Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design

Black mulberry, <i<Morus nigra</i< L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solvent-free microwave extraction. The aim of this study was to optimize for the first time the MHG so...
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Autor*in:	Ahmed M. Mustafa [verfasserIn] Eugenia Mazzara [verfasserIn] Doaa Abouelenein [verfasserIn] Simone Angeloni [verfasserIn] Sonia Nunez [verfasserIn] Gianni Sagratini [verfasserIn] Víctor López [verfasserIn] Marco Cespi [verfasserIn] Sauro Vittori [verfasserIn] Giovanni Caprioli [verfasserIn] Filippo Maggi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	microwave hydrodiffusion and gravity polyphenols sugar content lipase

Übergeordnetes Werk:	In: Pharmaceuticals - MDPI AG, 2005, 15(2022), 1, p 99
Übergeordnetes Werk:	volume:15 ; year:2022 ; number:1, p 99

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ph15010099

Katalog-ID:	DOAJ012117277

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520			\|a Black mulberry, <i<Morus nigra</i< L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solvent-free microwave extraction. The aim of this study was to optimize for the first time the MHG solvent-free extraction of polyphenols and sugars from <i<M. nigra</i< fruits. Optimization was carried out using a central composite design (CCD) with selected responses such as extraction yield, total polyphenol (TPC), flavonoid (TFC), anthocyanin (TAC), and sugar (TSC) contents, in addition to DPPH radical scavenging, and α-glucosidase (AGHi), lipase (Li), and xanthine oxidase (XOi) inhibition as tools to evaluate the best parameters for efficient and rapid extraction of black mulberry. The optimized extract was characterized in terms of the aforementioned parameters to validate the models, and was further analyzed for 36 individual polyphenols using HPLC-MS/MS. The optimized MHG extract was finally compared with traditional extracts, and demonstrated much better performance in terms of TPC, TAC, and Li, while the traditional extracts showed better XOi and AGHi. In conclusion, MHG is a valuable green technique for the production of non-degraded black mulberry polyphenol-rich extract and we suggest its larger use in the pharmaceutical and food industries.
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allfields	10.3390/ph15010099 doi (DE-627)DOAJ012117277 (DE-599)DOAJ214fb8dacce044928ecf322d3e2e31da DE-627 ger DE-627 rakwb eng RS1-441 Ahmed M. Mustafa verfasserin aut Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Black mulberry, <i<Morus nigra</i< L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solvent-free microwave extraction. The aim of this study was to optimize for the first time the MHG solvent-free extraction of polyphenols and sugars from <i<M. nigra</i< fruits. Optimization was carried out using a central composite design (CCD) with selected responses such as extraction yield, total polyphenol (TPC), flavonoid (TFC), anthocyanin (TAC), and sugar (TSC) contents, in addition to DPPH radical scavenging, and α-glucosidase (AGHi), lipase (Li), and xanthine oxidase (XOi) inhibition as tools to evaluate the best parameters for efficient and rapid extraction of black mulberry. The optimized extract was characterized in terms of the aforementioned parameters to validate the models, and was further analyzed for 36 individual polyphenols using HPLC-MS/MS. The optimized MHG extract was finally compared with traditional extracts, and demonstrated much better performance in terms of TPC, TAC, and Li, while the traditional extracts showed better XOi and AGHi. In conclusion, MHG is a valuable green technique for the production of non-degraded black mulberry polyphenol-rich extract and we suggest its larger use in the pharmaceutical and food industries. <i<Morus nigra</i< microwave hydrodiffusion and gravity polyphenols sugar content <i<α</i<-glucosidase lipase Medicine R Pharmacy and materia medica Eugenia Mazzara verfasserin aut Doaa Abouelenein verfasserin aut Simone Angeloni verfasserin aut Sonia Nunez verfasserin aut Gianni Sagratini verfasserin aut Víctor López verfasserin aut Marco Cespi verfasserin aut Sauro Vittori verfasserin aut Giovanni Caprioli verfasserin aut Filippo Maggi verfasserin aut In Pharmaceuticals MDPI AG, 2005 15(2022), 1, p 99 (DE-627)491437528 (DE-600)2193542-7 14248247 nnns volume:15 year:2022 number:1, p 99 https://doi.org/10.3390/ph15010099 kostenfrei https://doaj.org/article/214fb8dacce044928ecf322d3e2e31da kostenfrei https://www.mdpi.com/1424-8247/15/1/99 kostenfrei https://doaj.org/toc/1424-8247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 1, p 99
spelling	10.3390/ph15010099 doi (DE-627)DOAJ012117277 (DE-599)DOAJ214fb8dacce044928ecf322d3e2e31da DE-627 ger DE-627 rakwb eng RS1-441 Ahmed M. Mustafa verfasserin aut Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Black mulberry, <i<Morus nigra</i< L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solvent-free microwave extraction. The aim of this study was to optimize for the first time the MHG solvent-free extraction of polyphenols and sugars from <i<M. nigra</i< fruits. Optimization was carried out using a central composite design (CCD) with selected responses such as extraction yield, total polyphenol (TPC), flavonoid (TFC), anthocyanin (TAC), and sugar (TSC) contents, in addition to DPPH radical scavenging, and α-glucosidase (AGHi), lipase (Li), and xanthine oxidase (XOi) inhibition as tools to evaluate the best parameters for efficient and rapid extraction of black mulberry. The optimized extract was characterized in terms of the aforementioned parameters to validate the models, and was further analyzed for 36 individual polyphenols using HPLC-MS/MS. The optimized MHG extract was finally compared with traditional extracts, and demonstrated much better performance in terms of TPC, TAC, and Li, while the traditional extracts showed better XOi and AGHi. In conclusion, MHG is a valuable green technique for the production of non-degraded black mulberry polyphenol-rich extract and we suggest its larger use in the pharmaceutical and food industries. <i<Morus nigra</i< microwave hydrodiffusion and gravity polyphenols sugar content <i<α</i<-glucosidase lipase Medicine R Pharmacy and materia medica Eugenia Mazzara verfasserin aut Doaa Abouelenein verfasserin aut Simone Angeloni verfasserin aut Sonia Nunez verfasserin aut Gianni Sagratini verfasserin aut Víctor López verfasserin aut Marco Cespi verfasserin aut Sauro Vittori verfasserin aut Giovanni Caprioli verfasserin aut Filippo Maggi verfasserin aut In Pharmaceuticals MDPI AG, 2005 15(2022), 1, p 99 (DE-627)491437528 (DE-600)2193542-7 14248247 nnns volume:15 year:2022 number:1, p 99 https://doi.org/10.3390/ph15010099 kostenfrei https://doaj.org/article/214fb8dacce044928ecf322d3e2e31da kostenfrei https://www.mdpi.com/1424-8247/15/1/99 kostenfrei https://doaj.org/toc/1424-8247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 1, p 99
allfields_unstemmed	10.3390/ph15010099 doi (DE-627)DOAJ012117277 (DE-599)DOAJ214fb8dacce044928ecf322d3e2e31da DE-627 ger DE-627 rakwb eng RS1-441 Ahmed M. Mustafa verfasserin aut Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Black mulberry, <i<Morus nigra</i< L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solvent-free microwave extraction. The aim of this study was to optimize for the first time the MHG solvent-free extraction of polyphenols and sugars from <i<M. nigra</i< fruits. Optimization was carried out using a central composite design (CCD) with selected responses such as extraction yield, total polyphenol (TPC), flavonoid (TFC), anthocyanin (TAC), and sugar (TSC) contents, in addition to DPPH radical scavenging, and α-glucosidase (AGHi), lipase (Li), and xanthine oxidase (XOi) inhibition as tools to evaluate the best parameters for efficient and rapid extraction of black mulberry. The optimized extract was characterized in terms of the aforementioned parameters to validate the models, and was further analyzed for 36 individual polyphenols using HPLC-MS/MS. The optimized MHG extract was finally compared with traditional extracts, and demonstrated much better performance in terms of TPC, TAC, and Li, while the traditional extracts showed better XOi and AGHi. In conclusion, MHG is a valuable green technique for the production of non-degraded black mulberry polyphenol-rich extract and we suggest its larger use in the pharmaceutical and food industries. <i<Morus nigra</i< microwave hydrodiffusion and gravity polyphenols sugar content <i<α</i<-glucosidase lipase Medicine R Pharmacy and materia medica Eugenia Mazzara verfasserin aut Doaa Abouelenein verfasserin aut Simone Angeloni verfasserin aut Sonia Nunez verfasserin aut Gianni Sagratini verfasserin aut Víctor López verfasserin aut Marco Cespi verfasserin aut Sauro Vittori verfasserin aut Giovanni Caprioli verfasserin aut Filippo Maggi verfasserin aut In Pharmaceuticals MDPI AG, 2005 15(2022), 1, p 99 (DE-627)491437528 (DE-600)2193542-7 14248247 nnns volume:15 year:2022 number:1, p 99 https://doi.org/10.3390/ph15010099 kostenfrei https://doaj.org/article/214fb8dacce044928ecf322d3e2e31da kostenfrei https://www.mdpi.com/1424-8247/15/1/99 kostenfrei https://doaj.org/toc/1424-8247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 1, p 99
allfieldsGer	10.3390/ph15010099 doi (DE-627)DOAJ012117277 (DE-599)DOAJ214fb8dacce044928ecf322d3e2e31da DE-627 ger DE-627 rakwb eng RS1-441 Ahmed M. Mustafa verfasserin aut Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Black mulberry, <i<Morus nigra</i< L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solvent-free microwave extraction. The aim of this study was to optimize for the first time the MHG solvent-free extraction of polyphenols and sugars from <i<M. nigra</i< fruits. Optimization was carried out using a central composite design (CCD) with selected responses such as extraction yield, total polyphenol (TPC), flavonoid (TFC), anthocyanin (TAC), and sugar (TSC) contents, in addition to DPPH radical scavenging, and α-glucosidase (AGHi), lipase (Li), and xanthine oxidase (XOi) inhibition as tools to evaluate the best parameters for efficient and rapid extraction of black mulberry. The optimized extract was characterized in terms of the aforementioned parameters to validate the models, and was further analyzed for 36 individual polyphenols using HPLC-MS/MS. The optimized MHG extract was finally compared with traditional extracts, and demonstrated much better performance in terms of TPC, TAC, and Li, while the traditional extracts showed better XOi and AGHi. In conclusion, MHG is a valuable green technique for the production of non-degraded black mulberry polyphenol-rich extract and we suggest its larger use in the pharmaceutical and food industries. <i<Morus nigra</i< microwave hydrodiffusion and gravity polyphenols sugar content <i<α</i<-glucosidase lipase Medicine R Pharmacy and materia medica Eugenia Mazzara verfasserin aut Doaa Abouelenein verfasserin aut Simone Angeloni verfasserin aut Sonia Nunez verfasserin aut Gianni Sagratini verfasserin aut Víctor López verfasserin aut Marco Cespi verfasserin aut Sauro Vittori verfasserin aut Giovanni Caprioli verfasserin aut Filippo Maggi verfasserin aut In Pharmaceuticals MDPI AG, 2005 15(2022), 1, p 99 (DE-627)491437528 (DE-600)2193542-7 14248247 nnns volume:15 year:2022 number:1, p 99 https://doi.org/10.3390/ph15010099 kostenfrei https://doaj.org/article/214fb8dacce044928ecf322d3e2e31da kostenfrei https://www.mdpi.com/1424-8247/15/1/99 kostenfrei https://doaj.org/toc/1424-8247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 1, p 99
allfieldsSound	10.3390/ph15010099 doi (DE-627)DOAJ012117277 (DE-599)DOAJ214fb8dacce044928ecf322d3e2e31da DE-627 ger DE-627 rakwb eng RS1-441 Ahmed M. Mustafa verfasserin aut Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Black mulberry, <i<Morus nigra</i< L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solvent-free microwave extraction. The aim of this study was to optimize for the first time the MHG solvent-free extraction of polyphenols and sugars from <i<M. nigra</i< fruits. Optimization was carried out using a central composite design (CCD) with selected responses such as extraction yield, total polyphenol (TPC), flavonoid (TFC), anthocyanin (TAC), and sugar (TSC) contents, in addition to DPPH radical scavenging, and α-glucosidase (AGHi), lipase (Li), and xanthine oxidase (XOi) inhibition as tools to evaluate the best parameters for efficient and rapid extraction of black mulberry. The optimized extract was characterized in terms of the aforementioned parameters to validate the models, and was further analyzed for 36 individual polyphenols using HPLC-MS/MS. The optimized MHG extract was finally compared with traditional extracts, and demonstrated much better performance in terms of TPC, TAC, and Li, while the traditional extracts showed better XOi and AGHi. In conclusion, MHG is a valuable green technique for the production of non-degraded black mulberry polyphenol-rich extract and we suggest its larger use in the pharmaceutical and food industries. <i<Morus nigra</i< microwave hydrodiffusion and gravity polyphenols sugar content <i<α</i<-glucosidase lipase Medicine R Pharmacy and materia medica Eugenia Mazzara verfasserin aut Doaa Abouelenein verfasserin aut Simone Angeloni verfasserin aut Sonia Nunez verfasserin aut Gianni Sagratini verfasserin aut Víctor López verfasserin aut Marco Cespi verfasserin aut Sauro Vittori verfasserin aut Giovanni Caprioli verfasserin aut Filippo Maggi verfasserin aut In Pharmaceuticals MDPI AG, 2005 15(2022), 1, p 99 (DE-627)491437528 (DE-600)2193542-7 14248247 nnns volume:15 year:2022 number:1, p 99 https://doi.org/10.3390/ph15010099 kostenfrei https://doaj.org/article/214fb8dacce044928ecf322d3e2e31da kostenfrei https://www.mdpi.com/1424-8247/15/1/99 kostenfrei https://doaj.org/toc/1424-8247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 1, p 99
language	English
source	In Pharmaceuticals 15(2022), 1, p 99 volume:15 year:2022 number:1, p 99
sourceStr	In Pharmaceuticals 15(2022), 1, p 99 volume:15 year:2022 number:1, p 99
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	<i<Morus nigra</i< microwave hydrodiffusion and gravity polyphenols sugar content <i<α</i<-glucosidase lipase Medicine R Pharmacy and materia medica
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container_title	Pharmaceuticals
authorswithroles_txt_mv	Ahmed M. Mustafa @@aut@@ Eugenia Mazzara @@aut@@ Doaa Abouelenein @@aut@@ Simone Angeloni @@aut@@ Sonia Nunez @@aut@@ Gianni Sagratini @@aut@@ Víctor López @@aut@@ Marco Cespi @@aut@@ Sauro Vittori @@aut@@ Giovanni Caprioli @@aut@@ Filippo Maggi @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Ahmed M. Mustafa
spellingShingle	Ahmed M. Mustafa misc RS1-441 misc <i<Morus nigra</i< misc microwave hydrodiffusion and gravity misc polyphenols misc sugar content misc <i<α</i<-glucosidase misc lipase misc Medicine misc R misc Pharmacy and materia medica Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design
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topic_title	RS1-441 Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design <i<Morus nigra</i< microwave hydrodiffusion and gravity polyphenols sugar content <i<α</i<-glucosidase lipase
topic	misc RS1-441 misc <i<Morus nigra</i< misc microwave hydrodiffusion and gravity misc polyphenols misc sugar content misc <i<α</i<-glucosidase misc lipase misc Medicine misc R misc Pharmacy and materia medica
topic_unstemmed	misc RS1-441 misc <i<Morus nigra</i< misc microwave hydrodiffusion and gravity misc polyphenols misc sugar content misc <i<α</i<-glucosidase misc lipase misc Medicine misc R misc Pharmacy and materia medica
topic_browse	misc RS1-441 misc <i<Morus nigra</i< misc microwave hydrodiffusion and gravity misc polyphenols misc sugar content misc <i<α</i<-glucosidase misc lipase misc Medicine misc R misc Pharmacy and materia medica
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title	Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design
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title_full	Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design
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author_browse	Ahmed M. Mustafa Eugenia Mazzara Doaa Abouelenein Simone Angeloni Sonia Nunez Gianni Sagratini Víctor López Marco Cespi Sauro Vittori Giovanni Caprioli Filippo Maggi
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title_sort	optimization of solvent-free microwave-assisted hydrodiffusion and gravity extraction of <i<morus nigra</i< l. fruits maximizing polyphenols, sugar content, and biological activities using central composite design
callnumber	RS1-441
title_auth	Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design
abstract	Black mulberry, <i<Morus nigra</i< L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solvent-free microwave extraction. The aim of this study was to optimize for the first time the MHG solvent-free extraction of polyphenols and sugars from <i<M. nigra</i< fruits. Optimization was carried out using a central composite design (CCD) with selected responses such as extraction yield, total polyphenol (TPC), flavonoid (TFC), anthocyanin (TAC), and sugar (TSC) contents, in addition to DPPH radical scavenging, and α-glucosidase (AGHi), lipase (Li), and xanthine oxidase (XOi) inhibition as tools to evaluate the best parameters for efficient and rapid extraction of black mulberry. The optimized extract was characterized in terms of the aforementioned parameters to validate the models, and was further analyzed for 36 individual polyphenols using HPLC-MS/MS. The optimized MHG extract was finally compared with traditional extracts, and demonstrated much better performance in terms of TPC, TAC, and Li, while the traditional extracts showed better XOi and AGHi. In conclusion, MHG is a valuable green technique for the production of non-degraded black mulberry polyphenol-rich extract and we suggest its larger use in the pharmaceutical and food industries.
abstractGer	Black mulberry, <i<Morus nigra</i< L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solvent-free microwave extraction. The aim of this study was to optimize for the first time the MHG solvent-free extraction of polyphenols and sugars from <i<M. nigra</i< fruits. Optimization was carried out using a central composite design (CCD) with selected responses such as extraction yield, total polyphenol (TPC), flavonoid (TFC), anthocyanin (TAC), and sugar (TSC) contents, in addition to DPPH radical scavenging, and α-glucosidase (AGHi), lipase (Li), and xanthine oxidase (XOi) inhibition as tools to evaluate the best parameters for efficient and rapid extraction of black mulberry. The optimized extract was characterized in terms of the aforementioned parameters to validate the models, and was further analyzed for 36 individual polyphenols using HPLC-MS/MS. The optimized MHG extract was finally compared with traditional extracts, and demonstrated much better performance in terms of TPC, TAC, and Li, while the traditional extracts showed better XOi and AGHi. In conclusion, MHG is a valuable green technique for the production of non-degraded black mulberry polyphenol-rich extract and we suggest its larger use in the pharmaceutical and food industries.
abstract_unstemmed	Black mulberry, <i<Morus nigra</i< L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solvent-free microwave extraction. The aim of this study was to optimize for the first time the MHG solvent-free extraction of polyphenols and sugars from <i<M. nigra</i< fruits. Optimization was carried out using a central composite design (CCD) with selected responses such as extraction yield, total polyphenol (TPC), flavonoid (TFC), anthocyanin (TAC), and sugar (TSC) contents, in addition to DPPH radical scavenging, and α-glucosidase (AGHi), lipase (Li), and xanthine oxidase (XOi) inhibition as tools to evaluate the best parameters for efficient and rapid extraction of black mulberry. The optimized extract was characterized in terms of the aforementioned parameters to validate the models, and was further analyzed for 36 individual polyphenols using HPLC-MS/MS. The optimized MHG extract was finally compared with traditional extracts, and demonstrated much better performance in terms of TPC, TAC, and Li, while the traditional extracts showed better XOi and AGHi. In conclusion, MHG is a valuable green technique for the production of non-degraded black mulberry polyphenol-rich extract and we suggest its larger use in the pharmaceutical and food industries.
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title_short	Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of <i<Morus nigra</i< L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design
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author2	Eugenia Mazzara Doaa Abouelenein Simone Angeloni Sonia Nunez Gianni Sagratini Víctor López Marco Cespi Sauro Vittori Giovanni Caprioli Filippo Maggi
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