Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies

The human E74-like ETS transcription factor 3 (Elf-3) is an epithelium-specific member of the ETS family, all members of which are characterized by a highly conserved DNA-binding domain. Elf-3 plays a crucial role in epithelial cell differentiation by participating in morphogenesis and terminal diff...
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Autor*in:	Michaela A. Boti [verfasserIn] Panagiotis G. Adamopoulos [verfasserIn] Panagiotis Tsiakanikas [verfasserIn] Andreas Scorilas [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	alternative splicing nanopore sequencing transcription factor long-read sequencing transcriptome ETS transcription factor 3 (Elf-3)

Übergeordnetes Werk:	In: Genes - MDPI AG, 2010, 12(2021), 6, p 839
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:6, p 839

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/genes12060839

Katalog-ID:	DOAJ011482125

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allfieldsSound	10.3390/genes12060839 doi (DE-627)DOAJ011482125 (DE-599)DOAJ93e5b14371574cebb33f0617a751f3cd DE-627 ger DE-627 rakwb eng QH426-470 Michaela A. Boti verfasserin aut Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The human E74-like ETS transcription factor 3 (Elf-3) is an epithelium-specific member of the ETS family, all members of which are characterized by a highly conserved DNA-binding domain. Elf-3 plays a crucial role in epithelial cell differentiation by participating in morphogenesis and terminal differentiation of the murine small intestinal epithelium, and also acts as an indispensable regulator of mesenchymal to epithelial transition, underlying its significant involvement in development and in pathological states, such as cancer. Although previous research works have deciphered the functional role of Elf-3 in normal physiology as well as in tumorigenesis, the present study highlights for the first time the wide spectrum of <i<ELF3</i< mRNAs that are transcribed, providing an in-depth analysis of splicing events and exon/intron boundaries in a broad panel of human cell lines. The implementation of a versatile targeted nanopore sequencing approach led to the identification of 25 novel <i<ELF3</i< mRNA transcript variants (<i<ELF3</i< v.3–v.27) with new alternative splicing events, as well as two novel exons. Although the current study provides a qualitative transcriptional profile regarding <i<ELF3</i<, further studies must be conducted, so the biological function of all novel alternative transcript variants as well as the putative protein isoforms are elucidated. alternative splicing nanopore sequencing transcription factor long-read sequencing transcriptome ETS transcription factor 3 (Elf-3) Genetics Panagiotis G. Adamopoulos verfasserin aut Panagiotis Tsiakanikas verfasserin aut Andreas Scorilas verfasserin aut In Genes MDPI AG, 2010 12(2021), 6, p 839 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:12 year:2021 number:6, p 839 https://doi.org/10.3390/genes12060839 kostenfrei https://doaj.org/article/93e5b14371574cebb33f0617a751f3cd kostenfrei https://www.mdpi.com/2073-4425/12/6/839 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 6, p 839
language	English
source	In Genes 12(2021), 6, p 839 volume:12 year:2021 number:6, p 839
sourceStr	In Genes 12(2021), 6, p 839 volume:12 year:2021 number:6, p 839
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	alternative splicing nanopore sequencing transcription factor long-read sequencing transcriptome ETS transcription factor 3 (Elf-3) Genetics
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container_title	Genes
authorswithroles_txt_mv	Michaela A. Boti @@aut@@ Panagiotis G. Adamopoulos @@aut@@ Panagiotis Tsiakanikas @@aut@@ Andreas Scorilas @@aut@@
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callnumber-first	Q - Science
author	Michaela A. Boti
spellingShingle	Michaela A. Boti misc QH426-470 misc alternative splicing misc nanopore sequencing misc transcription factor misc long-read sequencing misc transcriptome misc ETS transcription factor 3 (Elf-3) misc Genetics Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies
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topic_title	QH426-470 Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies alternative splicing nanopore sequencing transcription factor long-read sequencing transcriptome ETS transcription factor 3 (Elf-3)
topic	misc QH426-470 misc alternative splicing misc nanopore sequencing misc transcription factor misc long-read sequencing misc transcriptome misc ETS transcription factor 3 (Elf-3) misc Genetics
topic_unstemmed	misc QH426-470 misc alternative splicing misc nanopore sequencing misc transcription factor misc long-read sequencing misc transcriptome misc ETS transcription factor 3 (Elf-3) misc Genetics
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title	Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies
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title_full	Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies
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title_sort	nanopore sequencing unveils diverse transcript variants of the epithelial cell-specific transcription factor elf-3 in human malignancies
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title_auth	Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies
abstract	The human E74-like ETS transcription factor 3 (Elf-3) is an epithelium-specific member of the ETS family, all members of which are characterized by a highly conserved DNA-binding domain. Elf-3 plays a crucial role in epithelial cell differentiation by participating in morphogenesis and terminal differentiation of the murine small intestinal epithelium, and also acts as an indispensable regulator of mesenchymal to epithelial transition, underlying its significant involvement in development and in pathological states, such as cancer. Although previous research works have deciphered the functional role of Elf-3 in normal physiology as well as in tumorigenesis, the present study highlights for the first time the wide spectrum of <i<ELF3</i< mRNAs that are transcribed, providing an in-depth analysis of splicing events and exon/intron boundaries in a broad panel of human cell lines. The implementation of a versatile targeted nanopore sequencing approach led to the identification of 25 novel <i<ELF3</i< mRNA transcript variants (<i<ELF3</i< v.3–v.27) with new alternative splicing events, as well as two novel exons. Although the current study provides a qualitative transcriptional profile regarding <i<ELF3</i<, further studies must be conducted, so the biological function of all novel alternative transcript variants as well as the putative protein isoforms are elucidated.
abstractGer	The human E74-like ETS transcription factor 3 (Elf-3) is an epithelium-specific member of the ETS family, all members of which are characterized by a highly conserved DNA-binding domain. Elf-3 plays a crucial role in epithelial cell differentiation by participating in morphogenesis and terminal differentiation of the murine small intestinal epithelium, and also acts as an indispensable regulator of mesenchymal to epithelial transition, underlying its significant involvement in development and in pathological states, such as cancer. Although previous research works have deciphered the functional role of Elf-3 in normal physiology as well as in tumorigenesis, the present study highlights for the first time the wide spectrum of <i<ELF3</i< mRNAs that are transcribed, providing an in-depth analysis of splicing events and exon/intron boundaries in a broad panel of human cell lines. The implementation of a versatile targeted nanopore sequencing approach led to the identification of 25 novel <i<ELF3</i< mRNA transcript variants (<i<ELF3</i< v.3–v.27) with new alternative splicing events, as well as two novel exons. Although the current study provides a qualitative transcriptional profile regarding <i<ELF3</i<, further studies must be conducted, so the biological function of all novel alternative transcript variants as well as the putative protein isoforms are elucidated.
abstract_unstemmed	The human E74-like ETS transcription factor 3 (Elf-3) is an epithelium-specific member of the ETS family, all members of which are characterized by a highly conserved DNA-binding domain. Elf-3 plays a crucial role in epithelial cell differentiation by participating in morphogenesis and terminal differentiation of the murine small intestinal epithelium, and also acts as an indispensable regulator of mesenchymal to epithelial transition, underlying its significant involvement in development and in pathological states, such as cancer. Although previous research works have deciphered the functional role of Elf-3 in normal physiology as well as in tumorigenesis, the present study highlights for the first time the wide spectrum of <i<ELF3</i< mRNAs that are transcribed, providing an in-depth analysis of splicing events and exon/intron boundaries in a broad panel of human cell lines. The implementation of a versatile targeted nanopore sequencing approach led to the identification of 25 novel <i<ELF3</i< mRNA transcript variants (<i<ELF3</i< v.3–v.27) with new alternative splicing events, as well as two novel exons. Although the current study provides a qualitative transcriptional profile regarding <i<ELF3</i<, further studies must be conducted, so the biological function of all novel alternative transcript variants as well as the putative protein isoforms are elucidated.
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title_short	Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies
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Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies

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