Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis.

The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sara F Jastrebski [verfasserIn] Susan J Lamont [verfasserIn] Carl J Schmidt [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 12(2017), 7, p e0181900
Übergeordnetes Werk:	volume:12 ; year:2017 ; number:7, p e0181900

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0181900

Katalog-ID:	DOAJ011241578

Internformat


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allfieldsSound	10.1371/journal.pone.0181900 doi (DE-627)DOAJ011241578 (DE-599)DOAJ29ddab0d83c44cc8b01e2db3d1260890 DE-627 ger DE-627 rakwb eng Sara F Jastrebski verfasserin aut Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis. 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation. Medicine R Science Q Susan J Lamont verfasserin aut Carl J Schmidt verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 12(2017), 7, p e0181900 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:12 year:2017 number:7, p e0181900 https://doi.org/10.1371/journal.pone.0181900 kostenfrei https://doaj.org/article/29ddab0d83c44cc8b01e2db3d1260890 kostenfrei http://europepmc.org/articles/PMC5536301?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2017 7, p e0181900
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author	Sara F Jastrebski
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title	Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis.
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title_full	Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis
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title_sort	chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis
title_auth	Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis.
abstract	The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation.
abstractGer	The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation.
abstract_unstemmed	The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation.
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container_issue	7, p e0181900
title_short	Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis.
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up_date	2024-07-03T19:16:06.884Z
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Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis.

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