Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes

Abstract Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients...
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Autor*in:	Panpan He [verfasserIn] Xiaoqin Gan [verfasserIn] Qimeng Wu [verfasserIn] Ziliang Ye [verfasserIn] Sisi Yang [verfasserIn] Yanjun Zhang [verfasserIn] Huan Li [verfasserIn] Chun Zhou [verfasserIn] Yuanyuan Zhang [verfasserIn] Mengyi Liu [verfasserIn] Xianhui Qin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Visit-to-visit LDL-C variability Visit-to-visit HbA1c variability Visit-to-visit HDL-C variability Type 2 diabetes Mortality

Übergeordnetes Werk:	In: Diabetology & Metabolic Syndrome - BMC, 2010, 14(2022), 1, Seite 7
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:1 ; pages:7

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13098-022-00905-x

Katalog-ID:	DOAJ010055339

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520			\|a Abstract Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes. Methods Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality. Results Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality). Conclusion VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality.
650		4	\|a Visit-to-visit LDL-C variability
650		4	\|a Visit-to-visit HbA1c variability
650		4	\|a Visit-to-visit HDL-C variability
650		4	\|a Type 2 diabetes
650		4	\|a Mortality
653		0	\|a Nutritional diseases. Deficiency diseases
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700	0		\|a Qimeng Wu \|e verfasserin \|4 aut
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700	0		\|a Sisi Yang \|e verfasserin \|4 aut
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700	0		\|a Chun Zhou \|e verfasserin \|4 aut
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700	0		\|a Mengyi Liu \|e verfasserin \|4 aut
700	0		\|a Xianhui Qin \|e verfasserin \|4 aut
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allfields	10.1186/s13098-022-00905-x doi (DE-627)DOAJ010055339 (DE-599)DOAJ46c2257be89a430da024ab993dcafc7d DE-627 ger DE-627 rakwb eng RC620-627 Panpan He verfasserin aut Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes. Methods Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality. Results Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality). Conclusion VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality. Visit-to-visit LDL-C variability Visit-to-visit HbA1c variability Visit-to-visit HDL-C variability Type 2 diabetes Mortality Nutritional diseases. Deficiency diseases Xiaoqin Gan verfasserin aut Qimeng Wu verfasserin aut Ziliang Ye verfasserin aut Sisi Yang verfasserin aut Yanjun Zhang verfasserin aut Huan Li verfasserin aut Chun Zhou verfasserin aut Yuanyuan Zhang verfasserin aut Mengyi Liu verfasserin aut Xianhui Qin verfasserin aut In Diabetology & Metabolic Syndrome BMC, 2010 14(2022), 1, Seite 7 (DE-627)610606689 (DE-600)2518786-7 17585996 nnns volume:14 year:2022 number:1 pages:7 https://doi.org/10.1186/s13098-022-00905-x kostenfrei https://doaj.org/article/46c2257be89a430da024ab993dcafc7d kostenfrei https://doi.org/10.1186/s13098-022-00905-x kostenfrei https://doaj.org/toc/1758-5996 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 7
spelling	10.1186/s13098-022-00905-x doi (DE-627)DOAJ010055339 (DE-599)DOAJ46c2257be89a430da024ab993dcafc7d DE-627 ger DE-627 rakwb eng RC620-627 Panpan He verfasserin aut Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes. Methods Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality. Results Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality). Conclusion VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality. Visit-to-visit LDL-C variability Visit-to-visit HbA1c variability Visit-to-visit HDL-C variability Type 2 diabetes Mortality Nutritional diseases. Deficiency diseases Xiaoqin Gan verfasserin aut Qimeng Wu verfasserin aut Ziliang Ye verfasserin aut Sisi Yang verfasserin aut Yanjun Zhang verfasserin aut Huan Li verfasserin aut Chun Zhou verfasserin aut Yuanyuan Zhang verfasserin aut Mengyi Liu verfasserin aut Xianhui Qin verfasserin aut In Diabetology & Metabolic Syndrome BMC, 2010 14(2022), 1, Seite 7 (DE-627)610606689 (DE-600)2518786-7 17585996 nnns volume:14 year:2022 number:1 pages:7 https://doi.org/10.1186/s13098-022-00905-x kostenfrei https://doaj.org/article/46c2257be89a430da024ab993dcafc7d kostenfrei https://doi.org/10.1186/s13098-022-00905-x kostenfrei https://doaj.org/toc/1758-5996 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 7
allfields_unstemmed	10.1186/s13098-022-00905-x doi (DE-627)DOAJ010055339 (DE-599)DOAJ46c2257be89a430da024ab993dcafc7d DE-627 ger DE-627 rakwb eng RC620-627 Panpan He verfasserin aut Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes. Methods Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality. Results Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality). Conclusion VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality. Visit-to-visit LDL-C variability Visit-to-visit HbA1c variability Visit-to-visit HDL-C variability Type 2 diabetes Mortality Nutritional diseases. Deficiency diseases Xiaoqin Gan verfasserin aut Qimeng Wu verfasserin aut Ziliang Ye verfasserin aut Sisi Yang verfasserin aut Yanjun Zhang verfasserin aut Huan Li verfasserin aut Chun Zhou verfasserin aut Yuanyuan Zhang verfasserin aut Mengyi Liu verfasserin aut Xianhui Qin verfasserin aut In Diabetology & Metabolic Syndrome BMC, 2010 14(2022), 1, Seite 7 (DE-627)610606689 (DE-600)2518786-7 17585996 nnns volume:14 year:2022 number:1 pages:7 https://doi.org/10.1186/s13098-022-00905-x kostenfrei https://doaj.org/article/46c2257be89a430da024ab993dcafc7d kostenfrei https://doi.org/10.1186/s13098-022-00905-x kostenfrei https://doaj.org/toc/1758-5996 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 7
allfieldsGer	10.1186/s13098-022-00905-x doi (DE-627)DOAJ010055339 (DE-599)DOAJ46c2257be89a430da024ab993dcafc7d DE-627 ger DE-627 rakwb eng RC620-627 Panpan He verfasserin aut Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes. Methods Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality. Results Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality). Conclusion VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality. Visit-to-visit LDL-C variability Visit-to-visit HbA1c variability Visit-to-visit HDL-C variability Type 2 diabetes Mortality Nutritional diseases. Deficiency diseases Xiaoqin Gan verfasserin aut Qimeng Wu verfasserin aut Ziliang Ye verfasserin aut Sisi Yang verfasserin aut Yanjun Zhang verfasserin aut Huan Li verfasserin aut Chun Zhou verfasserin aut Yuanyuan Zhang verfasserin aut Mengyi Liu verfasserin aut Xianhui Qin verfasserin aut In Diabetology & Metabolic Syndrome BMC, 2010 14(2022), 1, Seite 7 (DE-627)610606689 (DE-600)2518786-7 17585996 nnns volume:14 year:2022 number:1 pages:7 https://doi.org/10.1186/s13098-022-00905-x kostenfrei https://doaj.org/article/46c2257be89a430da024ab993dcafc7d kostenfrei https://doi.org/10.1186/s13098-022-00905-x kostenfrei https://doaj.org/toc/1758-5996 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 7
allfieldsSound	10.1186/s13098-022-00905-x doi (DE-627)DOAJ010055339 (DE-599)DOAJ46c2257be89a430da024ab993dcafc7d DE-627 ger DE-627 rakwb eng RC620-627 Panpan He verfasserin aut Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes. Methods Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality. Results Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality). Conclusion VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality. Visit-to-visit LDL-C variability Visit-to-visit HbA1c variability Visit-to-visit HDL-C variability Type 2 diabetes Mortality Nutritional diseases. Deficiency diseases Xiaoqin Gan verfasserin aut Qimeng Wu verfasserin aut Ziliang Ye verfasserin aut Sisi Yang verfasserin aut Yanjun Zhang verfasserin aut Huan Li verfasserin aut Chun Zhou verfasserin aut Yuanyuan Zhang verfasserin aut Mengyi Liu verfasserin aut Xianhui Qin verfasserin aut In Diabetology & Metabolic Syndrome BMC, 2010 14(2022), 1, Seite 7 (DE-627)610606689 (DE-600)2518786-7 17585996 nnns volume:14 year:2022 number:1 pages:7 https://doi.org/10.1186/s13098-022-00905-x kostenfrei https://doaj.org/article/46c2257be89a430da024ab993dcafc7d kostenfrei https://doi.org/10.1186/s13098-022-00905-x kostenfrei https://doaj.org/toc/1758-5996 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 7
language	English
source	In Diabetology & Metabolic Syndrome 14(2022), 1, Seite 7 volume:14 year:2022 number:1 pages:7
sourceStr	In Diabetology & Metabolic Syndrome 14(2022), 1, Seite 7 volume:14 year:2022 number:1 pages:7
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Visit-to-visit LDL-C variability Visit-to-visit HbA1c variability Visit-to-visit HDL-C variability Type 2 diabetes Mortality Nutritional diseases. Deficiency diseases
isfreeaccess_bool	true
container_title	Diabetology & Metabolic Syndrome
authorswithroles_txt_mv	Panpan He @@aut@@ Xiaoqin Gan @@aut@@ Qimeng Wu @@aut@@ Ziliang Ye @@aut@@ Sisi Yang @@aut@@ Yanjun Zhang @@aut@@ Huan Li @@aut@@ Chun Zhou @@aut@@ Yuanyuan Zhang @@aut@@ Mengyi Liu @@aut@@ Xianhui Qin @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	610606689
id	DOAJ010055339
language_de	englisch
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Methods Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality. Results Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality). Conclusion VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. 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callnumber-first	R - Medicine
author	Panpan He
spellingShingle	Panpan He misc RC620-627 misc Visit-to-visit LDL-C variability misc Visit-to-visit HbA1c variability misc Visit-to-visit HDL-C variability misc Type 2 diabetes misc Mortality misc Nutritional diseases. Deficiency diseases Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes
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topic_title	RC620-627 Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes Visit-to-visit LDL-C variability Visit-to-visit HbA1c variability Visit-to-visit HDL-C variability Type 2 diabetes Mortality
topic	misc RC620-627 misc Visit-to-visit LDL-C variability misc Visit-to-visit HbA1c variability misc Visit-to-visit HDL-C variability misc Type 2 diabetes misc Mortality misc Nutritional diseases. Deficiency diseases
topic_unstemmed	misc RC620-627 misc Visit-to-visit LDL-C variability misc Visit-to-visit HbA1c variability misc Visit-to-visit HDL-C variability misc Type 2 diabetes misc Mortality misc Nutritional diseases. Deficiency diseases
topic_browse	misc RC620-627 misc Visit-to-visit LDL-C variability misc Visit-to-visit HbA1c variability misc Visit-to-visit HDL-C variability misc Type 2 diabetes misc Mortality misc Nutritional diseases. Deficiency diseases
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title	Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes
ctrlnum	(DE-627)DOAJ010055339 (DE-599)DOAJ46c2257be89a430da024ab993dcafc7d
title_full	Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes
author_sort	Panpan He
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author_browse	Panpan He Xiaoqin Gan Qimeng Wu Ziliang Ye Sisi Yang Yanjun Zhang Huan Li Chun Zhou Yuanyuan Zhang Mengyi Liu Xianhui Qin
container_volume	14
class	RC620-627
format_se	Elektronische Aufsätze
author-letter	Panpan He
doi_str_mv	10.1186/s13098-022-00905-x
author2-role	verfasserin
title_sort	joint effect of visit-to-visit variability in ldl-cholesterol, hdl-cholesterol and hba1c on cardiovascular and total mortality in patients with diabetes
callnumber	RC620-627
title_auth	Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes
abstract	Abstract Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes. Methods Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality. Results Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality). Conclusion VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality.
abstractGer	Abstract Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes. Methods Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality. Results Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality). Conclusion VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality.
abstract_unstemmed	Abstract Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes. Methods Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality. Results Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality). Conclusion VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality.
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container_issue	1
title_short	Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes
url	https://doi.org/10.1186/s13098-022-00905-x https://doaj.org/article/46c2257be89a430da024ab993dcafc7d https://doaj.org/toc/1758-5996
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author2	Xiaoqin Gan Qimeng Wu Ziliang Ye Sisi Yang Yanjun Zhang Huan Li Chun Zhou Yuanyuan Zhang Mengyi Liu Xianhui Qin
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up_date	2024-07-04T02:04:07.092Z
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Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes

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