Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse

Objective: Perimenopausal women are at high risk for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) diseases. In the present study, the expression of VIP in the vaginal epithelium of 70 perimenopausal women was correlated with the severity of POP with or without SUI. Materials and...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jie-Mei Hu [verfasserIn] Xiao Cheng [verfasserIn] Lin Wang [verfasserIn] Jie-Ning Zhu [verfasserIn] Li-Hua Zhou [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	human vaginal tissue menopause pelvic organ prolapse vasoactive intestinal peptide

Übergeordnetes Werk:	In: Taiwanese Journal of Obstetrics & Gynecology - Elsevier, 2017, 52(2013), 2, Seite 233-240
Übergeordnetes Werk:	volume:52 ; year:2013 ; number:2 ; pages:233-240

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.tjog.2013.04.014

Katalog-ID:	DOAJ011643951

Internformat


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520			\|a Objective: Perimenopausal women are at high risk for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) diseases. In the present study, the expression of VIP in the vaginal epithelium of 70 perimenopausal women was correlated with the severity of POP with or without SUI. Materials and Methods: Seventy biopsy specimens from the anterior vaginal epithelium were obtained from postmenopausal patients. Immunohistochemical labeling for vasoactive intestinal peptide (VIP) and hematoxylin and eosin staining were performed. The VIP innervation was then compared between eight patient groups. Semiquantitative analysis of VIP protein by Western blotting was performed and compared between the eight patient groups. Results: The results of the immunohistochemical study showed that the intensity of VIP-immunoreactivity (VIP-ir) in the eight groups was as follows (in decreasing order): Control; POPI; POP II; POP II + SUI; POP III; POP IV and POP III + SUI; and POP IV + SUI. The intensity of VIP-ir was obviously weak and similar among the POP IV, POP III + SUI, and POP IV + SUI groups. This result was validated by the Western blotting analysis. The level of the VIP peptide also deceased in POP patients and was as follows (in decreasing order): Control; POPI; POP II and POP II + SUI; POP III and POP III + SUI; and POP IV and POP IV + SUI. Conclusion: The present study found that reduced VIP innervation in the vaginal epithelium of the perimenopausal women was correlated with the severity of POP with or without SUI.
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allfields	10.1016/j.tjog.2013.04.014 doi (DE-627)DOAJ011643951 (DE-599)DOAJb931344ff228415197755e1eaf4cab9a DE-627 ger DE-627 rakwb eng RG1-991 Jie-Mei Hu verfasserin aut Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Perimenopausal women are at high risk for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) diseases. In the present study, the expression of VIP in the vaginal epithelium of 70 perimenopausal women was correlated with the severity of POP with or without SUI. Materials and Methods: Seventy biopsy specimens from the anterior vaginal epithelium were obtained from postmenopausal patients. Immunohistochemical labeling for vasoactive intestinal peptide (VIP) and hematoxylin and eosin staining were performed. The VIP innervation was then compared between eight patient groups. Semiquantitative analysis of VIP protein by Western blotting was performed and compared between the eight patient groups. Results: The results of the immunohistochemical study showed that the intensity of VIP-immunoreactivity (VIP-ir) in the eight groups was as follows (in decreasing order): Control; POPI; POP II; POP II + SUI; POP III; POP IV and POP III + SUI; and POP IV + SUI. The intensity of VIP-ir was obviously weak and similar among the POP IV, POP III + SUI, and POP IV + SUI groups. This result was validated by the Western blotting analysis. The level of the VIP peptide also deceased in POP patients and was as follows (in decreasing order): Control; POPI; POP II and POP II + SUI; POP III and POP III + SUI; and POP IV and POP IV + SUI. Conclusion: The present study found that reduced VIP innervation in the vaginal epithelium of the perimenopausal women was correlated with the severity of POP with or without SUI. human vaginal tissue menopause pelvic organ prolapse vasoactive intestinal peptide Gynecology and obstetrics Xiao Cheng verfasserin aut Lin Wang verfasserin aut Jie-Ning Zhu verfasserin aut Li-Hua Zhou verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 52(2013), 2, Seite 233-240 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:52 year:2013 number:2 pages:233-240 https://doi.org/10.1016/j.tjog.2013.04.014 kostenfrei https://doaj.org/article/b931344ff228415197755e1eaf4cab9a kostenfrei http://www.sciencedirect.com/science/article/pii/S1028455913000703 kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 2013 2 233-240
spelling	10.1016/j.tjog.2013.04.014 doi (DE-627)DOAJ011643951 (DE-599)DOAJb931344ff228415197755e1eaf4cab9a DE-627 ger DE-627 rakwb eng RG1-991 Jie-Mei Hu verfasserin aut Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Perimenopausal women are at high risk for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) diseases. In the present study, the expression of VIP in the vaginal epithelium of 70 perimenopausal women was correlated with the severity of POP with or without SUI. Materials and Methods: Seventy biopsy specimens from the anterior vaginal epithelium were obtained from postmenopausal patients. Immunohistochemical labeling for vasoactive intestinal peptide (VIP) and hematoxylin and eosin staining were performed. The VIP innervation was then compared between eight patient groups. Semiquantitative analysis of VIP protein by Western blotting was performed and compared between the eight patient groups. Results: The results of the immunohistochemical study showed that the intensity of VIP-immunoreactivity (VIP-ir) in the eight groups was as follows (in decreasing order): Control; POPI; POP II; POP II + SUI; POP III; POP IV and POP III + SUI; and POP IV + SUI. The intensity of VIP-ir was obviously weak and similar among the POP IV, POP III + SUI, and POP IV + SUI groups. This result was validated by the Western blotting analysis. The level of the VIP peptide also deceased in POP patients and was as follows (in decreasing order): Control; POPI; POP II and POP II + SUI; POP III and POP III + SUI; and POP IV and POP IV + SUI. Conclusion: The present study found that reduced VIP innervation in the vaginal epithelium of the perimenopausal women was correlated with the severity of POP with or without SUI. human vaginal tissue menopause pelvic organ prolapse vasoactive intestinal peptide Gynecology and obstetrics Xiao Cheng verfasserin aut Lin Wang verfasserin aut Jie-Ning Zhu verfasserin aut Li-Hua Zhou verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 52(2013), 2, Seite 233-240 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:52 year:2013 number:2 pages:233-240 https://doi.org/10.1016/j.tjog.2013.04.014 kostenfrei https://doaj.org/article/b931344ff228415197755e1eaf4cab9a kostenfrei http://www.sciencedirect.com/science/article/pii/S1028455913000703 kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 2013 2 233-240
allfields_unstemmed	10.1016/j.tjog.2013.04.014 doi (DE-627)DOAJ011643951 (DE-599)DOAJb931344ff228415197755e1eaf4cab9a DE-627 ger DE-627 rakwb eng RG1-991 Jie-Mei Hu verfasserin aut Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Perimenopausal women are at high risk for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) diseases. In the present study, the expression of VIP in the vaginal epithelium of 70 perimenopausal women was correlated with the severity of POP with or without SUI. Materials and Methods: Seventy biopsy specimens from the anterior vaginal epithelium were obtained from postmenopausal patients. Immunohistochemical labeling for vasoactive intestinal peptide (VIP) and hematoxylin and eosin staining were performed. The VIP innervation was then compared between eight patient groups. Semiquantitative analysis of VIP protein by Western blotting was performed and compared between the eight patient groups. Results: The results of the immunohistochemical study showed that the intensity of VIP-immunoreactivity (VIP-ir) in the eight groups was as follows (in decreasing order): Control; POPI; POP II; POP II + SUI; POP III; POP IV and POP III + SUI; and POP IV + SUI. The intensity of VIP-ir was obviously weak and similar among the POP IV, POP III + SUI, and POP IV + SUI groups. This result was validated by the Western blotting analysis. The level of the VIP peptide also deceased in POP patients and was as follows (in decreasing order): Control; POPI; POP II and POP II + SUI; POP III and POP III + SUI; and POP IV and POP IV + SUI. Conclusion: The present study found that reduced VIP innervation in the vaginal epithelium of the perimenopausal women was correlated with the severity of POP with or without SUI. human vaginal tissue menopause pelvic organ prolapse vasoactive intestinal peptide Gynecology and obstetrics Xiao Cheng verfasserin aut Lin Wang verfasserin aut Jie-Ning Zhu verfasserin aut Li-Hua Zhou verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 52(2013), 2, Seite 233-240 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:52 year:2013 number:2 pages:233-240 https://doi.org/10.1016/j.tjog.2013.04.014 kostenfrei https://doaj.org/article/b931344ff228415197755e1eaf4cab9a kostenfrei http://www.sciencedirect.com/science/article/pii/S1028455913000703 kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 2013 2 233-240
allfieldsGer	10.1016/j.tjog.2013.04.014 doi (DE-627)DOAJ011643951 (DE-599)DOAJb931344ff228415197755e1eaf4cab9a DE-627 ger DE-627 rakwb eng RG1-991 Jie-Mei Hu verfasserin aut Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Perimenopausal women are at high risk for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) diseases. In the present study, the expression of VIP in the vaginal epithelium of 70 perimenopausal women was correlated with the severity of POP with or without SUI. Materials and Methods: Seventy biopsy specimens from the anterior vaginal epithelium were obtained from postmenopausal patients. Immunohistochemical labeling for vasoactive intestinal peptide (VIP) and hematoxylin and eosin staining were performed. The VIP innervation was then compared between eight patient groups. Semiquantitative analysis of VIP protein by Western blotting was performed and compared between the eight patient groups. Results: The results of the immunohistochemical study showed that the intensity of VIP-immunoreactivity (VIP-ir) in the eight groups was as follows (in decreasing order): Control; POPI; POP II; POP II + SUI; POP III; POP IV and POP III + SUI; and POP IV + SUI. The intensity of VIP-ir was obviously weak and similar among the POP IV, POP III + SUI, and POP IV + SUI groups. This result was validated by the Western blotting analysis. The level of the VIP peptide also deceased in POP patients and was as follows (in decreasing order): Control; POPI; POP II and POP II + SUI; POP III and POP III + SUI; and POP IV and POP IV + SUI. Conclusion: The present study found that reduced VIP innervation in the vaginal epithelium of the perimenopausal women was correlated with the severity of POP with or without SUI. human vaginal tissue menopause pelvic organ prolapse vasoactive intestinal peptide Gynecology and obstetrics Xiao Cheng verfasserin aut Lin Wang verfasserin aut Jie-Ning Zhu verfasserin aut Li-Hua Zhou verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 52(2013), 2, Seite 233-240 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:52 year:2013 number:2 pages:233-240 https://doi.org/10.1016/j.tjog.2013.04.014 kostenfrei https://doaj.org/article/b931344ff228415197755e1eaf4cab9a kostenfrei http://www.sciencedirect.com/science/article/pii/S1028455913000703 kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 2013 2 233-240
allfieldsSound	10.1016/j.tjog.2013.04.014 doi (DE-627)DOAJ011643951 (DE-599)DOAJb931344ff228415197755e1eaf4cab9a DE-627 ger DE-627 rakwb eng RG1-991 Jie-Mei Hu verfasserin aut Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Perimenopausal women are at high risk for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) diseases. In the present study, the expression of VIP in the vaginal epithelium of 70 perimenopausal women was correlated with the severity of POP with or without SUI. Materials and Methods: Seventy biopsy specimens from the anterior vaginal epithelium were obtained from postmenopausal patients. Immunohistochemical labeling for vasoactive intestinal peptide (VIP) and hematoxylin and eosin staining were performed. The VIP innervation was then compared between eight patient groups. Semiquantitative analysis of VIP protein by Western blotting was performed and compared between the eight patient groups. Results: The results of the immunohistochemical study showed that the intensity of VIP-immunoreactivity (VIP-ir) in the eight groups was as follows (in decreasing order): Control; POPI; POP II; POP II + SUI; POP III; POP IV and POP III + SUI; and POP IV + SUI. The intensity of VIP-ir was obviously weak and similar among the POP IV, POP III + SUI, and POP IV + SUI groups. This result was validated by the Western blotting analysis. The level of the VIP peptide also deceased in POP patients and was as follows (in decreasing order): Control; POPI; POP II and POP II + SUI; POP III and POP III + SUI; and POP IV and POP IV + SUI. Conclusion: The present study found that reduced VIP innervation in the vaginal epithelium of the perimenopausal women was correlated with the severity of POP with or without SUI. human vaginal tissue menopause pelvic organ prolapse vasoactive intestinal peptide Gynecology and obstetrics Xiao Cheng verfasserin aut Lin Wang verfasserin aut Jie-Ning Zhu verfasserin aut Li-Hua Zhou verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 52(2013), 2, Seite 233-240 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:52 year:2013 number:2 pages:233-240 https://doi.org/10.1016/j.tjog.2013.04.014 kostenfrei https://doaj.org/article/b931344ff228415197755e1eaf4cab9a kostenfrei http://www.sciencedirect.com/science/article/pii/S1028455913000703 kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 52 2013 2 233-240
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source	In Taiwanese Journal of Obstetrics & Gynecology 52(2013), 2, Seite 233-240 volume:52 year:2013 number:2 pages:233-240
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container_title	Taiwanese Journal of Obstetrics & Gynecology
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callnumber-first	R - Medicine
author	Jie-Mei Hu
spellingShingle	Jie-Mei Hu misc RG1-991 misc human vaginal tissue misc menopause misc pelvic organ prolapse misc vasoactive intestinal peptide misc Gynecology and obstetrics Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse
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topic_title	RG1-991 Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse human vaginal tissue menopause pelvic organ prolapse vasoactive intestinal peptide
topic	misc RG1-991 misc human vaginal tissue misc menopause misc pelvic organ prolapse misc vasoactive intestinal peptide misc Gynecology and obstetrics
topic_unstemmed	misc RG1-991 misc human vaginal tissue misc menopause misc pelvic organ prolapse misc vasoactive intestinal peptide misc Gynecology and obstetrics
topic_browse	misc RG1-991 misc human vaginal tissue misc menopause misc pelvic organ prolapse misc vasoactive intestinal peptide misc Gynecology and obstetrics
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title	Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse
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title_full	Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse
author_sort	Jie-Mei Hu
journal	Taiwanese Journal of Obstetrics & Gynecology
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author_browse	Jie-Mei Hu Xiao Cheng Lin Wang Jie-Ning Zhu Li-Hua Zhou
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title_sort	vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse
callnumber	RG1-991
title_auth	Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse
abstract	Objective: Perimenopausal women are at high risk for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) diseases. In the present study, the expression of VIP in the vaginal epithelium of 70 perimenopausal women was correlated with the severity of POP with or without SUI. Materials and Methods: Seventy biopsy specimens from the anterior vaginal epithelium were obtained from postmenopausal patients. Immunohistochemical labeling for vasoactive intestinal peptide (VIP) and hematoxylin and eosin staining were performed. The VIP innervation was then compared between eight patient groups. Semiquantitative analysis of VIP protein by Western blotting was performed and compared between the eight patient groups. Results: The results of the immunohistochemical study showed that the intensity of VIP-immunoreactivity (VIP-ir) in the eight groups was as follows (in decreasing order): Control; POPI; POP II; POP II + SUI; POP III; POP IV and POP III + SUI; and POP IV + SUI. The intensity of VIP-ir was obviously weak and similar among the POP IV, POP III + SUI, and POP IV + SUI groups. This result was validated by the Western blotting analysis. The level of the VIP peptide also deceased in POP patients and was as follows (in decreasing order): Control; POPI; POP II and POP II + SUI; POP III and POP III + SUI; and POP IV and POP IV + SUI. Conclusion: The present study found that reduced VIP innervation in the vaginal epithelium of the perimenopausal women was correlated with the severity of POP with or without SUI.
abstractGer	Objective: Perimenopausal women are at high risk for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) diseases. In the present study, the expression of VIP in the vaginal epithelium of 70 perimenopausal women was correlated with the severity of POP with or without SUI. Materials and Methods: Seventy biopsy specimens from the anterior vaginal epithelium were obtained from postmenopausal patients. Immunohistochemical labeling for vasoactive intestinal peptide (VIP) and hematoxylin and eosin staining were performed. The VIP innervation was then compared between eight patient groups. Semiquantitative analysis of VIP protein by Western blotting was performed and compared between the eight patient groups. Results: The results of the immunohistochemical study showed that the intensity of VIP-immunoreactivity (VIP-ir) in the eight groups was as follows (in decreasing order): Control; POPI; POP II; POP II + SUI; POP III; POP IV and POP III + SUI; and POP IV + SUI. The intensity of VIP-ir was obviously weak and similar among the POP IV, POP III + SUI, and POP IV + SUI groups. This result was validated by the Western blotting analysis. The level of the VIP peptide also deceased in POP patients and was as follows (in decreasing order): Control; POPI; POP II and POP II + SUI; POP III and POP III + SUI; and POP IV and POP IV + SUI. Conclusion: The present study found that reduced VIP innervation in the vaginal epithelium of the perimenopausal women was correlated with the severity of POP with or without SUI.
abstract_unstemmed	Objective: Perimenopausal women are at high risk for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) diseases. In the present study, the expression of VIP in the vaginal epithelium of 70 perimenopausal women was correlated with the severity of POP with or without SUI. Materials and Methods: Seventy biopsy specimens from the anterior vaginal epithelium were obtained from postmenopausal patients. Immunohistochemical labeling for vasoactive intestinal peptide (VIP) and hematoxylin and eosin staining were performed. The VIP innervation was then compared between eight patient groups. Semiquantitative analysis of VIP protein by Western blotting was performed and compared between the eight patient groups. Results: The results of the immunohistochemical study showed that the intensity of VIP-immunoreactivity (VIP-ir) in the eight groups was as follows (in decreasing order): Control; POPI; POP II; POP II + SUI; POP III; POP IV and POP III + SUI; and POP IV + SUI. The intensity of VIP-ir was obviously weak and similar among the POP IV, POP III + SUI, and POP IV + SUI groups. This result was validated by the Western blotting analysis. The level of the VIP peptide also deceased in POP patients and was as follows (in decreasing order): Control; POPI; POP II and POP II + SUI; POP III and POP III + SUI; and POP IV and POP IV + SUI. Conclusion: The present study found that reduced VIP innervation in the vaginal epithelium of the perimenopausal women was correlated with the severity of POP with or without SUI.
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title_short	Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse
url	https://doi.org/10.1016/j.tjog.2013.04.014 https://doaj.org/article/b931344ff228415197755e1eaf4cab9a http://www.sciencedirect.com/science/article/pii/S1028455913000703 https://doaj.org/toc/1028-4559
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author2	Xiao Cheng Lin Wang Jie-Ning Zhu Li-Hua Zhou
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up_date	2024-07-03T21:26:46.618Z
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Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse

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