MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers

MicroRNAs are a class of small non-coding regulatory RNAs playing key roles in cancer. Breast cancer is the most common female malignancy worldwide and is categorized into four molecular subtypes: luminal A and B, HER2+ and triple-negative breast cancer (TNBC). Despite the development of multiple ta...
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Gespeichert in:

Autor*in:	Ilaria Plantamura [verfasserIn] Giulia Cosentino [verfasserIn] Alessandra Cataldo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	breast cancer DNA repair DNA damage response DNA-damaging drugs microRNAs

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 8(2018)
Übergeordnetes Werk:	volume:8 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2018.00352

Katalog-ID:	DOAJ012091960

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language	English
source	In Frontiers in Oncology 8(2018) volume:8 year:2018
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topic_facet	breast cancer DNA repair DNA damage response DNA-damaging drugs microRNAs Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Frontiers in Oncology
authorswithroles_txt_mv	Ilaria Plantamura @@aut@@ Giulia Cosentino @@aut@@ Alessandra Cataldo @@aut@@
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callnumber-first	R - Medicine
author	Ilaria Plantamura
spellingShingle	Ilaria Plantamura misc RC254-282 misc breast cancer misc DNA repair misc DNA damage response misc DNA-damaging drugs misc microRNAs misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers
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topic_title	RC254-282 MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers breast cancer DNA repair DNA damage response DNA-damaging drugs microRNAs
topic	misc RC254-282 misc breast cancer misc DNA repair misc DNA damage response misc DNA-damaging drugs misc microRNAs misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc breast cancer misc DNA repair misc DNA damage response misc DNA-damaging drugs misc microRNAs misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers
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title_sort	micrornas and dna-damaging drugs in breast cancer: strength in numbers
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title_auth	MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers
abstract	MicroRNAs are a class of small non-coding regulatory RNAs playing key roles in cancer. Breast cancer is the most common female malignancy worldwide and is categorized into four molecular subtypes: luminal A and B, HER2+ and triple-negative breast cancer (TNBC). Despite the development of multiple targeted therapies for luminal and HER2+ breast tumors, TNBC lacks specific therapeutic approaches, thus they are treated mainly with radio- and chemotherapy. The effectiveness of these therapeutic regimens is based on their ability to induce DNA damage, which is differentially resolved and repaired by normal vs. cancer cells. Recently, drugs directly targeting DNA repair mechanisms, such as PARP inhibitors, have emerged as attractive candidates for the future molecular targeted-therapy in breast cancer. These compounds prevent cancer cells to appropriate repair DNA double strand breaks and induce a phenomenon called synthetic lethality, that results from the concurrent inhibition of PARP and the absence of functional BRCA genes which prompt cell death. MicroRNAs are relevant players in most of the biological processes including DNA damage repair mechanisms. Consistently, the downregulation of DNA repair genes by miRNAs have been probe to improve the therapeutic effect of genotoxic drugs. In this review, we discuss how microRNAs can sensitize cancer cells to DNA-damaging drugs, through the regulation of DNA repair genes, and examine the most recent findings on their possible use as a therapeutic tools of treatment response in breast cancer.
abstractGer	MicroRNAs are a class of small non-coding regulatory RNAs playing key roles in cancer. Breast cancer is the most common female malignancy worldwide and is categorized into four molecular subtypes: luminal A and B, HER2+ and triple-negative breast cancer (TNBC). Despite the development of multiple targeted therapies for luminal and HER2+ breast tumors, TNBC lacks specific therapeutic approaches, thus they are treated mainly with radio- and chemotherapy. The effectiveness of these therapeutic regimens is based on their ability to induce DNA damage, which is differentially resolved and repaired by normal vs. cancer cells. Recently, drugs directly targeting DNA repair mechanisms, such as PARP inhibitors, have emerged as attractive candidates for the future molecular targeted-therapy in breast cancer. These compounds prevent cancer cells to appropriate repair DNA double strand breaks and induce a phenomenon called synthetic lethality, that results from the concurrent inhibition of PARP and the absence of functional BRCA genes which prompt cell death. MicroRNAs are relevant players in most of the biological processes including DNA damage repair mechanisms. Consistently, the downregulation of DNA repair genes by miRNAs have been probe to improve the therapeutic effect of genotoxic drugs. In this review, we discuss how microRNAs can sensitize cancer cells to DNA-damaging drugs, through the regulation of DNA repair genes, and examine the most recent findings on their possible use as a therapeutic tools of treatment response in breast cancer.
abstract_unstemmed	MicroRNAs are a class of small non-coding regulatory RNAs playing key roles in cancer. Breast cancer is the most common female malignancy worldwide and is categorized into four molecular subtypes: luminal A and B, HER2+ and triple-negative breast cancer (TNBC). Despite the development of multiple targeted therapies for luminal and HER2+ breast tumors, TNBC lacks specific therapeutic approaches, thus they are treated mainly with radio- and chemotherapy. The effectiveness of these therapeutic regimens is based on their ability to induce DNA damage, which is differentially resolved and repaired by normal vs. cancer cells. Recently, drugs directly targeting DNA repair mechanisms, such as PARP inhibitors, have emerged as attractive candidates for the future molecular targeted-therapy in breast cancer. These compounds prevent cancer cells to appropriate repair DNA double strand breaks and induce a phenomenon called synthetic lethality, that results from the concurrent inhibition of PARP and the absence of functional BRCA genes which prompt cell death. MicroRNAs are relevant players in most of the biological processes including DNA damage repair mechanisms. Consistently, the downregulation of DNA repair genes by miRNAs have been probe to improve the therapeutic effect of genotoxic drugs. In this review, we discuss how microRNAs can sensitize cancer cells to DNA-damaging drugs, through the regulation of DNA repair genes, and examine the most recent findings on their possible use as a therapeutic tools of treatment response in breast cancer.
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title_short	MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers
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