Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis
IntroductionThe mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.Materials and MethodsThe protein expression of all ligaments in ankylosing spondylitis with femora...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jie Jiang [verfasserIn] Xinli Zhan [verfasserIn] Tuo Liang [verfasserIn] Liyi Chen [verfasserIn] Shengsheng Huang [verfasserIn] Xuhua Sun [verfasserIn] Wenyong Jiang [verfasserIn] Jiarui Chen [verfasserIn] Tianyou Chen [verfasserIn] Hao Li [verfasserIn] Yuanlin Yao [verfasserIn] Shaofeng Wu [verfasserIn] Jichong Zhu [verfasserIn] Chong Liu [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Übergeordnetes Werk: |
In: Frontiers in Immunology - Frontiers Media S.A., 2011, 12(2022) |
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| Übergeordnetes Werk: |
volume:12 ; year:2022 |
| Links: |
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| DOI / URN: |
10.3389/fimmu.2021.814278 |
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| Katalog-ID: |
DOAJ012100250 |
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| 520 | |a IntroductionThe mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.Materials and MethodsThe protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis.ResultsSAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P < 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P < 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity.ConclusionDysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis. | ||
| 650 | 4 | |a ankylosing spondylitis | |
| 650 | 4 | |a immune cell infiltration | |
| 650 | 4 | |a immune cell composition analysis | |
| 650 | 4 | |a femoral head necrosis | |
| 650 | 4 | |a protein park analysis | |
| 650 | 4 | |a weighted gene co-expression network analysis | |
| 653 | 0 | |a Immunologic diseases. Allergy | |
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| 700 | 0 | |a Jichong Zhu |e verfasserin |4 aut | |
| 700 | 0 | |a Chong Liu |e verfasserin |4 aut | |
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10.3389/fimmu.2021.814278 doi (DE-627)DOAJ012100250 (DE-599)DOAJd5fdde98fc244d66986aab806a816bfc DE-627 ger DE-627 rakwb eng RC581-607 Jie Jiang verfasserin aut Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.Materials and MethodsThe protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis.ResultsSAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P < 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P < 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity.ConclusionDysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis. ankylosing spondylitis immune cell infiltration immune cell composition analysis femoral head necrosis protein park analysis weighted gene co-expression network analysis Immunologic diseases. Allergy Xinli Zhan verfasserin aut Tuo Liang verfasserin aut Liyi Chen verfasserin aut Shengsheng Huang verfasserin aut Xuhua Sun verfasserin aut Wenyong Jiang verfasserin aut Jiarui Chen verfasserin aut Tianyou Chen verfasserin aut Hao Li verfasserin aut Yuanlin Yao verfasserin aut Shaofeng Wu verfasserin aut Jichong Zhu verfasserin aut Chong Liu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2022 https://doi.org/10.3389/fimmu.2021.814278 kostenfrei https://doaj.org/article/d5fdde98fc244d66986aab806a816bfc kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.814278/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 |
| spelling |
10.3389/fimmu.2021.814278 doi (DE-627)DOAJ012100250 (DE-599)DOAJd5fdde98fc244d66986aab806a816bfc DE-627 ger DE-627 rakwb eng RC581-607 Jie Jiang verfasserin aut Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.Materials and MethodsThe protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis.ResultsSAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P < 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P < 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity.ConclusionDysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis. ankylosing spondylitis immune cell infiltration immune cell composition analysis femoral head necrosis protein park analysis weighted gene co-expression network analysis Immunologic diseases. Allergy Xinli Zhan verfasserin aut Tuo Liang verfasserin aut Liyi Chen verfasserin aut Shengsheng Huang verfasserin aut Xuhua Sun verfasserin aut Wenyong Jiang verfasserin aut Jiarui Chen verfasserin aut Tianyou Chen verfasserin aut Hao Li verfasserin aut Yuanlin Yao verfasserin aut Shaofeng Wu verfasserin aut Jichong Zhu verfasserin aut Chong Liu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2022 https://doi.org/10.3389/fimmu.2021.814278 kostenfrei https://doaj.org/article/d5fdde98fc244d66986aab806a816bfc kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.814278/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 |
| allfields_unstemmed |
10.3389/fimmu.2021.814278 doi (DE-627)DOAJ012100250 (DE-599)DOAJd5fdde98fc244d66986aab806a816bfc DE-627 ger DE-627 rakwb eng RC581-607 Jie Jiang verfasserin aut Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.Materials and MethodsThe protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis.ResultsSAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P < 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P < 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity.ConclusionDysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis. ankylosing spondylitis immune cell infiltration immune cell composition analysis femoral head necrosis protein park analysis weighted gene co-expression network analysis Immunologic diseases. Allergy Xinli Zhan verfasserin aut Tuo Liang verfasserin aut Liyi Chen verfasserin aut Shengsheng Huang verfasserin aut Xuhua Sun verfasserin aut Wenyong Jiang verfasserin aut Jiarui Chen verfasserin aut Tianyou Chen verfasserin aut Hao Li verfasserin aut Yuanlin Yao verfasserin aut Shaofeng Wu verfasserin aut Jichong Zhu verfasserin aut Chong Liu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2022 https://doi.org/10.3389/fimmu.2021.814278 kostenfrei https://doaj.org/article/d5fdde98fc244d66986aab806a816bfc kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.814278/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 |
| allfieldsGer |
10.3389/fimmu.2021.814278 doi (DE-627)DOAJ012100250 (DE-599)DOAJd5fdde98fc244d66986aab806a816bfc DE-627 ger DE-627 rakwb eng RC581-607 Jie Jiang verfasserin aut Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.Materials and MethodsThe protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis.ResultsSAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P < 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P < 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity.ConclusionDysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis. ankylosing spondylitis immune cell infiltration immune cell composition analysis femoral head necrosis protein park analysis weighted gene co-expression network analysis Immunologic diseases. Allergy Xinli Zhan verfasserin aut Tuo Liang verfasserin aut Liyi Chen verfasserin aut Shengsheng Huang verfasserin aut Xuhua Sun verfasserin aut Wenyong Jiang verfasserin aut Jiarui Chen verfasserin aut Tianyou Chen verfasserin aut Hao Li verfasserin aut Yuanlin Yao verfasserin aut Shaofeng Wu verfasserin aut Jichong Zhu verfasserin aut Chong Liu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2022 https://doi.org/10.3389/fimmu.2021.814278 kostenfrei https://doaj.org/article/d5fdde98fc244d66986aab806a816bfc kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.814278/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 |
| allfieldsSound |
10.3389/fimmu.2021.814278 doi (DE-627)DOAJ012100250 (DE-599)DOAJd5fdde98fc244d66986aab806a816bfc DE-627 ger DE-627 rakwb eng RC581-607 Jie Jiang verfasserin aut Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.Materials and MethodsThe protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis.ResultsSAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P < 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P < 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity.ConclusionDysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis. ankylosing spondylitis immune cell infiltration immune cell composition analysis femoral head necrosis protein park analysis weighted gene co-expression network analysis Immunologic diseases. Allergy Xinli Zhan verfasserin aut Tuo Liang verfasserin aut Liyi Chen verfasserin aut Shengsheng Huang verfasserin aut Xuhua Sun verfasserin aut Wenyong Jiang verfasserin aut Jiarui Chen verfasserin aut Tianyou Chen verfasserin aut Hao Li verfasserin aut Yuanlin Yao verfasserin aut Shaofeng Wu verfasserin aut Jichong Zhu verfasserin aut Chong Liu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2022 https://doi.org/10.3389/fimmu.2021.814278 kostenfrei https://doaj.org/article/d5fdde98fc244d66986aab806a816bfc kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.814278/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 |
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Jie Jiang @@aut@@ Xinli Zhan @@aut@@ Tuo Liang @@aut@@ Liyi Chen @@aut@@ Shengsheng Huang @@aut@@ Xuhua Sun @@aut@@ Wenyong Jiang @@aut@@ Jiarui Chen @@aut@@ Tianyou Chen @@aut@@ Hao Li @@aut@@ Yuanlin Yao @@aut@@ Shaofeng Wu @@aut@@ Jichong Zhu @@aut@@ Chong Liu @@aut@@ |
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RC581-607 Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis ankylosing spondylitis immune cell infiltration immune cell composition analysis femoral head necrosis protein park analysis weighted gene co-expression network analysis |
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dysregulation of saa1, tuba8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis |
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Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis |
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IntroductionThe mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.Materials and MethodsThe protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis.ResultsSAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P < 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P < 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity.ConclusionDysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis. |
| abstractGer |
IntroductionThe mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.Materials and MethodsThe protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis.ResultsSAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P < 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P < 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity.ConclusionDysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis. |
| abstract_unstemmed |
IntroductionThe mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.Materials and MethodsThe protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis.ResultsSAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P < 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P < 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity.ConclusionDysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ012100250</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230310042305.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3389/fimmu.2021.814278</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ012100250</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJd5fdde98fc244d66986aab806a816bfc</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC581-607</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Jie Jiang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">IntroductionThe mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.Materials and MethodsThe protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis.ResultsSAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P &lt; 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P &lt; 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity.ConclusionDysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ankylosing spondylitis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">immune cell infiltration</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">immune cell composition analysis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">femoral head necrosis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">protein park analysis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">weighted gene co-expression network analysis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Immunologic diseases. Allergy</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xinli Zhan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tuo Liang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Liyi Chen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shengsheng Huang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xuhua Sun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wenyong Jiang</subfield><subfield code="e">verfasserin</subfield><subfield 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