Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer

The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the R...
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Autor*in:	Patricio Gonzalez-Hormazabal [verfasserIn] Maher Musleh [verfasserIn] Marco Bustamante [verfasserIn] Juan Stambuk [verfasserIn] Raul Pisano [verfasserIn] Hector Valladares [verfasserIn] Enrique Lanzarini [verfasserIn] Hector Chiong [verfasserIn] Jorge Rojas [verfasserIn] Jose Suazo [verfasserIn] V. Gonzalo Castro [verfasserIn] Lilian Jara [verfasserIn] Zoltan Berger [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study

Übergeordnetes Werk:	In: Genes - MDPI AG, 2010, 10(2018), 1, p 20
Übergeordnetes Werk:	volume:10 ; year:2018 ; number:1, p 20

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/genes10010020

Katalog-ID:	DOAJ011086661

Internformat


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520			\|a The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer.
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allfields	10.3390/genes10010020 doi (DE-627)DOAJ011086661 (DE-599)DOAJ00888238d02543089cba252037e21e63 DE-627 ger DE-627 rakwb eng QH426-470 Patricio Gonzalez-Hormazabal verfasserin aut Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study Genetics Maher Musleh verfasserin aut Marco Bustamante verfasserin aut Juan Stambuk verfasserin aut Raul Pisano verfasserin aut Hector Valladares verfasserin aut Enrique Lanzarini verfasserin aut Hector Chiong verfasserin aut Jorge Rojas verfasserin aut Jose Suazo verfasserin aut V. Gonzalo Castro verfasserin aut Lilian Jara verfasserin aut Zoltan Berger verfasserin aut In Genes MDPI AG, 2010 10(2018), 1, p 20 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:10 year:2018 number:1, p 20 https://doi.org/10.3390/genes10010020 kostenfrei https://doaj.org/article/00888238d02543089cba252037e21e63 kostenfrei http://www.mdpi.com/2073-4425/10/1/20 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 1, p 20
spelling	10.3390/genes10010020 doi (DE-627)DOAJ011086661 (DE-599)DOAJ00888238d02543089cba252037e21e63 DE-627 ger DE-627 rakwb eng QH426-470 Patricio Gonzalez-Hormazabal verfasserin aut Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study Genetics Maher Musleh verfasserin aut Marco Bustamante verfasserin aut Juan Stambuk verfasserin aut Raul Pisano verfasserin aut Hector Valladares verfasserin aut Enrique Lanzarini verfasserin aut Hector Chiong verfasserin aut Jorge Rojas verfasserin aut Jose Suazo verfasserin aut V. Gonzalo Castro verfasserin aut Lilian Jara verfasserin aut Zoltan Berger verfasserin aut In Genes MDPI AG, 2010 10(2018), 1, p 20 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:10 year:2018 number:1, p 20 https://doi.org/10.3390/genes10010020 kostenfrei https://doaj.org/article/00888238d02543089cba252037e21e63 kostenfrei http://www.mdpi.com/2073-4425/10/1/20 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 1, p 20
allfields_unstemmed	10.3390/genes10010020 doi (DE-627)DOAJ011086661 (DE-599)DOAJ00888238d02543089cba252037e21e63 DE-627 ger DE-627 rakwb eng QH426-470 Patricio Gonzalez-Hormazabal verfasserin aut Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study Genetics Maher Musleh verfasserin aut Marco Bustamante verfasserin aut Juan Stambuk verfasserin aut Raul Pisano verfasserin aut Hector Valladares verfasserin aut Enrique Lanzarini verfasserin aut Hector Chiong verfasserin aut Jorge Rojas verfasserin aut Jose Suazo verfasserin aut V. Gonzalo Castro verfasserin aut Lilian Jara verfasserin aut Zoltan Berger verfasserin aut In Genes MDPI AG, 2010 10(2018), 1, p 20 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:10 year:2018 number:1, p 20 https://doi.org/10.3390/genes10010020 kostenfrei https://doaj.org/article/00888238d02543089cba252037e21e63 kostenfrei http://www.mdpi.com/2073-4425/10/1/20 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 1, p 20
allfieldsGer	10.3390/genes10010020 doi (DE-627)DOAJ011086661 (DE-599)DOAJ00888238d02543089cba252037e21e63 DE-627 ger DE-627 rakwb eng QH426-470 Patricio Gonzalez-Hormazabal verfasserin aut Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study Genetics Maher Musleh verfasserin aut Marco Bustamante verfasserin aut Juan Stambuk verfasserin aut Raul Pisano verfasserin aut Hector Valladares verfasserin aut Enrique Lanzarini verfasserin aut Hector Chiong verfasserin aut Jorge Rojas verfasserin aut Jose Suazo verfasserin aut V. Gonzalo Castro verfasserin aut Lilian Jara verfasserin aut Zoltan Berger verfasserin aut In Genes MDPI AG, 2010 10(2018), 1, p 20 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:10 year:2018 number:1, p 20 https://doi.org/10.3390/genes10010020 kostenfrei https://doaj.org/article/00888238d02543089cba252037e21e63 kostenfrei http://www.mdpi.com/2073-4425/10/1/20 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 1, p 20
allfieldsSound	10.3390/genes10010020 doi (DE-627)DOAJ011086661 (DE-599)DOAJ00888238d02543089cba252037e21e63 DE-627 ger DE-627 rakwb eng QH426-470 Patricio Gonzalez-Hormazabal verfasserin aut Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study Genetics Maher Musleh verfasserin aut Marco Bustamante verfasserin aut Juan Stambuk verfasserin aut Raul Pisano verfasserin aut Hector Valladares verfasserin aut Enrique Lanzarini verfasserin aut Hector Chiong verfasserin aut Jorge Rojas verfasserin aut Jose Suazo verfasserin aut V. Gonzalo Castro verfasserin aut Lilian Jara verfasserin aut Zoltan Berger verfasserin aut In Genes MDPI AG, 2010 10(2018), 1, p 20 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:10 year:2018 number:1, p 20 https://doi.org/10.3390/genes10010020 kostenfrei https://doaj.org/article/00888238d02543089cba252037e21e63 kostenfrei http://www.mdpi.com/2073-4425/10/1/20 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 1, p 20
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source	In Genes 10(2018), 1, p 20 volume:10 year:2018 number:1, p 20
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topic_facet	gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study Genetics
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authorswithroles_txt_mv	Patricio Gonzalez-Hormazabal @@aut@@ Maher Musleh @@aut@@ Marco Bustamante @@aut@@ Juan Stambuk @@aut@@ Raul Pisano @@aut@@ Hector Valladares @@aut@@ Enrique Lanzarini @@aut@@ Hector Chiong @@aut@@ Jorge Rojas @@aut@@ Jose Suazo @@aut@@ V. Gonzalo Castro @@aut@@ Lilian Jara @@aut@@ Zoltan Berger @@aut@@
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callnumber-first	Q - Science
author	Patricio Gonzalez-Hormazabal
spellingShingle	Patricio Gonzalez-Hormazabal misc QH426-470 misc gastric cancer misc polymorphism misc RAS/RAF/MEK/ERK pathway misc MAPK pathway misc association study misc Genetics Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer
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topic_title	QH426-470 Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study
topic	misc QH426-470 misc gastric cancer misc polymorphism misc RAS/RAF/MEK/ERK pathway misc MAPK pathway misc association study misc Genetics
topic_unstemmed	misc QH426-470 misc gastric cancer misc polymorphism misc RAS/RAF/MEK/ERK pathway misc MAPK pathway misc association study misc Genetics
topic_browse	misc QH426-470 misc gastric cancer misc polymorphism misc RAS/RAF/MEK/ERK pathway misc MAPK pathway misc association study misc Genetics
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title	Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer
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title_full	Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer
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author_browse	Patricio Gonzalez-Hormazabal Maher Musleh Marco Bustamante Juan Stambuk Raul Pisano Hector Valladares Enrique Lanzarini Hector Chiong Jorge Rojas Jose Suazo V. Gonzalo Castro Lilian Jara Zoltan Berger
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title_sort	polymorphisms in ras/raf/mek/erk pathway are associated with gastric cancer
callnumber	QH426-470
title_auth	Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer
abstract	The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer.
abstractGer	The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer.
abstract_unstemmed	The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer.
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title_short	Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer
url	https://doi.org/10.3390/genes10010020 https://doaj.org/article/00888238d02543089cba252037e21e63 http://www.mdpi.com/2073-4425/10/1/20 https://doaj.org/toc/2073-4425
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up_date	2024-07-03T18:25:11.093Z
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Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20&ndash;1.98, p-value = 7.95 &times; 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16&ndash;2.22, p-value = 4.68 &times; 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12&ndash;1.87, p-value = 4.91 &times; 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42&ndash;0.87, p-value = 6.64 &times; 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. 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Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer

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