Malaria Vaccine Candidate Diversity Offers Challenges and Opportunities for Effective Vaccine Development

Malaria is one of the most deadly diseases caused by protozoan parasites of genus Plasmodium. It affects 300-500 million people annually, of which more than a million lives are lost; among them majority under 5 years of age. By conventional wisdom, the immune mechanisms responsible for protection ag...
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Autor*in:	Kamal CHOWDHURY [verfasserIn] Mihail KANTOR [verfasserIn] Radu E. SESTRAS [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Übergeordnetes Werk:	In: Notulae Botanicae Horti Agrobotanici Cluj-Napoca - AcademicPres, 2021, 37(2009), 1, Seite 9-16
Übergeordnetes Werk:	volume:37 ; year:2009 ; number:1 ; pages:9-16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.15835/nbha3713136

Katalog-ID:	DOAJ012370932

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allfieldsGer	10.15835/nbha3713136 doi (DE-627)DOAJ012370932 (DE-599)DOAJ588a10ec62ae4840bcd48694ce6e229d DE-627 ger DE-627 rakwb eng SD1-669.5 S1-972 Kamal CHOWDHURY verfasserin aut Malaria Vaccine Candidate Diversity Offers Challenges and Opportunities for Effective Vaccine Development 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Malaria is one of the most deadly diseases caused by protozoan parasites of genus Plasmodium. It affects 300-500 million people annually, of which more than a million lives are lost; among them majority under 5 years of age. By conventional wisdom, the immune mechanisms responsible for protection against malaria will require a multiple of 10-15 antigen targets for proper protection against various stages of malarial infection. Such large number of targets cannot be delivered to humans, by this method. Moreover, each antigen is reported to be highly polymorphic in nature and the malaria-affected populations live in economically poor part of the world. Development of anti-malarial vaccines is therefore, a very tough challenge from technical, delivery and affordability points of view. Technical challenges include identification of epitopes / antigens against appropriate targets, construction of DNA vector(s) that will express properly folded functional protein. Vaccine delivery challenges include developing an easy method to deliver multiple doses within a short period of time to infants and children of less than five years of age. Affordability challenges include development of cost-effective vaccines that can be stored at room temperature and be easily delivered. Although the complex life cycle of Plasmodium is challenging for anti-malarial vaccine development, it also offers a lot of antigen targets (opportunities) to combat malaria. Information on anti-malarial vaccine candidates, DNA constructs and cost-effective delivery mechanism will be discussed. Forestry Agriculture (General) Mihail KANTOR verfasserin aut Radu E. SESTRAS verfasserin aut In Notulae Botanicae Horti Agrobotanici Cluj-Napoca AcademicPres, 2021 37(2009), 1, Seite 9-16 (DE-627)525088415 (DE-600)2271404-2 18424309 nnns volume:37 year:2009 number:1 pages:9-16 https://doi.org/10.15835/nbha3713136 kostenfrei https://doaj.org/article/588a10ec62ae4840bcd48694ce6e229d kostenfrei http://www.notulaebotanicae.ro/index.php/nbha/article/view/3136 kostenfrei https://doaj.org/toc/0255-965X Journal toc kostenfrei https://doaj.org/toc/1842-4309 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2009 1 9-16
allfieldsSound	10.15835/nbha3713136 doi (DE-627)DOAJ012370932 (DE-599)DOAJ588a10ec62ae4840bcd48694ce6e229d DE-627 ger DE-627 rakwb eng SD1-669.5 S1-972 Kamal CHOWDHURY verfasserin aut Malaria Vaccine Candidate Diversity Offers Challenges and Opportunities for Effective Vaccine Development 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Malaria is one of the most deadly diseases caused by protozoan parasites of genus Plasmodium. It affects 300-500 million people annually, of which more than a million lives are lost; among them majority under 5 years of age. By conventional wisdom, the immune mechanisms responsible for protection against malaria will require a multiple of 10-15 antigen targets for proper protection against various stages of malarial infection. Such large number of targets cannot be delivered to humans, by this method. Moreover, each antigen is reported to be highly polymorphic in nature and the malaria-affected populations live in economically poor part of the world. Development of anti-malarial vaccines is therefore, a very tough challenge from technical, delivery and affordability points of view. Technical challenges include identification of epitopes / antigens against appropriate targets, construction of DNA vector(s) that will express properly folded functional protein. Vaccine delivery challenges include developing an easy method to deliver multiple doses within a short period of time to infants and children of less than five years of age. Affordability challenges include development of cost-effective vaccines that can be stored at room temperature and be easily delivered. Although the complex life cycle of Plasmodium is challenging for anti-malarial vaccine development, it also offers a lot of antigen targets (opportunities) to combat malaria. Information on anti-malarial vaccine candidates, DNA constructs and cost-effective delivery mechanism will be discussed. Forestry Agriculture (General) Mihail KANTOR verfasserin aut Radu E. SESTRAS verfasserin aut In Notulae Botanicae Horti Agrobotanici Cluj-Napoca AcademicPres, 2021 37(2009), 1, Seite 9-16 (DE-627)525088415 (DE-600)2271404-2 18424309 nnns volume:37 year:2009 number:1 pages:9-16 https://doi.org/10.15835/nbha3713136 kostenfrei https://doaj.org/article/588a10ec62ae4840bcd48694ce6e229d kostenfrei http://www.notulaebotanicae.ro/index.php/nbha/article/view/3136 kostenfrei https://doaj.org/toc/0255-965X Journal toc kostenfrei https://doaj.org/toc/1842-4309 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2009 1 9-16
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source	In Notulae Botanicae Horti Agrobotanici Cluj-Napoca 37(2009), 1, Seite 9-16 volume:37 year:2009 number:1 pages:9-16
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callnumber-first	S - Agriculture
author	Kamal CHOWDHURY
spellingShingle	Kamal CHOWDHURY misc SD1-669.5 misc S1-972 misc Forestry misc Agriculture (General) Malaria Vaccine Candidate Diversity Offers Challenges and Opportunities for Effective Vaccine Development
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title	Malaria Vaccine Candidate Diversity Offers Challenges and Opportunities for Effective Vaccine Development
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title_sort	malaria vaccine candidate diversity offers challenges and opportunities for effective vaccine development
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title_auth	Malaria Vaccine Candidate Diversity Offers Challenges and Opportunities for Effective Vaccine Development
abstract	Malaria is one of the most deadly diseases caused by protozoan parasites of genus Plasmodium. It affects 300-500 million people annually, of which more than a million lives are lost; among them majority under 5 years of age. By conventional wisdom, the immune mechanisms responsible for protection against malaria will require a multiple of 10-15 antigen targets for proper protection against various stages of malarial infection. Such large number of targets cannot be delivered to humans, by this method. Moreover, each antigen is reported to be highly polymorphic in nature and the malaria-affected populations live in economically poor part of the world. Development of anti-malarial vaccines is therefore, a very tough challenge from technical, delivery and affordability points of view. Technical challenges include identification of epitopes / antigens against appropriate targets, construction of DNA vector(s) that will express properly folded functional protein. Vaccine delivery challenges include developing an easy method to deliver multiple doses within a short period of time to infants and children of less than five years of age. Affordability challenges include development of cost-effective vaccines that can be stored at room temperature and be easily delivered. Although the complex life cycle of Plasmodium is challenging for anti-malarial vaccine development, it also offers a lot of antigen targets (opportunities) to combat malaria. Information on anti-malarial vaccine candidates, DNA constructs and cost-effective delivery mechanism will be discussed.
abstractGer	Malaria is one of the most deadly diseases caused by protozoan parasites of genus Plasmodium. It affects 300-500 million people annually, of which more than a million lives are lost; among them majority under 5 years of age. By conventional wisdom, the immune mechanisms responsible for protection against malaria will require a multiple of 10-15 antigen targets for proper protection against various stages of malarial infection. Such large number of targets cannot be delivered to humans, by this method. Moreover, each antigen is reported to be highly polymorphic in nature and the malaria-affected populations live in economically poor part of the world. Development of anti-malarial vaccines is therefore, a very tough challenge from technical, delivery and affordability points of view. Technical challenges include identification of epitopes / antigens against appropriate targets, construction of DNA vector(s) that will express properly folded functional protein. Vaccine delivery challenges include developing an easy method to deliver multiple doses within a short period of time to infants and children of less than five years of age. Affordability challenges include development of cost-effective vaccines that can be stored at room temperature and be easily delivered. Although the complex life cycle of Plasmodium is challenging for anti-malarial vaccine development, it also offers a lot of antigen targets (opportunities) to combat malaria. Information on anti-malarial vaccine candidates, DNA constructs and cost-effective delivery mechanism will be discussed.
abstract_unstemmed	Malaria is one of the most deadly diseases caused by protozoan parasites of genus Plasmodium. It affects 300-500 million people annually, of which more than a million lives are lost; among them majority under 5 years of age. By conventional wisdom, the immune mechanisms responsible for protection against malaria will require a multiple of 10-15 antigen targets for proper protection against various stages of malarial infection. Such large number of targets cannot be delivered to humans, by this method. Moreover, each antigen is reported to be highly polymorphic in nature and the malaria-affected populations live in economically poor part of the world. Development of anti-malarial vaccines is therefore, a very tough challenge from technical, delivery and affordability points of view. Technical challenges include identification of epitopes / antigens against appropriate targets, construction of DNA vector(s) that will express properly folded functional protein. Vaccine delivery challenges include developing an easy method to deliver multiple doses within a short period of time to infants and children of less than five years of age. Affordability challenges include development of cost-effective vaccines that can be stored at room temperature and be easily delivered. Although the complex life cycle of Plasmodium is challenging for anti-malarial vaccine development, it also offers a lot of antigen targets (opportunities) to combat malaria. Information on anti-malarial vaccine candidates, DNA constructs and cost-effective delivery mechanism will be discussed.
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title_short	Malaria Vaccine Candidate Diversity Offers Challenges and Opportunities for Effective Vaccine Development
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