Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells

Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-β-D-glucopyranosyl platycodigenin (6) and polygalacin D (7), were isolated from the roots...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Wansheng Chen [verfasserIn] Feng Zhang [verfasserIn] Zhijun Wu [verfasserIn] Lianna Sun [verfasserIn] Qin Zhan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Platycodon grandiflorum oleanane-type triterpenoid triterpenoid saponin

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 17(2012), 12, Seite 14899-14907
Übergeordnetes Werk:	volume:17 ; year:2012 ; number:12 ; pages:14899-14907

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules171214899

Katalog-ID:	DOAJ010730044

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spelling	10.3390/molecules171214899 doi (DE-627)DOAJ010730044 (DE-599)DOAJ59bfddbfc72d4e769971a7dcd64ee31f DE-627 ger DE-627 rakwb eng QD241-441 Wansheng Chen verfasserin aut Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-β-D-glucopyranosyl platycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum. On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2β,3β,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2β,3β,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-β-D-glucopyranoside (2). Compounds 1–7 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line. Platycodon grandiflorum oleanane-type triterpenoid triterpenoid saponin Organic chemistry Feng Zhang verfasserin aut Zhijun Wu verfasserin aut Lianna Sun verfasserin aut Qin Zhan verfasserin aut In Molecules MDPI AG, 2003 17(2012), 12, Seite 14899-14907 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:17 year:2012 number:12 pages:14899-14907 https://doi.org/10.3390/molecules171214899 kostenfrei https://doaj.org/article/59bfddbfc72d4e769971a7dcd64ee31f kostenfrei http://www.mdpi.com/1420-3049/17/12/14899 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2012 12 14899-14907
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topic_facet	Platycodon grandiflorum oleanane-type triterpenoid triterpenoid saponin Organic chemistry
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authorswithroles_txt_mv	Wansheng Chen @@aut@@ Feng Zhang @@aut@@ Zhijun Wu @@aut@@ Lianna Sun @@aut@@ Qin Zhan @@aut@@
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callnumber-first	Q - Science
author	Wansheng Chen
spellingShingle	Wansheng Chen misc QD241-441 misc Platycodon grandiflorum misc oleanane-type triterpenoid misc triterpenoid saponin misc Organic chemistry Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells
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topic_title	QD241-441 Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells Platycodon grandiflorum oleanane-type triterpenoid triterpenoid saponin
topic	misc QD241-441 misc Platycodon grandiflorum misc oleanane-type triterpenoid misc triterpenoid saponin misc Organic chemistry
topic_unstemmed	misc QD241-441 misc Platycodon grandiflorum misc oleanane-type triterpenoid misc triterpenoid saponin misc Organic chemistry
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title	Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells
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title_full	Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells
author_sort	Wansheng Chen
journal	Molecules
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title_sort	two new oleanane-type triterpenoids from platycodi radix and anti-proliferative activity in hsc-t6 cells
callnumber	QD241-441
title_auth	Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells
abstract	Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-β-D-glucopyranosyl platycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum. On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2β,3β,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2β,3β,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-β-D-glucopyranoside (2). Compounds 1–7 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line.
abstractGer	Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-β-D-glucopyranosyl platycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum. On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2β,3β,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2β,3β,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-β-D-glucopyranoside (2). Compounds 1–7 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line.
abstract_unstemmed	Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-β-D-glucopyranosyl platycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum. On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2β,3β,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2β,3β,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-β-D-glucopyranoside (2). Compounds 1–7 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line.
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title_short	Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells
url	https://doi.org/10.3390/molecules171214899 https://doaj.org/article/59bfddbfc72d4e769971a7dcd64ee31f http://www.mdpi.com/1420-3049/17/12/14899 https://doaj.org/toc/1420-3049
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up_date	2024-07-03T16:26:44.094Z
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Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells

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