The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study

Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism.Des...
Ausführliche Beschreibung

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Autor*in:	Thozhukat Sathyapalan [verfasserIn] Alison J. Dawson [verfasserIn] Alan S. Rigby [verfasserIn] Natalie J. Thatcher [verfasserIn] Eric S. Kilpatrick [verfasserIn] Stephen L. Atkin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	subclinical hypothyroidisim phytoestrogen isoflavones daidzein genistein glucosides

Übergeordnetes Werk:	In: Frontiers in Endocrinology - Frontiers Media S.A., 2011, 9(2018)
Übergeordnetes Werk:	volume:9 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fendo.2018.00531

Katalog-ID:	DOAJ009534709

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520			\|a Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism.Design and setting: Randomized, double-blind, crossover study.Participants: Forty four patients with subclinical hypothyroidism.Intervention: Participants were randomly allocated to either 66 mg phytoestrogen with 30 g soy protein (active) or 0 mg phytoestrogen with 30 g soy protein (placebo) supplementation for 8 weeks, washed out for 8 weeks and then crossed over for another 8 week period.Main outcome measures: The primary outcome was progression to overt hypothyroidism with the secondary outcome measures were changes in thyroid function tests.Results: Two patients in this trial progressed into overt hypothyroidism after high dose phytoestrogen supplementation. TSH, free thyroxine and triiodothyronine did not differ between groups.Conclusion: A pharmacological dose of 66 mg of soy phytoestrogens did not increase the overt thyroid failure rate or alter thyroid function tests in patients with subclinical hypothyroidism.
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allfields	10.3389/fendo.2018.00531 doi (DE-627)DOAJ009534709 (DE-599)DOAJc52bcfc29443498c8b7b62a4cfd2326f DE-627 ger DE-627 rakwb eng RC648-665 Thozhukat Sathyapalan verfasserin aut The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism.Design and setting: Randomized, double-blind, crossover study.Participants: Forty four patients with subclinical hypothyroidism.Intervention: Participants were randomly allocated to either 66 mg phytoestrogen with 30 g soy protein (active) or 0 mg phytoestrogen with 30 g soy protein (placebo) supplementation for 8 weeks, washed out for 8 weeks and then crossed over for another 8 week period.Main outcome measures: The primary outcome was progression to overt hypothyroidism with the secondary outcome measures were changes in thyroid function tests.Results: Two patients in this trial progressed into overt hypothyroidism after high dose phytoestrogen supplementation. TSH, free thyroxine and triiodothyronine did not differ between groups.Conclusion: A pharmacological dose of 66 mg of soy phytoestrogens did not increase the overt thyroid failure rate or alter thyroid function tests in patients with subclinical hypothyroidism. subclinical hypothyroidisim phytoestrogen isoflavones daidzein genistein glucosides Diseases of the endocrine glands. Clinical endocrinology Alison J. Dawson verfasserin aut Alan S. Rigby verfasserin aut Natalie J. Thatcher verfasserin aut Eric S. Kilpatrick verfasserin aut Stephen L. Atkin verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 9(2018) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:9 year:2018 https://doi.org/10.3389/fendo.2018.00531 kostenfrei https://doaj.org/article/c52bcfc29443498c8b7b62a4cfd2326f kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2018.00531/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
spelling	10.3389/fendo.2018.00531 doi (DE-627)DOAJ009534709 (DE-599)DOAJc52bcfc29443498c8b7b62a4cfd2326f DE-627 ger DE-627 rakwb eng RC648-665 Thozhukat Sathyapalan verfasserin aut The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism.Design and setting: Randomized, double-blind, crossover study.Participants: Forty four patients with subclinical hypothyroidism.Intervention: Participants were randomly allocated to either 66 mg phytoestrogen with 30 g soy protein (active) or 0 mg phytoestrogen with 30 g soy protein (placebo) supplementation for 8 weeks, washed out for 8 weeks and then crossed over for another 8 week period.Main outcome measures: The primary outcome was progression to overt hypothyroidism with the secondary outcome measures were changes in thyroid function tests.Results: Two patients in this trial progressed into overt hypothyroidism after high dose phytoestrogen supplementation. TSH, free thyroxine and triiodothyronine did not differ between groups.Conclusion: A pharmacological dose of 66 mg of soy phytoestrogens did not increase the overt thyroid failure rate or alter thyroid function tests in patients with subclinical hypothyroidism. subclinical hypothyroidisim phytoestrogen isoflavones daidzein genistein glucosides Diseases of the endocrine glands. Clinical endocrinology Alison J. Dawson verfasserin aut Alan S. Rigby verfasserin aut Natalie J. Thatcher verfasserin aut Eric S. Kilpatrick verfasserin aut Stephen L. Atkin verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 9(2018) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:9 year:2018 https://doi.org/10.3389/fendo.2018.00531 kostenfrei https://doaj.org/article/c52bcfc29443498c8b7b62a4cfd2326f kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2018.00531/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfields_unstemmed	10.3389/fendo.2018.00531 doi (DE-627)DOAJ009534709 (DE-599)DOAJc52bcfc29443498c8b7b62a4cfd2326f DE-627 ger DE-627 rakwb eng RC648-665 Thozhukat Sathyapalan verfasserin aut The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism.Design and setting: Randomized, double-blind, crossover study.Participants: Forty four patients with subclinical hypothyroidism.Intervention: Participants were randomly allocated to either 66 mg phytoestrogen with 30 g soy protein (active) or 0 mg phytoestrogen with 30 g soy protein (placebo) supplementation for 8 weeks, washed out for 8 weeks and then crossed over for another 8 week period.Main outcome measures: The primary outcome was progression to overt hypothyroidism with the secondary outcome measures were changes in thyroid function tests.Results: Two patients in this trial progressed into overt hypothyroidism after high dose phytoestrogen supplementation. TSH, free thyroxine and triiodothyronine did not differ between groups.Conclusion: A pharmacological dose of 66 mg of soy phytoestrogens did not increase the overt thyroid failure rate or alter thyroid function tests in patients with subclinical hypothyroidism. subclinical hypothyroidisim phytoestrogen isoflavones daidzein genistein glucosides Diseases of the endocrine glands. Clinical endocrinology Alison J. Dawson verfasserin aut Alan S. Rigby verfasserin aut Natalie J. Thatcher verfasserin aut Eric S. Kilpatrick verfasserin aut Stephen L. Atkin verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 9(2018) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:9 year:2018 https://doi.org/10.3389/fendo.2018.00531 kostenfrei https://doaj.org/article/c52bcfc29443498c8b7b62a4cfd2326f kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2018.00531/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfieldsGer	10.3389/fendo.2018.00531 doi (DE-627)DOAJ009534709 (DE-599)DOAJc52bcfc29443498c8b7b62a4cfd2326f DE-627 ger DE-627 rakwb eng RC648-665 Thozhukat Sathyapalan verfasserin aut The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism.Design and setting: Randomized, double-blind, crossover study.Participants: Forty four patients with subclinical hypothyroidism.Intervention: Participants were randomly allocated to either 66 mg phytoestrogen with 30 g soy protein (active) or 0 mg phytoestrogen with 30 g soy protein (placebo) supplementation for 8 weeks, washed out for 8 weeks and then crossed over for another 8 week period.Main outcome measures: The primary outcome was progression to overt hypothyroidism with the secondary outcome measures were changes in thyroid function tests.Results: Two patients in this trial progressed into overt hypothyroidism after high dose phytoestrogen supplementation. TSH, free thyroxine and triiodothyronine did not differ between groups.Conclusion: A pharmacological dose of 66 mg of soy phytoestrogens did not increase the overt thyroid failure rate or alter thyroid function tests in patients with subclinical hypothyroidism. subclinical hypothyroidisim phytoestrogen isoflavones daidzein genistein glucosides Diseases of the endocrine glands. Clinical endocrinology Alison J. Dawson verfasserin aut Alan S. Rigby verfasserin aut Natalie J. Thatcher verfasserin aut Eric S. Kilpatrick verfasserin aut Stephen L. Atkin verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 9(2018) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:9 year:2018 https://doi.org/10.3389/fendo.2018.00531 kostenfrei https://doaj.org/article/c52bcfc29443498c8b7b62a4cfd2326f kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2018.00531/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfieldsSound	10.3389/fendo.2018.00531 doi (DE-627)DOAJ009534709 (DE-599)DOAJc52bcfc29443498c8b7b62a4cfd2326f DE-627 ger DE-627 rakwb eng RC648-665 Thozhukat Sathyapalan verfasserin aut The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism.Design and setting: Randomized, double-blind, crossover study.Participants: Forty four patients with subclinical hypothyroidism.Intervention: Participants were randomly allocated to either 66 mg phytoestrogen with 30 g soy protein (active) or 0 mg phytoestrogen with 30 g soy protein (placebo) supplementation for 8 weeks, washed out for 8 weeks and then crossed over for another 8 week period.Main outcome measures: The primary outcome was progression to overt hypothyroidism with the secondary outcome measures were changes in thyroid function tests.Results: Two patients in this trial progressed into overt hypothyroidism after high dose phytoestrogen supplementation. TSH, free thyroxine and triiodothyronine did not differ between groups.Conclusion: A pharmacological dose of 66 mg of soy phytoestrogens did not increase the overt thyroid failure rate or alter thyroid function tests in patients with subclinical hypothyroidism. subclinical hypothyroidisim phytoestrogen isoflavones daidzein genistein glucosides Diseases of the endocrine glands. Clinical endocrinology Alison J. Dawson verfasserin aut Alan S. Rigby verfasserin aut Natalie J. Thatcher verfasserin aut Eric S. Kilpatrick verfasserin aut Stephen L. Atkin verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 9(2018) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:9 year:2018 https://doi.org/10.3389/fendo.2018.00531 kostenfrei https://doaj.org/article/c52bcfc29443498c8b7b62a4cfd2326f kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2018.00531/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
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topic_facet	subclinical hypothyroidisim phytoestrogen isoflavones daidzein genistein glucosides Diseases of the endocrine glands. Clinical endocrinology
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authorswithroles_txt_mv	Thozhukat Sathyapalan @@aut@@ Alison J. Dawson @@aut@@ Alan S. Rigby @@aut@@ Natalie J. Thatcher @@aut@@ Eric S. Kilpatrick @@aut@@ Stephen L. Atkin @@aut@@
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callnumber-first	R - Medicine
author	Thozhukat Sathyapalan
spellingShingle	Thozhukat Sathyapalan misc RC648-665 misc subclinical hypothyroidisim misc phytoestrogen misc isoflavones misc daidzein misc genistein glucosides misc Diseases of the endocrine glands. Clinical endocrinology The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study
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topic_title	RC648-665 The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study subclinical hypothyroidisim phytoestrogen isoflavones daidzein genistein glucosides
topic	misc RC648-665 misc subclinical hypothyroidisim misc phytoestrogen misc isoflavones misc daidzein misc genistein glucosides misc Diseases of the endocrine glands. Clinical endocrinology
topic_unstemmed	misc RC648-665 misc subclinical hypothyroidisim misc phytoestrogen misc isoflavones misc daidzein misc genistein glucosides misc Diseases of the endocrine glands. Clinical endocrinology
topic_browse	misc RC648-665 misc subclinical hypothyroidisim misc phytoestrogen misc isoflavones misc daidzein misc genistein glucosides misc Diseases of the endocrine glands. Clinical endocrinology
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title	The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study
ctrlnum	(DE-627)DOAJ009534709 (DE-599)DOAJc52bcfc29443498c8b7b62a4cfd2326f
title_full	The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study
author_sort	Thozhukat Sathyapalan
journal	Frontiers in Endocrinology
journalStr	Frontiers in Endocrinology
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author_browse	Thozhukat Sathyapalan Alison J. Dawson Alan S. Rigby Natalie J. Thatcher Eric S. Kilpatrick Stephen L. Atkin
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author-letter	Thozhukat Sathyapalan
doi_str_mv	10.3389/fendo.2018.00531
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title_sort	effect of phytoestrogen on thyroid in subclinical hypothyroidism: randomized, double blind, crossover study
callnumber	RC648-665
title_auth	The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study
abstract	Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism.Design and setting: Randomized, double-blind, crossover study.Participants: Forty four patients with subclinical hypothyroidism.Intervention: Participants were randomly allocated to either 66 mg phytoestrogen with 30 g soy protein (active) or 0 mg phytoestrogen with 30 g soy protein (placebo) supplementation for 8 weeks, washed out for 8 weeks and then crossed over for another 8 week period.Main outcome measures: The primary outcome was progression to overt hypothyroidism with the secondary outcome measures were changes in thyroid function tests.Results: Two patients in this trial progressed into overt hypothyroidism after high dose phytoestrogen supplementation. TSH, free thyroxine and triiodothyronine did not differ between groups.Conclusion: A pharmacological dose of 66 mg of soy phytoestrogens did not increase the overt thyroid failure rate or alter thyroid function tests in patients with subclinical hypothyroidism.
abstractGer	Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism.Design and setting: Randomized, double-blind, crossover study.Participants: Forty four patients with subclinical hypothyroidism.Intervention: Participants were randomly allocated to either 66 mg phytoestrogen with 30 g soy protein (active) or 0 mg phytoestrogen with 30 g soy protein (placebo) supplementation for 8 weeks, washed out for 8 weeks and then crossed over for another 8 week period.Main outcome measures: The primary outcome was progression to overt hypothyroidism with the secondary outcome measures were changes in thyroid function tests.Results: Two patients in this trial progressed into overt hypothyroidism after high dose phytoestrogen supplementation. TSH, free thyroxine and triiodothyronine did not differ between groups.Conclusion: A pharmacological dose of 66 mg of soy phytoestrogens did not increase the overt thyroid failure rate or alter thyroid function tests in patients with subclinical hypothyroidism.
abstract_unstemmed	Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism.Design and setting: Randomized, double-blind, crossover study.Participants: Forty four patients with subclinical hypothyroidism.Intervention: Participants were randomly allocated to either 66 mg phytoestrogen with 30 g soy protein (active) or 0 mg phytoestrogen with 30 g soy protein (placebo) supplementation for 8 weeks, washed out for 8 weeks and then crossed over for another 8 week period.Main outcome measures: The primary outcome was progression to overt hypothyroidism with the secondary outcome measures were changes in thyroid function tests.Results: Two patients in this trial progressed into overt hypothyroidism after high dose phytoestrogen supplementation. TSH, free thyroxine and triiodothyronine did not differ between groups.Conclusion: A pharmacological dose of 66 mg of soy phytoestrogens did not increase the overt thyroid failure rate or alter thyroid function tests in patients with subclinical hypothyroidism.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
title_short	The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study
url	https://doi.org/10.3389/fendo.2018.00531 https://doaj.org/article/c52bcfc29443498c8b7b62a4cfd2326f https://www.frontiersin.org/article/10.3389/fendo.2018.00531/full https://doaj.org/toc/1664-2392
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author2	Alison J. Dawson Alan S. Rigby Natalie J. Thatcher Eric S. Kilpatrick Stephen L. Atkin
author2Str	Alison J. Dawson Alan S. Rigby Natalie J. Thatcher Eric S. Kilpatrick Stephen L. Atkin
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doi_str	10.3389/fendo.2018.00531
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up_date	2024-07-04T00:02:45.439Z
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