B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma

Ting-Ting Yu,1,* Tao Zhang,2,* Xi Lu,3 Ruo-Zheng Wang3 1Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China; 2Department of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, People&rsquo...
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Gespeichert in:

Autor*in:	Yu TT [verfasserIn] Zhang T [verfasserIn] Lu X [verfasserIn] Wang RZ [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	lung adenocarcinomar;B7-H3 epithelial-mesenchymal transition metastasis proliferation

Übergeordnetes Werk:	In: OncoTargets and Therapy - Dove Medical Press, 2009, (2018), Seite 4693-4700
Übergeordnetes Werk:	year:2018 ; pages:4693-4700

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Katalog-ID:	DOAJ01069725X

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520			\|a Ting-Ting Yu,1,* Tao Zhang,2,* Xi Lu,3 Ruo-Zheng Wang3 1Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China; 2Department of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, People’s Republic of China; 3Radiation Therapy Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China *These authors contributed equally to this work Background: Lung adenocarcinoma is the most common pathological type of lung cancer. However, the mechanisms underlying its development are still poorly understood. B7-H3 was discovered as a new member of the B7 costimulatory family.Methods: We detected the expression status of B7-H3 protein in lung adenocarcinoma tissues, and evaluated the relationship of B7-H3 expression and patients’ prognosis. Then, we silenced its expression in A549 cells by transient siRNA transfection to ascertain the function of B7-H3 in lung adenocarcinoma cells. Western blotting was used to detect the expression of epithelial–mesenchymal transition (EMT) related proteins.Results: We found that B7-H3 overexpressed in lung adenocarcinoma. It is correlated with lymph node metastasis, distant metastasis, and disease stage. The Cox regression analysis showed that B7-H3 might serve as an independent prognostic marker of lung adenocarcinoma. We also found that B7-H3 promoted proliferation, invasion and migration of A549 cells in vitro. B7-H3 also could promote EMT progression by regulating EMT-related molecules.Conclusion: B7-H3 is a potential target for the treatment of lung adenocarcinoma. Keywords: lung adenocarcinoma, B7-H3, epithelial–mesenchymal transition, metastasis, proliferation
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allfields	(DE-627)DOAJ01069725X (DE-599)DOAJ529aab17da294eae8653e60bafacd73f DE-627 ger DE-627 rakwb eng RC254-282 Yu TT verfasserin aut B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ting-Ting Yu,1,* Tao Zhang,2,* Xi Lu,3 Ruo-Zheng Wang3 1Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China; 2Department of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, People’s Republic of China; 3Radiation Therapy Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China *These authors contributed equally to this work Background: Lung adenocarcinoma is the most common pathological type of lung cancer. However, the mechanisms underlying its development are still poorly understood. B7-H3 was discovered as a new member of the B7 costimulatory family.Methods: We detected the expression status of B7-H3 protein in lung adenocarcinoma tissues, and evaluated the relationship of B7-H3 expression and patients’ prognosis. Then, we silenced its expression in A549 cells by transient siRNA transfection to ascertain the function of B7-H3 in lung adenocarcinoma cells. Western blotting was used to detect the expression of epithelial–mesenchymal transition (EMT) related proteins.Results: We found that B7-H3 overexpressed in lung adenocarcinoma. It is correlated with lymph node metastasis, distant metastasis, and disease stage. The Cox regression analysis showed that B7-H3 might serve as an independent prognostic marker of lung adenocarcinoma. We also found that B7-H3 promoted proliferation, invasion and migration of A549 cells in vitro. B7-H3 also could promote EMT progression by regulating EMT-related molecules.Conclusion: B7-H3 is a potential target for the treatment of lung adenocarcinoma. Keywords: lung adenocarcinoma, B7-H3, epithelial–mesenchymal transition, metastasis, proliferation lung adenocarcinomar;B7-H3 epithelial-mesenchymal transition metastasis proliferation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zhang T verfasserin aut Lu X verfasserin aut Wang RZ verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2018), Seite 4693-4700 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2018 pages:4693-4700 https://doaj.org/article/529aab17da294eae8653e60bafacd73f kostenfrei https://www.dovepress.com/b7-h3-promotes-metastasis-proliferation-and-epithelial-mesenchymal-tra-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 4693-4700
spelling	(DE-627)DOAJ01069725X (DE-599)DOAJ529aab17da294eae8653e60bafacd73f DE-627 ger DE-627 rakwb eng RC254-282 Yu TT verfasserin aut B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ting-Ting Yu,1,* Tao Zhang,2,* Xi Lu,3 Ruo-Zheng Wang3 1Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China; 2Department of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, People’s Republic of China; 3Radiation Therapy Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China *These authors contributed equally to this work Background: Lung adenocarcinoma is the most common pathological type of lung cancer. However, the mechanisms underlying its development are still poorly understood. B7-H3 was discovered as a new member of the B7 costimulatory family.Methods: We detected the expression status of B7-H3 protein in lung adenocarcinoma tissues, and evaluated the relationship of B7-H3 expression and patients’ prognosis. Then, we silenced its expression in A549 cells by transient siRNA transfection to ascertain the function of B7-H3 in lung adenocarcinoma cells. Western blotting was used to detect the expression of epithelial–mesenchymal transition (EMT) related proteins.Results: We found that B7-H3 overexpressed in lung adenocarcinoma. It is correlated with lymph node metastasis, distant metastasis, and disease stage. The Cox regression analysis showed that B7-H3 might serve as an independent prognostic marker of lung adenocarcinoma. We also found that B7-H3 promoted proliferation, invasion and migration of A549 cells in vitro. B7-H3 also could promote EMT progression by regulating EMT-related molecules.Conclusion: B7-H3 is a potential target for the treatment of lung adenocarcinoma. Keywords: lung adenocarcinoma, B7-H3, epithelial–mesenchymal transition, metastasis, proliferation lung adenocarcinomar;B7-H3 epithelial-mesenchymal transition metastasis proliferation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zhang T verfasserin aut Lu X verfasserin aut Wang RZ verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2018), Seite 4693-4700 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2018 pages:4693-4700 https://doaj.org/article/529aab17da294eae8653e60bafacd73f kostenfrei https://www.dovepress.com/b7-h3-promotes-metastasis-proliferation-and-epithelial-mesenchymal-tra-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 4693-4700
allfields_unstemmed	(DE-627)DOAJ01069725X (DE-599)DOAJ529aab17da294eae8653e60bafacd73f DE-627 ger DE-627 rakwb eng RC254-282 Yu TT verfasserin aut B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ting-Ting Yu,1,* Tao Zhang,2,* Xi Lu,3 Ruo-Zheng Wang3 1Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China; 2Department of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, People’s Republic of China; 3Radiation Therapy Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China *These authors contributed equally to this work Background: Lung adenocarcinoma is the most common pathological type of lung cancer. However, the mechanisms underlying its development are still poorly understood. B7-H3 was discovered as a new member of the B7 costimulatory family.Methods: We detected the expression status of B7-H3 protein in lung adenocarcinoma tissues, and evaluated the relationship of B7-H3 expression and patients’ prognosis. Then, we silenced its expression in A549 cells by transient siRNA transfection to ascertain the function of B7-H3 in lung adenocarcinoma cells. Western blotting was used to detect the expression of epithelial–mesenchymal transition (EMT) related proteins.Results: We found that B7-H3 overexpressed in lung adenocarcinoma. It is correlated with lymph node metastasis, distant metastasis, and disease stage. The Cox regression analysis showed that B7-H3 might serve as an independent prognostic marker of lung adenocarcinoma. We also found that B7-H3 promoted proliferation, invasion and migration of A549 cells in vitro. B7-H3 also could promote EMT progression by regulating EMT-related molecules.Conclusion: B7-H3 is a potential target for the treatment of lung adenocarcinoma. Keywords: lung adenocarcinoma, B7-H3, epithelial–mesenchymal transition, metastasis, proliferation lung adenocarcinomar;B7-H3 epithelial-mesenchymal transition metastasis proliferation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zhang T verfasserin aut Lu X verfasserin aut Wang RZ verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2018), Seite 4693-4700 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2018 pages:4693-4700 https://doaj.org/article/529aab17da294eae8653e60bafacd73f kostenfrei https://www.dovepress.com/b7-h3-promotes-metastasis-proliferation-and-epithelial-mesenchymal-tra-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 4693-4700
allfieldsGer	(DE-627)DOAJ01069725X (DE-599)DOAJ529aab17da294eae8653e60bafacd73f DE-627 ger DE-627 rakwb eng RC254-282 Yu TT verfasserin aut B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ting-Ting Yu,1,* Tao Zhang,2,* Xi Lu,3 Ruo-Zheng Wang3 1Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China; 2Department of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, People’s Republic of China; 3Radiation Therapy Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China *These authors contributed equally to this work Background: Lung adenocarcinoma is the most common pathological type of lung cancer. However, the mechanisms underlying its development are still poorly understood. B7-H3 was discovered as a new member of the B7 costimulatory family.Methods: We detected the expression status of B7-H3 protein in lung adenocarcinoma tissues, and evaluated the relationship of B7-H3 expression and patients’ prognosis. Then, we silenced its expression in A549 cells by transient siRNA transfection to ascertain the function of B7-H3 in lung adenocarcinoma cells. Western blotting was used to detect the expression of epithelial–mesenchymal transition (EMT) related proteins.Results: We found that B7-H3 overexpressed in lung adenocarcinoma. It is correlated with lymph node metastasis, distant metastasis, and disease stage. The Cox regression analysis showed that B7-H3 might serve as an independent prognostic marker of lung adenocarcinoma. We also found that B7-H3 promoted proliferation, invasion and migration of A549 cells in vitro. B7-H3 also could promote EMT progression by regulating EMT-related molecules.Conclusion: B7-H3 is a potential target for the treatment of lung adenocarcinoma. Keywords: lung adenocarcinoma, B7-H3, epithelial–mesenchymal transition, metastasis, proliferation lung adenocarcinomar;B7-H3 epithelial-mesenchymal transition metastasis proliferation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zhang T verfasserin aut Lu X verfasserin aut Wang RZ verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2018), Seite 4693-4700 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2018 pages:4693-4700 https://doaj.org/article/529aab17da294eae8653e60bafacd73f kostenfrei https://www.dovepress.com/b7-h3-promotes-metastasis-proliferation-and-epithelial-mesenchymal-tra-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 4693-4700
allfieldsSound	(DE-627)DOAJ01069725X (DE-599)DOAJ529aab17da294eae8653e60bafacd73f DE-627 ger DE-627 rakwb eng RC254-282 Yu TT verfasserin aut B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ting-Ting Yu,1,* Tao Zhang,2,* Xi Lu,3 Ruo-Zheng Wang3 1Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China; 2Department of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, People’s Republic of China; 3Radiation Therapy Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China *These authors contributed equally to this work Background: Lung adenocarcinoma is the most common pathological type of lung cancer. However, the mechanisms underlying its development are still poorly understood. B7-H3 was discovered as a new member of the B7 costimulatory family.Methods: We detected the expression status of B7-H3 protein in lung adenocarcinoma tissues, and evaluated the relationship of B7-H3 expression and patients’ prognosis. Then, we silenced its expression in A549 cells by transient siRNA transfection to ascertain the function of B7-H3 in lung adenocarcinoma cells. Western blotting was used to detect the expression of epithelial–mesenchymal transition (EMT) related proteins.Results: We found that B7-H3 overexpressed in lung adenocarcinoma. It is correlated with lymph node metastasis, distant metastasis, and disease stage. The Cox regression analysis showed that B7-H3 might serve as an independent prognostic marker of lung adenocarcinoma. We also found that B7-H3 promoted proliferation, invasion and migration of A549 cells in vitro. B7-H3 also could promote EMT progression by regulating EMT-related molecules.Conclusion: B7-H3 is a potential target for the treatment of lung adenocarcinoma. Keywords: lung adenocarcinoma, B7-H3, epithelial–mesenchymal transition, metastasis, proliferation lung adenocarcinomar;B7-H3 epithelial-mesenchymal transition metastasis proliferation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zhang T verfasserin aut Lu X verfasserin aut Wang RZ verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2018), Seite 4693-4700 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2018 pages:4693-4700 https://doaj.org/article/529aab17da294eae8653e60bafacd73f kostenfrei https://www.dovepress.com/b7-h3-promotes-metastasis-proliferation-and-epithelial-mesenchymal-tra-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 4693-4700
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callnumber-first	R - Medicine
author	Yu TT
spellingShingle	Yu TT misc RC254-282 misc lung adenocarcinomar;B7-H3 misc epithelial-mesenchymal transition misc metastasis misc proliferation misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma
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topic_title	RC254-282 B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma lung adenocarcinomar;B7-H3 epithelial-mesenchymal transition metastasis proliferation
topic	misc RC254-282 misc lung adenocarcinomar;B7-H3 misc epithelial-mesenchymal transition misc metastasis misc proliferation misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc lung adenocarcinomar;B7-H3 misc epithelial-mesenchymal transition misc metastasis misc proliferation misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma
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title_full	B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma
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title_sort	b7-h3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma
callnumber	RC254-282
title_auth	B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma
abstract	Ting-Ting Yu,1,* Tao Zhang,2,* Xi Lu,3 Ruo-Zheng Wang3 1Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China; 2Department of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, People’s Republic of China; 3Radiation Therapy Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China *These authors contributed equally to this work Background: Lung adenocarcinoma is the most common pathological type of lung cancer. However, the mechanisms underlying its development are still poorly understood. B7-H3 was discovered as a new member of the B7 costimulatory family.Methods: We detected the expression status of B7-H3 protein in lung adenocarcinoma tissues, and evaluated the relationship of B7-H3 expression and patients’ prognosis. Then, we silenced its expression in A549 cells by transient siRNA transfection to ascertain the function of B7-H3 in lung adenocarcinoma cells. Western blotting was used to detect the expression of epithelial–mesenchymal transition (EMT) related proteins.Results: We found that B7-H3 overexpressed in lung adenocarcinoma. It is correlated with lymph node metastasis, distant metastasis, and disease stage. The Cox regression analysis showed that B7-H3 might serve as an independent prognostic marker of lung adenocarcinoma. We also found that B7-H3 promoted proliferation, invasion and migration of A549 cells in vitro. B7-H3 also could promote EMT progression by regulating EMT-related molecules.Conclusion: B7-H3 is a potential target for the treatment of lung adenocarcinoma. Keywords: lung adenocarcinoma, B7-H3, epithelial–mesenchymal transition, metastasis, proliferation
abstractGer	Ting-Ting Yu,1,* Tao Zhang,2,* Xi Lu,3 Ruo-Zheng Wang3 1Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China; 2Department of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, People’s Republic of China; 3Radiation Therapy Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China *These authors contributed equally to this work Background: Lung adenocarcinoma is the most common pathological type of lung cancer. However, the mechanisms underlying its development are still poorly understood. B7-H3 was discovered as a new member of the B7 costimulatory family.Methods: We detected the expression status of B7-H3 protein in lung adenocarcinoma tissues, and evaluated the relationship of B7-H3 expression and patients’ prognosis. Then, we silenced its expression in A549 cells by transient siRNA transfection to ascertain the function of B7-H3 in lung adenocarcinoma cells. Western blotting was used to detect the expression of epithelial–mesenchymal transition (EMT) related proteins.Results: We found that B7-H3 overexpressed in lung adenocarcinoma. It is correlated with lymph node metastasis, distant metastasis, and disease stage. The Cox regression analysis showed that B7-H3 might serve as an independent prognostic marker of lung adenocarcinoma. We also found that B7-H3 promoted proliferation, invasion and migration of A549 cells in vitro. B7-H3 also could promote EMT progression by regulating EMT-related molecules.Conclusion: B7-H3 is a potential target for the treatment of lung adenocarcinoma. Keywords: lung adenocarcinoma, B7-H3, epithelial–mesenchymal transition, metastasis, proliferation
abstract_unstemmed	Ting-Ting Yu,1,* Tao Zhang,2,* Xi Lu,3 Ruo-Zheng Wang3 1Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China; 2Department of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, People’s Republic of China; 3Radiation Therapy Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China *These authors contributed equally to this work Background: Lung adenocarcinoma is the most common pathological type of lung cancer. However, the mechanisms underlying its development are still poorly understood. B7-H3 was discovered as a new member of the B7 costimulatory family.Methods: We detected the expression status of B7-H3 protein in lung adenocarcinoma tissues, and evaluated the relationship of B7-H3 expression and patients’ prognosis. Then, we silenced its expression in A549 cells by transient siRNA transfection to ascertain the function of B7-H3 in lung adenocarcinoma cells. Western blotting was used to detect the expression of epithelial–mesenchymal transition (EMT) related proteins.Results: We found that B7-H3 overexpressed in lung adenocarcinoma. It is correlated with lymph node metastasis, distant metastasis, and disease stage. The Cox regression analysis showed that B7-H3 might serve as an independent prognostic marker of lung adenocarcinoma. We also found that B7-H3 promoted proliferation, invasion and migration of A549 cells in vitro. B7-H3 also could promote EMT progression by regulating EMT-related molecules.Conclusion: B7-H3 is a potential target for the treatment of lung adenocarcinoma. Keywords: lung adenocarcinoma, B7-H3, epithelial–mesenchymal transition, metastasis, proliferation
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title_short	B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma
url	https://doaj.org/article/529aab17da294eae8653e60bafacd73f https://www.dovepress.com/b7-h3-promotes-metastasis-proliferation-and-epithelial-mesenchymal-tra-peer-reviewed-article-OTT https://doaj.org/toc/1178-6930
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up_date	2024-07-03T16:15:31.943Z
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However, the mechanisms underlying its development are still poorly understood. B7-H3 was discovered as a new member of the B7 costimulatory family.Methods: We detected the expression status of B7-H3 protein in lung adenocarcinoma tissues, and evaluated the relationship of B7-H3 expression and patients&rsquo; prognosis. Then, we silenced its expression in A549 cells by transient siRNA transfection to ascertain the function of B7-H3 in lung adenocarcinoma cells. Western blotting was used to detect the expression of epithelial&ndash;mesenchymal transition (EMT) related proteins.Results: We found that B7-H3 overexpressed in lung adenocarcinoma. It is correlated with lymph node metastasis, distant metastasis, and disease stage. The Cox regression analysis showed that B7-H3 might serve as an independent prognostic marker of lung adenocarcinoma. We also found that B7-H3 promoted proliferation, invasion and migration of A549 cells in vitro. B7-H3 also could promote EMT progression by regulating EMT-related molecules.Conclusion: B7-H3 is a potential target for the treatment of lung adenocarcinoma. Keywords: lung adenocarcinoma, B7-H3, epithelial&ndash;mesenchymal transition, metastasis, proliferation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">lung adenocarcinomar;B7-H3</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">epithelial-mesenchymal transition</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">metastasis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">proliferation</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma

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