Aktivitas Antioksidan dan Penghambatan Xantin Oksidase Kulit Batang Songi (Dillenia serrata Thunb.)
Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Carla Wulandari Sabandar [verfasserIn] Juriyati Jalil [verfasserIn] Norizan Ahmat [verfasserIn] Nor-Ashila Aladdin [verfasserIn] Harni Sartika Kamaruddin [verfasserIn] Retno Wahyuningrum [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Indonesisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) - Universitas Tadulako, 2018, 6(2020), 1, Seite 151-159 |
|---|---|
| Übergeordnetes Werk: |
volume:6 ; year:2020 ; number:1 ; pages:151-159 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.22487/j24428744.2020.v6.i1.15008 |
|---|
| Katalog-ID: |
DOAJ010774556 |
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| 520 | |a Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and xanthine oxidase (XO) inhibitory activity of the stem bark of the plant. Methanol extract and organic fractions (petroleum ether, ethyl acetate, and methanol) of the dried powdered stem bark of songi were evaluated for phytochemical screening, total phenolic (TPC), total flavonoid contents (TFC), DPPH, FRAP, and XO in vitro assays. Flavonoids, tannins, terpenoids, steroids, and saponins present in the extract. TPC and TFC in extract were 59.2 mg GAE/g and 23.4 mg QE/g. The contents in organic fractions were in solvent-dependent manner (methanol<ethyl acetate<petroleum ether). Extract and fractions scavenged DPPH radicals (48.2–59.7%) at 100 μg/mL compared to ascorbic acid, trolox, and gallic acid (90.3–93.8%). FRAP values varied from 0.8–3.4 μg/μg equivalent trolox amount (quercetin and gallic acid were 25.7 dan 32.4 μg/μg, respectively). They also inhibited xanthine oxidase (15.3–50.3%) at 100 μg/mL (allopurinol, 98.2%). The study concluded the potential of methanol extract and organic fraction of the stem bark of songi, thus highlighted the prospect of songi to be used in herbal and drugs development from nature. | ||
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10.22487/j24428744.2020.v6.i1.15008 doi (DE-627)DOAJ010774556 (DE-599)DOAJd3aaaa495bd24fcb91b0bc4f4976218f DE-627 ger DE-627 rakwb eng ind RM1-950 Carla Wulandari Sabandar verfasserin aut Aktivitas Antioksidan dan Penghambatan Xantin Oksidase Kulit Batang Songi (Dillenia serrata Thunb.) 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and xanthine oxidase (XO) inhibitory activity of the stem bark of the plant. Methanol extract and organic fractions (petroleum ether, ethyl acetate, and methanol) of the dried powdered stem bark of songi were evaluated for phytochemical screening, total phenolic (TPC), total flavonoid contents (TFC), DPPH, FRAP, and XO in vitro assays. Flavonoids, tannins, terpenoids, steroids, and saponins present in the extract. TPC and TFC in extract were 59.2 mg GAE/g and 23.4 mg QE/g. The contents in organic fractions were in solvent-dependent manner (methanol<ethyl acetate<petroleum ether). Extract and fractions scavenged DPPH radicals (48.2–59.7%) at 100 μg/mL compared to ascorbic acid, trolox, and gallic acid (90.3–93.8%). FRAP values varied from 0.8–3.4 μg/μg equivalent trolox amount (quercetin and gallic acid were 25.7 dan 32.4 μg/μg, respectively). They also inhibited xanthine oxidase (15.3–50.3%) at 100 μg/mL (allopurinol, 98.2%). The study concluded the potential of methanol extract and organic fraction of the stem bark of songi, thus highlighted the prospect of songi to be used in herbal and drugs development from nature. dilleniaceae dillenia serrata thunb. fenolik flavonoid antioksidan xantin oksidase Therapeutics. Pharmacology Juriyati Jalil verfasserin aut Norizan Ahmat verfasserin aut Nor-Ashila Aladdin verfasserin aut Harni Sartika Kamaruddin verfasserin aut Retno Wahyuningrum verfasserin aut In Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Universitas Tadulako, 2018 6(2020), 1, Seite 151-159 (DE-627)1760615722 24428744 nnns volume:6 year:2020 number:1 pages:151-159 https://doi.org/10.22487/j24428744.2020.v6.i1.15008 kostenfrei https://doaj.org/article/d3aaaa495bd24fcb91b0bc4f4976218f kostenfrei https://bestjournal.untad.ac.id/index.php/Galenika/article/view/15008 kostenfrei https://doaj.org/toc/2442-7284 Journal toc kostenfrei https://doaj.org/toc/2442-8744 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 6 2020 1 151-159 |
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10.22487/j24428744.2020.v6.i1.15008 doi (DE-627)DOAJ010774556 (DE-599)DOAJd3aaaa495bd24fcb91b0bc4f4976218f DE-627 ger DE-627 rakwb eng ind RM1-950 Carla Wulandari Sabandar verfasserin aut Aktivitas Antioksidan dan Penghambatan Xantin Oksidase Kulit Batang Songi (Dillenia serrata Thunb.) 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and xanthine oxidase (XO) inhibitory activity of the stem bark of the plant. Methanol extract and organic fractions (petroleum ether, ethyl acetate, and methanol) of the dried powdered stem bark of songi were evaluated for phytochemical screening, total phenolic (TPC), total flavonoid contents (TFC), DPPH, FRAP, and XO in vitro assays. Flavonoids, tannins, terpenoids, steroids, and saponins present in the extract. TPC and TFC in extract were 59.2 mg GAE/g and 23.4 mg QE/g. The contents in organic fractions were in solvent-dependent manner (methanol<ethyl acetate<petroleum ether). Extract and fractions scavenged DPPH radicals (48.2–59.7%) at 100 μg/mL compared to ascorbic acid, trolox, and gallic acid (90.3–93.8%). FRAP values varied from 0.8–3.4 μg/μg equivalent trolox amount (quercetin and gallic acid were 25.7 dan 32.4 μg/μg, respectively). They also inhibited xanthine oxidase (15.3–50.3%) at 100 μg/mL (allopurinol, 98.2%). The study concluded the potential of methanol extract and organic fraction of the stem bark of songi, thus highlighted the prospect of songi to be used in herbal and drugs development from nature. dilleniaceae dillenia serrata thunb. fenolik flavonoid antioksidan xantin oksidase Therapeutics. Pharmacology Juriyati Jalil verfasserin aut Norizan Ahmat verfasserin aut Nor-Ashila Aladdin verfasserin aut Harni Sartika Kamaruddin verfasserin aut Retno Wahyuningrum verfasserin aut In Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Universitas Tadulako, 2018 6(2020), 1, Seite 151-159 (DE-627)1760615722 24428744 nnns volume:6 year:2020 number:1 pages:151-159 https://doi.org/10.22487/j24428744.2020.v6.i1.15008 kostenfrei https://doaj.org/article/d3aaaa495bd24fcb91b0bc4f4976218f kostenfrei https://bestjournal.untad.ac.id/index.php/Galenika/article/view/15008 kostenfrei https://doaj.org/toc/2442-7284 Journal toc kostenfrei https://doaj.org/toc/2442-8744 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 6 2020 1 151-159 |
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10.22487/j24428744.2020.v6.i1.15008 doi (DE-627)DOAJ010774556 (DE-599)DOAJd3aaaa495bd24fcb91b0bc4f4976218f DE-627 ger DE-627 rakwb eng ind RM1-950 Carla Wulandari Sabandar verfasserin aut Aktivitas Antioksidan dan Penghambatan Xantin Oksidase Kulit Batang Songi (Dillenia serrata Thunb.) 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and xanthine oxidase (XO) inhibitory activity of the stem bark of the plant. Methanol extract and organic fractions (petroleum ether, ethyl acetate, and methanol) of the dried powdered stem bark of songi were evaluated for phytochemical screening, total phenolic (TPC), total flavonoid contents (TFC), DPPH, FRAP, and XO in vitro assays. Flavonoids, tannins, terpenoids, steroids, and saponins present in the extract. TPC and TFC in extract were 59.2 mg GAE/g and 23.4 mg QE/g. The contents in organic fractions were in solvent-dependent manner (methanol<ethyl acetate<petroleum ether). Extract and fractions scavenged DPPH radicals (48.2–59.7%) at 100 μg/mL compared to ascorbic acid, trolox, and gallic acid (90.3–93.8%). FRAP values varied from 0.8–3.4 μg/μg equivalent trolox amount (quercetin and gallic acid were 25.7 dan 32.4 μg/μg, respectively). They also inhibited xanthine oxidase (15.3–50.3%) at 100 μg/mL (allopurinol, 98.2%). The study concluded the potential of methanol extract and organic fraction of the stem bark of songi, thus highlighted the prospect of songi to be used in herbal and drugs development from nature. dilleniaceae dillenia serrata thunb. fenolik flavonoid antioksidan xantin oksidase Therapeutics. Pharmacology Juriyati Jalil verfasserin aut Norizan Ahmat verfasserin aut Nor-Ashila Aladdin verfasserin aut Harni Sartika Kamaruddin verfasserin aut Retno Wahyuningrum verfasserin aut In Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Universitas Tadulako, 2018 6(2020), 1, Seite 151-159 (DE-627)1760615722 24428744 nnns volume:6 year:2020 number:1 pages:151-159 https://doi.org/10.22487/j24428744.2020.v6.i1.15008 kostenfrei https://doaj.org/article/d3aaaa495bd24fcb91b0bc4f4976218f kostenfrei https://bestjournal.untad.ac.id/index.php/Galenika/article/view/15008 kostenfrei https://doaj.org/toc/2442-7284 Journal toc kostenfrei https://doaj.org/toc/2442-8744 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 6 2020 1 151-159 |
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10.22487/j24428744.2020.v6.i1.15008 doi (DE-627)DOAJ010774556 (DE-599)DOAJd3aaaa495bd24fcb91b0bc4f4976218f DE-627 ger DE-627 rakwb eng ind RM1-950 Carla Wulandari Sabandar verfasserin aut Aktivitas Antioksidan dan Penghambatan Xantin Oksidase Kulit Batang Songi (Dillenia serrata Thunb.) 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and xanthine oxidase (XO) inhibitory activity of the stem bark of the plant. Methanol extract and organic fractions (petroleum ether, ethyl acetate, and methanol) of the dried powdered stem bark of songi were evaluated for phytochemical screening, total phenolic (TPC), total flavonoid contents (TFC), DPPH, FRAP, and XO in vitro assays. Flavonoids, tannins, terpenoids, steroids, and saponins present in the extract. TPC and TFC in extract were 59.2 mg GAE/g and 23.4 mg QE/g. The contents in organic fractions were in solvent-dependent manner (methanol<ethyl acetate<petroleum ether). Extract and fractions scavenged DPPH radicals (48.2–59.7%) at 100 μg/mL compared to ascorbic acid, trolox, and gallic acid (90.3–93.8%). FRAP values varied from 0.8–3.4 μg/μg equivalent trolox amount (quercetin and gallic acid were 25.7 dan 32.4 μg/μg, respectively). They also inhibited xanthine oxidase (15.3–50.3%) at 100 μg/mL (allopurinol, 98.2%). The study concluded the potential of methanol extract and organic fraction of the stem bark of songi, thus highlighted the prospect of songi to be used in herbal and drugs development from nature. dilleniaceae dillenia serrata thunb. fenolik flavonoid antioksidan xantin oksidase Therapeutics. Pharmacology Juriyati Jalil verfasserin aut Norizan Ahmat verfasserin aut Nor-Ashila Aladdin verfasserin aut Harni Sartika Kamaruddin verfasserin aut Retno Wahyuningrum verfasserin aut In Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Universitas Tadulako, 2018 6(2020), 1, Seite 151-159 (DE-627)1760615722 24428744 nnns volume:6 year:2020 number:1 pages:151-159 https://doi.org/10.22487/j24428744.2020.v6.i1.15008 kostenfrei https://doaj.org/article/d3aaaa495bd24fcb91b0bc4f4976218f kostenfrei https://bestjournal.untad.ac.id/index.php/Galenika/article/view/15008 kostenfrei https://doaj.org/toc/2442-7284 Journal toc kostenfrei https://doaj.org/toc/2442-8744 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 6 2020 1 151-159 |
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10.22487/j24428744.2020.v6.i1.15008 doi (DE-627)DOAJ010774556 (DE-599)DOAJd3aaaa495bd24fcb91b0bc4f4976218f DE-627 ger DE-627 rakwb eng ind RM1-950 Carla Wulandari Sabandar verfasserin aut Aktivitas Antioksidan dan Penghambatan Xantin Oksidase Kulit Batang Songi (Dillenia serrata Thunb.) 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and xanthine oxidase (XO) inhibitory activity of the stem bark of the plant. Methanol extract and organic fractions (petroleum ether, ethyl acetate, and methanol) of the dried powdered stem bark of songi were evaluated for phytochemical screening, total phenolic (TPC), total flavonoid contents (TFC), DPPH, FRAP, and XO in vitro assays. Flavonoids, tannins, terpenoids, steroids, and saponins present in the extract. TPC and TFC in extract were 59.2 mg GAE/g and 23.4 mg QE/g. The contents in organic fractions were in solvent-dependent manner (methanol<ethyl acetate<petroleum ether). Extract and fractions scavenged DPPH radicals (48.2–59.7%) at 100 μg/mL compared to ascorbic acid, trolox, and gallic acid (90.3–93.8%). FRAP values varied from 0.8–3.4 μg/μg equivalent trolox amount (quercetin and gallic acid were 25.7 dan 32.4 μg/μg, respectively). They also inhibited xanthine oxidase (15.3–50.3%) at 100 μg/mL (allopurinol, 98.2%). The study concluded the potential of methanol extract and organic fraction of the stem bark of songi, thus highlighted the prospect of songi to be used in herbal and drugs development from nature. dilleniaceae dillenia serrata thunb. fenolik flavonoid antioksidan xantin oksidase Therapeutics. Pharmacology Juriyati Jalil verfasserin aut Norizan Ahmat verfasserin aut Nor-Ashila Aladdin verfasserin aut Harni Sartika Kamaruddin verfasserin aut Retno Wahyuningrum verfasserin aut In Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Universitas Tadulako, 2018 6(2020), 1, Seite 151-159 (DE-627)1760615722 24428744 nnns volume:6 year:2020 number:1 pages:151-159 https://doi.org/10.22487/j24428744.2020.v6.i1.15008 kostenfrei https://doaj.org/article/d3aaaa495bd24fcb91b0bc4f4976218f kostenfrei https://bestjournal.untad.ac.id/index.php/Galenika/article/view/15008 kostenfrei https://doaj.org/toc/2442-7284 Journal toc kostenfrei https://doaj.org/toc/2442-8744 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 6 2020 1 151-159 |
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aktivitas antioksidan dan penghambatan xantin oksidase kulit batang songi (dillenia serrata thunb.) |
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Aktivitas Antioksidan dan Penghambatan Xantin Oksidase Kulit Batang Songi (Dillenia serrata Thunb.) |
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Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and xanthine oxidase (XO) inhibitory activity of the stem bark of the plant. Methanol extract and organic fractions (petroleum ether, ethyl acetate, and methanol) of the dried powdered stem bark of songi were evaluated for phytochemical screening, total phenolic (TPC), total flavonoid contents (TFC), DPPH, FRAP, and XO in vitro assays. Flavonoids, tannins, terpenoids, steroids, and saponins present in the extract. TPC and TFC in extract were 59.2 mg GAE/g and 23.4 mg QE/g. The contents in organic fractions were in solvent-dependent manner (methanol<ethyl acetate<petroleum ether). Extract and fractions scavenged DPPH radicals (48.2–59.7%) at 100 μg/mL compared to ascorbic acid, trolox, and gallic acid (90.3–93.8%). FRAP values varied from 0.8–3.4 μg/μg equivalent trolox amount (quercetin and gallic acid were 25.7 dan 32.4 μg/μg, respectively). They also inhibited xanthine oxidase (15.3–50.3%) at 100 μg/mL (allopurinol, 98.2%). The study concluded the potential of methanol extract and organic fraction of the stem bark of songi, thus highlighted the prospect of songi to be used in herbal and drugs development from nature. |
| abstractGer |
Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and xanthine oxidase (XO) inhibitory activity of the stem bark of the plant. Methanol extract and organic fractions (petroleum ether, ethyl acetate, and methanol) of the dried powdered stem bark of songi were evaluated for phytochemical screening, total phenolic (TPC), total flavonoid contents (TFC), DPPH, FRAP, and XO in vitro assays. Flavonoids, tannins, terpenoids, steroids, and saponins present in the extract. TPC and TFC in extract were 59.2 mg GAE/g and 23.4 mg QE/g. The contents in organic fractions were in solvent-dependent manner (methanol<ethyl acetate<petroleum ether). Extract and fractions scavenged DPPH radicals (48.2–59.7%) at 100 μg/mL compared to ascorbic acid, trolox, and gallic acid (90.3–93.8%). FRAP values varied from 0.8–3.4 μg/μg equivalent trolox amount (quercetin and gallic acid were 25.7 dan 32.4 μg/μg, respectively). They also inhibited xanthine oxidase (15.3–50.3%) at 100 μg/mL (allopurinol, 98.2%). The study concluded the potential of methanol extract and organic fraction of the stem bark of songi, thus highlighted the prospect of songi to be used in herbal and drugs development from nature. |
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Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and xanthine oxidase (XO) inhibitory activity of the stem bark of the plant. Methanol extract and organic fractions (petroleum ether, ethyl acetate, and methanol) of the dried powdered stem bark of songi were evaluated for phytochemical screening, total phenolic (TPC), total flavonoid contents (TFC), DPPH, FRAP, and XO in vitro assays. Flavonoids, tannins, terpenoids, steroids, and saponins present in the extract. TPC and TFC in extract were 59.2 mg GAE/g and 23.4 mg QE/g. The contents in organic fractions were in solvent-dependent manner (methanol<ethyl acetate<petroleum ether). Extract and fractions scavenged DPPH radicals (48.2–59.7%) at 100 μg/mL compared to ascorbic acid, trolox, and gallic acid (90.3–93.8%). FRAP values varied from 0.8–3.4 μg/μg equivalent trolox amount (quercetin and gallic acid were 25.7 dan 32.4 μg/μg, respectively). They also inhibited xanthine oxidase (15.3–50.3%) at 100 μg/mL (allopurinol, 98.2%). The study concluded the potential of methanol extract and organic fraction of the stem bark of songi, thus highlighted the prospect of songi to be used in herbal and drugs development from nature. |
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