Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer
The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the R...
Ausführliche Beschreibung
Autor*in: |
Patricio Gonzalez-Hormazabal [verfasserIn] Maher Musleh [verfasserIn] Marco Bustamante [verfasserIn] Juan Stambuk [verfasserIn] Raul Pisano [verfasserIn] Hector Valladares [verfasserIn] Enrique Lanzarini [verfasserIn] Hector Chiong [verfasserIn] Jorge Rojas [verfasserIn] Jose Suazo [verfasserIn] V. Gonzalo Castro [verfasserIn] Lilian Jara [verfasserIn] Zoltan Berger [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2018 |
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Übergeordnetes Werk: |
In: Genes - MDPI AG, 2010, 10(2018), 1, p 20 |
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Übergeordnetes Werk: |
volume:10 ; year:2018 ; number:1, p 20 |
Links: |
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DOI / URN: |
10.3390/genes10010020 |
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Katalog-ID: |
DOAJ011086661 |
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520 | |a The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. | ||
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10.3390/genes10010020 doi (DE-627)DOAJ011086661 (DE-599)DOAJ00888238d02543089cba252037e21e63 DE-627 ger DE-627 rakwb eng QH426-470 Patricio Gonzalez-Hormazabal verfasserin aut Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study Genetics Maher Musleh verfasserin aut Marco Bustamante verfasserin aut Juan Stambuk verfasserin aut Raul Pisano verfasserin aut Hector Valladares verfasserin aut Enrique Lanzarini verfasserin aut Hector Chiong verfasserin aut Jorge Rojas verfasserin aut Jose Suazo verfasserin aut V. Gonzalo Castro verfasserin aut Lilian Jara verfasserin aut Zoltan Berger verfasserin aut In Genes MDPI AG, 2010 10(2018), 1, p 20 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:10 year:2018 number:1, p 20 https://doi.org/10.3390/genes10010020 kostenfrei https://doaj.org/article/00888238d02543089cba252037e21e63 kostenfrei http://www.mdpi.com/2073-4425/10/1/20 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 1, p 20 |
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10.3390/genes10010020 doi (DE-627)DOAJ011086661 (DE-599)DOAJ00888238d02543089cba252037e21e63 DE-627 ger DE-627 rakwb eng QH426-470 Patricio Gonzalez-Hormazabal verfasserin aut Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study Genetics Maher Musleh verfasserin aut Marco Bustamante verfasserin aut Juan Stambuk verfasserin aut Raul Pisano verfasserin aut Hector Valladares verfasserin aut Enrique Lanzarini verfasserin aut Hector Chiong verfasserin aut Jorge Rojas verfasserin aut Jose Suazo verfasserin aut V. Gonzalo Castro verfasserin aut Lilian Jara verfasserin aut Zoltan Berger verfasserin aut In Genes MDPI AG, 2010 10(2018), 1, p 20 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:10 year:2018 number:1, p 20 https://doi.org/10.3390/genes10010020 kostenfrei https://doaj.org/article/00888238d02543089cba252037e21e63 kostenfrei http://www.mdpi.com/2073-4425/10/1/20 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 1, p 20 |
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10.3390/genes10010020 doi (DE-627)DOAJ011086661 (DE-599)DOAJ00888238d02543089cba252037e21e63 DE-627 ger DE-627 rakwb eng QH426-470 Patricio Gonzalez-Hormazabal verfasserin aut Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study Genetics Maher Musleh verfasserin aut Marco Bustamante verfasserin aut Juan Stambuk verfasserin aut Raul Pisano verfasserin aut Hector Valladares verfasserin aut Enrique Lanzarini verfasserin aut Hector Chiong verfasserin aut Jorge Rojas verfasserin aut Jose Suazo verfasserin aut V. Gonzalo Castro verfasserin aut Lilian Jara verfasserin aut Zoltan Berger verfasserin aut In Genes MDPI AG, 2010 10(2018), 1, p 20 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:10 year:2018 number:1, p 20 https://doi.org/10.3390/genes10010020 kostenfrei https://doaj.org/article/00888238d02543089cba252037e21e63 kostenfrei http://www.mdpi.com/2073-4425/10/1/20 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 1, p 20 |
allfieldsGer |
10.3390/genes10010020 doi (DE-627)DOAJ011086661 (DE-599)DOAJ00888238d02543089cba252037e21e63 DE-627 ger DE-627 rakwb eng QH426-470 Patricio Gonzalez-Hormazabal verfasserin aut Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study Genetics Maher Musleh verfasserin aut Marco Bustamante verfasserin aut Juan Stambuk verfasserin aut Raul Pisano verfasserin aut Hector Valladares verfasserin aut Enrique Lanzarini verfasserin aut Hector Chiong verfasserin aut Jorge Rojas verfasserin aut Jose Suazo verfasserin aut V. Gonzalo Castro verfasserin aut Lilian Jara verfasserin aut Zoltan Berger verfasserin aut In Genes MDPI AG, 2010 10(2018), 1, p 20 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:10 year:2018 number:1, p 20 https://doi.org/10.3390/genes10010020 kostenfrei https://doaj.org/article/00888238d02543089cba252037e21e63 kostenfrei http://www.mdpi.com/2073-4425/10/1/20 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 1, p 20 |
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10.3390/genes10010020 doi (DE-627)DOAJ011086661 (DE-599)DOAJ00888238d02543089cba252037e21e63 DE-627 ger DE-627 rakwb eng QH426-470 Patricio Gonzalez-Hormazabal verfasserin aut Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study Genetics Maher Musleh verfasserin aut Marco Bustamante verfasserin aut Juan Stambuk verfasserin aut Raul Pisano verfasserin aut Hector Valladares verfasserin aut Enrique Lanzarini verfasserin aut Hector Chiong verfasserin aut Jorge Rojas verfasserin aut Jose Suazo verfasserin aut V. Gonzalo Castro verfasserin aut Lilian Jara verfasserin aut Zoltan Berger verfasserin aut In Genes MDPI AG, 2010 10(2018), 1, p 20 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:10 year:2018 number:1, p 20 https://doi.org/10.3390/genes10010020 kostenfrei https://doaj.org/article/00888238d02543089cba252037e21e63 kostenfrei http://www.mdpi.com/2073-4425/10/1/20 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 1, p 20 |
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QH426-470 Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer gastric cancer polymorphism RAS/RAF/MEK/ERK pathway MAPK pathway association study |
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Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer |
abstract |
The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. |
abstractGer |
The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. |
abstract_unstemmed |
The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20–1.98, p-value = 7.95 × 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16–2.22, p-value = 4.68 × 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12–1.87, p-value = 4.91 × 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42–0.87, p-value = 6.64 × 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. In conclusion, this study suggests that RAF1 rs3729931, HRAS rs45604736, MAPK1 rs2283792, and MAPK1 rs9610417 are associated with gastric cancer. |
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Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer |
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Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorphisms (SNPs) in the RAS/RAF/MEK/ERK pathway genes with gastric cancer. Analyses performed under the additive model (allele) showed four significantly associated SNPs: RAF1 rs3729931 (Odds ratio (OR) = 1.54, 95%, confidence interval (CI): 1.20&ndash;1.98, p-value = 7.95 &times; 10-4), HRAS rs45604736 (OR = 1.60, 95% CI: 1.16&ndash;2.22, p-value = 4.68 &times; 10-3), MAPK1 rs2283792 (OR = 1.45, 95% CI: 1.12&ndash;1.87, p-value = 4.91 &times; 10-3), and MAPK1 rs9610417 (OR = 0.60, 95% CI: 0.42&ndash;0.87, p-value = 6.64 &times; 10-3). Functional annotation suggested that those variants or their proxy variants may have a functional effect. 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