Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer

Ahmet Murat Aydin,1,* Solomon L Woldu,1,* Ryan C Hutchinson,1 Martin Boegemann,2 Aditya Bagrodia,1 Yair Lotan,1 Vitaly Margulis,1 Laura-Maria Krabbe1,2 1Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Urology, University of Münster Me...
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Gespeichert in:

Autor*in:	Aydin AM [verfasserIn] Woldu SL [verfasserIn] Hutchinson RC [verfasserIn] Boegemann M [verfasserIn] Bagrodia A [verfasserIn] Lotan Y [verfasserIn] Margulis V [verfasserIn] Krabbe LM [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	atezolizumab MPDL3280A bladder cancer PD-L1 immunotherapy metastatic

Übergeordnetes Werk:	In: OncoTargets and Therapy - Dove Medical Press, 2009, (2017), Seite 1487-1502
Übergeordnetes Werk:	year:2017 ; pages:1487-1502

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ011799099

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allfields_unstemmed	(DE-627)DOAJ011799099 (DE-599)DOAJ4dfe5936408945b9b45c32ce1eb52e41 DE-627 ger DE-627 rakwb eng RC254-282 Aydin AM verfasserin aut Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ahmet Murat Aydin,1,* Solomon L Woldu,1,* Ryan C Hutchinson,1 Martin Boegemann,2 Aditya Bagrodia,1 Yair Lotan,1 Vitaly Margulis,1 Laura-Maria Krabbe1,2 1Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Urology, University of Münster Medical Center, Münster, Germany *These authors contributed equally to this work Abstract: Metastatic urothelial carcinoma of the bladder is an aggressive malignancy with poor prognosis, reflecting a lack of effective systemic therapies. The current standard of care includes multiagent platinum-based chemotherapy; however a majority of patients do not respond to treatment and most eventually succumb to disease. Recently, renewed interest in immunotherapy in the form of immune-checkpoint inhibition has gained widespread attention for a number of malignancies. Atezolizumab, an anti-PDL1 antibody, has been shown to be effective in a subset of patients previously treated with or unfit for platinum-based chemotherapy, and has shown durable responses with a good tolerability profile. We review the mechanism of action and clinical evidence of atezolizumab for metastatic urothelial bladder cancer, and discuss this drug within the context of ongoing developments in this dynamic field of immunooncology. Keywords: atezolizumab, MPDL3280A, bladder cancer, PDL1, immunotherapy, metastatic atezolizumab MPDL3280A bladder cancer PD-L1 immunotherapy metastatic Neoplasms. Tumors. Oncology. Including cancer and carcinogens Woldu SL verfasserin aut Hutchinson RC verfasserin aut Boegemann M verfasserin aut Bagrodia A verfasserin aut Lotan Y verfasserin aut Margulis V verfasserin aut Krabbe LM verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2017), Seite 1487-1502 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2017 pages:1487-1502 https://doaj.org/article/4dfe5936408945b9b45c32ce1eb52e41 kostenfrei https://www.dovepress.com/spotlight-on-atezolizumab-and-its-potential-in-the-treatment-of-advanc-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2017 1487-1502
allfieldsGer	(DE-627)DOAJ011799099 (DE-599)DOAJ4dfe5936408945b9b45c32ce1eb52e41 DE-627 ger DE-627 rakwb eng RC254-282 Aydin AM verfasserin aut Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ahmet Murat Aydin,1,* Solomon L Woldu,1,* Ryan C Hutchinson,1 Martin Boegemann,2 Aditya Bagrodia,1 Yair Lotan,1 Vitaly Margulis,1 Laura-Maria Krabbe1,2 1Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Urology, University of Münster Medical Center, Münster, Germany *These authors contributed equally to this work Abstract: Metastatic urothelial carcinoma of the bladder is an aggressive malignancy with poor prognosis, reflecting a lack of effective systemic therapies. The current standard of care includes multiagent platinum-based chemotherapy; however a majority of patients do not respond to treatment and most eventually succumb to disease. Recently, renewed interest in immunotherapy in the form of immune-checkpoint inhibition has gained widespread attention for a number of malignancies. Atezolizumab, an anti-PDL1 antibody, has been shown to be effective in a subset of patients previously treated with or unfit for platinum-based chemotherapy, and has shown durable responses with a good tolerability profile. We review the mechanism of action and clinical evidence of atezolizumab for metastatic urothelial bladder cancer, and discuss this drug within the context of ongoing developments in this dynamic field of immunooncology. Keywords: atezolizumab, MPDL3280A, bladder cancer, PDL1, immunotherapy, metastatic atezolizumab MPDL3280A bladder cancer PD-L1 immunotherapy metastatic Neoplasms. Tumors. Oncology. Including cancer and carcinogens Woldu SL verfasserin aut Hutchinson RC verfasserin aut Boegemann M verfasserin aut Bagrodia A verfasserin aut Lotan Y verfasserin aut Margulis V verfasserin aut Krabbe LM verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2017), Seite 1487-1502 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2017 pages:1487-1502 https://doaj.org/article/4dfe5936408945b9b45c32ce1eb52e41 kostenfrei https://www.dovepress.com/spotlight-on-atezolizumab-and-its-potential-in-the-treatment-of-advanc-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2017 1487-1502
allfieldsSound	(DE-627)DOAJ011799099 (DE-599)DOAJ4dfe5936408945b9b45c32ce1eb52e41 DE-627 ger DE-627 rakwb eng RC254-282 Aydin AM verfasserin aut Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ahmet Murat Aydin,1,* Solomon L Woldu,1,* Ryan C Hutchinson,1 Martin Boegemann,2 Aditya Bagrodia,1 Yair Lotan,1 Vitaly Margulis,1 Laura-Maria Krabbe1,2 1Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Urology, University of Münster Medical Center, Münster, Germany *These authors contributed equally to this work Abstract: Metastatic urothelial carcinoma of the bladder is an aggressive malignancy with poor prognosis, reflecting a lack of effective systemic therapies. The current standard of care includes multiagent platinum-based chemotherapy; however a majority of patients do not respond to treatment and most eventually succumb to disease. Recently, renewed interest in immunotherapy in the form of immune-checkpoint inhibition has gained widespread attention for a number of malignancies. Atezolizumab, an anti-PDL1 antibody, has been shown to be effective in a subset of patients previously treated with or unfit for platinum-based chemotherapy, and has shown durable responses with a good tolerability profile. We review the mechanism of action and clinical evidence of atezolizumab for metastatic urothelial bladder cancer, and discuss this drug within the context of ongoing developments in this dynamic field of immunooncology. Keywords: atezolizumab, MPDL3280A, bladder cancer, PDL1, immunotherapy, metastatic atezolizumab MPDL3280A bladder cancer PD-L1 immunotherapy metastatic Neoplasms. Tumors. Oncology. Including cancer and carcinogens Woldu SL verfasserin aut Hutchinson RC verfasserin aut Boegemann M verfasserin aut Bagrodia A verfasserin aut Lotan Y verfasserin aut Margulis V verfasserin aut Krabbe LM verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2017), Seite 1487-1502 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2017 pages:1487-1502 https://doaj.org/article/4dfe5936408945b9b45c32ce1eb52e41 kostenfrei https://www.dovepress.com/spotlight-on-atezolizumab-and-its-potential-in-the-treatment-of-advanc-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2017 1487-1502
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callnumber-first	R - Medicine
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spellingShingle	Aydin AM misc RC254-282 misc atezolizumab misc MPDL3280A misc bladder cancer misc PD-L1 misc immunotherapy misc metastatic misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer
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topic_title	RC254-282 Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer atezolizumab MPDL3280A bladder cancer PD-L1 immunotherapy metastatic
topic	misc RC254-282 misc atezolizumab misc MPDL3280A misc bladder cancer misc PD-L1 misc immunotherapy misc metastatic misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc atezolizumab misc MPDL3280A misc bladder cancer misc PD-L1 misc immunotherapy misc metastatic misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer
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title_full	Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer
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title_sort	spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer
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title_auth	Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer
abstract	Ahmet Murat Aydin,1,* Solomon L Woldu,1,* Ryan C Hutchinson,1 Martin Boegemann,2 Aditya Bagrodia,1 Yair Lotan,1 Vitaly Margulis,1 Laura-Maria Krabbe1,2 1Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Urology, University of Münster Medical Center, Münster, Germany *These authors contributed equally to this work Abstract: Metastatic urothelial carcinoma of the bladder is an aggressive malignancy with poor prognosis, reflecting a lack of effective systemic therapies. The current standard of care includes multiagent platinum-based chemotherapy; however a majority of patients do not respond to treatment and most eventually succumb to disease. Recently, renewed interest in immunotherapy in the form of immune-checkpoint inhibition has gained widespread attention for a number of malignancies. Atezolizumab, an anti-PDL1 antibody, has been shown to be effective in a subset of patients previously treated with or unfit for platinum-based chemotherapy, and has shown durable responses with a good tolerability profile. We review the mechanism of action and clinical evidence of atezolizumab for metastatic urothelial bladder cancer, and discuss this drug within the context of ongoing developments in this dynamic field of immunooncology. Keywords: atezolizumab, MPDL3280A, bladder cancer, PDL1, immunotherapy, metastatic
abstractGer	Ahmet Murat Aydin,1,* Solomon L Woldu,1,* Ryan C Hutchinson,1 Martin Boegemann,2 Aditya Bagrodia,1 Yair Lotan,1 Vitaly Margulis,1 Laura-Maria Krabbe1,2 1Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Urology, University of Münster Medical Center, Münster, Germany *These authors contributed equally to this work Abstract: Metastatic urothelial carcinoma of the bladder is an aggressive malignancy with poor prognosis, reflecting a lack of effective systemic therapies. The current standard of care includes multiagent platinum-based chemotherapy; however a majority of patients do not respond to treatment and most eventually succumb to disease. Recently, renewed interest in immunotherapy in the form of immune-checkpoint inhibition has gained widespread attention for a number of malignancies. Atezolizumab, an anti-PDL1 antibody, has been shown to be effective in a subset of patients previously treated with or unfit for platinum-based chemotherapy, and has shown durable responses with a good tolerability profile. We review the mechanism of action and clinical evidence of atezolizumab for metastatic urothelial bladder cancer, and discuss this drug within the context of ongoing developments in this dynamic field of immunooncology. Keywords: atezolizumab, MPDL3280A, bladder cancer, PDL1, immunotherapy, metastatic
abstract_unstemmed	Ahmet Murat Aydin,1,* Solomon L Woldu,1,* Ryan C Hutchinson,1 Martin Boegemann,2 Aditya Bagrodia,1 Yair Lotan,1 Vitaly Margulis,1 Laura-Maria Krabbe1,2 1Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Urology, University of Münster Medical Center, Münster, Germany *These authors contributed equally to this work Abstract: Metastatic urothelial carcinoma of the bladder is an aggressive malignancy with poor prognosis, reflecting a lack of effective systemic therapies. The current standard of care includes multiagent platinum-based chemotherapy; however a majority of patients do not respond to treatment and most eventually succumb to disease. Recently, renewed interest in immunotherapy in the form of immune-checkpoint inhibition has gained widespread attention for a number of malignancies. Atezolizumab, an anti-PDL1 antibody, has been shown to be effective in a subset of patients previously treated with or unfit for platinum-based chemotherapy, and has shown durable responses with a good tolerability profile. We review the mechanism of action and clinical evidence of atezolizumab for metastatic urothelial bladder cancer, and discuss this drug within the context of ongoing developments in this dynamic field of immunooncology. Keywords: atezolizumab, MPDL3280A, bladder cancer, PDL1, immunotherapy, metastatic
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title_short	Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer
url	https://doaj.org/article/4dfe5936408945b9b45c32ce1eb52e41 https://www.dovepress.com/spotlight-on-atezolizumab-and-its-potential-in-the-treatment-of-advanc-peer-reviewed-article-OTT https://doaj.org/toc/1178-6930
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