Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts

The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. Additionally, all extracts were able to contrast hydrogen peroxide-induced oxidative stress, in HypoE22 cells, thus restoring basal catecholamine and 3-hydroxykinurenine levels, whereas only methanol and water extracts stimulated basal dopamine release. Overall, data from the present study contribute to the biological assessment of <i<P. africanum</i< that appears to be a promising source of natural compounds with protective and neuromodulatory effects. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kouadio Ibrahime Sinan [verfasserIn] Annalisa Chiavaroli [verfasserIn] Giustino Orlando [verfasserIn] Kouadio Bene [verfasserIn] Gokhan Zengin [verfasserIn] Zoltán Cziáky [verfasserIn] József Jekő [verfasserIn] Mohamad Fawzi Mahomoodally [verfasserIn] Marie Carene Nancy Picot-Allain [verfasserIn] Luigi Menghini [verfasserIn] Lucia Recinella [verfasserIn] Luigi Brunetti [verfasserIn] Sheila Leone [verfasserIn] Maria Chiara Ciferri [verfasserIn] Simonetta Di Simone [verfasserIn] Claudio Ferrante [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	medicinal plants bioactive compounds hyperpigmentation diabetes dopamine

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 10(2020), 4, p 516
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:4, p 516

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom10040516

Katalog-ID:	DOAJ010457313

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520			\|a The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. Additionally, all extracts were able to contrast hydrogen peroxide-induced oxidative stress, in HypoE22 cells, thus restoring basal catecholamine and 3-hydroxykinurenine levels, whereas only methanol and water extracts stimulated basal dopamine release. Overall, data from the present study contribute to the biological assessment of <i<P. africanum</i< that appears to be a promising source of natural compounds with protective and neuromodulatory effects.
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650		4	\|a diabetes
650		4	\|a dopamine
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700	0		\|a Giustino Orlando \|e verfasserin \|4 aut
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700	0		\|a Gokhan Zengin \|e verfasserin \|4 aut
700	0		\|a Zoltán Cziáky \|e verfasserin \|4 aut
700	0		\|a József Jekő \|e verfasserin \|4 aut
700	0		\|a Mohamad Fawzi Mahomoodally \|e verfasserin \|4 aut
700	0		\|a Marie Carene Nancy Picot-Allain \|e verfasserin \|4 aut
700	0		\|a Luigi Menghini \|e verfasserin \|4 aut
700	0		\|a Lucia Recinella \|e verfasserin \|4 aut
700	0		\|a Luigi Brunetti \|e verfasserin \|4 aut
700	0		\|a Sheila Leone \|e verfasserin \|4 aut
700	0		\|a Maria Chiara Ciferri \|e verfasserin \|4 aut
700	0		\|a Simonetta Di Simone \|e verfasserin \|4 aut
700	0		\|a Claudio Ferrante \|e verfasserin \|4 aut
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allfields	10.3390/biom10040516 doi (DE-627)DOAJ010457313 (DE-599)DOAJff7295118d5b4833be322e4084fe10c8 DE-627 ger DE-627 rakwb eng QR1-502 Kouadio Ibrahime Sinan verfasserin aut Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. Additionally, all extracts were able to contrast hydrogen peroxide-induced oxidative stress, in HypoE22 cells, thus restoring basal catecholamine and 3-hydroxykinurenine levels, whereas only methanol and water extracts stimulated basal dopamine release. Overall, data from the present study contribute to the biological assessment of <i<P. africanum</i< that appears to be a promising source of natural compounds with protective and neuromodulatory effects. medicinal plants bioactive compounds hyperpigmentation diabetes dopamine Microbiology Annalisa Chiavaroli verfasserin aut Giustino Orlando verfasserin aut Kouadio Bene verfasserin aut Gokhan Zengin verfasserin aut Zoltán Cziáky verfasserin aut József Jekő verfasserin aut Mohamad Fawzi Mahomoodally verfasserin aut Marie Carene Nancy Picot-Allain verfasserin aut Luigi Menghini verfasserin aut Lucia Recinella verfasserin aut Luigi Brunetti verfasserin aut Sheila Leone verfasserin aut Maria Chiara Ciferri verfasserin aut Simonetta Di Simone verfasserin aut Claudio Ferrante verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 4, p 516 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:4, p 516 https://doi.org/10.3390/biom10040516 kostenfrei https://doaj.org/article/ff7295118d5b4833be322e4084fe10c8 kostenfrei https://www.mdpi.com/2218-273X/10/4/516 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 4, p 516
spelling	10.3390/biom10040516 doi (DE-627)DOAJ010457313 (DE-599)DOAJff7295118d5b4833be322e4084fe10c8 DE-627 ger DE-627 rakwb eng QR1-502 Kouadio Ibrahime Sinan verfasserin aut Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. Additionally, all extracts were able to contrast hydrogen peroxide-induced oxidative stress, in HypoE22 cells, thus restoring basal catecholamine and 3-hydroxykinurenine levels, whereas only methanol and water extracts stimulated basal dopamine release. Overall, data from the present study contribute to the biological assessment of <i<P. africanum</i< that appears to be a promising source of natural compounds with protective and neuromodulatory effects. medicinal plants bioactive compounds hyperpigmentation diabetes dopamine Microbiology Annalisa Chiavaroli verfasserin aut Giustino Orlando verfasserin aut Kouadio Bene verfasserin aut Gokhan Zengin verfasserin aut Zoltán Cziáky verfasserin aut József Jekő verfasserin aut Mohamad Fawzi Mahomoodally verfasserin aut Marie Carene Nancy Picot-Allain verfasserin aut Luigi Menghini verfasserin aut Lucia Recinella verfasserin aut Luigi Brunetti verfasserin aut Sheila Leone verfasserin aut Maria Chiara Ciferri verfasserin aut Simonetta Di Simone verfasserin aut Claudio Ferrante verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 4, p 516 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:4, p 516 https://doi.org/10.3390/biom10040516 kostenfrei https://doaj.org/article/ff7295118d5b4833be322e4084fe10c8 kostenfrei https://www.mdpi.com/2218-273X/10/4/516 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 4, p 516
allfields_unstemmed	10.3390/biom10040516 doi (DE-627)DOAJ010457313 (DE-599)DOAJff7295118d5b4833be322e4084fe10c8 DE-627 ger DE-627 rakwb eng QR1-502 Kouadio Ibrahime Sinan verfasserin aut Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. Additionally, all extracts were able to contrast hydrogen peroxide-induced oxidative stress, in HypoE22 cells, thus restoring basal catecholamine and 3-hydroxykinurenine levels, whereas only methanol and water extracts stimulated basal dopamine release. Overall, data from the present study contribute to the biological assessment of <i<P. africanum</i< that appears to be a promising source of natural compounds with protective and neuromodulatory effects. medicinal plants bioactive compounds hyperpigmentation diabetes dopamine Microbiology Annalisa Chiavaroli verfasserin aut Giustino Orlando verfasserin aut Kouadio Bene verfasserin aut Gokhan Zengin verfasserin aut Zoltán Cziáky verfasserin aut József Jekő verfasserin aut Mohamad Fawzi Mahomoodally verfasserin aut Marie Carene Nancy Picot-Allain verfasserin aut Luigi Menghini verfasserin aut Lucia Recinella verfasserin aut Luigi Brunetti verfasserin aut Sheila Leone verfasserin aut Maria Chiara Ciferri verfasserin aut Simonetta Di Simone verfasserin aut Claudio Ferrante verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 4, p 516 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:4, p 516 https://doi.org/10.3390/biom10040516 kostenfrei https://doaj.org/article/ff7295118d5b4833be322e4084fe10c8 kostenfrei https://www.mdpi.com/2218-273X/10/4/516 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 4, p 516
allfieldsGer	10.3390/biom10040516 doi (DE-627)DOAJ010457313 (DE-599)DOAJff7295118d5b4833be322e4084fe10c8 DE-627 ger DE-627 rakwb eng QR1-502 Kouadio Ibrahime Sinan verfasserin aut Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. Additionally, all extracts were able to contrast hydrogen peroxide-induced oxidative stress, in HypoE22 cells, thus restoring basal catecholamine and 3-hydroxykinurenine levels, whereas only methanol and water extracts stimulated basal dopamine release. Overall, data from the present study contribute to the biological assessment of <i<P. africanum</i< that appears to be a promising source of natural compounds with protective and neuromodulatory effects. medicinal plants bioactive compounds hyperpigmentation diabetes dopamine Microbiology Annalisa Chiavaroli verfasserin aut Giustino Orlando verfasserin aut Kouadio Bene verfasserin aut Gokhan Zengin verfasserin aut Zoltán Cziáky verfasserin aut József Jekő verfasserin aut Mohamad Fawzi Mahomoodally verfasserin aut Marie Carene Nancy Picot-Allain verfasserin aut Luigi Menghini verfasserin aut Lucia Recinella verfasserin aut Luigi Brunetti verfasserin aut Sheila Leone verfasserin aut Maria Chiara Ciferri verfasserin aut Simonetta Di Simone verfasserin aut Claudio Ferrante verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 4, p 516 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:4, p 516 https://doi.org/10.3390/biom10040516 kostenfrei https://doaj.org/article/ff7295118d5b4833be322e4084fe10c8 kostenfrei https://www.mdpi.com/2218-273X/10/4/516 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 4, p 516
allfieldsSound	10.3390/biom10040516 doi (DE-627)DOAJ010457313 (DE-599)DOAJff7295118d5b4833be322e4084fe10c8 DE-627 ger DE-627 rakwb eng QR1-502 Kouadio Ibrahime Sinan verfasserin aut Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. Additionally, all extracts were able to contrast hydrogen peroxide-induced oxidative stress, in HypoE22 cells, thus restoring basal catecholamine and 3-hydroxykinurenine levels, whereas only methanol and water extracts stimulated basal dopamine release. Overall, data from the present study contribute to the biological assessment of <i<P. africanum</i< that appears to be a promising source of natural compounds with protective and neuromodulatory effects. medicinal plants bioactive compounds hyperpigmentation diabetes dopamine Microbiology Annalisa Chiavaroli verfasserin aut Giustino Orlando verfasserin aut Kouadio Bene verfasserin aut Gokhan Zengin verfasserin aut Zoltán Cziáky verfasserin aut József Jekő verfasserin aut Mohamad Fawzi Mahomoodally verfasserin aut Marie Carene Nancy Picot-Allain verfasserin aut Luigi Menghini verfasserin aut Lucia Recinella verfasserin aut Luigi Brunetti verfasserin aut Sheila Leone verfasserin aut Maria Chiara Ciferri verfasserin aut Simonetta Di Simone verfasserin aut Claudio Ferrante verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 4, p 516 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:4, p 516 https://doi.org/10.3390/biom10040516 kostenfrei https://doaj.org/article/ff7295118d5b4833be322e4084fe10c8 kostenfrei https://www.mdpi.com/2218-273X/10/4/516 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 4, p 516
language	English
source	In Biomolecules 10(2020), 4, p 516 volume:10 year:2020 number:4, p 516
sourceStr	In Biomolecules 10(2020), 4, p 516 volume:10 year:2020 number:4, p 516
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	medicinal plants bioactive compounds hyperpigmentation diabetes dopamine Microbiology
isfreeaccess_bool	true
container_title	Biomolecules
authorswithroles_txt_mv	Kouadio Ibrahime Sinan @@aut@@ Annalisa Chiavaroli @@aut@@ Giustino Orlando @@aut@@ Kouadio Bene @@aut@@ Gokhan Zengin @@aut@@ Zoltán Cziáky @@aut@@ József Jekő @@aut@@ Mohamad Fawzi Mahomoodally @@aut@@ Marie Carene Nancy Picot-Allain @@aut@@ Luigi Menghini @@aut@@ Lucia Recinella @@aut@@ Luigi Brunetti @@aut@@ Sheila Leone @@aut@@ Maria Chiara Ciferri @@aut@@ Simonetta Di Simone @@aut@@ Claudio Ferrante @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	735688915
id	DOAJ010457313
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ010457313</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240413071805.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/biom10040516</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ010457313</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJff7295118d5b4833be322e4084fe10c8</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QR1-502</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Kouadio Ibrahime Sinan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. 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callnumber-first	Q - Science
author	Kouadio Ibrahime Sinan
spellingShingle	Kouadio Ibrahime Sinan misc QR1-502 misc medicinal plants misc bioactive compounds misc hyperpigmentation misc diabetes misc dopamine misc Microbiology Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts
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topic_title	QR1-502 Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts medicinal plants bioactive compounds hyperpigmentation diabetes dopamine
topic	misc QR1-502 misc medicinal plants misc bioactive compounds misc hyperpigmentation misc diabetes misc dopamine misc Microbiology
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title	Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts
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title_full	Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts
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author_browse	Kouadio Ibrahime Sinan Annalisa Chiavaroli Giustino Orlando Kouadio Bene Gokhan Zengin Zoltán Cziáky József Jekő Mohamad Fawzi Mahomoodally Marie Carene Nancy Picot-Allain Luigi Menghini Lucia Recinella Luigi Brunetti Sheila Leone Maria Chiara Ciferri Simonetta Di Simone Claudio Ferrante
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title_sort	evaluation of pharmacological and phytochemical profiles of <i<piptadeniastrum africanum</i< (hook.f.) brenan stem bark extracts
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title_auth	Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts
abstract	The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. Additionally, all extracts were able to contrast hydrogen peroxide-induced oxidative stress, in HypoE22 cells, thus restoring basal catecholamine and 3-hydroxykinurenine levels, whereas only methanol and water extracts stimulated basal dopamine release. Overall, data from the present study contribute to the biological assessment of <i<P. africanum</i< that appears to be a promising source of natural compounds with protective and neuromodulatory effects.
abstractGer	The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. Additionally, all extracts were able to contrast hydrogen peroxide-induced oxidative stress, in HypoE22 cells, thus restoring basal catecholamine and 3-hydroxykinurenine levels, whereas only methanol and water extracts stimulated basal dopamine release. Overall, data from the present study contribute to the biological assessment of <i<P. africanum</i< that appears to be a promising source of natural compounds with protective and neuromodulatory effects.
abstract_unstemmed	The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. Additionally, all extracts were able to contrast hydrogen peroxide-induced oxidative stress, in HypoE22 cells, thus restoring basal catecholamine and 3-hydroxykinurenine levels, whereas only methanol and water extracts stimulated basal dopamine release. Overall, data from the present study contribute to the biological assessment of <i<P. africanum</i< that appears to be a promising source of natural compounds with protective and neuromodulatory effects.
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title_short	Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts
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Brenan Stem Bark Extracts</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The stem bark (SB) of <i<Piptadeniastrum africanum</i< (PA) has been extensively used in African traditional medicinal systems. However, there is a dearth of scientific information regarding its possible activity in the management of type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. This study therefore attempted to elucidate the in vitro inhibitory action of ethyl acetate, methanol, and water extracts of <i<P. africanum</i< stem bark (PA-SB) on α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Cell viability, catecholamine, and 3-hydroxykynurenine levels of hypothalamic HypoE22 cells exposed to PA-SB extracts were also investigated. The phytochemical profiles of the extracts were determined by high performance liquid chromatography (HPLC) and antioxidant properties were investigated. Saponin (867.42 mg quillaja equivalent/g) and tannin (33.81 mg catechin equivalent/g) contents were higher in the methanol extract. Multiple dihydroxy-trimethoxy(iso)flavone isomers, loliolide, eriodictyol, naringenin, luteolin, chrysoeriol, apigenin, and liquiritigenin, were characterized from PA-SB extracts using HPLC. The methanol extract of PA-SB showed highest inhibitory activity against acetylcholinesterase (4.88 mg galantamine equivalent (GALAE)/g extract), butyrylcholinesterase (5.37 mg GALAE/g extract), and tyrosinase (154.86 mg kojic acid equivalent/g extract) while α-glucosidase was effectively inhibited by the ethyl acetate extract (15.22 mmol acarbose equivalent/g extract). The methanol extract of PA-SB also showed potent antioxidant properties (493.87, 818.12, 953.07, and 732.19 mg Trolox equivalent/g extract, for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively). PA-SB extracts exhibited antioxidant activity and promising inhibition against key enzymes related to type II diabetes, Alzheimer’s disease, and skin hyperpigmentation disorders. Additionally, all extracts were able to contrast hydrogen peroxide-induced oxidative stress, in HypoE22 cells, thus restoring basal catecholamine and 3-hydroxykinurenine levels, whereas only methanol and water extracts stimulated basal dopamine release. 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Evaluation of Pharmacological and Phytochemical Profiles of <i<Piptadeniastrum africanum</i< (Hook.f.) Brenan Stem Bark Extracts

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