Reads Binning Improves Alignment-Free Metagenome Comparison
Comparing metagenomic samples is a critical step in understanding the relationships among microbial communities. Recently, next-generation sequencing (NGS) technologies have produced a massive amount of short reads data for microbial communities from different environments. The assembly of these sho...
Ausführliche Beschreibung
Autor*in: |
Kai Song [verfasserIn] Jie Ren [verfasserIn] Fengzhu Sun [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Übergeordnetes Werk: |
In: Frontiers in Genetics - Frontiers Media S.A., 2011, 10(2019) |
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Übergeordnetes Werk: |
volume:10 ; year:2019 |
Links: |
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DOI / URN: |
10.3389/fgene.2019.01156 |
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Katalog-ID: |
DOAJ011357452 |
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10.3389/fgene.2019.01156 doi (DE-627)DOAJ011357452 (DE-599)DOAJ4592f2fbe92a44abb6a98200f9cc602e DE-627 ger DE-627 rakwb eng QH426-470 Kai Song verfasserin aut Reads Binning Improves Alignment-Free Metagenome Comparison 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Comparing metagenomic samples is a critical step in understanding the relationships among microbial communities. Recently, next-generation sequencing (NGS) technologies have produced a massive amount of short reads data for microbial communities from different environments. The assembly of these short reads can, however, be time-consuming and challenging. In addition, alignment-based methods for metagenome comparison are limited by incomplete genome and/or pathway databases. In contrast, alignment-free methods for metagenome comparison do not depend on the completeness of genome or pathway databases. Still, the existing alignment-free methods, d2S and d2*, which model k-tuple patterns using only one Markov chain for each sample, neglect the heterogeneity within metagenomic data wherein potentially thousands of types of microorganisms are sequenced. To address this imperfection in d2S and d2*, we organized NGS sequences into different reads bins and constructed several corresponding Markov models. Next, we modified the definition of our previous alignment-free methods, d2S and d2*, to make them more compatible with a scheme of analysis which uses the proposed reads bins. We then used two simulated and three real metagenomic datasets to test the effect of the k-tuple size and Markov orders of background sequences on the performance of these de novo alignment-free methods. For dependable comparison of metagenomic samples, our newly developed alignment-free methods with reads binning outperformed alignment-free methods without reads binning in detecting the relationship among microbial communities, including whether they form groups or change according to some environmental gradients. alignment-free methods metagenomic samples Markov model reads binning beta-diversity Genetics Jie Ren verfasserin aut Fengzhu Sun verfasserin aut In Frontiers in Genetics Frontiers Media S.A., 2011 10(2019) (DE-627)65799829X (DE-600)2606823-0 16648021 nnns volume:10 year:2019 https://doi.org/10.3389/fgene.2019.01156 kostenfrei https://doaj.org/article/4592f2fbe92a44abb6a98200f9cc602e kostenfrei https://www.frontiersin.org/article/10.3389/fgene.2019.01156/full kostenfrei https://doaj.org/toc/1664-8021 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019 |
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Comparing metagenomic samples is a critical step in understanding the relationships among microbial communities. Recently, next-generation sequencing (NGS) technologies have produced a massive amount of short reads data for microbial communities from different environments. The assembly of these short reads can, however, be time-consuming and challenging. In addition, alignment-based methods for metagenome comparison are limited by incomplete genome and/or pathway databases. In contrast, alignment-free methods for metagenome comparison do not depend on the completeness of genome or pathway databases. Still, the existing alignment-free methods, d2S and d2*, which model k-tuple patterns using only one Markov chain for each sample, neglect the heterogeneity within metagenomic data wherein potentially thousands of types of microorganisms are sequenced. To address this imperfection in d2S and d2*, we organized NGS sequences into different reads bins and constructed several corresponding Markov models. Next, we modified the definition of our previous alignment-free methods, d2S and d2*, to make them more compatible with a scheme of analysis which uses the proposed reads bins. We then used two simulated and three real metagenomic datasets to test the effect of the k-tuple size and Markov orders of background sequences on the performance of these de novo alignment-free methods. For dependable comparison of metagenomic samples, our newly developed alignment-free methods with reads binning outperformed alignment-free methods without reads binning in detecting the relationship among microbial communities, including whether they form groups or change according to some environmental gradients. |
abstractGer |
Comparing metagenomic samples is a critical step in understanding the relationships among microbial communities. Recently, next-generation sequencing (NGS) technologies have produced a massive amount of short reads data for microbial communities from different environments. The assembly of these short reads can, however, be time-consuming and challenging. In addition, alignment-based methods for metagenome comparison are limited by incomplete genome and/or pathway databases. In contrast, alignment-free methods for metagenome comparison do not depend on the completeness of genome or pathway databases. Still, the existing alignment-free methods, d2S and d2*, which model k-tuple patterns using only one Markov chain for each sample, neglect the heterogeneity within metagenomic data wherein potentially thousands of types of microorganisms are sequenced. To address this imperfection in d2S and d2*, we organized NGS sequences into different reads bins and constructed several corresponding Markov models. Next, we modified the definition of our previous alignment-free methods, d2S and d2*, to make them more compatible with a scheme of analysis which uses the proposed reads bins. We then used two simulated and three real metagenomic datasets to test the effect of the k-tuple size and Markov orders of background sequences on the performance of these de novo alignment-free methods. For dependable comparison of metagenomic samples, our newly developed alignment-free methods with reads binning outperformed alignment-free methods without reads binning in detecting the relationship among microbial communities, including whether they form groups or change according to some environmental gradients. |
abstract_unstemmed |
Comparing metagenomic samples is a critical step in understanding the relationships among microbial communities. Recently, next-generation sequencing (NGS) technologies have produced a massive amount of short reads data for microbial communities from different environments. The assembly of these short reads can, however, be time-consuming and challenging. In addition, alignment-based methods for metagenome comparison are limited by incomplete genome and/or pathway databases. In contrast, alignment-free methods for metagenome comparison do not depend on the completeness of genome or pathway databases. Still, the existing alignment-free methods, d2S and d2*, which model k-tuple patterns using only one Markov chain for each sample, neglect the heterogeneity within metagenomic data wherein potentially thousands of types of microorganisms are sequenced. To address this imperfection in d2S and d2*, we organized NGS sequences into different reads bins and constructed several corresponding Markov models. Next, we modified the definition of our previous alignment-free methods, d2S and d2*, to make them more compatible with a scheme of analysis which uses the proposed reads bins. We then used two simulated and three real metagenomic datasets to test the effect of the k-tuple size and Markov orders of background sequences on the performance of these de novo alignment-free methods. For dependable comparison of metagenomic samples, our newly developed alignment-free methods with reads binning outperformed alignment-free methods without reads binning in detecting the relationship among microbial communities, including whether they form groups or change according to some environmental gradients. |
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