Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT)

Abstract In the ATEMPT trial, adjuvant trastuzumab emtansine (T-DM1) compared to paclitaxel plus trastuzumab (TH) for stage I HER2-positive breast cancer improved patient-reported outcomes (PROs), while maintaining excellent disease outcomes. We report treatment discontinuation and use multivariable...
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Autor*in:	Tal Sella [verfasserIn] Yue Zheng [verfasserIn] Nabihah Tayob [verfasserIn] Kathryn J. Ruddy [verfasserIn] Rachel A. Freedman [verfasserIn] Chau Dang [verfasserIn] Denise Yardley [verfasserIn] Steven J. Isakoff [verfasserIn] Vicente Valero [verfasserIn] Michelle DeMeo [verfasserIn] Harold J. Burstein [verfasserIn] Eric P. Winer [verfasserIn] Antonio C. Wolff [verfasserIn] Ian Krop [verfasserIn] Ann H. Partridge [verfasserIn] Sara M. Tolaney [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: npj Breast Cancer - Nature Portfolio, 2016, 8(2022), 1, Seite 9
Übergeordnetes Werk:	volume:8 ; year:2022 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41523-022-00495-x

Katalog-ID:	DOAJ010003118

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allfields	10.1038/s41523-022-00495-x doi (DE-627)DOAJ010003118 (DE-599)DOAJdb47278c15ae47048316e04bc579a690 DE-627 ger DE-627 rakwb eng RC254-282 Tal Sella verfasserin aut Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In the ATEMPT trial, adjuvant trastuzumab emtansine (T-DM1) compared to paclitaxel plus trastuzumab (TH) for stage I HER2-positive breast cancer improved patient-reported outcomes (PROs), while maintaining excellent disease outcomes. We report treatment discontinuation and use multivariable models to compare, patient-reported toxicity and quality-of-life (QOL) by age (≤50, <50) and treatment arm at 18 months post-enrollment among 366 eligible participants randomized in a 3:1 ratio to T-DM1 or TH. T-DM1 discontinuation was higher among women <50 vs. ≤50 (23% vs. 9%, p = 0.003, Fisher’s Exact test) with 4%, 8%, and 17% of older patients discontinuing treatment by 3, 6, and 9 months, respectively. Superior QOL with T-DM1 vs. TH was observed among women ≤50 with estimated mean difference of 6.48 (95% confidence interval (CI) 0.51–12.46) and driven by better social/family well-being and breast cancer-specific sub-scores. Among women <50, T-DM1 was associated with superior physical well-being and less activity impairment, with no differences in global QOL. Older women had decreased neuropathy with T-DM1 vs. TH. De-escalated treatment regimens for HER2 positive breast cancer may have age-varying impact on treatment tolerance, toxicities and subsequent QOL, which should be considered when selecting therapy options. Clinical Trial Registration: ClinicalTrials.gov, NCT01853748 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yue Zheng verfasserin aut Nabihah Tayob verfasserin aut Kathryn J. Ruddy verfasserin aut Rachel A. Freedman verfasserin aut Chau Dang verfasserin aut Denise Yardley verfasserin aut Steven J. Isakoff verfasserin aut Vicente Valero verfasserin aut Michelle DeMeo verfasserin aut Harold J. Burstein verfasserin aut Eric P. Winer verfasserin aut Antonio C. Wolff verfasserin aut Ian Krop verfasserin aut Ann H. Partridge verfasserin aut Sara M. Tolaney verfasserin aut In npj Breast Cancer Nature Portfolio, 2016 8(2022), 1, Seite 9 (DE-627)844762113 (DE-600)2843288-5 23744677 nnns volume:8 year:2022 number:1 pages:9 https://doi.org/10.1038/s41523-022-00495-x kostenfrei https://doaj.org/article/db47278c15ae47048316e04bc579a690 kostenfrei https://doi.org/10.1038/s41523-022-00495-x kostenfrei https://doaj.org/toc/2374-4677 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2022 1 9
spelling	10.1038/s41523-022-00495-x doi (DE-627)DOAJ010003118 (DE-599)DOAJdb47278c15ae47048316e04bc579a690 DE-627 ger DE-627 rakwb eng RC254-282 Tal Sella verfasserin aut Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In the ATEMPT trial, adjuvant trastuzumab emtansine (T-DM1) compared to paclitaxel plus trastuzumab (TH) for stage I HER2-positive breast cancer improved patient-reported outcomes (PROs), while maintaining excellent disease outcomes. We report treatment discontinuation and use multivariable models to compare, patient-reported toxicity and quality-of-life (QOL) by age (≤50, <50) and treatment arm at 18 months post-enrollment among 366 eligible participants randomized in a 3:1 ratio to T-DM1 or TH. T-DM1 discontinuation was higher among women <50 vs. ≤50 (23% vs. 9%, p = 0.003, Fisher’s Exact test) with 4%, 8%, and 17% of older patients discontinuing treatment by 3, 6, and 9 months, respectively. Superior QOL with T-DM1 vs. TH was observed among women ≤50 with estimated mean difference of 6.48 (95% confidence interval (CI) 0.51–12.46) and driven by better social/family well-being and breast cancer-specific sub-scores. Among women <50, T-DM1 was associated with superior physical well-being and less activity impairment, with no differences in global QOL. Older women had decreased neuropathy with T-DM1 vs. TH. De-escalated treatment regimens for HER2 positive breast cancer may have age-varying impact on treatment tolerance, toxicities and subsequent QOL, which should be considered when selecting therapy options. Clinical Trial Registration: ClinicalTrials.gov, NCT01853748 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yue Zheng verfasserin aut Nabihah Tayob verfasserin aut Kathryn J. Ruddy verfasserin aut Rachel A. Freedman verfasserin aut Chau Dang verfasserin aut Denise Yardley verfasserin aut Steven J. Isakoff verfasserin aut Vicente Valero verfasserin aut Michelle DeMeo verfasserin aut Harold J. Burstein verfasserin aut Eric P. Winer verfasserin aut Antonio C. Wolff verfasserin aut Ian Krop verfasserin aut Ann H. Partridge verfasserin aut Sara M. Tolaney verfasserin aut In npj Breast Cancer Nature Portfolio, 2016 8(2022), 1, Seite 9 (DE-627)844762113 (DE-600)2843288-5 23744677 nnns volume:8 year:2022 number:1 pages:9 https://doi.org/10.1038/s41523-022-00495-x kostenfrei https://doaj.org/article/db47278c15ae47048316e04bc579a690 kostenfrei https://doi.org/10.1038/s41523-022-00495-x kostenfrei https://doaj.org/toc/2374-4677 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2022 1 9
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allfieldsGer	10.1038/s41523-022-00495-x doi (DE-627)DOAJ010003118 (DE-599)DOAJdb47278c15ae47048316e04bc579a690 DE-627 ger DE-627 rakwb eng RC254-282 Tal Sella verfasserin aut Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In the ATEMPT trial, adjuvant trastuzumab emtansine (T-DM1) compared to paclitaxel plus trastuzumab (TH) for stage I HER2-positive breast cancer improved patient-reported outcomes (PROs), while maintaining excellent disease outcomes. We report treatment discontinuation and use multivariable models to compare, patient-reported toxicity and quality-of-life (QOL) by age (≤50, <50) and treatment arm at 18 months post-enrollment among 366 eligible participants randomized in a 3:1 ratio to T-DM1 or TH. T-DM1 discontinuation was higher among women <50 vs. ≤50 (23% vs. 9%, p = 0.003, Fisher’s Exact test) with 4%, 8%, and 17% of older patients discontinuing treatment by 3, 6, and 9 months, respectively. Superior QOL with T-DM1 vs. TH was observed among women ≤50 with estimated mean difference of 6.48 (95% confidence interval (CI) 0.51–12.46) and driven by better social/family well-being and breast cancer-specific sub-scores. Among women <50, T-DM1 was associated with superior physical well-being and less activity impairment, with no differences in global QOL. Older women had decreased neuropathy with T-DM1 vs. TH. De-escalated treatment regimens for HER2 positive breast cancer may have age-varying impact on treatment tolerance, toxicities and subsequent QOL, which should be considered when selecting therapy options. Clinical Trial Registration: ClinicalTrials.gov, NCT01853748 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yue Zheng verfasserin aut Nabihah Tayob verfasserin aut Kathryn J. Ruddy verfasserin aut Rachel A. Freedman verfasserin aut Chau Dang verfasserin aut Denise Yardley verfasserin aut Steven J. Isakoff verfasserin aut Vicente Valero verfasserin aut Michelle DeMeo verfasserin aut Harold J. Burstein verfasserin aut Eric P. Winer verfasserin aut Antonio C. Wolff verfasserin aut Ian Krop verfasserin aut Ann H. Partridge verfasserin aut Sara M. Tolaney verfasserin aut In npj Breast Cancer Nature Portfolio, 2016 8(2022), 1, Seite 9 (DE-627)844762113 (DE-600)2843288-5 23744677 nnns volume:8 year:2022 number:1 pages:9 https://doi.org/10.1038/s41523-022-00495-x kostenfrei https://doaj.org/article/db47278c15ae47048316e04bc579a690 kostenfrei https://doi.org/10.1038/s41523-022-00495-x kostenfrei https://doaj.org/toc/2374-4677 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2022 1 9
allfieldsSound	10.1038/s41523-022-00495-x doi (DE-627)DOAJ010003118 (DE-599)DOAJdb47278c15ae47048316e04bc579a690 DE-627 ger DE-627 rakwb eng RC254-282 Tal Sella verfasserin aut Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In the ATEMPT trial, adjuvant trastuzumab emtansine (T-DM1) compared to paclitaxel plus trastuzumab (TH) for stage I HER2-positive breast cancer improved patient-reported outcomes (PROs), while maintaining excellent disease outcomes. We report treatment discontinuation and use multivariable models to compare, patient-reported toxicity and quality-of-life (QOL) by age (≤50, <50) and treatment arm at 18 months post-enrollment among 366 eligible participants randomized in a 3:1 ratio to T-DM1 or TH. T-DM1 discontinuation was higher among women <50 vs. ≤50 (23% vs. 9%, p = 0.003, Fisher’s Exact test) with 4%, 8%, and 17% of older patients discontinuing treatment by 3, 6, and 9 months, respectively. Superior QOL with T-DM1 vs. TH was observed among women ≤50 with estimated mean difference of 6.48 (95% confidence interval (CI) 0.51–12.46) and driven by better social/family well-being and breast cancer-specific sub-scores. Among women <50, T-DM1 was associated with superior physical well-being and less activity impairment, with no differences in global QOL. Older women had decreased neuropathy with T-DM1 vs. TH. De-escalated treatment regimens for HER2 positive breast cancer may have age-varying impact on treatment tolerance, toxicities and subsequent QOL, which should be considered when selecting therapy options. Clinical Trial Registration: ClinicalTrials.gov, NCT01853748 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yue Zheng verfasserin aut Nabihah Tayob verfasserin aut Kathryn J. Ruddy verfasserin aut Rachel A. Freedman verfasserin aut Chau Dang verfasserin aut Denise Yardley verfasserin aut Steven J. Isakoff verfasserin aut Vicente Valero verfasserin aut Michelle DeMeo verfasserin aut Harold J. Burstein verfasserin aut Eric P. Winer verfasserin aut Antonio C. Wolff verfasserin aut Ian Krop verfasserin aut Ann H. Partridge verfasserin aut Sara M. Tolaney verfasserin aut In npj Breast Cancer Nature Portfolio, 2016 8(2022), 1, Seite 9 (DE-627)844762113 (DE-600)2843288-5 23744677 nnns volume:8 year:2022 number:1 pages:9 https://doi.org/10.1038/s41523-022-00495-x kostenfrei https://doaj.org/article/db47278c15ae47048316e04bc579a690 kostenfrei https://doi.org/10.1038/s41523-022-00495-x kostenfrei https://doaj.org/toc/2374-4677 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2022 1 9
language	English
source	In npj Breast Cancer 8(2022), 1, Seite 9 volume:8 year:2022 number:1 pages:9
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container_title	npj Breast Cancer
authorswithroles_txt_mv	Tal Sella @@aut@@ Yue Zheng @@aut@@ Nabihah Tayob @@aut@@ Kathryn J. Ruddy @@aut@@ Rachel A. Freedman @@aut@@ Chau Dang @@aut@@ Denise Yardley @@aut@@ Steven J. Isakoff @@aut@@ Vicente Valero @@aut@@ Michelle DeMeo @@aut@@ Harold J. Burstein @@aut@@ Eric P. Winer @@aut@@ Antonio C. Wolff @@aut@@ Ian Krop @@aut@@ Ann H. Partridge @@aut@@ Sara M. Tolaney @@aut@@
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spellingShingle	Tal Sella misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT)
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topic_title	RC254-282 Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT)
topic	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT)
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title_full	Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT)
author_sort	Tal Sella
journal	npj Breast Cancer
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author_browse	Tal Sella Yue Zheng Nabihah Tayob Kathryn J. Ruddy Rachel A. Freedman Chau Dang Denise Yardley Steven J. Isakoff Vicente Valero Michelle DeMeo Harold J. Burstein Eric P. Winer Antonio C. Wolff Ian Krop Ann H. Partridge Sara M. Tolaney
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author-letter	Tal Sella
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title_sort	treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (atempt)
callnumber	RC254-282
title_auth	Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT)
abstract	Abstract In the ATEMPT trial, adjuvant trastuzumab emtansine (T-DM1) compared to paclitaxel plus trastuzumab (TH) for stage I HER2-positive breast cancer improved patient-reported outcomes (PROs), while maintaining excellent disease outcomes. We report treatment discontinuation and use multivariable models to compare, patient-reported toxicity and quality-of-life (QOL) by age (≤50, <50) and treatment arm at 18 months post-enrollment among 366 eligible participants randomized in a 3:1 ratio to T-DM1 or TH. T-DM1 discontinuation was higher among women <50 vs. ≤50 (23% vs. 9%, p = 0.003, Fisher’s Exact test) with 4%, 8%, and 17% of older patients discontinuing treatment by 3, 6, and 9 months, respectively. Superior QOL with T-DM1 vs. TH was observed among women ≤50 with estimated mean difference of 6.48 (95% confidence interval (CI) 0.51–12.46) and driven by better social/family well-being and breast cancer-specific sub-scores. Among women <50, T-DM1 was associated with superior physical well-being and less activity impairment, with no differences in global QOL. Older women had decreased neuropathy with T-DM1 vs. TH. De-escalated treatment regimens for HER2 positive breast cancer may have age-varying impact on treatment tolerance, toxicities and subsequent QOL, which should be considered when selecting therapy options. Clinical Trial Registration: ClinicalTrials.gov, NCT01853748
abstractGer	Abstract In the ATEMPT trial, adjuvant trastuzumab emtansine (T-DM1) compared to paclitaxel plus trastuzumab (TH) for stage I HER2-positive breast cancer improved patient-reported outcomes (PROs), while maintaining excellent disease outcomes. We report treatment discontinuation and use multivariable models to compare, patient-reported toxicity and quality-of-life (QOL) by age (≤50, <50) and treatment arm at 18 months post-enrollment among 366 eligible participants randomized in a 3:1 ratio to T-DM1 or TH. T-DM1 discontinuation was higher among women <50 vs. ≤50 (23% vs. 9%, p = 0.003, Fisher’s Exact test) with 4%, 8%, and 17% of older patients discontinuing treatment by 3, 6, and 9 months, respectively. Superior QOL with T-DM1 vs. TH was observed among women ≤50 with estimated mean difference of 6.48 (95% confidence interval (CI) 0.51–12.46) and driven by better social/family well-being and breast cancer-specific sub-scores. Among women <50, T-DM1 was associated with superior physical well-being and less activity impairment, with no differences in global QOL. Older women had decreased neuropathy with T-DM1 vs. TH. De-escalated treatment regimens for HER2 positive breast cancer may have age-varying impact on treatment tolerance, toxicities and subsequent QOL, which should be considered when selecting therapy options. Clinical Trial Registration: ClinicalTrials.gov, NCT01853748
abstract_unstemmed	Abstract In the ATEMPT trial, adjuvant trastuzumab emtansine (T-DM1) compared to paclitaxel plus trastuzumab (TH) for stage I HER2-positive breast cancer improved patient-reported outcomes (PROs), while maintaining excellent disease outcomes. We report treatment discontinuation and use multivariable models to compare, patient-reported toxicity and quality-of-life (QOL) by age (≤50, <50) and treatment arm at 18 months post-enrollment among 366 eligible participants randomized in a 3:1 ratio to T-DM1 or TH. T-DM1 discontinuation was higher among women <50 vs. ≤50 (23% vs. 9%, p = 0.003, Fisher’s Exact test) with 4%, 8%, and 17% of older patients discontinuing treatment by 3, 6, and 9 months, respectively. Superior QOL with T-DM1 vs. TH was observed among women ≤50 with estimated mean difference of 6.48 (95% confidence interval (CI) 0.51–12.46) and driven by better social/family well-being and breast cancer-specific sub-scores. Among women <50, T-DM1 was associated with superior physical well-being and less activity impairment, with no differences in global QOL. Older women had decreased neuropathy with T-DM1 vs. TH. De-escalated treatment regimens for HER2 positive breast cancer may have age-varying impact on treatment tolerance, toxicities and subsequent QOL, which should be considered when selecting therapy options. Clinical Trial Registration: ClinicalTrials.gov, NCT01853748
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title_short	Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT)
url	https://doi.org/10.1038/s41523-022-00495-x https://doaj.org/article/db47278c15ae47048316e04bc579a690 https://doaj.org/toc/2374-4677
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author2	Yue Zheng Nabihah Tayob Kathryn J. Ruddy Rachel A. Freedman Chau Dang Denise Yardley Steven J. Isakoff Vicente Valero Michelle DeMeo Harold J. Burstein Eric P. Winer Antonio C. Wolff Ian Krop Ann H. Partridge Sara M. Tolaney
author2Str	Yue Zheng Nabihah Tayob Kathryn J. Ruddy Rachel A. Freedman Chau Dang Denise Yardley Steven J. Isakoff Vicente Valero Michelle DeMeo Harold J. Burstein Eric P. Winer Antonio C. Wolff Ian Krop Ann H. Partridge Sara M. Tolaney
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