Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains
Immunoglobulin G (IgG) is the predominant serum immunoglobulin and has the longest serum half-life of all the antibody classes. The European rabbit IgG has been of significant importance in immunological research, and is therefore well characterized. However, the IgG of other leporids has been disre...
Ausführliche Beschreibung
Autor*in: |
Ana Pinheiro [verfasserIn] Jenny M. Woof [verfasserIn] Tereza Almeida [verfasserIn] Joana Abrantes [verfasserIn] Paulo C. Alves [verfasserIn] Christian Gortázar [verfasserIn] Pedro J. Esteves [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2014 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Open Biology - The Royal Society, 2012, 4(2014), 9 |
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Übergeordnetes Werk: |
volume:4 ; year:2014 ; number:9 |
Links: |
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DOI / URN: |
10.1098/rsob.140088 |
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Katalog-ID: |
DOAJ009706739 |
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10.1098/rsob.140088 doi (DE-627)DOAJ009706739 (DE-599)DOAJ5a51ac0f6d00498b9b506d5bf22c12ba DE-627 ger DE-627 rakwb eng QH301-705.5 Ana Pinheiro verfasserin aut Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immunoglobulin G (IgG) is the predominant serum immunoglobulin and has the longest serum half-life of all the antibody classes. The European rabbit IgG has been of significant importance in immunological research, and is therefore well characterized. However, the IgG of other leporids has been disregarded. To evaluate the evolution of this gene in leporids, we sequenced the complete IGHG for six other genera: Bunolagus, Brachylagus, Lepus, Pentalagus, Romerolagus and Sylvilagus. The newly sequenced leporid IGHG gene has an organization and structure similar to that of the European rabbit IgG. A gradient in leporid IgG constant domain diversity was observed, with the CH1 being the most conserved and the CH3 the most variable domain. Positive selection was found to be acting on all constant domains, but with a greater incidence in the CH3 domain, where a cluster of three positively selected sites was identified. In the hinge region, only three polymorphic positions were observed. The same hinge length was observed for all leporids. Unlike the variation observed for the European rabbit, all 11 Lepus species studied share exactly the same hinge motif, suggesting its maintenance as a result of an advantageous structure or conformation. rabbit ighg genetic diversity immunoglobulins constant region hinge region evolution Biology (General) Jenny M. Woof verfasserin aut Tereza Almeida verfasserin aut Joana Abrantes verfasserin aut Paulo C. Alves verfasserin aut Christian Gortázar verfasserin aut Pedro J. Esteves verfasserin aut In Open Biology The Royal Society, 2012 4(2014), 9 (DE-627)669884146 (DE-600)2630944-0 20462441 nnns volume:4 year:2014 number:9 https://doi.org/10.1098/rsob.140088 kostenfrei https://doaj.org/article/5a51ac0f6d00498b9b506d5bf22c12ba kostenfrei https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140088 kostenfrei https://doaj.org/toc/2046-2441 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 9 |
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10.1098/rsob.140088 doi (DE-627)DOAJ009706739 (DE-599)DOAJ5a51ac0f6d00498b9b506d5bf22c12ba DE-627 ger DE-627 rakwb eng QH301-705.5 Ana Pinheiro verfasserin aut Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immunoglobulin G (IgG) is the predominant serum immunoglobulin and has the longest serum half-life of all the antibody classes. The European rabbit IgG has been of significant importance in immunological research, and is therefore well characterized. However, the IgG of other leporids has been disregarded. To evaluate the evolution of this gene in leporids, we sequenced the complete IGHG for six other genera: Bunolagus, Brachylagus, Lepus, Pentalagus, Romerolagus and Sylvilagus. The newly sequenced leporid IGHG gene has an organization and structure similar to that of the European rabbit IgG. A gradient in leporid IgG constant domain diversity was observed, with the CH1 being the most conserved and the CH3 the most variable domain. Positive selection was found to be acting on all constant domains, but with a greater incidence in the CH3 domain, where a cluster of three positively selected sites was identified. In the hinge region, only three polymorphic positions were observed. The same hinge length was observed for all leporids. Unlike the variation observed for the European rabbit, all 11 Lepus species studied share exactly the same hinge motif, suggesting its maintenance as a result of an advantageous structure or conformation. rabbit ighg genetic diversity immunoglobulins constant region hinge region evolution Biology (General) Jenny M. Woof verfasserin aut Tereza Almeida verfasserin aut Joana Abrantes verfasserin aut Paulo C. Alves verfasserin aut Christian Gortázar verfasserin aut Pedro J. Esteves verfasserin aut In Open Biology The Royal Society, 2012 4(2014), 9 (DE-627)669884146 (DE-600)2630944-0 20462441 nnns volume:4 year:2014 number:9 https://doi.org/10.1098/rsob.140088 kostenfrei https://doaj.org/article/5a51ac0f6d00498b9b506d5bf22c12ba kostenfrei https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140088 kostenfrei https://doaj.org/toc/2046-2441 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 9 |
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10.1098/rsob.140088 doi (DE-627)DOAJ009706739 (DE-599)DOAJ5a51ac0f6d00498b9b506d5bf22c12ba DE-627 ger DE-627 rakwb eng QH301-705.5 Ana Pinheiro verfasserin aut Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immunoglobulin G (IgG) is the predominant serum immunoglobulin and has the longest serum half-life of all the antibody classes. The European rabbit IgG has been of significant importance in immunological research, and is therefore well characterized. However, the IgG of other leporids has been disregarded. To evaluate the evolution of this gene in leporids, we sequenced the complete IGHG for six other genera: Bunolagus, Brachylagus, Lepus, Pentalagus, Romerolagus and Sylvilagus. The newly sequenced leporid IGHG gene has an organization and structure similar to that of the European rabbit IgG. A gradient in leporid IgG constant domain diversity was observed, with the CH1 being the most conserved and the CH3 the most variable domain. Positive selection was found to be acting on all constant domains, but with a greater incidence in the CH3 domain, where a cluster of three positively selected sites was identified. In the hinge region, only three polymorphic positions were observed. The same hinge length was observed for all leporids. Unlike the variation observed for the European rabbit, all 11 Lepus species studied share exactly the same hinge motif, suggesting its maintenance as a result of an advantageous structure or conformation. rabbit ighg genetic diversity immunoglobulins constant region hinge region evolution Biology (General) Jenny M. Woof verfasserin aut Tereza Almeida verfasserin aut Joana Abrantes verfasserin aut Paulo C. Alves verfasserin aut Christian Gortázar verfasserin aut Pedro J. Esteves verfasserin aut In Open Biology The Royal Society, 2012 4(2014), 9 (DE-627)669884146 (DE-600)2630944-0 20462441 nnns volume:4 year:2014 number:9 https://doi.org/10.1098/rsob.140088 kostenfrei https://doaj.org/article/5a51ac0f6d00498b9b506d5bf22c12ba kostenfrei https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140088 kostenfrei https://doaj.org/toc/2046-2441 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 9 |
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10.1098/rsob.140088 doi (DE-627)DOAJ009706739 (DE-599)DOAJ5a51ac0f6d00498b9b506d5bf22c12ba DE-627 ger DE-627 rakwb eng QH301-705.5 Ana Pinheiro verfasserin aut Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immunoglobulin G (IgG) is the predominant serum immunoglobulin and has the longest serum half-life of all the antibody classes. The European rabbit IgG has been of significant importance in immunological research, and is therefore well characterized. However, the IgG of other leporids has been disregarded. To evaluate the evolution of this gene in leporids, we sequenced the complete IGHG for six other genera: Bunolagus, Brachylagus, Lepus, Pentalagus, Romerolagus and Sylvilagus. The newly sequenced leporid IGHG gene has an organization and structure similar to that of the European rabbit IgG. A gradient in leporid IgG constant domain diversity was observed, with the CH1 being the most conserved and the CH3 the most variable domain. Positive selection was found to be acting on all constant domains, but with a greater incidence in the CH3 domain, where a cluster of three positively selected sites was identified. In the hinge region, only three polymorphic positions were observed. The same hinge length was observed for all leporids. Unlike the variation observed for the European rabbit, all 11 Lepus species studied share exactly the same hinge motif, suggesting its maintenance as a result of an advantageous structure or conformation. rabbit ighg genetic diversity immunoglobulins constant region hinge region evolution Biology (General) Jenny M. Woof verfasserin aut Tereza Almeida verfasserin aut Joana Abrantes verfasserin aut Paulo C. Alves verfasserin aut Christian Gortázar verfasserin aut Pedro J. Esteves verfasserin aut In Open Biology The Royal Society, 2012 4(2014), 9 (DE-627)669884146 (DE-600)2630944-0 20462441 nnns volume:4 year:2014 number:9 https://doi.org/10.1098/rsob.140088 kostenfrei https://doaj.org/article/5a51ac0f6d00498b9b506d5bf22c12ba kostenfrei https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140088 kostenfrei https://doaj.org/toc/2046-2441 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 9 |
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10.1098/rsob.140088 doi (DE-627)DOAJ009706739 (DE-599)DOAJ5a51ac0f6d00498b9b506d5bf22c12ba DE-627 ger DE-627 rakwb eng QH301-705.5 Ana Pinheiro verfasserin aut Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immunoglobulin G (IgG) is the predominant serum immunoglobulin and has the longest serum half-life of all the antibody classes. The European rabbit IgG has been of significant importance in immunological research, and is therefore well characterized. However, the IgG of other leporids has been disregarded. To evaluate the evolution of this gene in leporids, we sequenced the complete IGHG for six other genera: Bunolagus, Brachylagus, Lepus, Pentalagus, Romerolagus and Sylvilagus. The newly sequenced leporid IGHG gene has an organization and structure similar to that of the European rabbit IgG. A gradient in leporid IgG constant domain diversity was observed, with the CH1 being the most conserved and the CH3 the most variable domain. Positive selection was found to be acting on all constant domains, but with a greater incidence in the CH3 domain, where a cluster of three positively selected sites was identified. In the hinge region, only three polymorphic positions were observed. The same hinge length was observed for all leporids. Unlike the variation observed for the European rabbit, all 11 Lepus species studied share exactly the same hinge motif, suggesting its maintenance as a result of an advantageous structure or conformation. rabbit ighg genetic diversity immunoglobulins constant region hinge region evolution Biology (General) Jenny M. Woof verfasserin aut Tereza Almeida verfasserin aut Joana Abrantes verfasserin aut Paulo C. Alves verfasserin aut Christian Gortázar verfasserin aut Pedro J. Esteves verfasserin aut In Open Biology The Royal Society, 2012 4(2014), 9 (DE-627)669884146 (DE-600)2630944-0 20462441 nnns volume:4 year:2014 number:9 https://doi.org/10.1098/rsob.140088 kostenfrei https://doaj.org/article/5a51ac0f6d00498b9b506d5bf22c12ba kostenfrei https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140088 kostenfrei https://doaj.org/toc/2046-2441 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 9 |
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Ana Pinheiro misc QH301-705.5 misc rabbit misc ighg misc genetic diversity misc immunoglobulins constant region misc hinge region misc evolution misc Biology (General) Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains |
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Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains |
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Immunoglobulin G (IgG) is the predominant serum immunoglobulin and has the longest serum half-life of all the antibody classes. The European rabbit IgG has been of significant importance in immunological research, and is therefore well characterized. However, the IgG of other leporids has been disregarded. To evaluate the evolution of this gene in leporids, we sequenced the complete IGHG for six other genera: Bunolagus, Brachylagus, Lepus, Pentalagus, Romerolagus and Sylvilagus. The newly sequenced leporid IGHG gene has an organization and structure similar to that of the European rabbit IgG. A gradient in leporid IgG constant domain diversity was observed, with the CH1 being the most conserved and the CH3 the most variable domain. Positive selection was found to be acting on all constant domains, but with a greater incidence in the CH3 domain, where a cluster of three positively selected sites was identified. In the hinge region, only three polymorphic positions were observed. The same hinge length was observed for all leporids. Unlike the variation observed for the European rabbit, all 11 Lepus species studied share exactly the same hinge motif, suggesting its maintenance as a result of an advantageous structure or conformation. |
abstractGer |
Immunoglobulin G (IgG) is the predominant serum immunoglobulin and has the longest serum half-life of all the antibody classes. The European rabbit IgG has been of significant importance in immunological research, and is therefore well characterized. However, the IgG of other leporids has been disregarded. To evaluate the evolution of this gene in leporids, we sequenced the complete IGHG for six other genera: Bunolagus, Brachylagus, Lepus, Pentalagus, Romerolagus and Sylvilagus. The newly sequenced leporid IGHG gene has an organization and structure similar to that of the European rabbit IgG. A gradient in leporid IgG constant domain diversity was observed, with the CH1 being the most conserved and the CH3 the most variable domain. Positive selection was found to be acting on all constant domains, but with a greater incidence in the CH3 domain, where a cluster of three positively selected sites was identified. In the hinge region, only three polymorphic positions were observed. The same hinge length was observed for all leporids. Unlike the variation observed for the European rabbit, all 11 Lepus species studied share exactly the same hinge motif, suggesting its maintenance as a result of an advantageous structure or conformation. |
abstract_unstemmed |
Immunoglobulin G (IgG) is the predominant serum immunoglobulin and has the longest serum half-life of all the antibody classes. The European rabbit IgG has been of significant importance in immunological research, and is therefore well characterized. However, the IgG of other leporids has been disregarded. To evaluate the evolution of this gene in leporids, we sequenced the complete IGHG for six other genera: Bunolagus, Brachylagus, Lepus, Pentalagus, Romerolagus and Sylvilagus. The newly sequenced leporid IGHG gene has an organization and structure similar to that of the European rabbit IgG. A gradient in leporid IgG constant domain diversity was observed, with the CH1 being the most conserved and the CH3 the most variable domain. Positive selection was found to be acting on all constant domains, but with a greater incidence in the CH3 domain, where a cluster of three positively selected sites was identified. In the hinge region, only three polymorphic positions were observed. The same hinge length was observed for all leporids. Unlike the variation observed for the European rabbit, all 11 Lepus species studied share exactly the same hinge motif, suggesting its maintenance as a result of an advantageous structure or conformation. |
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Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains |
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https://doi.org/10.1098/rsob.140088 https://doaj.org/article/5a51ac0f6d00498b9b506d5bf22c12ba https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140088 https://doaj.org/toc/2046-2441 |
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