Advances in the pathogenesis of psoriasis: from keratinocyte perspective

Abstract Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factor...
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Autor*in:	Xue Zhou [verfasserIn] Youdong Chen [verfasserIn] Lian Cui [verfasserIn] Yuling Shi [verfasserIn] Chunyuan Guo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: Cell Death and Disease - Nature Publishing Group, 2010, 13(2022), 1, Seite 13
Übergeordnetes Werk:	volume:13 ; year:2022 ; number:1 ; pages:13

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41419-022-04523-3

Katalog-ID:	DOAJ012000523

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allfields	10.1038/s41419-022-04523-3 doi (DE-627)DOAJ012000523 (DE-599)DOAJ96af80440909418e8f83366b0ab44993 DE-627 ger DE-627 rakwb eng QH573-671 Xue Zhou verfasserin aut Advances in the pathogenesis of psoriasis: from keratinocyte perspective 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis. Cytology Youdong Chen verfasserin aut Lian Cui verfasserin aut Yuling Shi verfasserin aut Chunyuan Guo verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 13(2022), 1, Seite 13 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:13 year:2022 number:1 pages:13 https://doi.org/10.1038/s41419-022-04523-3 kostenfrei https://doaj.org/article/96af80440909418e8f83366b0ab44993 kostenfrei https://doi.org/10.1038/s41419-022-04523-3 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 1 13
spelling	10.1038/s41419-022-04523-3 doi (DE-627)DOAJ012000523 (DE-599)DOAJ96af80440909418e8f83366b0ab44993 DE-627 ger DE-627 rakwb eng QH573-671 Xue Zhou verfasserin aut Advances in the pathogenesis of psoriasis: from keratinocyte perspective 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis. Cytology Youdong Chen verfasserin aut Lian Cui verfasserin aut Yuling Shi verfasserin aut Chunyuan Guo verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 13(2022), 1, Seite 13 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:13 year:2022 number:1 pages:13 https://doi.org/10.1038/s41419-022-04523-3 kostenfrei https://doaj.org/article/96af80440909418e8f83366b0ab44993 kostenfrei https://doi.org/10.1038/s41419-022-04523-3 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 1 13
allfields_unstemmed	10.1038/s41419-022-04523-3 doi (DE-627)DOAJ012000523 (DE-599)DOAJ96af80440909418e8f83366b0ab44993 DE-627 ger DE-627 rakwb eng QH573-671 Xue Zhou verfasserin aut Advances in the pathogenesis of psoriasis: from keratinocyte perspective 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis. Cytology Youdong Chen verfasserin aut Lian Cui verfasserin aut Yuling Shi verfasserin aut Chunyuan Guo verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 13(2022), 1, Seite 13 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:13 year:2022 number:1 pages:13 https://doi.org/10.1038/s41419-022-04523-3 kostenfrei https://doaj.org/article/96af80440909418e8f83366b0ab44993 kostenfrei https://doi.org/10.1038/s41419-022-04523-3 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 1 13
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title	Advances in the pathogenesis of psoriasis: from keratinocyte perspective
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title_sort	advances in the pathogenesis of psoriasis: from keratinocyte perspective
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title_auth	Advances in the pathogenesis of psoriasis: from keratinocyte perspective
abstract	Abstract Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis.
abstractGer	Abstract Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis.
abstract_unstemmed	Abstract Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis.
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title_short	Advances in the pathogenesis of psoriasis: from keratinocyte perspective
url	https://doi.org/10.1038/s41419-022-04523-3 https://doaj.org/article/96af80440909418e8f83366b0ab44993 https://doaj.org/toc/2041-4889
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