VI Brazilian consensus guidelines for detection of anti-cell autoantibodies on HEp-2 cells
Abstract Background The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were formulated by the group of Brazilian exper...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wilson de Melo Cruvinel [verfasserIn] Luis Eduardo Coelho Andrade [verfasserIn] Alessandra Dellavance [verfasserIn] Antônio Carlos Ximenes [verfasserIn] Carlos David Araújo Bichara [verfasserIn] Cristóvão Luis Pitangueira Mangueira [verfasserIn] Eloísa Bonfá [verfasserIn] Fabiano de Almeida Brito [verfasserIn] Henrique Ataíde Mariz [verfasserIn] Lisiane Maria Enriconi dos Anjos [verfasserIn] Sandra Gofinet Pasoto [verfasserIn] Valeria Valim [verfasserIn] Wilton Ferreira Silva dos Santos [verfasserIn] Clayson Moura Gomes [verfasserIn] Roberpaulo Anacleto Neves [verfasserIn] Paulo Luiz Carvalho Francescantonio [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Übergeordnetes Werk: |
In: Advances in Rheumatology - BMC, 2019, 62(2022), 1, Seite 11 |
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| Übergeordnetes Werk: |
volume:62 ; year:2022 ; number:1 ; pages:11 |
| Links: |
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| DOI / URN: |
10.1186/s42358-022-00266-z |
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| Katalog-ID: |
DOAJ01224340X |
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| 520 | |a Abstract Background The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were formulated by the group of Brazilian experts discussing the classification of complex patterns, the classification of the nuclear discrete dots (few and multiple), the identification of the discrete fine speckled pattern (AC-4a) and improvements on the ANA report. Mainbody Sixteen Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of Brazil participated in the meeting. Four main topics were discussed: (1) How to classify patterns with fluorescence in more than one cell compartment considering three relevant categoris: composite patterns, mixed patterns and multiple patterns; (2) The splitting of the discrete nuclear dots pattern into the multiple discrete nuclear dots (AC-6) and few discrete nuclear dots (AC-7) patterns, respectively; (3) Inclusion of a novel nuclear pattern characterized by discrete fine speckled pattern highly associated with antibodies to SS-A/Ro60, classified as AC-4a. In addition, adjustments on the Brazilian Consensus nomenclature were implemented aiming to harmonize the designation of some patterns with the International Consensus on ANA Patterns (ICAP). Furthermore, the designations of the PCNA-like pattern (AC-13), CENP-F-like pattern (AC-14) and Topo I-like pattern (AC-29) were adjusted in accordance to ICAP. Finally, there was a recommendation for adjustment in the test report in order to address the status of nuclear envelope staining. For all topics, the aim was to establish specific guidelines for laboratories and clinicians. All recommendations were based on consensus among participants. All recommendations from the V Consensus were maintained and there was relevant progress in the BCA/HEp-2 guidelines and further harmonization with ICAP. Conclusion The VI BCA/HEp-2 edition was successful in establishing important recommendations regarding the classification of complex patterns, in supporting the identification of a novel pattern within the AC-4 group and in the harmonization process with the ICAP terminology. | ||
| 653 | 0 | |a Diseases of the musculoskeletal system | |
| 653 | 0 | |a Immunologic diseases. Allergy | |
| 700 | 0 | |a Luis Eduardo Coelho Andrade |e verfasserin |4 aut | |
| 700 | 0 | |a Alessandra Dellavance |e verfasserin |4 aut | |
| 700 | 0 | |a Antônio Carlos Ximenes |e verfasserin |4 aut | |
| 700 | 0 | |a Carlos David Araújo Bichara |e verfasserin |4 aut | |
| 700 | 0 | |a Cristóvão Luis Pitangueira Mangueira |e verfasserin |4 aut | |
| 700 | 0 | |a Eloísa Bonfá |e verfasserin |4 aut | |
| 700 | 0 | |a Fabiano de Almeida Brito |e verfasserin |4 aut | |
| 700 | 0 | |a Henrique Ataíde Mariz |e verfasserin |4 aut | |
| 700 | 0 | |a Lisiane Maria Enriconi dos Anjos |e verfasserin |4 aut | |
| 700 | 0 | |a Sandra Gofinet Pasoto |e verfasserin |4 aut | |
| 700 | 0 | |a Valeria Valim |e verfasserin |4 aut | |
| 700 | 0 | |a Wilton Ferreira Silva dos Santos |e verfasserin |4 aut | |
| 700 | 0 | |a Clayson Moura Gomes |e verfasserin |4 aut | |
| 700 | 0 | |a Roberpaulo Anacleto Neves |e verfasserin |4 aut | |
| 700 | 0 | |a Paulo Luiz Carvalho Francescantonio |e verfasserin |4 aut | |
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10.1186/s42358-022-00266-z doi (DE-627)DOAJ01224340X (DE-599)DOAJa4da1864fc4d4b3faa0ffb4634db1c2c DE-627 ger DE-627 rakwb eng RC925-935 RC581-607 Wilson de Melo Cruvinel verfasserin aut VI Brazilian consensus guidelines for detection of anti-cell autoantibodies on HEp-2 cells 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were formulated by the group of Brazilian experts discussing the classification of complex patterns, the classification of the nuclear discrete dots (few and multiple), the identification of the discrete fine speckled pattern (AC-4a) and improvements on the ANA report. Mainbody Sixteen Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of Brazil participated in the meeting. Four main topics were discussed: (1) How to classify patterns with fluorescence in more than one cell compartment considering three relevant categoris: composite patterns, mixed patterns and multiple patterns; (2) The splitting of the discrete nuclear dots pattern into the multiple discrete nuclear dots (AC-6) and few discrete nuclear dots (AC-7) patterns, respectively; (3) Inclusion of a novel nuclear pattern characterized by discrete fine speckled pattern highly associated with antibodies to SS-A/Ro60, classified as AC-4a. In addition, adjustments on the Brazilian Consensus nomenclature were implemented aiming to harmonize the designation of some patterns with the International Consensus on ANA Patterns (ICAP). Furthermore, the designations of the PCNA-like pattern (AC-13), CENP-F-like pattern (AC-14) and Topo I-like pattern (AC-29) were adjusted in accordance to ICAP. Finally, there was a recommendation for adjustment in the test report in order to address the status of nuclear envelope staining. For all topics, the aim was to establish specific guidelines for laboratories and clinicians. All recommendations were based on consensus among participants. All recommendations from the V Consensus were maintained and there was relevant progress in the BCA/HEp-2 guidelines and further harmonization with ICAP. Conclusion The VI BCA/HEp-2 edition was successful in establishing important recommendations regarding the classification of complex patterns, in supporting the identification of a novel pattern within the AC-4 group and in the harmonization process with the ICAP terminology. Diseases of the musculoskeletal system Immunologic diseases. Allergy Luis Eduardo Coelho Andrade verfasserin aut Alessandra Dellavance verfasserin aut Antônio Carlos Ximenes verfasserin aut Carlos David Araújo Bichara verfasserin aut Cristóvão Luis Pitangueira Mangueira verfasserin aut Eloísa Bonfá verfasserin aut Fabiano de Almeida Brito verfasserin aut Henrique Ataíde Mariz verfasserin aut Lisiane Maria Enriconi dos Anjos verfasserin aut Sandra Gofinet Pasoto verfasserin aut Valeria Valim verfasserin aut Wilton Ferreira Silva dos Santos verfasserin aut Clayson Moura Gomes verfasserin aut Roberpaulo Anacleto Neves verfasserin aut Paulo Luiz Carvalho Francescantonio verfasserin aut In Advances in Rheumatology BMC, 2019 62(2022), 1, Seite 11 (DE-627)1028897588 25233106 nnns volume:62 year:2022 number:1 pages:11 https://doi.org/10.1186/s42358-022-00266-z kostenfrei https://doaj.org/article/a4da1864fc4d4b3faa0ffb4634db1c2c kostenfrei https://doi.org/10.1186/s42358-022-00266-z kostenfrei https://doaj.org/toc/2523-3106 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2022 1 11 |
| spelling |
10.1186/s42358-022-00266-z doi (DE-627)DOAJ01224340X (DE-599)DOAJa4da1864fc4d4b3faa0ffb4634db1c2c DE-627 ger DE-627 rakwb eng RC925-935 RC581-607 Wilson de Melo Cruvinel verfasserin aut VI Brazilian consensus guidelines for detection of anti-cell autoantibodies on HEp-2 cells 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were formulated by the group of Brazilian experts discussing the classification of complex patterns, the classification of the nuclear discrete dots (few and multiple), the identification of the discrete fine speckled pattern (AC-4a) and improvements on the ANA report. Mainbody Sixteen Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of Brazil participated in the meeting. Four main topics were discussed: (1) How to classify patterns with fluorescence in more than one cell compartment considering three relevant categoris: composite patterns, mixed patterns and multiple patterns; (2) The splitting of the discrete nuclear dots pattern into the multiple discrete nuclear dots (AC-6) and few discrete nuclear dots (AC-7) patterns, respectively; (3) Inclusion of a novel nuclear pattern characterized by discrete fine speckled pattern highly associated with antibodies to SS-A/Ro60, classified as AC-4a. In addition, adjustments on the Brazilian Consensus nomenclature were implemented aiming to harmonize the designation of some patterns with the International Consensus on ANA Patterns (ICAP). Furthermore, the designations of the PCNA-like pattern (AC-13), CENP-F-like pattern (AC-14) and Topo I-like pattern (AC-29) were adjusted in accordance to ICAP. Finally, there was a recommendation for adjustment in the test report in order to address the status of nuclear envelope staining. For all topics, the aim was to establish specific guidelines for laboratories and clinicians. All recommendations were based on consensus among participants. All recommendations from the V Consensus were maintained and there was relevant progress in the BCA/HEp-2 guidelines and further harmonization with ICAP. Conclusion The VI BCA/HEp-2 edition was successful in establishing important recommendations regarding the classification of complex patterns, in supporting the identification of a novel pattern within the AC-4 group and in the harmonization process with the ICAP terminology. Diseases of the musculoskeletal system Immunologic diseases. Allergy Luis Eduardo Coelho Andrade verfasserin aut Alessandra Dellavance verfasserin aut Antônio Carlos Ximenes verfasserin aut Carlos David Araújo Bichara verfasserin aut Cristóvão Luis Pitangueira Mangueira verfasserin aut Eloísa Bonfá verfasserin aut Fabiano de Almeida Brito verfasserin aut Henrique Ataíde Mariz verfasserin aut Lisiane Maria Enriconi dos Anjos verfasserin aut Sandra Gofinet Pasoto verfasserin aut Valeria Valim verfasserin aut Wilton Ferreira Silva dos Santos verfasserin aut Clayson Moura Gomes verfasserin aut Roberpaulo Anacleto Neves verfasserin aut Paulo Luiz Carvalho Francescantonio verfasserin aut In Advances in Rheumatology BMC, 2019 62(2022), 1, Seite 11 (DE-627)1028897588 25233106 nnns volume:62 year:2022 number:1 pages:11 https://doi.org/10.1186/s42358-022-00266-z kostenfrei https://doaj.org/article/a4da1864fc4d4b3faa0ffb4634db1c2c kostenfrei https://doi.org/10.1186/s42358-022-00266-z kostenfrei https://doaj.org/toc/2523-3106 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2022 1 11 |
| allfields_unstemmed |
10.1186/s42358-022-00266-z doi (DE-627)DOAJ01224340X (DE-599)DOAJa4da1864fc4d4b3faa0ffb4634db1c2c DE-627 ger DE-627 rakwb eng RC925-935 RC581-607 Wilson de Melo Cruvinel verfasserin aut VI Brazilian consensus guidelines for detection of anti-cell autoantibodies on HEp-2 cells 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were formulated by the group of Brazilian experts discussing the classification of complex patterns, the classification of the nuclear discrete dots (few and multiple), the identification of the discrete fine speckled pattern (AC-4a) and improvements on the ANA report. Mainbody Sixteen Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of Brazil participated in the meeting. Four main topics were discussed: (1) How to classify patterns with fluorescence in more than one cell compartment considering three relevant categoris: composite patterns, mixed patterns and multiple patterns; (2) The splitting of the discrete nuclear dots pattern into the multiple discrete nuclear dots (AC-6) and few discrete nuclear dots (AC-7) patterns, respectively; (3) Inclusion of a novel nuclear pattern characterized by discrete fine speckled pattern highly associated with antibodies to SS-A/Ro60, classified as AC-4a. In addition, adjustments on the Brazilian Consensus nomenclature were implemented aiming to harmonize the designation of some patterns with the International Consensus on ANA Patterns (ICAP). Furthermore, the designations of the PCNA-like pattern (AC-13), CENP-F-like pattern (AC-14) and Topo I-like pattern (AC-29) were adjusted in accordance to ICAP. Finally, there was a recommendation for adjustment in the test report in order to address the status of nuclear envelope staining. For all topics, the aim was to establish specific guidelines for laboratories and clinicians. All recommendations were based on consensus among participants. All recommendations from the V Consensus were maintained and there was relevant progress in the BCA/HEp-2 guidelines and further harmonization with ICAP. Conclusion The VI BCA/HEp-2 edition was successful in establishing important recommendations regarding the classification of complex patterns, in supporting the identification of a novel pattern within the AC-4 group and in the harmonization process with the ICAP terminology. Diseases of the musculoskeletal system Immunologic diseases. Allergy Luis Eduardo Coelho Andrade verfasserin aut Alessandra Dellavance verfasserin aut Antônio Carlos Ximenes verfasserin aut Carlos David Araújo Bichara verfasserin aut Cristóvão Luis Pitangueira Mangueira verfasserin aut Eloísa Bonfá verfasserin aut Fabiano de Almeida Brito verfasserin aut Henrique Ataíde Mariz verfasserin aut Lisiane Maria Enriconi dos Anjos verfasserin aut Sandra Gofinet Pasoto verfasserin aut Valeria Valim verfasserin aut Wilton Ferreira Silva dos Santos verfasserin aut Clayson Moura Gomes verfasserin aut Roberpaulo Anacleto Neves verfasserin aut Paulo Luiz Carvalho Francescantonio verfasserin aut In Advances in Rheumatology BMC, 2019 62(2022), 1, Seite 11 (DE-627)1028897588 25233106 nnns volume:62 year:2022 number:1 pages:11 https://doi.org/10.1186/s42358-022-00266-z kostenfrei https://doaj.org/article/a4da1864fc4d4b3faa0ffb4634db1c2c kostenfrei https://doi.org/10.1186/s42358-022-00266-z kostenfrei https://doaj.org/toc/2523-3106 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2022 1 11 |
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10.1186/s42358-022-00266-z doi (DE-627)DOAJ01224340X (DE-599)DOAJa4da1864fc4d4b3faa0ffb4634db1c2c DE-627 ger DE-627 rakwb eng RC925-935 RC581-607 Wilson de Melo Cruvinel verfasserin aut VI Brazilian consensus guidelines for detection of anti-cell autoantibodies on HEp-2 cells 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were formulated by the group of Brazilian experts discussing the classification of complex patterns, the classification of the nuclear discrete dots (few and multiple), the identification of the discrete fine speckled pattern (AC-4a) and improvements on the ANA report. Mainbody Sixteen Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of Brazil participated in the meeting. Four main topics were discussed: (1) How to classify patterns with fluorescence in more than one cell compartment considering three relevant categoris: composite patterns, mixed patterns and multiple patterns; (2) The splitting of the discrete nuclear dots pattern into the multiple discrete nuclear dots (AC-6) and few discrete nuclear dots (AC-7) patterns, respectively; (3) Inclusion of a novel nuclear pattern characterized by discrete fine speckled pattern highly associated with antibodies to SS-A/Ro60, classified as AC-4a. In addition, adjustments on the Brazilian Consensus nomenclature were implemented aiming to harmonize the designation of some patterns with the International Consensus on ANA Patterns (ICAP). Furthermore, the designations of the PCNA-like pattern (AC-13), CENP-F-like pattern (AC-14) and Topo I-like pattern (AC-29) were adjusted in accordance to ICAP. Finally, there was a recommendation for adjustment in the test report in order to address the status of nuclear envelope staining. For all topics, the aim was to establish specific guidelines for laboratories and clinicians. All recommendations were based on consensus among participants. All recommendations from the V Consensus were maintained and there was relevant progress in the BCA/HEp-2 guidelines and further harmonization with ICAP. Conclusion The VI BCA/HEp-2 edition was successful in establishing important recommendations regarding the classification of complex patterns, in supporting the identification of a novel pattern within the AC-4 group and in the harmonization process with the ICAP terminology. Diseases of the musculoskeletal system Immunologic diseases. Allergy Luis Eduardo Coelho Andrade verfasserin aut Alessandra Dellavance verfasserin aut Antônio Carlos Ximenes verfasserin aut Carlos David Araújo Bichara verfasserin aut Cristóvão Luis Pitangueira Mangueira verfasserin aut Eloísa Bonfá verfasserin aut Fabiano de Almeida Brito verfasserin aut Henrique Ataíde Mariz verfasserin aut Lisiane Maria Enriconi dos Anjos verfasserin aut Sandra Gofinet Pasoto verfasserin aut Valeria Valim verfasserin aut Wilton Ferreira Silva dos Santos verfasserin aut Clayson Moura Gomes verfasserin aut Roberpaulo Anacleto Neves verfasserin aut Paulo Luiz Carvalho Francescantonio verfasserin aut In Advances in Rheumatology BMC, 2019 62(2022), 1, Seite 11 (DE-627)1028897588 25233106 nnns volume:62 year:2022 number:1 pages:11 https://doi.org/10.1186/s42358-022-00266-z kostenfrei https://doaj.org/article/a4da1864fc4d4b3faa0ffb4634db1c2c kostenfrei https://doi.org/10.1186/s42358-022-00266-z kostenfrei https://doaj.org/toc/2523-3106 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2022 1 11 |
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10.1186/s42358-022-00266-z doi (DE-627)DOAJ01224340X (DE-599)DOAJa4da1864fc4d4b3faa0ffb4634db1c2c DE-627 ger DE-627 rakwb eng RC925-935 RC581-607 Wilson de Melo Cruvinel verfasserin aut VI Brazilian consensus guidelines for detection of anti-cell autoantibodies on HEp-2 cells 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were formulated by the group of Brazilian experts discussing the classification of complex patterns, the classification of the nuclear discrete dots (few and multiple), the identification of the discrete fine speckled pattern (AC-4a) and improvements on the ANA report. Mainbody Sixteen Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of Brazil participated in the meeting. Four main topics were discussed: (1) How to classify patterns with fluorescence in more than one cell compartment considering three relevant categoris: composite patterns, mixed patterns and multiple patterns; (2) The splitting of the discrete nuclear dots pattern into the multiple discrete nuclear dots (AC-6) and few discrete nuclear dots (AC-7) patterns, respectively; (3) Inclusion of a novel nuclear pattern characterized by discrete fine speckled pattern highly associated with antibodies to SS-A/Ro60, classified as AC-4a. In addition, adjustments on the Brazilian Consensus nomenclature were implemented aiming to harmonize the designation of some patterns with the International Consensus on ANA Patterns (ICAP). Furthermore, the designations of the PCNA-like pattern (AC-13), CENP-F-like pattern (AC-14) and Topo I-like pattern (AC-29) were adjusted in accordance to ICAP. Finally, there was a recommendation for adjustment in the test report in order to address the status of nuclear envelope staining. For all topics, the aim was to establish specific guidelines for laboratories and clinicians. All recommendations were based on consensus among participants. All recommendations from the V Consensus were maintained and there was relevant progress in the BCA/HEp-2 guidelines and further harmonization with ICAP. Conclusion The VI BCA/HEp-2 edition was successful in establishing important recommendations regarding the classification of complex patterns, in supporting the identification of a novel pattern within the AC-4 group and in the harmonization process with the ICAP terminology. Diseases of the musculoskeletal system Immunologic diseases. Allergy Luis Eduardo Coelho Andrade verfasserin aut Alessandra Dellavance verfasserin aut Antônio Carlos Ximenes verfasserin aut Carlos David Araújo Bichara verfasserin aut Cristóvão Luis Pitangueira Mangueira verfasserin aut Eloísa Bonfá verfasserin aut Fabiano de Almeida Brito verfasserin aut Henrique Ataíde Mariz verfasserin aut Lisiane Maria Enriconi dos Anjos verfasserin aut Sandra Gofinet Pasoto verfasserin aut Valeria Valim verfasserin aut Wilton Ferreira Silva dos Santos verfasserin aut Clayson Moura Gomes verfasserin aut Roberpaulo Anacleto Neves verfasserin aut Paulo Luiz Carvalho Francescantonio verfasserin aut In Advances in Rheumatology BMC, 2019 62(2022), 1, Seite 11 (DE-627)1028897588 25233106 nnns volume:62 year:2022 number:1 pages:11 https://doi.org/10.1186/s42358-022-00266-z kostenfrei https://doaj.org/article/a4da1864fc4d4b3faa0ffb4634db1c2c kostenfrei https://doi.org/10.1186/s42358-022-00266-z kostenfrei https://doaj.org/toc/2523-3106 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2022 1 11 |
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Wilson de Melo Cruvinel @@aut@@ Luis Eduardo Coelho Andrade @@aut@@ Alessandra Dellavance @@aut@@ Antônio Carlos Ximenes @@aut@@ Carlos David Araújo Bichara @@aut@@ Cristóvão Luis Pitangueira Mangueira @@aut@@ Eloísa Bonfá @@aut@@ Fabiano de Almeida Brito @@aut@@ Henrique Ataíde Mariz @@aut@@ Lisiane Maria Enriconi dos Anjos @@aut@@ Sandra Gofinet Pasoto @@aut@@ Valeria Valim @@aut@@ Wilton Ferreira Silva dos Santos @@aut@@ Clayson Moura Gomes @@aut@@ Roberpaulo Anacleto Neves @@aut@@ Paulo Luiz Carvalho Francescantonio @@aut@@ |
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Wilson de Melo Cruvinel Luis Eduardo Coelho Andrade Alessandra Dellavance Antônio Carlos Ximenes Carlos David Araújo Bichara Cristóvão Luis Pitangueira Mangueira Eloísa Bonfá Fabiano de Almeida Brito Henrique Ataíde Mariz Lisiane Maria Enriconi dos Anjos Sandra Gofinet Pasoto Valeria Valim Wilton Ferreira Silva dos Santos Clayson Moura Gomes Roberpaulo Anacleto Neves Paulo Luiz Carvalho Francescantonio |
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VI Brazilian consensus guidelines for detection of anti-cell autoantibodies on HEp-2 cells |
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Abstract Background The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were formulated by the group of Brazilian experts discussing the classification of complex patterns, the classification of the nuclear discrete dots (few and multiple), the identification of the discrete fine speckled pattern (AC-4a) and improvements on the ANA report. Mainbody Sixteen Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of Brazil participated in the meeting. Four main topics were discussed: (1) How to classify patterns with fluorescence in more than one cell compartment considering three relevant categoris: composite patterns, mixed patterns and multiple patterns; (2) The splitting of the discrete nuclear dots pattern into the multiple discrete nuclear dots (AC-6) and few discrete nuclear dots (AC-7) patterns, respectively; (3) Inclusion of a novel nuclear pattern characterized by discrete fine speckled pattern highly associated with antibodies to SS-A/Ro60, classified as AC-4a. In addition, adjustments on the Brazilian Consensus nomenclature were implemented aiming to harmonize the designation of some patterns with the International Consensus on ANA Patterns (ICAP). Furthermore, the designations of the PCNA-like pattern (AC-13), CENP-F-like pattern (AC-14) and Topo I-like pattern (AC-29) were adjusted in accordance to ICAP. Finally, there was a recommendation for adjustment in the test report in order to address the status of nuclear envelope staining. For all topics, the aim was to establish specific guidelines for laboratories and clinicians. All recommendations were based on consensus among participants. All recommendations from the V Consensus were maintained and there was relevant progress in the BCA/HEp-2 guidelines and further harmonization with ICAP. Conclusion The VI BCA/HEp-2 edition was successful in establishing important recommendations regarding the classification of complex patterns, in supporting the identification of a novel pattern within the AC-4 group and in the harmonization process with the ICAP terminology. |
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Abstract Background The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were formulated by the group of Brazilian experts discussing the classification of complex patterns, the classification of the nuclear discrete dots (few and multiple), the identification of the discrete fine speckled pattern (AC-4a) and improvements on the ANA report. Mainbody Sixteen Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of Brazil participated in the meeting. Four main topics were discussed: (1) How to classify patterns with fluorescence in more than one cell compartment considering three relevant categoris: composite patterns, mixed patterns and multiple patterns; (2) The splitting of the discrete nuclear dots pattern into the multiple discrete nuclear dots (AC-6) and few discrete nuclear dots (AC-7) patterns, respectively; (3) Inclusion of a novel nuclear pattern characterized by discrete fine speckled pattern highly associated with antibodies to SS-A/Ro60, classified as AC-4a. In addition, adjustments on the Brazilian Consensus nomenclature were implemented aiming to harmonize the designation of some patterns with the International Consensus on ANA Patterns (ICAP). Furthermore, the designations of the PCNA-like pattern (AC-13), CENP-F-like pattern (AC-14) and Topo I-like pattern (AC-29) were adjusted in accordance to ICAP. Finally, there was a recommendation for adjustment in the test report in order to address the status of nuclear envelope staining. For all topics, the aim was to establish specific guidelines for laboratories and clinicians. All recommendations were based on consensus among participants. All recommendations from the V Consensus were maintained and there was relevant progress in the BCA/HEp-2 guidelines and further harmonization with ICAP. Conclusion The VI BCA/HEp-2 edition was successful in establishing important recommendations regarding the classification of complex patterns, in supporting the identification of a novel pattern within the AC-4 group and in the harmonization process with the ICAP terminology. |
| abstract_unstemmed |
Abstract Background The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were formulated by the group of Brazilian experts discussing the classification of complex patterns, the classification of the nuclear discrete dots (few and multiple), the identification of the discrete fine speckled pattern (AC-4a) and improvements on the ANA report. Mainbody Sixteen Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of Brazil participated in the meeting. Four main topics were discussed: (1) How to classify patterns with fluorescence in more than one cell compartment considering three relevant categoris: composite patterns, mixed patterns and multiple patterns; (2) The splitting of the discrete nuclear dots pattern into the multiple discrete nuclear dots (AC-6) and few discrete nuclear dots (AC-7) patterns, respectively; (3) Inclusion of a novel nuclear pattern characterized by discrete fine speckled pattern highly associated with antibodies to SS-A/Ro60, classified as AC-4a. In addition, adjustments on the Brazilian Consensus nomenclature were implemented aiming to harmonize the designation of some patterns with the International Consensus on ANA Patterns (ICAP). Furthermore, the designations of the PCNA-like pattern (AC-13), CENP-F-like pattern (AC-14) and Topo I-like pattern (AC-29) were adjusted in accordance to ICAP. Finally, there was a recommendation for adjustment in the test report in order to address the status of nuclear envelope staining. For all topics, the aim was to establish specific guidelines for laboratories and clinicians. All recommendations were based on consensus among participants. All recommendations from the V Consensus were maintained and there was relevant progress in the BCA/HEp-2 guidelines and further harmonization with ICAP. Conclusion The VI BCA/HEp-2 edition was successful in establishing important recommendations regarding the classification of complex patterns, in supporting the identification of a novel pattern within the AC-4 group and in the harmonization process with the ICAP terminology. |
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