Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia
Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified,...
Ausführliche Beschreibung
Autor*in: |
Catherine Norton [verfasserIn] Manjula Hettiarachchi [verfasserIn] Rachel Cooke [verfasserIn] Marta Kozior [verfasserIn] Hilkka Kontro [verfasserIn] Rosemary Daniel [verfasserIn] Philip Jakeman [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2022 |
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Übergeordnetes Werk: |
In: Nutrients - MDPI AG, 2009, 14(2022), 17, p 3486 |
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Übergeordnetes Werk: |
volume:14 ; year:2022 ; number:17, p 3486 |
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DOI / URN: |
10.3390/nu14173486 |
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Katalog-ID: |
DOAJ012256951 |
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10.3390/nu14173486 doi (DE-627)DOAJ012256951 (DE-599)DOAJ89ed74c1e9e04121946db061ca55db71 DE-627 ger DE-627 rakwb eng TX341-641 Catherine Norton verfasserin aut Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers of bone resorption (C-terminal telopeptide of type I collagen, CTX) and formation (serum pro-collagen type 1 N-terminal propeptide, P1NP), and site-specific aerial bone mineral density (BMD), trabecular bone score (TBS), in postmenopausal women with osteopenia. The MBPM supplement increased mean daily energy, protein, and calcium intake, by 11, 30, and 107%, respectively. 24-week supplementation with MBPM decreased CTX by 23%, from 0.547 (0.107) to 0.416 (0.087) ng/mL (<i<p</i< < 0.001) and P1NP by 17%, from 60.6 (9.1) to 49.7 (7.2) μg/L (<i<p</i< < 0.001). Compared to CON, MBPM induced a significantly greater reduction in serum CTX (mean (CI<sub<95%</sub<); −9 (8.6) vs. −23 (8.5)%, <i<p</i< = 0.025 but not P1NP −19 (8.8) vs. −17 (5.2)%, <i<p</i< = 0.802). No significant change in TBS, AP spine or dual femur aerial BMD was observed for CON or MBPM. This study demonstrates the potential benefit of bed-time ingestion of a calcium-fortified, milk-based protein matrix on homeostatic bone remodelling but no resultant treatment effect on site-specific BMD in postmenopausal women with osteopenia. randomized control trial milk protein matrix nutrient intervention nutrient timing bone remodelling bone turnover markers Nutrition. Foods and food supply Manjula Hettiarachchi verfasserin aut Rachel Cooke verfasserin aut Marta Kozior verfasserin aut Hilkka Kontro verfasserin aut Rosemary Daniel verfasserin aut Philip Jakeman verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 17, p 3486 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:17, p 3486 https://doi.org/10.3390/nu14173486 kostenfrei https://doaj.org/article/89ed74c1e9e04121946db061ca55db71 kostenfrei https://www.mdpi.com/2072-6643/14/17/3486 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 17, p 3486 |
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10.3390/nu14173486 doi (DE-627)DOAJ012256951 (DE-599)DOAJ89ed74c1e9e04121946db061ca55db71 DE-627 ger DE-627 rakwb eng TX341-641 Catherine Norton verfasserin aut Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers of bone resorption (C-terminal telopeptide of type I collagen, CTX) and formation (serum pro-collagen type 1 N-terminal propeptide, P1NP), and site-specific aerial bone mineral density (BMD), trabecular bone score (TBS), in postmenopausal women with osteopenia. The MBPM supplement increased mean daily energy, protein, and calcium intake, by 11, 30, and 107%, respectively. 24-week supplementation with MBPM decreased CTX by 23%, from 0.547 (0.107) to 0.416 (0.087) ng/mL (<i<p</i< < 0.001) and P1NP by 17%, from 60.6 (9.1) to 49.7 (7.2) μg/L (<i<p</i< < 0.001). Compared to CON, MBPM induced a significantly greater reduction in serum CTX (mean (CI<sub<95%</sub<); −9 (8.6) vs. −23 (8.5)%, <i<p</i< = 0.025 but not P1NP −19 (8.8) vs. −17 (5.2)%, <i<p</i< = 0.802). No significant change in TBS, AP spine or dual femur aerial BMD was observed for CON or MBPM. This study demonstrates the potential benefit of bed-time ingestion of a calcium-fortified, milk-based protein matrix on homeostatic bone remodelling but no resultant treatment effect on site-specific BMD in postmenopausal women with osteopenia. randomized control trial milk protein matrix nutrient intervention nutrient timing bone remodelling bone turnover markers Nutrition. Foods and food supply Manjula Hettiarachchi verfasserin aut Rachel Cooke verfasserin aut Marta Kozior verfasserin aut Hilkka Kontro verfasserin aut Rosemary Daniel verfasserin aut Philip Jakeman verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 17, p 3486 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:17, p 3486 https://doi.org/10.3390/nu14173486 kostenfrei https://doaj.org/article/89ed74c1e9e04121946db061ca55db71 kostenfrei https://www.mdpi.com/2072-6643/14/17/3486 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 17, p 3486 |
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10.3390/nu14173486 doi (DE-627)DOAJ012256951 (DE-599)DOAJ89ed74c1e9e04121946db061ca55db71 DE-627 ger DE-627 rakwb eng TX341-641 Catherine Norton verfasserin aut Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers of bone resorption (C-terminal telopeptide of type I collagen, CTX) and formation (serum pro-collagen type 1 N-terminal propeptide, P1NP), and site-specific aerial bone mineral density (BMD), trabecular bone score (TBS), in postmenopausal women with osteopenia. The MBPM supplement increased mean daily energy, protein, and calcium intake, by 11, 30, and 107%, respectively. 24-week supplementation with MBPM decreased CTX by 23%, from 0.547 (0.107) to 0.416 (0.087) ng/mL (<i<p</i< < 0.001) and P1NP by 17%, from 60.6 (9.1) to 49.7 (7.2) μg/L (<i<p</i< < 0.001). Compared to CON, MBPM induced a significantly greater reduction in serum CTX (mean (CI<sub<95%</sub<); −9 (8.6) vs. −23 (8.5)%, <i<p</i< = 0.025 but not P1NP −19 (8.8) vs. −17 (5.2)%, <i<p</i< = 0.802). No significant change in TBS, AP spine or dual femur aerial BMD was observed for CON or MBPM. This study demonstrates the potential benefit of bed-time ingestion of a calcium-fortified, milk-based protein matrix on homeostatic bone remodelling but no resultant treatment effect on site-specific BMD in postmenopausal women with osteopenia. randomized control trial milk protein matrix nutrient intervention nutrient timing bone remodelling bone turnover markers Nutrition. Foods and food supply Manjula Hettiarachchi verfasserin aut Rachel Cooke verfasserin aut Marta Kozior verfasserin aut Hilkka Kontro verfasserin aut Rosemary Daniel verfasserin aut Philip Jakeman verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 17, p 3486 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:17, p 3486 https://doi.org/10.3390/nu14173486 kostenfrei https://doaj.org/article/89ed74c1e9e04121946db061ca55db71 kostenfrei https://www.mdpi.com/2072-6643/14/17/3486 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 17, p 3486 |
allfieldsGer |
10.3390/nu14173486 doi (DE-627)DOAJ012256951 (DE-599)DOAJ89ed74c1e9e04121946db061ca55db71 DE-627 ger DE-627 rakwb eng TX341-641 Catherine Norton verfasserin aut Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers of bone resorption (C-terminal telopeptide of type I collagen, CTX) and formation (serum pro-collagen type 1 N-terminal propeptide, P1NP), and site-specific aerial bone mineral density (BMD), trabecular bone score (TBS), in postmenopausal women with osteopenia. The MBPM supplement increased mean daily energy, protein, and calcium intake, by 11, 30, and 107%, respectively. 24-week supplementation with MBPM decreased CTX by 23%, from 0.547 (0.107) to 0.416 (0.087) ng/mL (<i<p</i< < 0.001) and P1NP by 17%, from 60.6 (9.1) to 49.7 (7.2) μg/L (<i<p</i< < 0.001). Compared to CON, MBPM induced a significantly greater reduction in serum CTX (mean (CI<sub<95%</sub<); −9 (8.6) vs. −23 (8.5)%, <i<p</i< = 0.025 but not P1NP −19 (8.8) vs. −17 (5.2)%, <i<p</i< = 0.802). No significant change in TBS, AP spine or dual femur aerial BMD was observed for CON or MBPM. This study demonstrates the potential benefit of bed-time ingestion of a calcium-fortified, milk-based protein matrix on homeostatic bone remodelling but no resultant treatment effect on site-specific BMD in postmenopausal women with osteopenia. randomized control trial milk protein matrix nutrient intervention nutrient timing bone remodelling bone turnover markers Nutrition. Foods and food supply Manjula Hettiarachchi verfasserin aut Rachel Cooke verfasserin aut Marta Kozior verfasserin aut Hilkka Kontro verfasserin aut Rosemary Daniel verfasserin aut Philip Jakeman verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 17, p 3486 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:17, p 3486 https://doi.org/10.3390/nu14173486 kostenfrei https://doaj.org/article/89ed74c1e9e04121946db061ca55db71 kostenfrei https://www.mdpi.com/2072-6643/14/17/3486 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 17, p 3486 |
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10.3390/nu14173486 doi (DE-627)DOAJ012256951 (DE-599)DOAJ89ed74c1e9e04121946db061ca55db71 DE-627 ger DE-627 rakwb eng TX341-641 Catherine Norton verfasserin aut Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers of bone resorption (C-terminal telopeptide of type I collagen, CTX) and formation (serum pro-collagen type 1 N-terminal propeptide, P1NP), and site-specific aerial bone mineral density (BMD), trabecular bone score (TBS), in postmenopausal women with osteopenia. The MBPM supplement increased mean daily energy, protein, and calcium intake, by 11, 30, and 107%, respectively. 24-week supplementation with MBPM decreased CTX by 23%, from 0.547 (0.107) to 0.416 (0.087) ng/mL (<i<p</i< < 0.001) and P1NP by 17%, from 60.6 (9.1) to 49.7 (7.2) μg/L (<i<p</i< < 0.001). Compared to CON, MBPM induced a significantly greater reduction in serum CTX (mean (CI<sub<95%</sub<); −9 (8.6) vs. −23 (8.5)%, <i<p</i< = 0.025 but not P1NP −19 (8.8) vs. −17 (5.2)%, <i<p</i< = 0.802). No significant change in TBS, AP spine or dual femur aerial BMD was observed for CON or MBPM. This study demonstrates the potential benefit of bed-time ingestion of a calcium-fortified, milk-based protein matrix on homeostatic bone remodelling but no resultant treatment effect on site-specific BMD in postmenopausal women with osteopenia. randomized control trial milk protein matrix nutrient intervention nutrient timing bone remodelling bone turnover markers Nutrition. Foods and food supply Manjula Hettiarachchi verfasserin aut Rachel Cooke verfasserin aut Marta Kozior verfasserin aut Hilkka Kontro verfasserin aut Rosemary Daniel verfasserin aut Philip Jakeman verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 17, p 3486 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:17, p 3486 https://doi.org/10.3390/nu14173486 kostenfrei https://doaj.org/article/89ed74c1e9e04121946db061ca55db71 kostenfrei https://www.mdpi.com/2072-6643/14/17/3486 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 17, p 3486 |
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Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia |
abstract |
Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers of bone resorption (C-terminal telopeptide of type I collagen, CTX) and formation (serum pro-collagen type 1 N-terminal propeptide, P1NP), and site-specific aerial bone mineral density (BMD), trabecular bone score (TBS), in postmenopausal women with osteopenia. The MBPM supplement increased mean daily energy, protein, and calcium intake, by 11, 30, and 107%, respectively. 24-week supplementation with MBPM decreased CTX by 23%, from 0.547 (0.107) to 0.416 (0.087) ng/mL (<i<p</i< < 0.001) and P1NP by 17%, from 60.6 (9.1) to 49.7 (7.2) μg/L (<i<p</i< < 0.001). Compared to CON, MBPM induced a significantly greater reduction in serum CTX (mean (CI<sub<95%</sub<); −9 (8.6) vs. −23 (8.5)%, <i<p</i< = 0.025 but not P1NP −19 (8.8) vs. −17 (5.2)%, <i<p</i< = 0.802). No significant change in TBS, AP spine or dual femur aerial BMD was observed for CON or MBPM. This study demonstrates the potential benefit of bed-time ingestion of a calcium-fortified, milk-based protein matrix on homeostatic bone remodelling but no resultant treatment effect on site-specific BMD in postmenopausal women with osteopenia. |
abstractGer |
Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers of bone resorption (C-terminal telopeptide of type I collagen, CTX) and formation (serum pro-collagen type 1 N-terminal propeptide, P1NP), and site-specific aerial bone mineral density (BMD), trabecular bone score (TBS), in postmenopausal women with osteopenia. The MBPM supplement increased mean daily energy, protein, and calcium intake, by 11, 30, and 107%, respectively. 24-week supplementation with MBPM decreased CTX by 23%, from 0.547 (0.107) to 0.416 (0.087) ng/mL (<i<p</i< < 0.001) and P1NP by 17%, from 60.6 (9.1) to 49.7 (7.2) μg/L (<i<p</i< < 0.001). Compared to CON, MBPM induced a significantly greater reduction in serum CTX (mean (CI<sub<95%</sub<); −9 (8.6) vs. −23 (8.5)%, <i<p</i< = 0.025 but not P1NP −19 (8.8) vs. −17 (5.2)%, <i<p</i< = 0.802). No significant change in TBS, AP spine or dual femur aerial BMD was observed for CON or MBPM. This study demonstrates the potential benefit of bed-time ingestion of a calcium-fortified, milk-based protein matrix on homeostatic bone remodelling but no resultant treatment effect on site-specific BMD in postmenopausal women with osteopenia. |
abstract_unstemmed |
Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers of bone resorption (C-terminal telopeptide of type I collagen, CTX) and formation (serum pro-collagen type 1 N-terminal propeptide, P1NP), and site-specific aerial bone mineral density (BMD), trabecular bone score (TBS), in postmenopausal women with osteopenia. The MBPM supplement increased mean daily energy, protein, and calcium intake, by 11, 30, and 107%, respectively. 24-week supplementation with MBPM decreased CTX by 23%, from 0.547 (0.107) to 0.416 (0.087) ng/mL (<i<p</i< < 0.001) and P1NP by 17%, from 60.6 (9.1) to 49.7 (7.2) μg/L (<i<p</i< < 0.001). Compared to CON, MBPM induced a significantly greater reduction in serum CTX (mean (CI<sub<95%</sub<); −9 (8.6) vs. −23 (8.5)%, <i<p</i< = 0.025 but not P1NP −19 (8.8) vs. −17 (5.2)%, <i<p</i< = 0.802). No significant change in TBS, AP spine or dual femur aerial BMD was observed for CON or MBPM. This study demonstrates the potential benefit of bed-time ingestion of a calcium-fortified, milk-based protein matrix on homeostatic bone remodelling but no resultant treatment effect on site-specific BMD in postmenopausal women with osteopenia. |
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17, p 3486 |
title_short |
Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia |
url |
https://doi.org/10.3390/nu14173486 https://doaj.org/article/89ed74c1e9e04121946db061ca55db71 https://www.mdpi.com/2072-6643/14/17/3486 https://doaj.org/toc/2072-6643 |
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Manjula Hettiarachchi Rachel Cooke Marta Kozior Hilkka Kontro Rosemary Daniel Philip Jakeman |
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