Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer
Vahid Kholghi Oskooei,1 Lobat Geranpayeh,2 Mir Davood Omrani,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Purpose: Vitamin D receptor (...
Ausführliche Beschreibung
Autor*in: |
Kholghi Oskooei V [verfasserIn] Geranpayeh L [verfasserIn] Omrani MD [verfasserIn] Ghafouri-Fard S [verfasserIn] |
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E-Artikel |
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Englisch |
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2018 |
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In: Cancer Management and Research - Dove Medical Press, 2009, (2018), Seite 3451-3462 |
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year:2018 ; pages:3451-3462 |
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DOAJ010747346 |
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520 | |a Vahid Kholghi Oskooei,1 Lobat Geranpayeh,2 Mir Davood Omrani,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Purpose: Vitamin D receptor (VDR) signaling pathway is implicated in the pathogenesis of breast cancer.Patients and methods: We selected VDR-associated long noncoding RNAs (lncRNAs) through an in silico analysis of available microarray and RNA-sequencing data and assessed their expression in 75 breast tumor samples and their adjacent noncancerous tissues (ANCTs). We also genotyped two functional polymorphisms within VDR gene in all patients.Results: VDR, MALAT1, and LINC00511 were significantly upregulated in tumoral tissues compared with ANCTs (fold change [FC] =1.85, P=0.03; FC =1.54, P=0.04; and FC =4.75, P=0.000, respectively). In patients younger than 55 years, significant associations were found between expression levels of both SNHG16 and LINC00511 genes and nuclear grade (P=0.03), expression of LINC00346 and tubule formation (P=0.01), expression of both SNHG16 and SNHG6 genes and family history of cancer (P=0.01 and 0.03, respectively), as well as expression of VDR and progesterone receptor status (P=0.03). We detected significant correlations between expression levels of VDR and SNHG16 in both tumoral tissues and ANCTs. The TT genotype of FokI polymorphism was associated with the higher expression levels of VDR. FokI variants were associated with expression levels of both MALAT1 and SNHG16 in ANCTs (P=0.01 and 0.03, respectively). CdxII variants were associated with expression levels of SNHG16 in ANCTs. A significant correlation was found between FC values of SNHG16 expression and vitamin D levels.Conclusion: The present study provides further evidence for the contribution of VDR signaling and the related lncRNAs in the pathogenesis of breast cancer and introduces some novel lncRNAs as putative molecules in the interactive functional network of VDR signaling in breast cancer. Keywords: breast cancer, MALAT1, SNHG16, SNHG6, LINC00346, LINC00511, VDR | ||
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(DE-627)DOAJ010747346 (DE-599)DOAJ24cbc70ca3844619902ec66d0e7ec18e DE-627 ger DE-627 rakwb eng RC254-282 Kholghi Oskooei V verfasserin aut Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vahid Kholghi Oskooei,1 Lobat Geranpayeh,2 Mir Davood Omrani,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Purpose: Vitamin D receptor (VDR) signaling pathway is implicated in the pathogenesis of breast cancer.Patients and methods: We selected VDR-associated long noncoding RNAs (lncRNAs) through an in silico analysis of available microarray and RNA-sequencing data and assessed their expression in 75 breast tumor samples and their adjacent noncancerous tissues (ANCTs). We also genotyped two functional polymorphisms within VDR gene in all patients.Results: VDR, MALAT1, and LINC00511 were significantly upregulated in tumoral tissues compared with ANCTs (fold change [FC] =1.85, P=0.03; FC =1.54, P=0.04; and FC =4.75, P=0.000, respectively). In patients younger than 55 years, significant associations were found between expression levels of both SNHG16 and LINC00511 genes and nuclear grade (P=0.03), expression of LINC00346 and tubule formation (P=0.01), expression of both SNHG16 and SNHG6 genes and family history of cancer (P=0.01 and 0.03, respectively), as well as expression of VDR and progesterone receptor status (P=0.03). We detected significant correlations between expression levels of VDR and SNHG16 in both tumoral tissues and ANCTs. The TT genotype of FokI polymorphism was associated with the higher expression levels of VDR. FokI variants were associated with expression levels of both MALAT1 and SNHG16 in ANCTs (P=0.01 and 0.03, respectively). CdxII variants were associated with expression levels of SNHG16 in ANCTs. A significant correlation was found between FC values of SNHG16 expression and vitamin D levels.Conclusion: The present study provides further evidence for the contribution of VDR signaling and the related lncRNAs in the pathogenesis of breast cancer and introduces some novel lncRNAs as putative molecules in the interactive functional network of VDR signaling in breast cancer. Keywords: breast cancer, MALAT1, SNHG16, SNHG6, LINC00346, LINC00511, VDR breast cancer MALAT1 SNHG16 SNHG6 LINC00346 LINC00511 VDR Neoplasms. Tumors. Oncology. Including cancer and carcinogens Geranpayeh L verfasserin aut Omrani MD verfasserin aut Ghafouri-Fard S verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2018), Seite 3451-3462 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2018 pages:3451-3462 https://doaj.org/article/24cbc70ca3844619902ec66d0e7ec18e kostenfrei https://www.dovepress.com/assessment-of-functional-variants-and-expression-of-long-noncoding-rna-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 3451-3462 |
spelling |
(DE-627)DOAJ010747346 (DE-599)DOAJ24cbc70ca3844619902ec66d0e7ec18e DE-627 ger DE-627 rakwb eng RC254-282 Kholghi Oskooei V verfasserin aut Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vahid Kholghi Oskooei,1 Lobat Geranpayeh,2 Mir Davood Omrani,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Purpose: Vitamin D receptor (VDR) signaling pathway is implicated in the pathogenesis of breast cancer.Patients and methods: We selected VDR-associated long noncoding RNAs (lncRNAs) through an in silico analysis of available microarray and RNA-sequencing data and assessed their expression in 75 breast tumor samples and their adjacent noncancerous tissues (ANCTs). We also genotyped two functional polymorphisms within VDR gene in all patients.Results: VDR, MALAT1, and LINC00511 were significantly upregulated in tumoral tissues compared with ANCTs (fold change [FC] =1.85, P=0.03; FC =1.54, P=0.04; and FC =4.75, P=0.000, respectively). In patients younger than 55 years, significant associations were found between expression levels of both SNHG16 and LINC00511 genes and nuclear grade (P=0.03), expression of LINC00346 and tubule formation (P=0.01), expression of both SNHG16 and SNHG6 genes and family history of cancer (P=0.01 and 0.03, respectively), as well as expression of VDR and progesterone receptor status (P=0.03). We detected significant correlations between expression levels of VDR and SNHG16 in both tumoral tissues and ANCTs. The TT genotype of FokI polymorphism was associated with the higher expression levels of VDR. FokI variants were associated with expression levels of both MALAT1 and SNHG16 in ANCTs (P=0.01 and 0.03, respectively). CdxII variants were associated with expression levels of SNHG16 in ANCTs. A significant correlation was found between FC values of SNHG16 expression and vitamin D levels.Conclusion: The present study provides further evidence for the contribution of VDR signaling and the related lncRNAs in the pathogenesis of breast cancer and introduces some novel lncRNAs as putative molecules in the interactive functional network of VDR signaling in breast cancer. Keywords: breast cancer, MALAT1, SNHG16, SNHG6, LINC00346, LINC00511, VDR breast cancer MALAT1 SNHG16 SNHG6 LINC00346 LINC00511 VDR Neoplasms. Tumors. Oncology. Including cancer and carcinogens Geranpayeh L verfasserin aut Omrani MD verfasserin aut Ghafouri-Fard S verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2018), Seite 3451-3462 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2018 pages:3451-3462 https://doaj.org/article/24cbc70ca3844619902ec66d0e7ec18e kostenfrei https://www.dovepress.com/assessment-of-functional-variants-and-expression-of-long-noncoding-rna-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 3451-3462 |
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(DE-627)DOAJ010747346 (DE-599)DOAJ24cbc70ca3844619902ec66d0e7ec18e DE-627 ger DE-627 rakwb eng RC254-282 Kholghi Oskooei V verfasserin aut Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vahid Kholghi Oskooei,1 Lobat Geranpayeh,2 Mir Davood Omrani,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Purpose: Vitamin D receptor (VDR) signaling pathway is implicated in the pathogenesis of breast cancer.Patients and methods: We selected VDR-associated long noncoding RNAs (lncRNAs) through an in silico analysis of available microarray and RNA-sequencing data and assessed their expression in 75 breast tumor samples and their adjacent noncancerous tissues (ANCTs). We also genotyped two functional polymorphisms within VDR gene in all patients.Results: VDR, MALAT1, and LINC00511 were significantly upregulated in tumoral tissues compared with ANCTs (fold change [FC] =1.85, P=0.03; FC =1.54, P=0.04; and FC =4.75, P=0.000, respectively). In patients younger than 55 years, significant associations were found between expression levels of both SNHG16 and LINC00511 genes and nuclear grade (P=0.03), expression of LINC00346 and tubule formation (P=0.01), expression of both SNHG16 and SNHG6 genes and family history of cancer (P=0.01 and 0.03, respectively), as well as expression of VDR and progesterone receptor status (P=0.03). We detected significant correlations between expression levels of VDR and SNHG16 in both tumoral tissues and ANCTs. The TT genotype of FokI polymorphism was associated with the higher expression levels of VDR. FokI variants were associated with expression levels of both MALAT1 and SNHG16 in ANCTs (P=0.01 and 0.03, respectively). CdxII variants were associated with expression levels of SNHG16 in ANCTs. A significant correlation was found between FC values of SNHG16 expression and vitamin D levels.Conclusion: The present study provides further evidence for the contribution of VDR signaling and the related lncRNAs in the pathogenesis of breast cancer and introduces some novel lncRNAs as putative molecules in the interactive functional network of VDR signaling in breast cancer. Keywords: breast cancer, MALAT1, SNHG16, SNHG6, LINC00346, LINC00511, VDR breast cancer MALAT1 SNHG16 SNHG6 LINC00346 LINC00511 VDR Neoplasms. Tumors. Oncology. Including cancer and carcinogens Geranpayeh L verfasserin aut Omrani MD verfasserin aut Ghafouri-Fard S verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2018), Seite 3451-3462 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2018 pages:3451-3462 https://doaj.org/article/24cbc70ca3844619902ec66d0e7ec18e kostenfrei https://www.dovepress.com/assessment-of-functional-variants-and-expression-of-long-noncoding-rna-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 3451-3462 |
allfieldsGer |
(DE-627)DOAJ010747346 (DE-599)DOAJ24cbc70ca3844619902ec66d0e7ec18e DE-627 ger DE-627 rakwb eng RC254-282 Kholghi Oskooei V verfasserin aut Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vahid Kholghi Oskooei,1 Lobat Geranpayeh,2 Mir Davood Omrani,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Purpose: Vitamin D receptor (VDR) signaling pathway is implicated in the pathogenesis of breast cancer.Patients and methods: We selected VDR-associated long noncoding RNAs (lncRNAs) through an in silico analysis of available microarray and RNA-sequencing data and assessed their expression in 75 breast tumor samples and their adjacent noncancerous tissues (ANCTs). We also genotyped two functional polymorphisms within VDR gene in all patients.Results: VDR, MALAT1, and LINC00511 were significantly upregulated in tumoral tissues compared with ANCTs (fold change [FC] =1.85, P=0.03; FC =1.54, P=0.04; and FC =4.75, P=0.000, respectively). In patients younger than 55 years, significant associations were found between expression levels of both SNHG16 and LINC00511 genes and nuclear grade (P=0.03), expression of LINC00346 and tubule formation (P=0.01), expression of both SNHG16 and SNHG6 genes and family history of cancer (P=0.01 and 0.03, respectively), as well as expression of VDR and progesterone receptor status (P=0.03). We detected significant correlations between expression levels of VDR and SNHG16 in both tumoral tissues and ANCTs. The TT genotype of FokI polymorphism was associated with the higher expression levels of VDR. FokI variants were associated with expression levels of both MALAT1 and SNHG16 in ANCTs (P=0.01 and 0.03, respectively). CdxII variants were associated with expression levels of SNHG16 in ANCTs. A significant correlation was found between FC values of SNHG16 expression and vitamin D levels.Conclusion: The present study provides further evidence for the contribution of VDR signaling and the related lncRNAs in the pathogenesis of breast cancer and introduces some novel lncRNAs as putative molecules in the interactive functional network of VDR signaling in breast cancer. Keywords: breast cancer, MALAT1, SNHG16, SNHG6, LINC00346, LINC00511, VDR breast cancer MALAT1 SNHG16 SNHG6 LINC00346 LINC00511 VDR Neoplasms. Tumors. Oncology. Including cancer and carcinogens Geranpayeh L verfasserin aut Omrani MD verfasserin aut Ghafouri-Fard S verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2018), Seite 3451-3462 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2018 pages:3451-3462 https://doaj.org/article/24cbc70ca3844619902ec66d0e7ec18e kostenfrei https://www.dovepress.com/assessment-of-functional-variants-and-expression-of-long-noncoding-rna-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 3451-3462 |
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Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer |
abstract |
Vahid Kholghi Oskooei,1 Lobat Geranpayeh,2 Mir Davood Omrani,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Purpose: Vitamin D receptor (VDR) signaling pathway is implicated in the pathogenesis of breast cancer.Patients and methods: We selected VDR-associated long noncoding RNAs (lncRNAs) through an in silico analysis of available microarray and RNA-sequencing data and assessed their expression in 75 breast tumor samples and their adjacent noncancerous tissues (ANCTs). We also genotyped two functional polymorphisms within VDR gene in all patients.Results: VDR, MALAT1, and LINC00511 were significantly upregulated in tumoral tissues compared with ANCTs (fold change [FC] =1.85, P=0.03; FC =1.54, P=0.04; and FC =4.75, P=0.000, respectively). In patients younger than 55 years, significant associations were found between expression levels of both SNHG16 and LINC00511 genes and nuclear grade (P=0.03), expression of LINC00346 and tubule formation (P=0.01), expression of both SNHG16 and SNHG6 genes and family history of cancer (P=0.01 and 0.03, respectively), as well as expression of VDR and progesterone receptor status (P=0.03). We detected significant correlations between expression levels of VDR and SNHG16 in both tumoral tissues and ANCTs. The TT genotype of FokI polymorphism was associated with the higher expression levels of VDR. FokI variants were associated with expression levels of both MALAT1 and SNHG16 in ANCTs (P=0.01 and 0.03, respectively). CdxII variants were associated with expression levels of SNHG16 in ANCTs. A significant correlation was found between FC values of SNHG16 expression and vitamin D levels.Conclusion: The present study provides further evidence for the contribution of VDR signaling and the related lncRNAs in the pathogenesis of breast cancer and introduces some novel lncRNAs as putative molecules in the interactive functional network of VDR signaling in breast cancer. Keywords: breast cancer, MALAT1, SNHG16, SNHG6, LINC00346, LINC00511, VDR |
abstractGer |
Vahid Kholghi Oskooei,1 Lobat Geranpayeh,2 Mir Davood Omrani,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Purpose: Vitamin D receptor (VDR) signaling pathway is implicated in the pathogenesis of breast cancer.Patients and methods: We selected VDR-associated long noncoding RNAs (lncRNAs) through an in silico analysis of available microarray and RNA-sequencing data and assessed their expression in 75 breast tumor samples and their adjacent noncancerous tissues (ANCTs). We also genotyped two functional polymorphisms within VDR gene in all patients.Results: VDR, MALAT1, and LINC00511 were significantly upregulated in tumoral tissues compared with ANCTs (fold change [FC] =1.85, P=0.03; FC =1.54, P=0.04; and FC =4.75, P=0.000, respectively). In patients younger than 55 years, significant associations were found between expression levels of both SNHG16 and LINC00511 genes and nuclear grade (P=0.03), expression of LINC00346 and tubule formation (P=0.01), expression of both SNHG16 and SNHG6 genes and family history of cancer (P=0.01 and 0.03, respectively), as well as expression of VDR and progesterone receptor status (P=0.03). We detected significant correlations between expression levels of VDR and SNHG16 in both tumoral tissues and ANCTs. The TT genotype of FokI polymorphism was associated with the higher expression levels of VDR. FokI variants were associated with expression levels of both MALAT1 and SNHG16 in ANCTs (P=0.01 and 0.03, respectively). CdxII variants were associated with expression levels of SNHG16 in ANCTs. A significant correlation was found between FC values of SNHG16 expression and vitamin D levels.Conclusion: The present study provides further evidence for the contribution of VDR signaling and the related lncRNAs in the pathogenesis of breast cancer and introduces some novel lncRNAs as putative molecules in the interactive functional network of VDR signaling in breast cancer. Keywords: breast cancer, MALAT1, SNHG16, SNHG6, LINC00346, LINC00511, VDR |
abstract_unstemmed |
Vahid Kholghi Oskooei,1 Lobat Geranpayeh,2 Mir Davood Omrani,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Purpose: Vitamin D receptor (VDR) signaling pathway is implicated in the pathogenesis of breast cancer.Patients and methods: We selected VDR-associated long noncoding RNAs (lncRNAs) through an in silico analysis of available microarray and RNA-sequencing data and assessed their expression in 75 breast tumor samples and their adjacent noncancerous tissues (ANCTs). We also genotyped two functional polymorphisms within VDR gene in all patients.Results: VDR, MALAT1, and LINC00511 were significantly upregulated in tumoral tissues compared with ANCTs (fold change [FC] =1.85, P=0.03; FC =1.54, P=0.04; and FC =4.75, P=0.000, respectively). In patients younger than 55 years, significant associations were found between expression levels of both SNHG16 and LINC00511 genes and nuclear grade (P=0.03), expression of LINC00346 and tubule formation (P=0.01), expression of both SNHG16 and SNHG6 genes and family history of cancer (P=0.01 and 0.03, respectively), as well as expression of VDR and progesterone receptor status (P=0.03). We detected significant correlations between expression levels of VDR and SNHG16 in both tumoral tissues and ANCTs. The TT genotype of FokI polymorphism was associated with the higher expression levels of VDR. FokI variants were associated with expression levels of both MALAT1 and SNHG16 in ANCTs (P=0.01 and 0.03, respectively). CdxII variants were associated with expression levels of SNHG16 in ANCTs. A significant correlation was found between FC values of SNHG16 expression and vitamin D levels.Conclusion: The present study provides further evidence for the contribution of VDR signaling and the related lncRNAs in the pathogenesis of breast cancer and introduces some novel lncRNAs as putative molecules in the interactive functional network of VDR signaling in breast cancer. Keywords: breast cancer, MALAT1, SNHG16, SNHG6, LINC00346, LINC00511, VDR |
collection_details |
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title_short |
Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer |
url |
https://doaj.org/article/24cbc70ca3844619902ec66d0e7ec18e https://www.dovepress.com/assessment-of-functional-variants-and-expression-of-long-noncoding-rna-peer-reviewed-article-CMAR https://doaj.org/toc/1179-1322 |
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up_date |
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