Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia

Different degrees of threat predictability are thought to induce either phasic fear or sustained anxiety. Maladaptive, sustained anxious apprehension is thought to result in overgeneralization of anxiety and thereby to contribute to the development of anxiety disorders. Therefore, differences in thr...
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Autor*in:	Anna Luisa Klahn [verfasserIn] Isabelle A. Klinkenberg [verfasserIn] Ulrike Lueken [verfasserIn] Swantje Notzon [verfasserIn] Volker Arolt [verfasserIn] Christo Pantev [verfasserIn] Peter Zwanzger [verfasserIn] Markus Junghoefer [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Anxiety Panic disorder MEG Ventromedial prefrontal cortex Dorsolateral prefrontal cortex

Übergeordnetes Werk:	In: NeuroImage: Clinical - Elsevier, 2015, 14(2017), C, Seite 530-537
Übergeordnetes Werk:	volume:14 ; year:2017 ; number:C ; pages:530-537

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.nicl.2017.02.013

Katalog-ID:	DOAJ009738495

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520			\|a Different degrees of threat predictability are thought to induce either phasic fear or sustained anxiety. Maladaptive, sustained anxious apprehension is thought to result in overgeneralization of anxiety and thereby to contribute to the development of anxiety disorders. Therefore, differences in threat predictability have been associated with pathological states of anxiety with specific phobia (SP) representing phasic fear as heightened response to predictable threat, while panic disorder (PD) is characterized by sustained anxiety (unpredictable threat) and, as a consequence, overgeneralization of fear. The present study aimed to delineate commonalities and differences in the neural substrates of the impact of threat predictability on affective processing in these two anxiety disorders. Twenty PD patients, 20 SP patients and 20 non-anxious control subjects were investigated with an adapted NPU-design (no, predictable, unpredictable threat) using whole-head magnetoencephalography (MEG). Group independent neural activity in the right dlPFC increased with decreasing threat predictability. PD patients showed a sustained hyperactivation of the vmPFC under threat and safety conditions. The magnitude of hyperactivation was inversely correlated with PDs subjective arousal and anxiety sensitivity. Both PD and SP patients revealed decreased parietal processing of affective stimuli. Findings indicate overgeneralization between threat and safety conditions and increased need for emotion regulation via the vmPFC in PD, but not SP patients. Both anxiety disorders showed decreased activation in parietal networks possibly indicating attentional avoidance of affective stimuli. Present results complement findings from fear conditioning studies and underline overgeneralization of fear, particularly in PD.
650		4	\|a Anxiety
650		4	\|a Panic disorder
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650		4	\|a Ventromedial prefrontal cortex
650		4	\|a Dorsolateral prefrontal cortex
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700	0		\|a Volker Arolt \|e verfasserin \|4 aut
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700	0		\|a Markus Junghoefer \|e verfasserin \|4 aut
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allfields_unstemmed	10.1016/j.nicl.2017.02.013 doi (DE-627)DOAJ009738495 (DE-599)DOAJ6dfa7a8475d24941b091256d543fd62d DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Anna Luisa Klahn verfasserin aut Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Different degrees of threat predictability are thought to induce either phasic fear or sustained anxiety. Maladaptive, sustained anxious apprehension is thought to result in overgeneralization of anxiety and thereby to contribute to the development of anxiety disorders. Therefore, differences in threat predictability have been associated with pathological states of anxiety with specific phobia (SP) representing phasic fear as heightened response to predictable threat, while panic disorder (PD) is characterized by sustained anxiety (unpredictable threat) and, as a consequence, overgeneralization of fear. The present study aimed to delineate commonalities and differences in the neural substrates of the impact of threat predictability on affective processing in these two anxiety disorders. Twenty PD patients, 20 SP patients and 20 non-anxious control subjects were investigated with an adapted NPU-design (no, predictable, unpredictable threat) using whole-head magnetoencephalography (MEG). Group independent neural activity in the right dlPFC increased with decreasing threat predictability. PD patients showed a sustained hyperactivation of the vmPFC under threat and safety conditions. The magnitude of hyperactivation was inversely correlated with PDs subjective arousal and anxiety sensitivity. Both PD and SP patients revealed decreased parietal processing of affective stimuli. Findings indicate overgeneralization between threat and safety conditions and increased need for emotion regulation via the vmPFC in PD, but not SP patients. Both anxiety disorders showed decreased activation in parietal networks possibly indicating attentional avoidance of affective stimuli. Present results complement findings from fear conditioning studies and underline overgeneralization of fear, particularly in PD. Anxiety Panic disorder MEG Ventromedial prefrontal cortex Dorsolateral prefrontal cortex Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Isabelle A. Klinkenberg verfasserin aut Ulrike Lueken verfasserin aut Swantje Notzon verfasserin aut Volker Arolt verfasserin aut Christo Pantev verfasserin aut Peter Zwanzger verfasserin aut Markus Junghoefer verfasserin aut In NeuroImage: Clinical Elsevier, 2015 14(2017), C, Seite 530-537 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:14 year:2017 number:C pages:530-537 https://doi.org/10.1016/j.nicl.2017.02.013 kostenfrei https://doaj.org/article/6dfa7a8475d24941b091256d543fd62d kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158217300475 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2017 C 530-537
allfieldsGer	10.1016/j.nicl.2017.02.013 doi (DE-627)DOAJ009738495 (DE-599)DOAJ6dfa7a8475d24941b091256d543fd62d DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Anna Luisa Klahn verfasserin aut Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Different degrees of threat predictability are thought to induce either phasic fear or sustained anxiety. Maladaptive, sustained anxious apprehension is thought to result in overgeneralization of anxiety and thereby to contribute to the development of anxiety disorders. Therefore, differences in threat predictability have been associated with pathological states of anxiety with specific phobia (SP) representing phasic fear as heightened response to predictable threat, while panic disorder (PD) is characterized by sustained anxiety (unpredictable threat) and, as a consequence, overgeneralization of fear. The present study aimed to delineate commonalities and differences in the neural substrates of the impact of threat predictability on affective processing in these two anxiety disorders. Twenty PD patients, 20 SP patients and 20 non-anxious control subjects were investigated with an adapted NPU-design (no, predictable, unpredictable threat) using whole-head magnetoencephalography (MEG). Group independent neural activity in the right dlPFC increased with decreasing threat predictability. PD patients showed a sustained hyperactivation of the vmPFC under threat and safety conditions. The magnitude of hyperactivation was inversely correlated with PDs subjective arousal and anxiety sensitivity. Both PD and SP patients revealed decreased parietal processing of affective stimuli. Findings indicate overgeneralization between threat and safety conditions and increased need for emotion regulation via the vmPFC in PD, but not SP patients. Both anxiety disorders showed decreased activation in parietal networks possibly indicating attentional avoidance of affective stimuli. Present results complement findings from fear conditioning studies and underline overgeneralization of fear, particularly in PD. Anxiety Panic disorder MEG Ventromedial prefrontal cortex Dorsolateral prefrontal cortex Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Isabelle A. Klinkenberg verfasserin aut Ulrike Lueken verfasserin aut Swantje Notzon verfasserin aut Volker Arolt verfasserin aut Christo Pantev verfasserin aut Peter Zwanzger verfasserin aut Markus Junghoefer verfasserin aut In NeuroImage: Clinical Elsevier, 2015 14(2017), C, Seite 530-537 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:14 year:2017 number:C pages:530-537 https://doi.org/10.1016/j.nicl.2017.02.013 kostenfrei https://doaj.org/article/6dfa7a8475d24941b091256d543fd62d kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158217300475 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2017 C 530-537
allfieldsSound	10.1016/j.nicl.2017.02.013 doi (DE-627)DOAJ009738495 (DE-599)DOAJ6dfa7a8475d24941b091256d543fd62d DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Anna Luisa Klahn verfasserin aut Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Different degrees of threat predictability are thought to induce either phasic fear or sustained anxiety. Maladaptive, sustained anxious apprehension is thought to result in overgeneralization of anxiety and thereby to contribute to the development of anxiety disorders. Therefore, differences in threat predictability have been associated with pathological states of anxiety with specific phobia (SP) representing phasic fear as heightened response to predictable threat, while panic disorder (PD) is characterized by sustained anxiety (unpredictable threat) and, as a consequence, overgeneralization of fear. The present study aimed to delineate commonalities and differences in the neural substrates of the impact of threat predictability on affective processing in these two anxiety disorders. Twenty PD patients, 20 SP patients and 20 non-anxious control subjects were investigated with an adapted NPU-design (no, predictable, unpredictable threat) using whole-head magnetoencephalography (MEG). Group independent neural activity in the right dlPFC increased with decreasing threat predictability. PD patients showed a sustained hyperactivation of the vmPFC under threat and safety conditions. The magnitude of hyperactivation was inversely correlated with PDs subjective arousal and anxiety sensitivity. Both PD and SP patients revealed decreased parietal processing of affective stimuli. Findings indicate overgeneralization between threat and safety conditions and increased need for emotion regulation via the vmPFC in PD, but not SP patients. Both anxiety disorders showed decreased activation in parietal networks possibly indicating attentional avoidance of affective stimuli. Present results complement findings from fear conditioning studies and underline overgeneralization of fear, particularly in PD. Anxiety Panic disorder MEG Ventromedial prefrontal cortex Dorsolateral prefrontal cortex Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Isabelle A. Klinkenberg verfasserin aut Ulrike Lueken verfasserin aut Swantje Notzon verfasserin aut Volker Arolt verfasserin aut Christo Pantev verfasserin aut Peter Zwanzger verfasserin aut Markus Junghoefer verfasserin aut In NeuroImage: Clinical Elsevier, 2015 14(2017), C, Seite 530-537 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:14 year:2017 number:C pages:530-537 https://doi.org/10.1016/j.nicl.2017.02.013 kostenfrei https://doaj.org/article/6dfa7a8475d24941b091256d543fd62d kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158217300475 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2017 C 530-537
language	English
source	In NeuroImage: Clinical 14(2017), C, Seite 530-537 volume:14 year:2017 number:C pages:530-537
sourceStr	In NeuroImage: Clinical 14(2017), C, Seite 530-537 volume:14 year:2017 number:C pages:530-537
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Anxiety Panic disorder MEG Ventromedial prefrontal cortex Dorsolateral prefrontal cortex Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	NeuroImage: Clinical
authorswithroles_txt_mv	Anna Luisa Klahn @@aut@@ Isabelle A. Klinkenberg @@aut@@ Ulrike Lueken @@aut@@ Swantje Notzon @@aut@@ Volker Arolt @@aut@@ Christo Pantev @@aut@@ Peter Zwanzger @@aut@@ Markus Junghoefer @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	735358869
id	DOAJ009738495
language_de	englisch
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callnumber-first	R - Medicine
author	Anna Luisa Klahn
spellingShingle	Anna Luisa Klahn misc R858-859.7 misc RC346-429 misc Anxiety misc Panic disorder misc MEG misc Ventromedial prefrontal cortex misc Dorsolateral prefrontal cortex misc Computer applications to medicine. Medical informatics misc Neurology. Diseases of the nervous system Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia
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topic_title	R858-859.7 RC346-429 Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia Anxiety Panic disorder MEG Ventromedial prefrontal cortex Dorsolateral prefrontal cortex
topic	misc R858-859.7 misc RC346-429 misc Anxiety misc Panic disorder misc MEG misc Ventromedial prefrontal cortex misc Dorsolateral prefrontal cortex misc Computer applications to medicine. Medical informatics misc Neurology. Diseases of the nervous system
topic_unstemmed	misc R858-859.7 misc RC346-429 misc Anxiety misc Panic disorder misc MEG misc Ventromedial prefrontal cortex misc Dorsolateral prefrontal cortex misc Computer applications to medicine. Medical informatics misc Neurology. Diseases of the nervous system
topic_browse	misc R858-859.7 misc RC346-429 misc Anxiety misc Panic disorder misc MEG misc Ventromedial prefrontal cortex misc Dorsolateral prefrontal cortex misc Computer applications to medicine. Medical informatics misc Neurology. Diseases of the nervous system
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title	Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia
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title_full	Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia
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author_browse	Anna Luisa Klahn Isabelle A. Klinkenberg Ulrike Lueken Swantje Notzon Volker Arolt Christo Pantev Peter Zwanzger Markus Junghoefer
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title_sort	commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia
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title_auth	Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia
abstract	Different degrees of threat predictability are thought to induce either phasic fear or sustained anxiety. Maladaptive, sustained anxious apprehension is thought to result in overgeneralization of anxiety and thereby to contribute to the development of anxiety disorders. Therefore, differences in threat predictability have been associated with pathological states of anxiety with specific phobia (SP) representing phasic fear as heightened response to predictable threat, while panic disorder (PD) is characterized by sustained anxiety (unpredictable threat) and, as a consequence, overgeneralization of fear. The present study aimed to delineate commonalities and differences in the neural substrates of the impact of threat predictability on affective processing in these two anxiety disorders. Twenty PD patients, 20 SP patients and 20 non-anxious control subjects were investigated with an adapted NPU-design (no, predictable, unpredictable threat) using whole-head magnetoencephalography (MEG). Group independent neural activity in the right dlPFC increased with decreasing threat predictability. PD patients showed a sustained hyperactivation of the vmPFC under threat and safety conditions. The magnitude of hyperactivation was inversely correlated with PDs subjective arousal and anxiety sensitivity. Both PD and SP patients revealed decreased parietal processing of affective stimuli. Findings indicate overgeneralization between threat and safety conditions and increased need for emotion regulation via the vmPFC in PD, but not SP patients. Both anxiety disorders showed decreased activation in parietal networks possibly indicating attentional avoidance of affective stimuli. Present results complement findings from fear conditioning studies and underline overgeneralization of fear, particularly in PD.
abstractGer	Different degrees of threat predictability are thought to induce either phasic fear or sustained anxiety. Maladaptive, sustained anxious apprehension is thought to result in overgeneralization of anxiety and thereby to contribute to the development of anxiety disorders. Therefore, differences in threat predictability have been associated with pathological states of anxiety with specific phobia (SP) representing phasic fear as heightened response to predictable threat, while panic disorder (PD) is characterized by sustained anxiety (unpredictable threat) and, as a consequence, overgeneralization of fear. The present study aimed to delineate commonalities and differences in the neural substrates of the impact of threat predictability on affective processing in these two anxiety disorders. Twenty PD patients, 20 SP patients and 20 non-anxious control subjects were investigated with an adapted NPU-design (no, predictable, unpredictable threat) using whole-head magnetoencephalography (MEG). Group independent neural activity in the right dlPFC increased with decreasing threat predictability. PD patients showed a sustained hyperactivation of the vmPFC under threat and safety conditions. The magnitude of hyperactivation was inversely correlated with PDs subjective arousal and anxiety sensitivity. Both PD and SP patients revealed decreased parietal processing of affective stimuli. Findings indicate overgeneralization between threat and safety conditions and increased need for emotion regulation via the vmPFC in PD, but not SP patients. Both anxiety disorders showed decreased activation in parietal networks possibly indicating attentional avoidance of affective stimuli. Present results complement findings from fear conditioning studies and underline overgeneralization of fear, particularly in PD.
abstract_unstemmed	Different degrees of threat predictability are thought to induce either phasic fear or sustained anxiety. Maladaptive, sustained anxious apprehension is thought to result in overgeneralization of anxiety and thereby to contribute to the development of anxiety disorders. Therefore, differences in threat predictability have been associated with pathological states of anxiety with specific phobia (SP) representing phasic fear as heightened response to predictable threat, while panic disorder (PD) is characterized by sustained anxiety (unpredictable threat) and, as a consequence, overgeneralization of fear. The present study aimed to delineate commonalities and differences in the neural substrates of the impact of threat predictability on affective processing in these two anxiety disorders. Twenty PD patients, 20 SP patients and 20 non-anxious control subjects were investigated with an adapted NPU-design (no, predictable, unpredictable threat) using whole-head magnetoencephalography (MEG). Group independent neural activity in the right dlPFC increased with decreasing threat predictability. PD patients showed a sustained hyperactivation of the vmPFC under threat and safety conditions. The magnitude of hyperactivation was inversely correlated with PDs subjective arousal and anxiety sensitivity. Both PD and SP patients revealed decreased parietal processing of affective stimuli. Findings indicate overgeneralization between threat and safety conditions and increased need for emotion regulation via the vmPFC in PD, but not SP patients. Both anxiety disorders showed decreased activation in parietal networks possibly indicating attentional avoidance of affective stimuli. Present results complement findings from fear conditioning studies and underline overgeneralization of fear, particularly in PD.
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title_short	Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia
url	https://doi.org/10.1016/j.nicl.2017.02.013 https://doaj.org/article/6dfa7a8475d24941b091256d543fd62d http://www.sciencedirect.com/science/article/pii/S2213158217300475 https://doaj.org/toc/2213-1582
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ009738495</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230310022144.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2017 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.nicl.2017.02.013</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ009738495</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ6dfa7a8475d24941b091256d543fd62d</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">R858-859.7</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC346-429</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Anna Luisa Klahn</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Different degrees of threat predictability are thought to induce either phasic fear or sustained anxiety. Maladaptive, sustained anxious apprehension is thought to result in overgeneralization of anxiety and thereby to contribute to the development of anxiety disorders. Therefore, differences in threat predictability have been associated with pathological states of anxiety with specific phobia (SP) representing phasic fear as heightened response to predictable threat, while panic disorder (PD) is characterized by sustained anxiety (unpredictable threat) and, as a consequence, overgeneralization of fear. The present study aimed to delineate commonalities and differences in the neural substrates of the impact of threat predictability on affective processing in these two anxiety disorders. Twenty PD patients, 20 SP patients and 20 non-anxious control subjects were investigated with an adapted NPU-design (no, predictable, unpredictable threat) using whole-head magnetoencephalography (MEG). Group independent neural activity in the right dlPFC increased with decreasing threat predictability. PD patients showed a sustained hyperactivation of the vmPFC under threat and safety conditions. The magnitude of hyperactivation was inversely correlated with PDs subjective arousal and anxiety sensitivity. Both PD and SP patients revealed decreased parietal processing of affective stimuli. Findings indicate overgeneralization between threat and safety conditions and increased need for emotion regulation via the vmPFC in PD, but not SP patients. Both anxiety disorders showed decreased activation in parietal networks possibly indicating attentional avoidance of affective stimuli. 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Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia

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