HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo.

We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-pr...
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Autor*in:	Charlotte V Hobbs [verfasserIn] Jillian Neal [verfasserIn] Solomon Conteh [verfasserIn] Liam Donnelly [verfasserIn] Jingyang Chen [verfasserIn] Kennan Marsh [verfasserIn] Lynn Lambert [verfasserIn] Sachy Orr-Gonzalez [verfasserIn] Jessica Hinderer [verfasserIn] Sara Healy [verfasserIn] William Borkowsky [verfasserIn] Scott R Penzak [verfasserIn] Sumana Chakravarty [verfasserIn] Stephen L Hoffman [verfasserIn] Patrick E Duffy [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 9(2014), 7, p e100138
Übergeordnetes Werk:	volume:9 ; year:2014 ; number:7, p e100138

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0100138

Katalog-ID:	DOAJ011046627

Internformat


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245	1	0	\|a HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo.
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520			\|a We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-primate model, and since Plasmodium knowlesi is an accepted animal model for the study of liver stages of malaria as a surrogate for P. falciparum infection, we investigated the antimalarial activity of these drugs on Plasmodium knowlesi liver stages in rhesus macaques. We demonstrate that TMP-SMX and TMP-SMX+LPV-RTV (in combination), but not LPV-RTV alone, inhibit liver stage parasite development. Because drugs that inhibit the clinically silent liver stages target parasites when they are present in lower numbers, these results may have implications for eradication efforts.
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700	0		\|a Jingyang Chen \|e verfasserin \|4 aut
700	0		\|a Kennan Marsh \|e verfasserin \|4 aut
700	0		\|a Lynn Lambert \|e verfasserin \|4 aut
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700	0		\|a William Borkowsky \|e verfasserin \|4 aut
700	0		\|a Scott R Penzak \|e verfasserin \|4 aut
700	0		\|a Sumana Chakravarty \|e verfasserin \|4 aut
700	0		\|a Stephen L Hoffman \|e verfasserin \|4 aut
700	0		\|a Patrick E Duffy \|e verfasserin \|4 aut
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912			\|a GBV_ILN_31
912			\|a GBV_ILN_34
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
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912			\|a GBV_ILN_230
912			\|a GBV_ILN_235
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
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912			\|a GBV_ILN_2021
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912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
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Indexfelder

author_variant	c v h cvh j n jn s c sc l d ld j c jc k m km l l ll s o g sog j h jh s h sh w b wb s r p srp s c sc s l h slh p e d ped
matchkey_str	article:19326203:2014----::itetetrdcmlraiesaeudnnnnuapiaeoeomlranetoacii
hierarchy_sort_str	2014
publishDate	2014
allfields	10.1371/journal.pone.0100138 doi (DE-627)DOAJ011046627 (DE-599)DOAJ353182e7d7cc4458a8f133409bc2339a DE-627 ger DE-627 rakwb eng Charlotte V Hobbs verfasserin aut HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-primate model, and since Plasmodium knowlesi is an accepted animal model for the study of liver stages of malaria as a surrogate for P. falciparum infection, we investigated the antimalarial activity of these drugs on Plasmodium knowlesi liver stages in rhesus macaques. We demonstrate that TMP-SMX and TMP-SMX+LPV-RTV (in combination), but not LPV-RTV alone, inhibit liver stage parasite development. Because drugs that inhibit the clinically silent liver stages target parasites when they are present in lower numbers, these results may have implications for eradication efforts. Medicine R Science Q Jillian Neal verfasserin aut Solomon Conteh verfasserin aut Liam Donnelly verfasserin aut Jingyang Chen verfasserin aut Kennan Marsh verfasserin aut Lynn Lambert verfasserin aut Sachy Orr-Gonzalez verfasserin aut Jessica Hinderer verfasserin aut Sara Healy verfasserin aut William Borkowsky verfasserin aut Scott R Penzak verfasserin aut Sumana Chakravarty verfasserin aut Stephen L Hoffman verfasserin aut Patrick E Duffy verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 7, p e100138 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:7, p e100138 https://doi.org/10.1371/journal.pone.0100138 kostenfrei https://doaj.org/article/353182e7d7cc4458a8f133409bc2339a kostenfrei http://europepmc.org/articles/PMC4079689?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 7, p e100138
spelling	10.1371/journal.pone.0100138 doi (DE-627)DOAJ011046627 (DE-599)DOAJ353182e7d7cc4458a8f133409bc2339a DE-627 ger DE-627 rakwb eng Charlotte V Hobbs verfasserin aut HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-primate model, and since Plasmodium knowlesi is an accepted animal model for the study of liver stages of malaria as a surrogate for P. falciparum infection, we investigated the antimalarial activity of these drugs on Plasmodium knowlesi liver stages in rhesus macaques. We demonstrate that TMP-SMX and TMP-SMX+LPV-RTV (in combination), but not LPV-RTV alone, inhibit liver stage parasite development. Because drugs that inhibit the clinically silent liver stages target parasites when they are present in lower numbers, these results may have implications for eradication efforts. Medicine R Science Q Jillian Neal verfasserin aut Solomon Conteh verfasserin aut Liam Donnelly verfasserin aut Jingyang Chen verfasserin aut Kennan Marsh verfasserin aut Lynn Lambert verfasserin aut Sachy Orr-Gonzalez verfasserin aut Jessica Hinderer verfasserin aut Sara Healy verfasserin aut William Borkowsky verfasserin aut Scott R Penzak verfasserin aut Sumana Chakravarty verfasserin aut Stephen L Hoffman verfasserin aut Patrick E Duffy verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 7, p e100138 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:7, p e100138 https://doi.org/10.1371/journal.pone.0100138 kostenfrei https://doaj.org/article/353182e7d7cc4458a8f133409bc2339a kostenfrei http://europepmc.org/articles/PMC4079689?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 7, p e100138
allfields_unstemmed	10.1371/journal.pone.0100138 doi (DE-627)DOAJ011046627 (DE-599)DOAJ353182e7d7cc4458a8f133409bc2339a DE-627 ger DE-627 rakwb eng Charlotte V Hobbs verfasserin aut HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-primate model, and since Plasmodium knowlesi is an accepted animal model for the study of liver stages of malaria as a surrogate for P. falciparum infection, we investigated the antimalarial activity of these drugs on Plasmodium knowlesi liver stages in rhesus macaques. We demonstrate that TMP-SMX and TMP-SMX+LPV-RTV (in combination), but not LPV-RTV alone, inhibit liver stage parasite development. Because drugs that inhibit the clinically silent liver stages target parasites when they are present in lower numbers, these results may have implications for eradication efforts. Medicine R Science Q Jillian Neal verfasserin aut Solomon Conteh verfasserin aut Liam Donnelly verfasserin aut Jingyang Chen verfasserin aut Kennan Marsh verfasserin aut Lynn Lambert verfasserin aut Sachy Orr-Gonzalez verfasserin aut Jessica Hinderer verfasserin aut Sara Healy verfasserin aut William Borkowsky verfasserin aut Scott R Penzak verfasserin aut Sumana Chakravarty verfasserin aut Stephen L Hoffman verfasserin aut Patrick E Duffy verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 7, p e100138 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:7, p e100138 https://doi.org/10.1371/journal.pone.0100138 kostenfrei https://doaj.org/article/353182e7d7cc4458a8f133409bc2339a kostenfrei http://europepmc.org/articles/PMC4079689?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 7, p e100138
allfieldsGer	10.1371/journal.pone.0100138 doi (DE-627)DOAJ011046627 (DE-599)DOAJ353182e7d7cc4458a8f133409bc2339a DE-627 ger DE-627 rakwb eng Charlotte V Hobbs verfasserin aut HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-primate model, and since Plasmodium knowlesi is an accepted animal model for the study of liver stages of malaria as a surrogate for P. falciparum infection, we investigated the antimalarial activity of these drugs on Plasmodium knowlesi liver stages in rhesus macaques. We demonstrate that TMP-SMX and TMP-SMX+LPV-RTV (in combination), but not LPV-RTV alone, inhibit liver stage parasite development. Because drugs that inhibit the clinically silent liver stages target parasites when they are present in lower numbers, these results may have implications for eradication efforts. Medicine R Science Q Jillian Neal verfasserin aut Solomon Conteh verfasserin aut Liam Donnelly verfasserin aut Jingyang Chen verfasserin aut Kennan Marsh verfasserin aut Lynn Lambert verfasserin aut Sachy Orr-Gonzalez verfasserin aut Jessica Hinderer verfasserin aut Sara Healy verfasserin aut William Borkowsky verfasserin aut Scott R Penzak verfasserin aut Sumana Chakravarty verfasserin aut Stephen L Hoffman verfasserin aut Patrick E Duffy verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 7, p e100138 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:7, p e100138 https://doi.org/10.1371/journal.pone.0100138 kostenfrei https://doaj.org/article/353182e7d7cc4458a8f133409bc2339a kostenfrei http://europepmc.org/articles/PMC4079689?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 7, p e100138
allfieldsSound	10.1371/journal.pone.0100138 doi (DE-627)DOAJ011046627 (DE-599)DOAJ353182e7d7cc4458a8f133409bc2339a DE-627 ger DE-627 rakwb eng Charlotte V Hobbs verfasserin aut HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-primate model, and since Plasmodium knowlesi is an accepted animal model for the study of liver stages of malaria as a surrogate for P. falciparum infection, we investigated the antimalarial activity of these drugs on Plasmodium knowlesi liver stages in rhesus macaques. We demonstrate that TMP-SMX and TMP-SMX+LPV-RTV (in combination), but not LPV-RTV alone, inhibit liver stage parasite development. Because drugs that inhibit the clinically silent liver stages target parasites when they are present in lower numbers, these results may have implications for eradication efforts. Medicine R Science Q Jillian Neal verfasserin aut Solomon Conteh verfasserin aut Liam Donnelly verfasserin aut Jingyang Chen verfasserin aut Kennan Marsh verfasserin aut Lynn Lambert verfasserin aut Sachy Orr-Gonzalez verfasserin aut Jessica Hinderer verfasserin aut Sara Healy verfasserin aut William Borkowsky verfasserin aut Scott R Penzak verfasserin aut Sumana Chakravarty verfasserin aut Stephen L Hoffman verfasserin aut Patrick E Duffy verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 7, p e100138 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:7, p e100138 https://doi.org/10.1371/journal.pone.0100138 kostenfrei https://doaj.org/article/353182e7d7cc4458a8f133409bc2339a kostenfrei http://europepmc.org/articles/PMC4079689?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 7, p e100138
language	English
source	In PLoS ONE 9(2014), 7, p e100138 volume:9 year:2014 number:7, p e100138
sourceStr	In PLoS ONE 9(2014), 7, p e100138 volume:9 year:2014 number:7, p e100138
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
isfreeaccess_bool	true
container_title	PLoS ONE
authorswithroles_txt_mv	Charlotte V Hobbs @@aut@@ Jillian Neal @@aut@@ Solomon Conteh @@aut@@ Liam Donnelly @@aut@@ Jingyang Chen @@aut@@ Kennan Marsh @@aut@@ Lynn Lambert @@aut@@ Sachy Orr-Gonzalez @@aut@@ Jessica Hinderer @@aut@@ Sara Healy @@aut@@ William Borkowsky @@aut@@ Scott R Penzak @@aut@@ Sumana Chakravarty @@aut@@ Stephen L Hoffman @@aut@@ Patrick E Duffy @@aut@@
publishDateDaySort_date	2014-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ011046627
language_de	englisch
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author	Charlotte V Hobbs
spellingShingle	Charlotte V Hobbs misc Medicine misc R misc Science misc Q HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo.
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topic_title	HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo
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title	HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo.
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title_full	HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo
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author_browse	Charlotte V Hobbs Jillian Neal Solomon Conteh Liam Donnelly Jingyang Chen Kennan Marsh Lynn Lambert Sachy Orr-Gonzalez Jessica Hinderer Sara Healy William Borkowsky Scott R Penzak Sumana Chakravarty Stephen L Hoffman Patrick E Duffy
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author-letter	Charlotte V Hobbs
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title_sort	hiv treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo
title_auth	HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo.
abstract	We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-primate model, and since Plasmodium knowlesi is an accepted animal model for the study of liver stages of malaria as a surrogate for P. falciparum infection, we investigated the antimalarial activity of these drugs on Plasmodium knowlesi liver stages in rhesus macaques. We demonstrate that TMP-SMX and TMP-SMX+LPV-RTV (in combination), but not LPV-RTV alone, inhibit liver stage parasite development. Because drugs that inhibit the clinically silent liver stages target parasites when they are present in lower numbers, these results may have implications for eradication efforts.
abstractGer	We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-primate model, and since Plasmodium knowlesi is an accepted animal model for the study of liver stages of malaria as a surrogate for P. falciparum infection, we investigated the antimalarial activity of these drugs on Plasmodium knowlesi liver stages in rhesus macaques. We demonstrate that TMP-SMX and TMP-SMX+LPV-RTV (in combination), but not LPV-RTV alone, inhibit liver stage parasite development. Because drugs that inhibit the clinically silent liver stages target parasites when they are present in lower numbers, these results may have implications for eradication efforts.
abstract_unstemmed	We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-primate model, and since Plasmodium knowlesi is an accepted animal model for the study of liver stages of malaria as a surrogate for P. falciparum infection, we investigated the antimalarial activity of these drugs on Plasmodium knowlesi liver stages in rhesus macaques. We demonstrate that TMP-SMX and TMP-SMX+LPV-RTV (in combination), but not LPV-RTV alone, inhibit liver stage parasite development. Because drugs that inhibit the clinically silent liver stages target parasites when they are present in lower numbers, these results may have implications for eradication efforts.
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title_short	HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo.
url	https://doi.org/10.1371/journal.pone.0100138 https://doaj.org/article/353182e7d7cc4458a8f133409bc2339a http://europepmc.org/articles/PMC4079689?pdf=render https://doaj.org/toc/1932-6203
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HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo.

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