Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma

Aim: Breast cancer is the most frequent cancer among women. The p16INK4a and bcl-2 genes are the two major pathways involved in control of the cell cycle. They also play key roles in breast carcinogenesis. In this study, we investigated the relationships between the histopathologic parameters in the...
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Autor*in:	Selma Erdoğan Düzcü [verfasserIn] Mihriban Gürbüzel [verfasserIn] Saime Gül Barut [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Türkisch

Erschienen:	2015

Schlagwörter:	Invasive ductal carcinoma of the breast p16 (ink4a) bcl

Übergeordnetes Werk:	In: Haseki Tıp Bülteni - Galenos Yayinevi, 2015, 53(2015), 3, Seite 229-236
Übergeordnetes Werk:	volume:53 ; year:2015 ; number:3 ; pages:229-236

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4274/haseki.2443

Katalog-ID:	DOAJ009911634

Internformat


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allfields	10.4274/haseki.2443 doi (DE-627)DOAJ009911634 (DE-599)DOAJ96829cde12544a5292076058bed02daf DE-627 ger DE-627 rakwb eng tur R5-920 Selma Erdoğan Düzcü verfasserin aut Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: Breast cancer is the most frequent cancer among women. The p16INK4a and bcl-2 genes are the two major pathways involved in control of the cell cycle. They also play key roles in breast carcinogenesis. In this study, we investigated the relationships between the histopathologic parameters in the “Modified ScarffBloom-Richardson” microscopic grading and expression of p16 and bcl-2 gene in cases with invasive ductal carcinoma. Methods: We examined 88 patients who were diagnosed with invasive ductal carcinoma between 2011 and 2013 in Haseki Educational and Research Hospital Pathology Department. Immunohistochemical staining for p16 and bcl-2 was performed. Results: Increased expression of p16 gene was statistically significantly related with increased tubule formation, pleomorfism, mitosis rate and histological grade (p=0.008, p=0.001, p=0.005, and p<0.001, respectively). We found a statistically significant relationship of the rise of the expression of bcl-2 gene with decreased mitosis rate and histological grade (p=0.026 and p=0.024, respectively). Conclusion: As a result, it was observed that there was a positive correlation between parameters included in Modified ScarffBloom-Richardson grading system with p16 in addition to negative correlation with bcl-2 expression. p16 and bcl-2 are important prognostic biomarkers in human breast cancer. (The Medical Bulletin of Haseki 2015; 53:229-36) Invasive ductal carcinoma of the breast p16 (ink4a) bcl Medicine R Medicine (General) Mihriban Gürbüzel verfasserin aut Saime Gül Barut verfasserin aut In Haseki Tıp Bülteni Galenos Yayinevi, 2015 53(2015), 3, Seite 229-236 (DE-627)656334894 (DE-600)2603482-7 21472688 nnns volume:53 year:2015 number:3 pages:229-236 https://doi.org/10.4274/haseki.2443 kostenfrei https://doaj.org/article/96829cde12544a5292076058bed02daf kostenfrei http://www.hasekidergisi.com/article_9707/Comparison-Of-Modified-Scarff-bloom-richardson-Grading-System-With-P16-And-Bcl-2-Expression-In-Invasive-Ductal-Carcinoma kostenfrei https://doaj.org/toc/1302-0072 Journal toc kostenfrei https://doaj.org/toc/2147-2688 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 53 2015 3 229-236
spelling	10.4274/haseki.2443 doi (DE-627)DOAJ009911634 (DE-599)DOAJ96829cde12544a5292076058bed02daf DE-627 ger DE-627 rakwb eng tur R5-920 Selma Erdoğan Düzcü verfasserin aut Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: Breast cancer is the most frequent cancer among women. The p16INK4a and bcl-2 genes are the two major pathways involved in control of the cell cycle. They also play key roles in breast carcinogenesis. In this study, we investigated the relationships between the histopathologic parameters in the “Modified ScarffBloom-Richardson” microscopic grading and expression of p16 and bcl-2 gene in cases with invasive ductal carcinoma. Methods: We examined 88 patients who were diagnosed with invasive ductal carcinoma between 2011 and 2013 in Haseki Educational and Research Hospital Pathology Department. Immunohistochemical staining for p16 and bcl-2 was performed. Results: Increased expression of p16 gene was statistically significantly related with increased tubule formation, pleomorfism, mitosis rate and histological grade (p=0.008, p=0.001, p=0.005, and p<0.001, respectively). We found a statistically significant relationship of the rise of the expression of bcl-2 gene with decreased mitosis rate and histological grade (p=0.026 and p=0.024, respectively). Conclusion: As a result, it was observed that there was a positive correlation between parameters included in Modified ScarffBloom-Richardson grading system with p16 in addition to negative correlation with bcl-2 expression. p16 and bcl-2 are important prognostic biomarkers in human breast cancer. (The Medical Bulletin of Haseki 2015; 53:229-36) Invasive ductal carcinoma of the breast p16 (ink4a) bcl Medicine R Medicine (General) Mihriban Gürbüzel verfasserin aut Saime Gül Barut verfasserin aut In Haseki Tıp Bülteni Galenos Yayinevi, 2015 53(2015), 3, Seite 229-236 (DE-627)656334894 (DE-600)2603482-7 21472688 nnns volume:53 year:2015 number:3 pages:229-236 https://doi.org/10.4274/haseki.2443 kostenfrei https://doaj.org/article/96829cde12544a5292076058bed02daf kostenfrei http://www.hasekidergisi.com/article_9707/Comparison-Of-Modified-Scarff-bloom-richardson-Grading-System-With-P16-And-Bcl-2-Expression-In-Invasive-Ductal-Carcinoma kostenfrei https://doaj.org/toc/1302-0072 Journal toc kostenfrei https://doaj.org/toc/2147-2688 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 53 2015 3 229-236
allfields_unstemmed	10.4274/haseki.2443 doi (DE-627)DOAJ009911634 (DE-599)DOAJ96829cde12544a5292076058bed02daf DE-627 ger DE-627 rakwb eng tur R5-920 Selma Erdoğan Düzcü verfasserin aut Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: Breast cancer is the most frequent cancer among women. The p16INK4a and bcl-2 genes are the two major pathways involved in control of the cell cycle. They also play key roles in breast carcinogenesis. In this study, we investigated the relationships between the histopathologic parameters in the “Modified ScarffBloom-Richardson” microscopic grading and expression of p16 and bcl-2 gene in cases with invasive ductal carcinoma. Methods: We examined 88 patients who were diagnosed with invasive ductal carcinoma between 2011 and 2013 in Haseki Educational and Research Hospital Pathology Department. Immunohistochemical staining for p16 and bcl-2 was performed. Results: Increased expression of p16 gene was statistically significantly related with increased tubule formation, pleomorfism, mitosis rate and histological grade (p=0.008, p=0.001, p=0.005, and p<0.001, respectively). We found a statistically significant relationship of the rise of the expression of bcl-2 gene with decreased mitosis rate and histological grade (p=0.026 and p=0.024, respectively). Conclusion: As a result, it was observed that there was a positive correlation between parameters included in Modified ScarffBloom-Richardson grading system with p16 in addition to negative correlation with bcl-2 expression. p16 and bcl-2 are important prognostic biomarkers in human breast cancer. (The Medical Bulletin of Haseki 2015; 53:229-36) Invasive ductal carcinoma of the breast p16 (ink4a) bcl Medicine R Medicine (General) Mihriban Gürbüzel verfasserin aut Saime Gül Barut verfasserin aut In Haseki Tıp Bülteni Galenos Yayinevi, 2015 53(2015), 3, Seite 229-236 (DE-627)656334894 (DE-600)2603482-7 21472688 nnns volume:53 year:2015 number:3 pages:229-236 https://doi.org/10.4274/haseki.2443 kostenfrei https://doaj.org/article/96829cde12544a5292076058bed02daf kostenfrei http://www.hasekidergisi.com/article_9707/Comparison-Of-Modified-Scarff-bloom-richardson-Grading-System-With-P16-And-Bcl-2-Expression-In-Invasive-Ductal-Carcinoma kostenfrei https://doaj.org/toc/1302-0072 Journal toc kostenfrei https://doaj.org/toc/2147-2688 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 53 2015 3 229-236
allfieldsGer	10.4274/haseki.2443 doi (DE-627)DOAJ009911634 (DE-599)DOAJ96829cde12544a5292076058bed02daf DE-627 ger DE-627 rakwb eng tur R5-920 Selma Erdoğan Düzcü verfasserin aut Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: Breast cancer is the most frequent cancer among women. The p16INK4a and bcl-2 genes are the two major pathways involved in control of the cell cycle. They also play key roles in breast carcinogenesis. In this study, we investigated the relationships between the histopathologic parameters in the “Modified ScarffBloom-Richardson” microscopic grading and expression of p16 and bcl-2 gene in cases with invasive ductal carcinoma. Methods: We examined 88 patients who were diagnosed with invasive ductal carcinoma between 2011 and 2013 in Haseki Educational and Research Hospital Pathology Department. Immunohistochemical staining for p16 and bcl-2 was performed. Results: Increased expression of p16 gene was statistically significantly related with increased tubule formation, pleomorfism, mitosis rate and histological grade (p=0.008, p=0.001, p=0.005, and p<0.001, respectively). We found a statistically significant relationship of the rise of the expression of bcl-2 gene with decreased mitosis rate and histological grade (p=0.026 and p=0.024, respectively). Conclusion: As a result, it was observed that there was a positive correlation between parameters included in Modified ScarffBloom-Richardson grading system with p16 in addition to negative correlation with bcl-2 expression. p16 and bcl-2 are important prognostic biomarkers in human breast cancer. (The Medical Bulletin of Haseki 2015; 53:229-36) Invasive ductal carcinoma of the breast p16 (ink4a) bcl Medicine R Medicine (General) Mihriban Gürbüzel verfasserin aut Saime Gül Barut verfasserin aut In Haseki Tıp Bülteni Galenos Yayinevi, 2015 53(2015), 3, Seite 229-236 (DE-627)656334894 (DE-600)2603482-7 21472688 nnns volume:53 year:2015 number:3 pages:229-236 https://doi.org/10.4274/haseki.2443 kostenfrei https://doaj.org/article/96829cde12544a5292076058bed02daf kostenfrei http://www.hasekidergisi.com/article_9707/Comparison-Of-Modified-Scarff-bloom-richardson-Grading-System-With-P16-And-Bcl-2-Expression-In-Invasive-Ductal-Carcinoma kostenfrei https://doaj.org/toc/1302-0072 Journal toc kostenfrei https://doaj.org/toc/2147-2688 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 53 2015 3 229-236
allfieldsSound	10.4274/haseki.2443 doi (DE-627)DOAJ009911634 (DE-599)DOAJ96829cde12544a5292076058bed02daf DE-627 ger DE-627 rakwb eng tur R5-920 Selma Erdoğan Düzcü verfasserin aut Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: Breast cancer is the most frequent cancer among women. The p16INK4a and bcl-2 genes are the two major pathways involved in control of the cell cycle. They also play key roles in breast carcinogenesis. In this study, we investigated the relationships between the histopathologic parameters in the “Modified ScarffBloom-Richardson” microscopic grading and expression of p16 and bcl-2 gene in cases with invasive ductal carcinoma. Methods: We examined 88 patients who were diagnosed with invasive ductal carcinoma between 2011 and 2013 in Haseki Educational and Research Hospital Pathology Department. Immunohistochemical staining for p16 and bcl-2 was performed. Results: Increased expression of p16 gene was statistically significantly related with increased tubule formation, pleomorfism, mitosis rate and histological grade (p=0.008, p=0.001, p=0.005, and p<0.001, respectively). We found a statistically significant relationship of the rise of the expression of bcl-2 gene with decreased mitosis rate and histological grade (p=0.026 and p=0.024, respectively). Conclusion: As a result, it was observed that there was a positive correlation between parameters included in Modified ScarffBloom-Richardson grading system with p16 in addition to negative correlation with bcl-2 expression. p16 and bcl-2 are important prognostic biomarkers in human breast cancer. (The Medical Bulletin of Haseki 2015; 53:229-36) Invasive ductal carcinoma of the breast p16 (ink4a) bcl Medicine R Medicine (General) Mihriban Gürbüzel verfasserin aut Saime Gül Barut verfasserin aut In Haseki Tıp Bülteni Galenos Yayinevi, 2015 53(2015), 3, Seite 229-236 (DE-627)656334894 (DE-600)2603482-7 21472688 nnns volume:53 year:2015 number:3 pages:229-236 https://doi.org/10.4274/haseki.2443 kostenfrei https://doaj.org/article/96829cde12544a5292076058bed02daf kostenfrei http://www.hasekidergisi.com/article_9707/Comparison-Of-Modified-Scarff-bloom-richardson-Grading-System-With-P16-And-Bcl-2-Expression-In-Invasive-Ductal-Carcinoma kostenfrei https://doaj.org/toc/1302-0072 Journal toc kostenfrei https://doaj.org/toc/2147-2688 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 53 2015 3 229-236
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callnumber-first	R - Medicine
author	Selma Erdoğan Düzcü
spellingShingle	Selma Erdoğan Düzcü misc R5-920 misc Invasive ductal carcinoma of the breast misc p16 (ink4a) misc bcl misc Medicine misc R misc Medicine (General) Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma
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topic_title	R5-920 Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma Invasive ductal carcinoma of the breast p16 (ink4a) bcl
topic	misc R5-920 misc Invasive ductal carcinoma of the breast misc p16 (ink4a) misc bcl misc Medicine misc R misc Medicine (General)
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title	Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma
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title_full	Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma
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title_sort	comparison of modified scarff-bloom-richardson grading system with p16 and bcl-2 expression in invasive ductal carcinoma
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title_auth	Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma
abstract	Aim: Breast cancer is the most frequent cancer among women. The p16INK4a and bcl-2 genes are the two major pathways involved in control of the cell cycle. They also play key roles in breast carcinogenesis. In this study, we investigated the relationships between the histopathologic parameters in the “Modified ScarffBloom-Richardson” microscopic grading and expression of p16 and bcl-2 gene in cases with invasive ductal carcinoma. Methods: We examined 88 patients who were diagnosed with invasive ductal carcinoma between 2011 and 2013 in Haseki Educational and Research Hospital Pathology Department. Immunohistochemical staining for p16 and bcl-2 was performed. Results: Increased expression of p16 gene was statistically significantly related with increased tubule formation, pleomorfism, mitosis rate and histological grade (p=0.008, p=0.001, p=0.005, and p<0.001, respectively). We found a statistically significant relationship of the rise of the expression of bcl-2 gene with decreased mitosis rate and histological grade (p=0.026 and p=0.024, respectively). Conclusion: As a result, it was observed that there was a positive correlation between parameters included in Modified ScarffBloom-Richardson grading system with p16 in addition to negative correlation with bcl-2 expression. p16 and bcl-2 are important prognostic biomarkers in human breast cancer. (The Medical Bulletin of Haseki 2015; 53:229-36)
abstractGer	Aim: Breast cancer is the most frequent cancer among women. The p16INK4a and bcl-2 genes are the two major pathways involved in control of the cell cycle. They also play key roles in breast carcinogenesis. In this study, we investigated the relationships between the histopathologic parameters in the “Modified ScarffBloom-Richardson” microscopic grading and expression of p16 and bcl-2 gene in cases with invasive ductal carcinoma. Methods: We examined 88 patients who were diagnosed with invasive ductal carcinoma between 2011 and 2013 in Haseki Educational and Research Hospital Pathology Department. Immunohistochemical staining for p16 and bcl-2 was performed. Results: Increased expression of p16 gene was statistically significantly related with increased tubule formation, pleomorfism, mitosis rate and histological grade (p=0.008, p=0.001, p=0.005, and p<0.001, respectively). We found a statistically significant relationship of the rise of the expression of bcl-2 gene with decreased mitosis rate and histological grade (p=0.026 and p=0.024, respectively). Conclusion: As a result, it was observed that there was a positive correlation between parameters included in Modified ScarffBloom-Richardson grading system with p16 in addition to negative correlation with bcl-2 expression. p16 and bcl-2 are important prognostic biomarkers in human breast cancer. (The Medical Bulletin of Haseki 2015; 53:229-36)
abstract_unstemmed	Aim: Breast cancer is the most frequent cancer among women. The p16INK4a and bcl-2 genes are the two major pathways involved in control of the cell cycle. They also play key roles in breast carcinogenesis. In this study, we investigated the relationships between the histopathologic parameters in the “Modified ScarffBloom-Richardson” microscopic grading and expression of p16 and bcl-2 gene in cases with invasive ductal carcinoma. Methods: We examined 88 patients who were diagnosed with invasive ductal carcinoma between 2011 and 2013 in Haseki Educational and Research Hospital Pathology Department. Immunohistochemical staining for p16 and bcl-2 was performed. Results: Increased expression of p16 gene was statistically significantly related with increased tubule formation, pleomorfism, mitosis rate and histological grade (p=0.008, p=0.001, p=0.005, and p<0.001, respectively). We found a statistically significant relationship of the rise of the expression of bcl-2 gene with decreased mitosis rate and histological grade (p=0.026 and p=0.024, respectively). Conclusion: As a result, it was observed that there was a positive correlation between parameters included in Modified ScarffBloom-Richardson grading system with p16 in addition to negative correlation with bcl-2 expression. p16 and bcl-2 are important prognostic biomarkers in human breast cancer. (The Medical Bulletin of Haseki 2015; 53:229-36)
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title_short	Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma
url	https://doi.org/10.4274/haseki.2443 https://doaj.org/article/96829cde12544a5292076058bed02daf http://www.hasekidergisi.com/article_9707/Comparison-Of-Modified-Scarff-bloom-richardson-Grading-System-With-P16-And-Bcl-2-Expression-In-Invasive-Ductal-Carcinoma https://doaj.org/toc/1302-0072 https://doaj.org/toc/2147-2688
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We found a statistically significant relationship of the rise of the expression of bcl-2 gene with decreased mitosis rate and histological grade (p=0.026 and p=0.024, respectively). Conclusion: As a result, it was observed that there was a positive correlation between parameters included in Modified ScarffBloom-Richardson grading system with p16 in addition to negative correlation with bcl-2 expression. p16 and bcl-2 are important prognostic biomarkers in human breast cancer. 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Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma

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