Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children

Abstract Background The aim of this study was to observe the effectiveness of botulinum toxin type A (BTA) in the treatment of intermittent exotropia (IXT) in children compared with strabismus surgery. Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surger...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Han Su [verfasserIn] Jing Fu [verfasserIn] Xiao Wu [verfasserIn] Ali Sun [verfasserIn] Bowen Zhao [verfasserIn] Jie Hong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Botulinum toxin type a Intermittent Exotropia Strabismus Childhood

Übergeordnetes Werk:	In: BMC Ophthalmology - BMC, 2003, 22(2022), 1, Seite 8
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12886-022-02285-2

Katalog-ID:	DOAJ011638176

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520			\|a Abstract Background The aim of this study was to observe the effectiveness of botulinum toxin type A (BTA) in the treatment of intermittent exotropia (IXT) in children compared with strabismus surgery. Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surgery were eligible for inclusion. Subjects were divided into two groups based on parental decision: the BTA injection group (injection group) or the conventional surgery group (surgery group). All cases were followed up for 6 months. The primary outcome was a comparison of the success rate (deviation between − 10 and + 10 PD) between the two groups at 6 months after the initial treatment. Secondary outcomes included change in deviation, visual function, and post-surgical complications. Results Seventy-two patients were enrolled in each group. At 6-month follow-up, there was no significant difference in the success rate between the injection and surgery groups (52.8% vs 66.7%, P = 0.13; postoperative deviation − 12.22 ± 10.80 PD vs − 9.17 ± 10.30 PD, P = 0.09). The binocular Visual function, except for near stereoacuity, improved after treatment in both groups, while the fusion recovery rate was higher in the surgical group (68.1% vs 95.8%, P < 0.001). Transient complications in the injection group included diplopia, ptosis, and subconjunctival hemorrhage, whereas subconjunctival hemorrhage, conjunctival edema, foreign body sensation, pain, and diplopia were seen in the surgical group. The complications of BTA were relatively mild. Conclusions BTA is as effective as surgery in the treatment of IXT in children, but the recovery of the fusion is lower than surgery. Trial registration The study has completed the clinical registration on ( ChiCTR-INR-17013777 ).
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allfields	10.1186/s12886-022-02285-2 doi (DE-627)DOAJ011638176 (DE-599)DOAJ59628d11ed17475d9314806d64e8c16a DE-627 ger DE-627 rakwb eng RE1-994 Han Su verfasserin aut Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The aim of this study was to observe the effectiveness of botulinum toxin type A (BTA) in the treatment of intermittent exotropia (IXT) in children compared with strabismus surgery. Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surgery were eligible for inclusion. Subjects were divided into two groups based on parental decision: the BTA injection group (injection group) or the conventional surgery group (surgery group). All cases were followed up for 6 months. The primary outcome was a comparison of the success rate (deviation between − 10 and + 10 PD) between the two groups at 6 months after the initial treatment. Secondary outcomes included change in deviation, visual function, and post-surgical complications. Results Seventy-two patients were enrolled in each group. At 6-month follow-up, there was no significant difference in the success rate between the injection and surgery groups (52.8% vs 66.7%, P = 0.13; postoperative deviation − 12.22 ± 10.80 PD vs − 9.17 ± 10.30 PD, P = 0.09). The binocular Visual function, except for near stereoacuity, improved after treatment in both groups, while the fusion recovery rate was higher in the surgical group (68.1% vs 95.8%, P < 0.001). Transient complications in the injection group included diplopia, ptosis, and subconjunctival hemorrhage, whereas subconjunctival hemorrhage, conjunctival edema, foreign body sensation, pain, and diplopia were seen in the surgical group. The complications of BTA were relatively mild. Conclusions BTA is as effective as surgery in the treatment of IXT in children, but the recovery of the fusion is lower than surgery. Trial registration The study has completed the clinical registration on ( ChiCTR-INR-17013777 ). Botulinum toxin type a Intermittent Exotropia Strabismus Childhood Ophthalmology Jing Fu verfasserin aut Xiao Wu verfasserin aut Ali Sun verfasserin aut Bowen Zhao verfasserin aut Jie Hong verfasserin aut In BMC Ophthalmology BMC, 2003 22(2022), 1, Seite 8 (DE-627)331018772 (DE-600)2050436-6 14712415 nnns volume:22 year:2022 number:1 pages:8 https://doi.org/10.1186/s12886-022-02285-2 kostenfrei https://doaj.org/article/59628d11ed17475d9314806d64e8c16a kostenfrei https://doi.org/10.1186/s12886-022-02285-2 kostenfrei https://doaj.org/toc/1471-2415 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 8
spelling	10.1186/s12886-022-02285-2 doi (DE-627)DOAJ011638176 (DE-599)DOAJ59628d11ed17475d9314806d64e8c16a DE-627 ger DE-627 rakwb eng RE1-994 Han Su verfasserin aut Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The aim of this study was to observe the effectiveness of botulinum toxin type A (BTA) in the treatment of intermittent exotropia (IXT) in children compared with strabismus surgery. Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surgery were eligible for inclusion. Subjects were divided into two groups based on parental decision: the BTA injection group (injection group) or the conventional surgery group (surgery group). All cases were followed up for 6 months. The primary outcome was a comparison of the success rate (deviation between − 10 and + 10 PD) between the two groups at 6 months after the initial treatment. Secondary outcomes included change in deviation, visual function, and post-surgical complications. Results Seventy-two patients were enrolled in each group. At 6-month follow-up, there was no significant difference in the success rate between the injection and surgery groups (52.8% vs 66.7%, P = 0.13; postoperative deviation − 12.22 ± 10.80 PD vs − 9.17 ± 10.30 PD, P = 0.09). The binocular Visual function, except for near stereoacuity, improved after treatment in both groups, while the fusion recovery rate was higher in the surgical group (68.1% vs 95.8%, P < 0.001). Transient complications in the injection group included diplopia, ptosis, and subconjunctival hemorrhage, whereas subconjunctival hemorrhage, conjunctival edema, foreign body sensation, pain, and diplopia were seen in the surgical group. The complications of BTA were relatively mild. Conclusions BTA is as effective as surgery in the treatment of IXT in children, but the recovery of the fusion is lower than surgery. Trial registration The study has completed the clinical registration on ( ChiCTR-INR-17013777 ). Botulinum toxin type a Intermittent Exotropia Strabismus Childhood Ophthalmology Jing Fu verfasserin aut Xiao Wu verfasserin aut Ali Sun verfasserin aut Bowen Zhao verfasserin aut Jie Hong verfasserin aut In BMC Ophthalmology BMC, 2003 22(2022), 1, Seite 8 (DE-627)331018772 (DE-600)2050436-6 14712415 nnns volume:22 year:2022 number:1 pages:8 https://doi.org/10.1186/s12886-022-02285-2 kostenfrei https://doaj.org/article/59628d11ed17475d9314806d64e8c16a kostenfrei https://doi.org/10.1186/s12886-022-02285-2 kostenfrei https://doaj.org/toc/1471-2415 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 8
allfields_unstemmed	10.1186/s12886-022-02285-2 doi (DE-627)DOAJ011638176 (DE-599)DOAJ59628d11ed17475d9314806d64e8c16a DE-627 ger DE-627 rakwb eng RE1-994 Han Su verfasserin aut Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The aim of this study was to observe the effectiveness of botulinum toxin type A (BTA) in the treatment of intermittent exotropia (IXT) in children compared with strabismus surgery. Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surgery were eligible for inclusion. Subjects were divided into two groups based on parental decision: the BTA injection group (injection group) or the conventional surgery group (surgery group). All cases were followed up for 6 months. The primary outcome was a comparison of the success rate (deviation between − 10 and + 10 PD) between the two groups at 6 months after the initial treatment. Secondary outcomes included change in deviation, visual function, and post-surgical complications. Results Seventy-two patients were enrolled in each group. At 6-month follow-up, there was no significant difference in the success rate between the injection and surgery groups (52.8% vs 66.7%, P = 0.13; postoperative deviation − 12.22 ± 10.80 PD vs − 9.17 ± 10.30 PD, P = 0.09). The binocular Visual function, except for near stereoacuity, improved after treatment in both groups, while the fusion recovery rate was higher in the surgical group (68.1% vs 95.8%, P < 0.001). Transient complications in the injection group included diplopia, ptosis, and subconjunctival hemorrhage, whereas subconjunctival hemorrhage, conjunctival edema, foreign body sensation, pain, and diplopia were seen in the surgical group. The complications of BTA were relatively mild. Conclusions BTA is as effective as surgery in the treatment of IXT in children, but the recovery of the fusion is lower than surgery. Trial registration The study has completed the clinical registration on ( ChiCTR-INR-17013777 ). Botulinum toxin type a Intermittent Exotropia Strabismus Childhood Ophthalmology Jing Fu verfasserin aut Xiao Wu verfasserin aut Ali Sun verfasserin aut Bowen Zhao verfasserin aut Jie Hong verfasserin aut In BMC Ophthalmology BMC, 2003 22(2022), 1, Seite 8 (DE-627)331018772 (DE-600)2050436-6 14712415 nnns volume:22 year:2022 number:1 pages:8 https://doi.org/10.1186/s12886-022-02285-2 kostenfrei https://doaj.org/article/59628d11ed17475d9314806d64e8c16a kostenfrei https://doi.org/10.1186/s12886-022-02285-2 kostenfrei https://doaj.org/toc/1471-2415 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 8
allfieldsGer	10.1186/s12886-022-02285-2 doi (DE-627)DOAJ011638176 (DE-599)DOAJ59628d11ed17475d9314806d64e8c16a DE-627 ger DE-627 rakwb eng RE1-994 Han Su verfasserin aut Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The aim of this study was to observe the effectiveness of botulinum toxin type A (BTA) in the treatment of intermittent exotropia (IXT) in children compared with strabismus surgery. Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surgery were eligible for inclusion. Subjects were divided into two groups based on parental decision: the BTA injection group (injection group) or the conventional surgery group (surgery group). All cases were followed up for 6 months. The primary outcome was a comparison of the success rate (deviation between − 10 and + 10 PD) between the two groups at 6 months after the initial treatment. Secondary outcomes included change in deviation, visual function, and post-surgical complications. Results Seventy-two patients were enrolled in each group. At 6-month follow-up, there was no significant difference in the success rate between the injection and surgery groups (52.8% vs 66.7%, P = 0.13; postoperative deviation − 12.22 ± 10.80 PD vs − 9.17 ± 10.30 PD, P = 0.09). The binocular Visual function, except for near stereoacuity, improved after treatment in both groups, while the fusion recovery rate was higher in the surgical group (68.1% vs 95.8%, P < 0.001). Transient complications in the injection group included diplopia, ptosis, and subconjunctival hemorrhage, whereas subconjunctival hemorrhage, conjunctival edema, foreign body sensation, pain, and diplopia were seen in the surgical group. The complications of BTA were relatively mild. Conclusions BTA is as effective as surgery in the treatment of IXT in children, but the recovery of the fusion is lower than surgery. Trial registration The study has completed the clinical registration on ( ChiCTR-INR-17013777 ). Botulinum toxin type a Intermittent Exotropia Strabismus Childhood Ophthalmology Jing Fu verfasserin aut Xiao Wu verfasserin aut Ali Sun verfasserin aut Bowen Zhao verfasserin aut Jie Hong verfasserin aut In BMC Ophthalmology BMC, 2003 22(2022), 1, Seite 8 (DE-627)331018772 (DE-600)2050436-6 14712415 nnns volume:22 year:2022 number:1 pages:8 https://doi.org/10.1186/s12886-022-02285-2 kostenfrei https://doaj.org/article/59628d11ed17475d9314806d64e8c16a kostenfrei https://doi.org/10.1186/s12886-022-02285-2 kostenfrei https://doaj.org/toc/1471-2415 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 8
allfieldsSound	10.1186/s12886-022-02285-2 doi (DE-627)DOAJ011638176 (DE-599)DOAJ59628d11ed17475d9314806d64e8c16a DE-627 ger DE-627 rakwb eng RE1-994 Han Su verfasserin aut Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The aim of this study was to observe the effectiveness of botulinum toxin type A (BTA) in the treatment of intermittent exotropia (IXT) in children compared with strabismus surgery. Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surgery were eligible for inclusion. Subjects were divided into two groups based on parental decision: the BTA injection group (injection group) or the conventional surgery group (surgery group). All cases were followed up for 6 months. The primary outcome was a comparison of the success rate (deviation between − 10 and + 10 PD) between the two groups at 6 months after the initial treatment. Secondary outcomes included change in deviation, visual function, and post-surgical complications. Results Seventy-two patients were enrolled in each group. At 6-month follow-up, there was no significant difference in the success rate between the injection and surgery groups (52.8% vs 66.7%, P = 0.13; postoperative deviation − 12.22 ± 10.80 PD vs − 9.17 ± 10.30 PD, P = 0.09). The binocular Visual function, except for near stereoacuity, improved after treatment in both groups, while the fusion recovery rate was higher in the surgical group (68.1% vs 95.8%, P < 0.001). Transient complications in the injection group included diplopia, ptosis, and subconjunctival hemorrhage, whereas subconjunctival hemorrhage, conjunctival edema, foreign body sensation, pain, and diplopia were seen in the surgical group. The complications of BTA were relatively mild. Conclusions BTA is as effective as surgery in the treatment of IXT in children, but the recovery of the fusion is lower than surgery. Trial registration The study has completed the clinical registration on ( ChiCTR-INR-17013777 ). Botulinum toxin type a Intermittent Exotropia Strabismus Childhood Ophthalmology Jing Fu verfasserin aut Xiao Wu verfasserin aut Ali Sun verfasserin aut Bowen Zhao verfasserin aut Jie Hong verfasserin aut In BMC Ophthalmology BMC, 2003 22(2022), 1, Seite 8 (DE-627)331018772 (DE-600)2050436-6 14712415 nnns volume:22 year:2022 number:1 pages:8 https://doi.org/10.1186/s12886-022-02285-2 kostenfrei https://doaj.org/article/59628d11ed17475d9314806d64e8c16a kostenfrei https://doi.org/10.1186/s12886-022-02285-2 kostenfrei https://doaj.org/toc/1471-2415 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 8
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Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surgery were eligible for inclusion. Subjects were divided into two groups based on parental decision: the BTA injection group (injection group) or the conventional surgery group (surgery group). All cases were followed up for 6 months. The primary outcome was a comparison of the success rate (deviation between − 10 and + 10 PD) between the two groups at 6 months after the initial treatment. Secondary outcomes included change in deviation, visual function, and post-surgical complications. Results Seventy-two patients were enrolled in each group. At 6-month follow-up, there was no significant difference in the success rate between the injection and surgery groups (52.8% vs 66.7%, P = 0.13; postoperative deviation − 12.22 ± 10.80 PD vs − 9.17 ± 10.30 PD, P = 0.09). The binocular Visual function, except for near stereoacuity, improved after treatment in both groups, while the fusion recovery rate was higher in the surgical group (68.1% vs 95.8%, P < 0.001). Transient complications in the injection group included diplopia, ptosis, and subconjunctival hemorrhage, whereas subconjunctival hemorrhage, conjunctival edema, foreign body sensation, pain, and diplopia were seen in the surgical group. The complications of BTA were relatively mild. Conclusions BTA is as effective as surgery in the treatment of IXT in children, but the recovery of the fusion is lower than surgery. 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callnumber-first	R - Medicine
author	Han Su
spellingShingle	Han Su misc RE1-994 misc Botulinum toxin type a misc Intermittent Exotropia misc Strabismus misc Childhood misc Ophthalmology Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children
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topic_title	RE1-994 Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children Botulinum toxin type a Intermittent Exotropia Strabismus Childhood
topic	misc RE1-994 misc Botulinum toxin type a misc Intermittent Exotropia misc Strabismus misc Childhood misc Ophthalmology
topic_unstemmed	misc RE1-994 misc Botulinum toxin type a misc Intermittent Exotropia misc Strabismus misc Childhood misc Ophthalmology
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title	Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children
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title_full	Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children
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title_sort	comparison of botulinum toxin type a with surgery for the treatment of intermittent exotropia in children
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title_auth	Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children
abstract	Abstract Background The aim of this study was to observe the effectiveness of botulinum toxin type A (BTA) in the treatment of intermittent exotropia (IXT) in children compared with strabismus surgery. Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surgery were eligible for inclusion. Subjects were divided into two groups based on parental decision: the BTA injection group (injection group) or the conventional surgery group (surgery group). All cases were followed up for 6 months. The primary outcome was a comparison of the success rate (deviation between − 10 and + 10 PD) between the two groups at 6 months after the initial treatment. Secondary outcomes included change in deviation, visual function, and post-surgical complications. Results Seventy-two patients were enrolled in each group. At 6-month follow-up, there was no significant difference in the success rate between the injection and surgery groups (52.8% vs 66.7%, P = 0.13; postoperative deviation − 12.22 ± 10.80 PD vs − 9.17 ± 10.30 PD, P = 0.09). The binocular Visual function, except for near stereoacuity, improved after treatment in both groups, while the fusion recovery rate was higher in the surgical group (68.1% vs 95.8%, P < 0.001). Transient complications in the injection group included diplopia, ptosis, and subconjunctival hemorrhage, whereas subconjunctival hemorrhage, conjunctival edema, foreign body sensation, pain, and diplopia were seen in the surgical group. The complications of BTA were relatively mild. Conclusions BTA is as effective as surgery in the treatment of IXT in children, but the recovery of the fusion is lower than surgery. Trial registration The study has completed the clinical registration on ( ChiCTR-INR-17013777 ).
abstractGer	Abstract Background The aim of this study was to observe the effectiveness of botulinum toxin type A (BTA) in the treatment of intermittent exotropia (IXT) in children compared with strabismus surgery. Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surgery were eligible for inclusion. Subjects were divided into two groups based on parental decision: the BTA injection group (injection group) or the conventional surgery group (surgery group). All cases were followed up for 6 months. The primary outcome was a comparison of the success rate (deviation between − 10 and + 10 PD) between the two groups at 6 months after the initial treatment. Secondary outcomes included change in deviation, visual function, and post-surgical complications. Results Seventy-two patients were enrolled in each group. At 6-month follow-up, there was no significant difference in the success rate between the injection and surgery groups (52.8% vs 66.7%, P = 0.13; postoperative deviation − 12.22 ± 10.80 PD vs − 9.17 ± 10.30 PD, P = 0.09). The binocular Visual function, except for near stereoacuity, improved after treatment in both groups, while the fusion recovery rate was higher in the surgical group (68.1% vs 95.8%, P < 0.001). Transient complications in the injection group included diplopia, ptosis, and subconjunctival hemorrhage, whereas subconjunctival hemorrhage, conjunctival edema, foreign body sensation, pain, and diplopia were seen in the surgical group. The complications of BTA were relatively mild. Conclusions BTA is as effective as surgery in the treatment of IXT in children, but the recovery of the fusion is lower than surgery. Trial registration The study has completed the clinical registration on ( ChiCTR-INR-17013777 ).
abstract_unstemmed	Abstract Background The aim of this study was to observe the effectiveness of botulinum toxin type A (BTA) in the treatment of intermittent exotropia (IXT) in children compared with strabismus surgery. Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surgery were eligible for inclusion. Subjects were divided into two groups based on parental decision: the BTA injection group (injection group) or the conventional surgery group (surgery group). All cases were followed up for 6 months. The primary outcome was a comparison of the success rate (deviation between − 10 and + 10 PD) between the two groups at 6 months after the initial treatment. Secondary outcomes included change in deviation, visual function, and post-surgical complications. Results Seventy-two patients were enrolled in each group. At 6-month follow-up, there was no significant difference in the success rate between the injection and surgery groups (52.8% vs 66.7%, P = 0.13; postoperative deviation − 12.22 ± 10.80 PD vs − 9.17 ± 10.30 PD, P = 0.09). The binocular Visual function, except for near stereoacuity, improved after treatment in both groups, while the fusion recovery rate was higher in the surgical group (68.1% vs 95.8%, P < 0.001). Transient complications in the injection group included diplopia, ptosis, and subconjunctival hemorrhage, whereas subconjunctival hemorrhage, conjunctival edema, foreign body sensation, pain, and diplopia were seen in the surgical group. The complications of BTA were relatively mild. Conclusions BTA is as effective as surgery in the treatment of IXT in children, but the recovery of the fusion is lower than surgery. Trial registration The study has completed the clinical registration on ( ChiCTR-INR-17013777 ).
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title_short	Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children
url	https://doi.org/10.1186/s12886-022-02285-2 https://doaj.org/article/59628d11ed17475d9314806d64e8c16a https://doaj.org/toc/1471-2415
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up_date	2024-07-03T21:24:59.915Z
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Methods One hundred forty-four children with a clear diagnosis of IXT and an indication for surgery were eligible for inclusion. Subjects were divided into two groups based on parental decision: the BTA injection group (injection group) or the conventional surgery group (surgery group). All cases were followed up for 6 months. The primary outcome was a comparison of the success rate (deviation between − 10 and + 10 PD) between the two groups at 6 months after the initial treatment. Secondary outcomes included change in deviation, visual function, and post-surgical complications. Results Seventy-two patients were enrolled in each group. At 6-month follow-up, there was no significant difference in the success rate between the injection and surgery groups (52.8% vs 66.7%, P = 0.13; postoperative deviation − 12.22 ± 10.80 PD vs − 9.17 ± 10.30 PD, P = 0.09). The binocular Visual function, except for near stereoacuity, improved after treatment in both groups, while the fusion recovery rate was higher in the surgical group (68.1% vs 95.8%, P < 0.001). Transient complications in the injection group included diplopia, ptosis, and subconjunctival hemorrhage, whereas subconjunctival hemorrhage, conjunctival edema, foreign body sensation, pain, and diplopia were seen in the surgical group. The complications of BTA were relatively mild. Conclusions BTA is as effective as surgery in the treatment of IXT in children, but the recovery of the fusion is lower than surgery. 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Comparison of Botulinum toxin type A with surgery for the treatment of intermittent exotropia in children

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