Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics

The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reac...
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Gespeichert in:

Autor*in:	Ting Chen [verfasserIn] Weiwei Zeng [verfasserIn] Changjun Tie [verfasserIn] Mian Yu [verfasserIn] Huisong Hao [verfasserIn] Yang Deng [verfasserIn] Qianqian Li [verfasserIn] Hairong Zheng [verfasserIn] Meiying Wu [verfasserIn] Lin Mei [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic

Übergeordnetes Werk:	In: Bioactive Materials - KeAi Communications Co., Ltd., 2017, 10(2022), Seite 515-525
Übergeordnetes Werk:	volume:10 ; year:2022 ; pages:515-525

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.bioactmat.2021.09.016

Katalog-ID:	DOAJ012150169

Internformat


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allfields	10.1016/j.bioactmat.2021.09.016 doi (DE-627)DOAJ012150169 (DE-599)DOAJ1736e1b770c14cbe97f461bab5836d95 DE-627 ger DE-627 rakwb eng TA401-492 QH301-705.5 Ting Chen verfasserin aut Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reactive oxygen species (ROS), which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety. Herein, we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO2 on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently (Au/BPMS). The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO2-mediated O2 generation and GSH depletion, thus leading to notable inhibition effect on tumor growth. Moreover, tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics. Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic Materials of engineering and construction. Mechanics of materials Biology (General) Weiwei Zeng verfasserin aut Changjun Tie verfasserin aut Mian Yu verfasserin aut Huisong Hao verfasserin aut Yang Deng verfasserin aut Qianqian Li verfasserin aut Hairong Zheng verfasserin aut Meiying Wu verfasserin aut Lin Mei verfasserin aut In Bioactive Materials KeAi Communications Co., Ltd., 2017 10(2022), Seite 515-525 (DE-627)1663654956 (DE-600)2970496-0 2452199X nnns volume:10 year:2022 pages:515-525 https://doi.org/10.1016/j.bioactmat.2021.09.016 kostenfrei https://doaj.org/article/1736e1b770c14cbe97f461bab5836d95 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452199X21004345 kostenfrei https://doaj.org/toc/2452-199X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 515-525
spelling	10.1016/j.bioactmat.2021.09.016 doi (DE-627)DOAJ012150169 (DE-599)DOAJ1736e1b770c14cbe97f461bab5836d95 DE-627 ger DE-627 rakwb eng TA401-492 QH301-705.5 Ting Chen verfasserin aut Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reactive oxygen species (ROS), which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety. Herein, we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO2 on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently (Au/BPMS). The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO2-mediated O2 generation and GSH depletion, thus leading to notable inhibition effect on tumor growth. Moreover, tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics. Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic Materials of engineering and construction. Mechanics of materials Biology (General) Weiwei Zeng verfasserin aut Changjun Tie verfasserin aut Mian Yu verfasserin aut Huisong Hao verfasserin aut Yang Deng verfasserin aut Qianqian Li verfasserin aut Hairong Zheng verfasserin aut Meiying Wu verfasserin aut Lin Mei verfasserin aut In Bioactive Materials KeAi Communications Co., Ltd., 2017 10(2022), Seite 515-525 (DE-627)1663654956 (DE-600)2970496-0 2452199X nnns volume:10 year:2022 pages:515-525 https://doi.org/10.1016/j.bioactmat.2021.09.016 kostenfrei https://doaj.org/article/1736e1b770c14cbe97f461bab5836d95 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452199X21004345 kostenfrei https://doaj.org/toc/2452-199X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 515-525
allfields_unstemmed	10.1016/j.bioactmat.2021.09.016 doi (DE-627)DOAJ012150169 (DE-599)DOAJ1736e1b770c14cbe97f461bab5836d95 DE-627 ger DE-627 rakwb eng TA401-492 QH301-705.5 Ting Chen verfasserin aut Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reactive oxygen species (ROS), which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety. Herein, we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO2 on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently (Au/BPMS). The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO2-mediated O2 generation and GSH depletion, thus leading to notable inhibition effect on tumor growth. Moreover, tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics. Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic Materials of engineering and construction. Mechanics of materials Biology (General) Weiwei Zeng verfasserin aut Changjun Tie verfasserin aut Mian Yu verfasserin aut Huisong Hao verfasserin aut Yang Deng verfasserin aut Qianqian Li verfasserin aut Hairong Zheng verfasserin aut Meiying Wu verfasserin aut Lin Mei verfasserin aut In Bioactive Materials KeAi Communications Co., Ltd., 2017 10(2022), Seite 515-525 (DE-627)1663654956 (DE-600)2970496-0 2452199X nnns volume:10 year:2022 pages:515-525 https://doi.org/10.1016/j.bioactmat.2021.09.016 kostenfrei https://doaj.org/article/1736e1b770c14cbe97f461bab5836d95 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452199X21004345 kostenfrei https://doaj.org/toc/2452-199X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 515-525
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allfieldsSound	10.1016/j.bioactmat.2021.09.016 doi (DE-627)DOAJ012150169 (DE-599)DOAJ1736e1b770c14cbe97f461bab5836d95 DE-627 ger DE-627 rakwb eng TA401-492 QH301-705.5 Ting Chen verfasserin aut Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reactive oxygen species (ROS), which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety. Herein, we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO2 on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently (Au/BPMS). The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO2-mediated O2 generation and GSH depletion, thus leading to notable inhibition effect on tumor growth. Moreover, tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics. Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic Materials of engineering and construction. Mechanics of materials Biology (General) Weiwei Zeng verfasserin aut Changjun Tie verfasserin aut Mian Yu verfasserin aut Huisong Hao verfasserin aut Yang Deng verfasserin aut Qianqian Li verfasserin aut Hairong Zheng verfasserin aut Meiying Wu verfasserin aut Lin Mei verfasserin aut In Bioactive Materials KeAi Communications Co., Ltd., 2017 10(2022), Seite 515-525 (DE-627)1663654956 (DE-600)2970496-0 2452199X nnns volume:10 year:2022 pages:515-525 https://doi.org/10.1016/j.bioactmat.2021.09.016 kostenfrei https://doaj.org/article/1736e1b770c14cbe97f461bab5836d95 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452199X21004345 kostenfrei https://doaj.org/toc/2452-199X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 515-525
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authorswithroles_txt_mv	Ting Chen @@aut@@ Weiwei Zeng @@aut@@ Changjun Tie @@aut@@ Mian Yu @@aut@@ Huisong Hao @@aut@@ Yang Deng @@aut@@ Qianqian Li @@aut@@ Hairong Zheng @@aut@@ Meiying Wu @@aut@@ Lin Mei @@aut@@
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callnumber-first	T - Technology
author	Ting Chen
spellingShingle	Ting Chen misc TA401-492 misc QH301-705.5 misc Black phosphorus misc Oxidative stress misc Tumor microenvironment misc Sonodynamic therapy misc Theranostic misc Materials of engineering and construction. Mechanics of materials misc Biology (General) Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
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topic_title	TA401-492 QH301-705.5 Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic
topic	misc TA401-492 misc QH301-705.5 misc Black phosphorus misc Oxidative stress misc Tumor microenvironment misc Sonodynamic therapy misc Theranostic misc Materials of engineering and construction. Mechanics of materials misc Biology (General)
topic_unstemmed	misc TA401-492 misc QH301-705.5 misc Black phosphorus misc Oxidative stress misc Tumor microenvironment misc Sonodynamic therapy misc Theranostic misc Materials of engineering and construction. Mechanics of materials misc Biology (General)
topic_browse	misc TA401-492 misc QH301-705.5 misc Black phosphorus misc Oxidative stress misc Tumor microenvironment misc Sonodynamic therapy misc Theranostic misc Materials of engineering and construction. Mechanics of materials misc Biology (General)
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title	Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
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title_full	Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
author_sort	Ting Chen
journal	Bioactive Materials
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title_sort	engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
callnumber	TA401-492
title_auth	Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
abstract	The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reactive oxygen species (ROS), which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety. Herein, we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO2 on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently (Au/BPMS). The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO2-mediated O2 generation and GSH depletion, thus leading to notable inhibition effect on tumor growth. Moreover, tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics.
abstractGer	The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reactive oxygen species (ROS), which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety. Herein, we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO2 on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently (Au/BPMS). The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO2-mediated O2 generation and GSH depletion, thus leading to notable inhibition effect on tumor growth. Moreover, tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics.
abstract_unstemmed	The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reactive oxygen species (ROS), which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety. Herein, we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO2 on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently (Au/BPMS). The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO2-mediated O2 generation and GSH depletion, thus leading to notable inhibition effect on tumor growth. Moreover, tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics.
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title_short	Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
url	https://doi.org/10.1016/j.bioactmat.2021.09.016 https://doaj.org/article/1736e1b770c14cbe97f461bab5836d95 http://www.sciencedirect.com/science/article/pii/S2452199X21004345 https://doaj.org/toc/2452-199X
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author2	Weiwei Zeng Changjun Tie Mian Yu Huisong Hao Yang Deng Qianqian Li Hairong Zheng Meiying Wu Lin Mei
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doi_str	10.1016/j.bioactmat.2021.09.016
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up_date	2024-07-03T23:55:35.492Z
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Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics

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