HIV DNA was higher in Fiebig III (550 copy/10(6) PBMC) vs. Fiebig I (8 copy/10(6) PBMC) (p = 0.01) while the median %CD4+CCR5+ gut T cells was lower in Fiebig III (19%) vs. Fiebig I (59%) (p = 0.0008). After 24 weeks of megaHAART, HIV RNA levels of <50 copies were achieved in 14/15 in blood and 13/13 in gut. Total blood HIV DNA at week 0 predicted reservoir size at week 24 (p<0.001). Total HIV DNA declined significantly and was undetectable in 3 of 15 in blood and 3 of 7 in gut. Frequency of CD4+CCR5+ gut T cells increased from 41% at baseline to 64% at week 24 (p<0.050); subjects with less than 40% at baseline had a significant increase in CD4+CCR5+ T cells from baseline to week 24 (14% vs. 71%, p = 0.02).Gut T cell depletion and HIV reservoir seeding increases with progression of AHI. MegaHAART was associated with immune restoration and reduced reservoir size. Our findings could inform research on strategies to achieve HIV drug-free remission.
abstractGer	Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy.We prospectively screened 24,430 subjects in Bangkok and identified 40 AHI individuals. Thirty Thais were enrolled (8 Fiebig I, 5 Fiebig II, 15 Fiebig III, 2 Fiebig IV) of whom 15 completed 24 weeks of megaHAART (tenofovir/emtricitabine/efavirenz/raltegravir/maraviroc). Sigmoid biopsies were completed in 24/30 at baseline and 13/15 at week 24. At baseline, the median age was 29 years and 83% were MSM. Most were symptomatic (87%), and were infected with R5-tropic (77%) CRF01_AE (70%). Median CD4 was 406 cells/mm(3). HIV RNA was 5.5 log(10) copies/ml. Median total blood HIV DNA was higher in Fiebig III (550 copy/10(6) PBMC) vs. Fiebig I (8 copy/10(6) PBMC) (p = 0.01) while the median %CD4+CCR5+ gut T cells was lower in Fiebig III (19%) vs. Fiebig I (59%) (p = 0.0008). After 24 weeks of megaHAART, HIV RNA levels of <50 copies were achieved in 14/15 in blood and 13/13 in gut. Total blood HIV DNA at week 0 predicted reservoir size at week 24 (p<0.001). Total HIV DNA declined significantly and was undetectable in 3 of 15 in blood and 3 of 7 in gut. Frequency of CD4+CCR5+ gut T cells increased from 41% at baseline to 64% at week 24 (p<0.050); subjects with less than 40% at baseline had a significant increase in CD4+CCR5+ T cells from baseline to week 24 (14% vs. 71%, p = 0.02).Gut T cell depletion and HIV reservoir seeding increases with progression of AHI. MegaHAART was associated with immune restoration and reduced reservoir size. Our findings could inform research on strategies to achieve HIV drug-free remission.
abstract_unstemmed	Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy.We prospectively screened 24,430 subjects in Bangkok and identified 40 AHI individuals. Thirty Thais were enrolled (8 Fiebig I, 5 Fiebig II, 15 Fiebig III, 2 Fiebig IV) of whom 15 completed 24 weeks of megaHAART (tenofovir/emtricitabine/efavirenz/raltegravir/maraviroc). Sigmoid biopsies were completed in 24/30 at baseline and 13/15 at week 24. At baseline, the median age was 29 years and 83% were MSM. Most were symptomatic (87%), and were infected with R5-tropic (77%) CRF01_AE (70%). Median CD4 was 406 cells/mm(3). HIV RNA was 5.5 log(10) copies/ml. Median total blood HIV DNA was higher in Fiebig III (550 copy/10(6) PBMC) vs. Fiebig I (8 copy/10(6) PBMC) (p = 0.01) while the median %CD4+CCR5+ gut T cells was lower in Fiebig III (19%) vs. Fiebig I (59%) (p = 0.0008). After 24 weeks of megaHAART, HIV RNA levels of <50 copies were achieved in 14/15 in blood and 13/13 in gut. Total blood HIV DNA at week 0 predicted reservoir size at week 24 (p<0.001). Total HIV DNA declined significantly and was undetectable in 3 of 15 in blood and 3 of 7 in gut. Frequency of CD4+CCR5+ gut T cells increased from 41% at baseline to 64% at week 24 (p<0.050); subjects with less than 40% at baseline had a significant increase in CD4+CCR5+ T cells from baseline to week 24 (14% vs. 71%, p = 0.02).Gut T cell depletion and HIV reservoir seeding increases with progression of AHI. MegaHAART was associated with immune restoration and reduced reservoir size. Our findings could inform research on strategies to achieve HIV drug-free remission.
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container_issue	3, p e33948
title_short	Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection.
url	https://doi.org/10.1371/journal.pone.0033948 https://doaj.org/article/c49702a6e259441ea7e70755a0451c1e http://europepmc.org/articles/PMC3316511?pdf=render https://doaj.org/toc/1932-6203
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author2	Alexandra Schuetz Claire Vandergeeten Irini Sereti Mark de Souza Rungsun Rerknimitr Robin Dewar Mary Marovich Frits van Griensven Rafick Sekaly Suteeraporn Pinyakorn Nittaya Phanuphak Rapee Trichavaroj Wiriya Rutvisuttinunt Nitiya Chomchey Robert Paris Sheila Peel Victor Valcour Frank Maldarelli Nicolas Chomont Nelson Michael Praphan Phanuphak Jerome H Kim RV254/SEARCH 010 Study Group
author2Str	Alexandra Schuetz Claire Vandergeeten Irini Sereti Mark de Souza Rungsun Rerknimitr Robin Dewar Mary Marovich Frits van Griensven Rafick Sekaly Suteeraporn Pinyakorn Nittaya Phanuphak Rapee Trichavaroj Wiriya Rutvisuttinunt Nitiya Chomchey Robert Paris Sheila Peel Victor Valcour Frank Maldarelli Nicolas Chomont Nelson Michael Praphan Phanuphak Jerome H Kim RV254/SEARCH 010 Study Group
ppnlink	523574592
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doi_str	10.1371/journal.pone.0033948
up_date	2024-07-03T23:54:02.858Z
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Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection.

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