New Peptaibiotics and a Cyclodepsipeptide from <i<Ijuhya vitellina</i<: Isolation, Identification, Cytotoxic and Nematicidal Activities

Fungal associations with nematodes have attracted scientific attention because of the need to develop new biocontrol agents. In this context, <i<Ijuhya vitellina</i<, an antagonistic fungus previously isolated from the plant parasitic cyst nematode <i<Heterodera filipjevi</i<...
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Gespeichert in:

Autor*in:	Ashaimaa Y. Moussa [verfasserIn] Christopher Lambert [verfasserIn] Theresia E.B. Stradal [verfasserIn] Samad Ashrafi [verfasserIn] Wolfgang Maier [verfasserIn] Marc Stadler [verfasserIn] Soleiman E. Helaly [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	cyclodepsipeptides nematicidal activity peptaibiotics sordariomycetes structure elucidation

Übergeordnetes Werk:	In: Antibiotics - MDPI AG, 2013, 9(2020), 3, p 132
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:3, p 132

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antibiotics9030132

Katalog-ID:	DOAJ009885129

Internformat


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allfieldsSound	10.3390/antibiotics9030132 doi (DE-627)DOAJ009885129 (DE-599)DOAJ7c02a802e2d74124bd69c1c8e77d1a32 DE-627 ger DE-627 rakwb eng RM1-950 Ashaimaa Y. Moussa verfasserin aut New Peptaibiotics and a Cyclodepsipeptide from <i<Ijuhya vitellina</i<: Isolation, Identification, Cytotoxic and Nematicidal Activities 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fungal associations with nematodes have attracted scientific attention because of the need to develop new biocontrol agents. In this context, <i<Ijuhya vitellina</i<, an antagonistic fungus previously isolated from the plant parasitic cyst nematode <i<Heterodera filipjevi</i<, was selected to carry out an in-depth metabolomic study for its active metabolites. Herein, three new nonapeptide peptaibols with leucinostatin based sequences were isolated and identified by 1, 2D NMR, and HR-ESI-MS-MS. The absolute configuration was assigned based on Marfay’s analysis and Mosher ester formation. The new leucinostatins manifested moderate nematicidal effect against the plant pathogenic nematode <i<Pratylenchus penetrans</i< with LD<sub<90</sub< values ranging from 5 to 7 µg/mL. Furthermore, a cyclodepsipeptide, named arthrichitin D, with five amino acid residues attached to a 3-hydroxy-2,4-dimethylhexadeca-4,6-dienoic fatty acid chain was discovered and showed weak nematicidal effect against <i<Caenorhabditis elegans</i<. Chaetoglobosin B and its 19-<i<O</i<-acetyl derivative were also obtained as minor metabolites, and the activity of chaetoglobosin B on the actin cytoskeleton of mammalian cells was assessed. cyclodepsipeptides nematicidal activity peptaibiotics sordariomycetes structure elucidation Therapeutics. Pharmacology Christopher Lambert verfasserin aut Theresia E.B. Stradal verfasserin aut Samad Ashrafi verfasserin aut Wolfgang Maier verfasserin aut Marc Stadler verfasserin aut Soleiman E. Helaly verfasserin aut In Antibiotics MDPI AG, 2013 9(2020), 3, p 132 (DE-627)726120596 (DE-600)2681345-2 20796382 nnns volume:9 year:2020 number:3, p 132 https://doi.org/10.3390/antibiotics9030132 kostenfrei https://doaj.org/article/7c02a802e2d74124bd69c1c8e77d1a32 kostenfrei https://www.mdpi.com/2079-6382/9/3/132 kostenfrei https://doaj.org/toc/2079-6382 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3, p 132
language	English
source	In Antibiotics 9(2020), 3, p 132 volume:9 year:2020 number:3, p 132
sourceStr	In Antibiotics 9(2020), 3, p 132 volume:9 year:2020 number:3, p 132
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	cyclodepsipeptides nematicidal activity peptaibiotics sordariomycetes structure elucidation Therapeutics. Pharmacology
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container_title	Antibiotics
authorswithroles_txt_mv	Ashaimaa Y. Moussa @@aut@@ Christopher Lambert @@aut@@ Theresia E.B. Stradal @@aut@@ Samad Ashrafi @@aut@@ Wolfgang Maier @@aut@@ Marc Stadler @@aut@@ Soleiman E. Helaly @@aut@@
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callnumber-first	R - Medicine
author	Ashaimaa Y. Moussa
spellingShingle	Ashaimaa Y. Moussa misc RM1-950 misc cyclodepsipeptides misc nematicidal activity misc peptaibiotics misc sordariomycetes misc structure elucidation misc Therapeutics. Pharmacology New Peptaibiotics and a Cyclodepsipeptide from <i<Ijuhya vitellina</i<: Isolation, Identification, Cytotoxic and Nematicidal Activities
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topic_title	RM1-950 New Peptaibiotics and a Cyclodepsipeptide from <i<Ijuhya vitellina</i<: Isolation, Identification, Cytotoxic and Nematicidal Activities cyclodepsipeptides nematicidal activity peptaibiotics sordariomycetes structure elucidation
topic	misc RM1-950 misc cyclodepsipeptides misc nematicidal activity misc peptaibiotics misc sordariomycetes misc structure elucidation misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc cyclodepsipeptides misc nematicidal activity misc peptaibiotics misc sordariomycetes misc structure elucidation misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc cyclodepsipeptides misc nematicidal activity misc peptaibiotics misc sordariomycetes misc structure elucidation misc Therapeutics. Pharmacology
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title	New Peptaibiotics and a Cyclodepsipeptide from <i<Ijuhya vitellina</i<: Isolation, Identification, Cytotoxic and Nematicidal Activities
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title_full	New Peptaibiotics and a Cyclodepsipeptide from <i<Ijuhya vitellina</i<: Isolation, Identification, Cytotoxic and Nematicidal Activities
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author_browse	Ashaimaa Y. Moussa Christopher Lambert Theresia E.B. Stradal Samad Ashrafi Wolfgang Maier Marc Stadler Soleiman E. Helaly
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author-letter	Ashaimaa Y. Moussa
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title_sort	new peptaibiotics and a cyclodepsipeptide from <i<ijuhya vitellina</i<: isolation, identification, cytotoxic and nematicidal activities
callnumber	RM1-950
title_auth	New Peptaibiotics and a Cyclodepsipeptide from <i<Ijuhya vitellina</i<: Isolation, Identification, Cytotoxic and Nematicidal Activities
abstract	Fungal associations with nematodes have attracted scientific attention because of the need to develop new biocontrol agents. In this context, <i<Ijuhya vitellina</i<, an antagonistic fungus previously isolated from the plant parasitic cyst nematode <i<Heterodera filipjevi</i<, was selected to carry out an in-depth metabolomic study for its active metabolites. Herein, three new nonapeptide peptaibols with leucinostatin based sequences were isolated and identified by 1, 2D NMR, and HR-ESI-MS-MS. The absolute configuration was assigned based on Marfay’s analysis and Mosher ester formation. The new leucinostatins manifested moderate nematicidal effect against the plant pathogenic nematode <i<Pratylenchus penetrans</i< with LD<sub<90</sub< values ranging from 5 to 7 µg/mL. Furthermore, a cyclodepsipeptide, named arthrichitin D, with five amino acid residues attached to a 3-hydroxy-2,4-dimethylhexadeca-4,6-dienoic fatty acid chain was discovered and showed weak nematicidal effect against <i<Caenorhabditis elegans</i<. Chaetoglobosin B and its 19-<i<O</i<-acetyl derivative were also obtained as minor metabolites, and the activity of chaetoglobosin B on the actin cytoskeleton of mammalian cells was assessed.
abstractGer	Fungal associations with nematodes have attracted scientific attention because of the need to develop new biocontrol agents. In this context, <i<Ijuhya vitellina</i<, an antagonistic fungus previously isolated from the plant parasitic cyst nematode <i<Heterodera filipjevi</i<, was selected to carry out an in-depth metabolomic study for its active metabolites. Herein, three new nonapeptide peptaibols with leucinostatin based sequences were isolated and identified by 1, 2D NMR, and HR-ESI-MS-MS. The absolute configuration was assigned based on Marfay’s analysis and Mosher ester formation. The new leucinostatins manifested moderate nematicidal effect against the plant pathogenic nematode <i<Pratylenchus penetrans</i< with LD<sub<90</sub< values ranging from 5 to 7 µg/mL. Furthermore, a cyclodepsipeptide, named arthrichitin D, with five amino acid residues attached to a 3-hydroxy-2,4-dimethylhexadeca-4,6-dienoic fatty acid chain was discovered and showed weak nematicidal effect against <i<Caenorhabditis elegans</i<. Chaetoglobosin B and its 19-<i<O</i<-acetyl derivative were also obtained as minor metabolites, and the activity of chaetoglobosin B on the actin cytoskeleton of mammalian cells was assessed.
abstract_unstemmed	Fungal associations with nematodes have attracted scientific attention because of the need to develop new biocontrol agents. In this context, <i<Ijuhya vitellina</i<, an antagonistic fungus previously isolated from the plant parasitic cyst nematode <i<Heterodera filipjevi</i<, was selected to carry out an in-depth metabolomic study for its active metabolites. Herein, three new nonapeptide peptaibols with leucinostatin based sequences were isolated and identified by 1, 2D NMR, and HR-ESI-MS-MS. The absolute configuration was assigned based on Marfay’s analysis and Mosher ester formation. The new leucinostatins manifested moderate nematicidal effect against the plant pathogenic nematode <i<Pratylenchus penetrans</i< with LD<sub<90</sub< values ranging from 5 to 7 µg/mL. Furthermore, a cyclodepsipeptide, named arthrichitin D, with five amino acid residues attached to a 3-hydroxy-2,4-dimethylhexadeca-4,6-dienoic fatty acid chain was discovered and showed weak nematicidal effect against <i<Caenorhabditis elegans</i<. Chaetoglobosin B and its 19-<i<O</i<-acetyl derivative were also obtained as minor metabolites, and the activity of chaetoglobosin B on the actin cytoskeleton of mammalian cells was assessed.
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container_issue	3, p 132
title_short	New Peptaibiotics and a Cyclodepsipeptide from <i<Ijuhya vitellina</i<: Isolation, Identification, Cytotoxic and Nematicidal Activities
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author2	Christopher Lambert Theresia E.B. Stradal Samad Ashrafi Wolfgang Maier Marc Stadler Soleiman E. Helaly
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up_date	2024-07-04T01:25:47.264Z
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