Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol

Objective: the objective of the present work is to study the effectiveness of treatment with silk fibroin nanoparticles loaded with resveratrol in experimental periodontitis in a diabetic rat model. Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as ty...
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Autor*in:	Ana Giménez-Siurana [verfasserIn] Francisco Gómez García [verfasserIn] Ana Pagan Bernabeu [verfasserIn] Antonio Abel Lozano-Pérez [verfasserIn] Salvador D. Aznar-Cervantes [verfasserIn] José Luis Cenis [verfasserIn] Pía López-Jornet [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	resveratrol periodontitis silk fibroin nanoparticles inflammation il-6 il-1β tgf-1β diabetes

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 9(2020), 1, p 85
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:1, p 85

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox9010085

Katalog-ID:	DOAJ011563338

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520			\|a Objective: the objective of the present work is to study the effectiveness of treatment with silk fibroin nanoparticles loaded with resveratrol in experimental periodontitis in a diabetic rat model. Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as type II diabetes. Both diseases have a specific inflammatory condition, with Interleukin (IL)-6, IL-1β and Transforming Grow Factor (TGF)-1β being the most relevant proinflammatory factors. Silk fibroin (SF) nanoparticles loaded with resveratrol (Res-SFN) are a new alternative as a treatment. Methods: 40 diabetic Sprague Dawley male rats were used and periodontitis was induced by ligation. The animals were divided into 5 treatment groups, and 1 mL of treatment was administered once a day for 4 weeks. The groups were: I: Carboxymethyl cellulose (CMC) 0.8%, II: CMC 0.8% + SF 1%, III: CMC 0.8% + RES-SFN 3 mg/mL, IV: CMC 0.8% + SF 1% + RES-SFN 3 mg/mL, V: Water. A peripheral blood sample was taken every week to quantify the inflammatory profile by ELISA (IL-6, IL-1β and TGF-1β). After 4 weeks the sacrifice was carried out and biopsies of the gum were taken. Results: Treatment with SF and RES-SFN reduced the amount of chemical inflammation mediators (with the exception of IL-1β in comparisons I-IV and II-IV (<i<p</i< > 0.05)), as well as the anatomopathological variables linked to it, in a significant way (<i<p</i< < 0.05). Conclusion: treatment with RES-SFN has reduced local inflammation in this experimental periodontitis model.
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allfields	10.3390/antiox9010085 doi (DE-627)DOAJ011563338 (DE-599)DOAJa66a09a24c3c442291601880527fca5e DE-627 ger DE-627 rakwb eng RM1-950 Ana Giménez-Siurana verfasserin aut Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: the objective of the present work is to study the effectiveness of treatment with silk fibroin nanoparticles loaded with resveratrol in experimental periodontitis in a diabetic rat model. Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as type II diabetes. Both diseases have a specific inflammatory condition, with Interleukin (IL)-6, IL-1β and Transforming Grow Factor (TGF)-1β being the most relevant proinflammatory factors. Silk fibroin (SF) nanoparticles loaded with resveratrol (Res-SFN) are a new alternative as a treatment. Methods: 40 diabetic Sprague Dawley male rats were used and periodontitis was induced by ligation. The animals were divided into 5 treatment groups, and 1 mL of treatment was administered once a day for 4 weeks. The groups were: I: Carboxymethyl cellulose (CMC) 0.8%, II: CMC 0.8% + SF 1%, III: CMC 0.8% + RES-SFN 3 mg/mL, IV: CMC 0.8% + SF 1% + RES-SFN 3 mg/mL, V: Water. A peripheral blood sample was taken every week to quantify the inflammatory profile by ELISA (IL-6, IL-1β and TGF-1β). After 4 weeks the sacrifice was carried out and biopsies of the gum were taken. Results: Treatment with SF and RES-SFN reduced the amount of chemical inflammation mediators (with the exception of IL-1β in comparisons I-IV and II-IV (<i<p</i< > 0.05)), as well as the anatomopathological variables linked to it, in a significant way (<i<p</i< < 0.05). Conclusion: treatment with RES-SFN has reduced local inflammation in this experimental periodontitis model. resveratrol periodontitis silk fibroin nanoparticles inflammation il-6 il-1β tgf-1β diabetes Therapeutics. Pharmacology Francisco Gómez García verfasserin aut Ana Pagan Bernabeu verfasserin aut Antonio Abel Lozano-Pérez verfasserin aut Salvador D. Aznar-Cervantes verfasserin aut José Luis Cenis verfasserin aut Pía López-Jornet verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 1, p 85 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:1, p 85 https://doi.org/10.3390/antiox9010085 kostenfrei https://doaj.org/article/a66a09a24c3c442291601880527fca5e kostenfrei https://www.mdpi.com/2076-3921/9/1/85 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1, p 85
spelling	10.3390/antiox9010085 doi (DE-627)DOAJ011563338 (DE-599)DOAJa66a09a24c3c442291601880527fca5e DE-627 ger DE-627 rakwb eng RM1-950 Ana Giménez-Siurana verfasserin aut Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: the objective of the present work is to study the effectiveness of treatment with silk fibroin nanoparticles loaded with resveratrol in experimental periodontitis in a diabetic rat model. Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as type II diabetes. Both diseases have a specific inflammatory condition, with Interleukin (IL)-6, IL-1β and Transforming Grow Factor (TGF)-1β being the most relevant proinflammatory factors. Silk fibroin (SF) nanoparticles loaded with resveratrol (Res-SFN) are a new alternative as a treatment. Methods: 40 diabetic Sprague Dawley male rats were used and periodontitis was induced by ligation. The animals were divided into 5 treatment groups, and 1 mL of treatment was administered once a day for 4 weeks. The groups were: I: Carboxymethyl cellulose (CMC) 0.8%, II: CMC 0.8% + SF 1%, III: CMC 0.8% + RES-SFN 3 mg/mL, IV: CMC 0.8% + SF 1% + RES-SFN 3 mg/mL, V: Water. A peripheral blood sample was taken every week to quantify the inflammatory profile by ELISA (IL-6, IL-1β and TGF-1β). After 4 weeks the sacrifice was carried out and biopsies of the gum were taken. Results: Treatment with SF and RES-SFN reduced the amount of chemical inflammation mediators (with the exception of IL-1β in comparisons I-IV and II-IV (<i<p</i< > 0.05)), as well as the anatomopathological variables linked to it, in a significant way (<i<p</i< < 0.05). Conclusion: treatment with RES-SFN has reduced local inflammation in this experimental periodontitis model. resveratrol periodontitis silk fibroin nanoparticles inflammation il-6 il-1β tgf-1β diabetes Therapeutics. Pharmacology Francisco Gómez García verfasserin aut Ana Pagan Bernabeu verfasserin aut Antonio Abel Lozano-Pérez verfasserin aut Salvador D. Aznar-Cervantes verfasserin aut José Luis Cenis verfasserin aut Pía López-Jornet verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 1, p 85 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:1, p 85 https://doi.org/10.3390/antiox9010085 kostenfrei https://doaj.org/article/a66a09a24c3c442291601880527fca5e kostenfrei https://www.mdpi.com/2076-3921/9/1/85 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1, p 85
allfields_unstemmed	10.3390/antiox9010085 doi (DE-627)DOAJ011563338 (DE-599)DOAJa66a09a24c3c442291601880527fca5e DE-627 ger DE-627 rakwb eng RM1-950 Ana Giménez-Siurana verfasserin aut Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: the objective of the present work is to study the effectiveness of treatment with silk fibroin nanoparticles loaded with resveratrol in experimental periodontitis in a diabetic rat model. Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as type II diabetes. Both diseases have a specific inflammatory condition, with Interleukin (IL)-6, IL-1β and Transforming Grow Factor (TGF)-1β being the most relevant proinflammatory factors. Silk fibroin (SF) nanoparticles loaded with resveratrol (Res-SFN) are a new alternative as a treatment. Methods: 40 diabetic Sprague Dawley male rats were used and periodontitis was induced by ligation. The animals were divided into 5 treatment groups, and 1 mL of treatment was administered once a day for 4 weeks. The groups were: I: Carboxymethyl cellulose (CMC) 0.8%, II: CMC 0.8% + SF 1%, III: CMC 0.8% + RES-SFN 3 mg/mL, IV: CMC 0.8% + SF 1% + RES-SFN 3 mg/mL, V: Water. A peripheral blood sample was taken every week to quantify the inflammatory profile by ELISA (IL-6, IL-1β and TGF-1β). After 4 weeks the sacrifice was carried out and biopsies of the gum were taken. Results: Treatment with SF and RES-SFN reduced the amount of chemical inflammation mediators (with the exception of IL-1β in comparisons I-IV and II-IV (<i<p</i< > 0.05)), as well as the anatomopathological variables linked to it, in a significant way (<i<p</i< < 0.05). Conclusion: treatment with RES-SFN has reduced local inflammation in this experimental periodontitis model. resveratrol periodontitis silk fibroin nanoparticles inflammation il-6 il-1β tgf-1β diabetes Therapeutics. Pharmacology Francisco Gómez García verfasserin aut Ana Pagan Bernabeu verfasserin aut Antonio Abel Lozano-Pérez verfasserin aut Salvador D. Aznar-Cervantes verfasserin aut José Luis Cenis verfasserin aut Pía López-Jornet verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 1, p 85 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:1, p 85 https://doi.org/10.3390/antiox9010085 kostenfrei https://doaj.org/article/a66a09a24c3c442291601880527fca5e kostenfrei https://www.mdpi.com/2076-3921/9/1/85 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1, p 85
allfieldsGer	10.3390/antiox9010085 doi (DE-627)DOAJ011563338 (DE-599)DOAJa66a09a24c3c442291601880527fca5e DE-627 ger DE-627 rakwb eng RM1-950 Ana Giménez-Siurana verfasserin aut Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: the objective of the present work is to study the effectiveness of treatment with silk fibroin nanoparticles loaded with resveratrol in experimental periodontitis in a diabetic rat model. Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as type II diabetes. Both diseases have a specific inflammatory condition, with Interleukin (IL)-6, IL-1β and Transforming Grow Factor (TGF)-1β being the most relevant proinflammatory factors. Silk fibroin (SF) nanoparticles loaded with resveratrol (Res-SFN) are a new alternative as a treatment. Methods: 40 diabetic Sprague Dawley male rats were used and periodontitis was induced by ligation. The animals were divided into 5 treatment groups, and 1 mL of treatment was administered once a day for 4 weeks. The groups were: I: Carboxymethyl cellulose (CMC) 0.8%, II: CMC 0.8% + SF 1%, III: CMC 0.8% + RES-SFN 3 mg/mL, IV: CMC 0.8% + SF 1% + RES-SFN 3 mg/mL, V: Water. A peripheral blood sample was taken every week to quantify the inflammatory profile by ELISA (IL-6, IL-1β and TGF-1β). After 4 weeks the sacrifice was carried out and biopsies of the gum were taken. Results: Treatment with SF and RES-SFN reduced the amount of chemical inflammation mediators (with the exception of IL-1β in comparisons I-IV and II-IV (<i<p</i< > 0.05)), as well as the anatomopathological variables linked to it, in a significant way (<i<p</i< < 0.05). Conclusion: treatment with RES-SFN has reduced local inflammation in this experimental periodontitis model. resveratrol periodontitis silk fibroin nanoparticles inflammation il-6 il-1β tgf-1β diabetes Therapeutics. Pharmacology Francisco Gómez García verfasserin aut Ana Pagan Bernabeu verfasserin aut Antonio Abel Lozano-Pérez verfasserin aut Salvador D. Aznar-Cervantes verfasserin aut José Luis Cenis verfasserin aut Pía López-Jornet verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 1, p 85 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:1, p 85 https://doi.org/10.3390/antiox9010085 kostenfrei https://doaj.org/article/a66a09a24c3c442291601880527fca5e kostenfrei https://www.mdpi.com/2076-3921/9/1/85 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1, p 85
allfieldsSound	10.3390/antiox9010085 doi (DE-627)DOAJ011563338 (DE-599)DOAJa66a09a24c3c442291601880527fca5e DE-627 ger DE-627 rakwb eng RM1-950 Ana Giménez-Siurana verfasserin aut Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: the objective of the present work is to study the effectiveness of treatment with silk fibroin nanoparticles loaded with resveratrol in experimental periodontitis in a diabetic rat model. Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as type II diabetes. Both diseases have a specific inflammatory condition, with Interleukin (IL)-6, IL-1β and Transforming Grow Factor (TGF)-1β being the most relevant proinflammatory factors. Silk fibroin (SF) nanoparticles loaded with resveratrol (Res-SFN) are a new alternative as a treatment. Methods: 40 diabetic Sprague Dawley male rats were used and periodontitis was induced by ligation. The animals were divided into 5 treatment groups, and 1 mL of treatment was administered once a day for 4 weeks. The groups were: I: Carboxymethyl cellulose (CMC) 0.8%, II: CMC 0.8% + SF 1%, III: CMC 0.8% + RES-SFN 3 mg/mL, IV: CMC 0.8% + SF 1% + RES-SFN 3 mg/mL, V: Water. A peripheral blood sample was taken every week to quantify the inflammatory profile by ELISA (IL-6, IL-1β and TGF-1β). After 4 weeks the sacrifice was carried out and biopsies of the gum were taken. Results: Treatment with SF and RES-SFN reduced the amount of chemical inflammation mediators (with the exception of IL-1β in comparisons I-IV and II-IV (<i<p</i< > 0.05)), as well as the anatomopathological variables linked to it, in a significant way (<i<p</i< < 0.05). Conclusion: treatment with RES-SFN has reduced local inflammation in this experimental periodontitis model. resveratrol periodontitis silk fibroin nanoparticles inflammation il-6 il-1β tgf-1β diabetes Therapeutics. Pharmacology Francisco Gómez García verfasserin aut Ana Pagan Bernabeu verfasserin aut Antonio Abel Lozano-Pérez verfasserin aut Salvador D. Aznar-Cervantes verfasserin aut José Luis Cenis verfasserin aut Pía López-Jornet verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 1, p 85 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:1, p 85 https://doi.org/10.3390/antiox9010085 kostenfrei https://doaj.org/article/a66a09a24c3c442291601880527fca5e kostenfrei https://www.mdpi.com/2076-3921/9/1/85 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1, p 85
language	English
source	In Antioxidants 9(2020), 1, p 85 volume:9 year:2020 number:1, p 85
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callnumber-first	R - Medicine
author	Ana Giménez-Siurana
spellingShingle	Ana Giménez-Siurana misc RM1-950 misc resveratrol misc periodontitis misc silk fibroin nanoparticles misc inflammation misc il-6 misc il-1β misc tgf-1β misc diabetes misc Therapeutics. Pharmacology Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol
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topic_title	RM1-950 Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol resveratrol periodontitis silk fibroin nanoparticles inflammation il-6 il-1β tgf-1β diabetes
topic	misc RM1-950 misc resveratrol misc periodontitis misc silk fibroin nanoparticles misc inflammation misc il-6 misc il-1β misc tgf-1β misc diabetes misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc resveratrol misc periodontitis misc silk fibroin nanoparticles misc inflammation misc il-6 misc il-1β misc tgf-1β misc diabetes misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc resveratrol misc periodontitis misc silk fibroin nanoparticles misc inflammation misc il-6 misc il-1β misc tgf-1β misc diabetes misc Therapeutics. Pharmacology
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title	Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol
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title_full	Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol
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title_sort	chemoprevention of experimental periodontitis in diabetic rats with silk fibroin nanoparticles loaded with resveratrol
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title_auth	Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol
abstract	Objective: the objective of the present work is to study the effectiveness of treatment with silk fibroin nanoparticles loaded with resveratrol in experimental periodontitis in a diabetic rat model. Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as type II diabetes. Both diseases have a specific inflammatory condition, with Interleukin (IL)-6, IL-1β and Transforming Grow Factor (TGF)-1β being the most relevant proinflammatory factors. Silk fibroin (SF) nanoparticles loaded with resveratrol (Res-SFN) are a new alternative as a treatment. Methods: 40 diabetic Sprague Dawley male rats were used and periodontitis was induced by ligation. The animals were divided into 5 treatment groups, and 1 mL of treatment was administered once a day for 4 weeks. The groups were: I: Carboxymethyl cellulose (CMC) 0.8%, II: CMC 0.8% + SF 1%, III: CMC 0.8% + RES-SFN 3 mg/mL, IV: CMC 0.8% + SF 1% + RES-SFN 3 mg/mL, V: Water. A peripheral blood sample was taken every week to quantify the inflammatory profile by ELISA (IL-6, IL-1β and TGF-1β). After 4 weeks the sacrifice was carried out and biopsies of the gum were taken. Results: Treatment with SF and RES-SFN reduced the amount of chemical inflammation mediators (with the exception of IL-1β in comparisons I-IV and II-IV (<i<p</i< > 0.05)), as well as the anatomopathological variables linked to it, in a significant way (<i<p</i< < 0.05). Conclusion: treatment with RES-SFN has reduced local inflammation in this experimental periodontitis model.
abstractGer	Objective: the objective of the present work is to study the effectiveness of treatment with silk fibroin nanoparticles loaded with resveratrol in experimental periodontitis in a diabetic rat model. Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as type II diabetes. Both diseases have a specific inflammatory condition, with Interleukin (IL)-6, IL-1β and Transforming Grow Factor (TGF)-1β being the most relevant proinflammatory factors. Silk fibroin (SF) nanoparticles loaded with resveratrol (Res-SFN) are a new alternative as a treatment. Methods: 40 diabetic Sprague Dawley male rats were used and periodontitis was induced by ligation. The animals were divided into 5 treatment groups, and 1 mL of treatment was administered once a day for 4 weeks. The groups were: I: Carboxymethyl cellulose (CMC) 0.8%, II: CMC 0.8% + SF 1%, III: CMC 0.8% + RES-SFN 3 mg/mL, IV: CMC 0.8% + SF 1% + RES-SFN 3 mg/mL, V: Water. A peripheral blood sample was taken every week to quantify the inflammatory profile by ELISA (IL-6, IL-1β and TGF-1β). After 4 weeks the sacrifice was carried out and biopsies of the gum were taken. Results: Treatment with SF and RES-SFN reduced the amount of chemical inflammation mediators (with the exception of IL-1β in comparisons I-IV and II-IV (<i<p</i< > 0.05)), as well as the anatomopathological variables linked to it, in a significant way (<i<p</i< < 0.05). Conclusion: treatment with RES-SFN has reduced local inflammation in this experimental periodontitis model.
abstract_unstemmed	Objective: the objective of the present work is to study the effectiveness of treatment with silk fibroin nanoparticles loaded with resveratrol in experimental periodontitis in a diabetic rat model. Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as type II diabetes. Both diseases have a specific inflammatory condition, with Interleukin (IL)-6, IL-1β and Transforming Grow Factor (TGF)-1β being the most relevant proinflammatory factors. Silk fibroin (SF) nanoparticles loaded with resveratrol (Res-SFN) are a new alternative as a treatment. Methods: 40 diabetic Sprague Dawley male rats were used and periodontitis was induced by ligation. The animals were divided into 5 treatment groups, and 1 mL of treatment was administered once a day for 4 weeks. The groups were: I: Carboxymethyl cellulose (CMC) 0.8%, II: CMC 0.8% + SF 1%, III: CMC 0.8% + RES-SFN 3 mg/mL, IV: CMC 0.8% + SF 1% + RES-SFN 3 mg/mL, V: Water. A peripheral blood sample was taken every week to quantify the inflammatory profile by ELISA (IL-6, IL-1β and TGF-1β). After 4 weeks the sacrifice was carried out and biopsies of the gum were taken. Results: Treatment with SF and RES-SFN reduced the amount of chemical inflammation mediators (with the exception of IL-1β in comparisons I-IV and II-IV (<i<p</i< > 0.05)), as well as the anatomopathological variables linked to it, in a significant way (<i<p</i< < 0.05). Conclusion: treatment with RES-SFN has reduced local inflammation in this experimental periodontitis model.
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title_short	Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol
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Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as type II diabetes. Both diseases have a specific inflammatory condition, with Interleukin (IL)-6, IL-1β and Transforming Grow Factor (TGF)-1β being the most relevant proinflammatory factors. Silk fibroin (SF) nanoparticles loaded with resveratrol (Res-SFN) are a new alternative as a treatment. Methods: 40 diabetic Sprague Dawley male rats were used and periodontitis was induced by ligation. The animals were divided into 5 treatment groups, and 1 mL of treatment was administered once a day for 4 weeks. The groups were: I: Carboxymethyl cellulose (CMC) 0.8%, II: CMC 0.8% + SF 1%, III: CMC 0.8% + RES-SFN 3 mg/mL, IV: CMC 0.8% + SF 1% + RES-SFN 3 mg/mL, V: Water. A peripheral blood sample was taken every week to quantify the inflammatory profile by ELISA (IL-6, IL-1β and TGF-1β). After 4 weeks the sacrifice was carried out and biopsies of the gum were taken. Results: Treatment with SF and RES-SFN reduced the amount of chemical inflammation mediators (with the exception of IL-1β in comparisons I-IV and II-IV (<i<p</i< &gt; 0.05)), as well as the anatomopathological variables linked to it, in a significant way (<i<p</i< &lt; 0.05). 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Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol

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