Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model

Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, partic...
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Autor*in:	Maarisha Upadhyay [verfasserIn] Meena Rajagopal [verfasserIn] Kirandeep Gill [verfasserIn] Yaoxiang Li [verfasserIn] Shivani Bansal [verfasserIn] Vijayalakshmi Sridharan [verfasserIn] John B. Tyburski [verfasserIn] Marjan Boerma [verfasserIn] Amrita K. Cheema [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	lipidomics oxygen radiation plasma metabolomics ionizing radiation untargeted profiling mass spectrometry

Übergeordnetes Werk:	In: Metabolites - MDPI AG, 2012, 10(2020), 6, p 252
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:6, p 252

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/metabo10060252

Katalog-ID:	DOAJ012658634

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language	English
source	In Metabolites 10(2020), 6, p 252 volume:10 year:2020 number:6, p 252
sourceStr	In Metabolites 10(2020), 6, p 252 volume:10 year:2020 number:6, p 252
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institution	findex.gbv.de
topic_facet	lipidomics oxygen radiation plasma metabolomics ionizing radiation untargeted profiling mass spectrometry Microbiology
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authorswithroles_txt_mv	Maarisha Upadhyay @@aut@@ Meena Rajagopal @@aut@@ Kirandeep Gill @@aut@@ Yaoxiang Li @@aut@@ Shivani Bansal @@aut@@ Vijayalakshmi Sridharan @@aut@@ John B. Tyburski @@aut@@ Marjan Boerma @@aut@@ Amrita K. Cheema @@aut@@
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callnumber-first	Q - Science
author	Maarisha Upadhyay
spellingShingle	Maarisha Upadhyay misc QR1-502 misc lipidomics misc oxygen radiation misc plasma metabolomics misc ionizing radiation misc untargeted profiling misc mass spectrometry misc Microbiology Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
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topic_title	QR1-502 Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model lipidomics oxygen radiation plasma metabolomics ionizing radiation untargeted profiling mass spectrometry
topic	misc QR1-502 misc lipidomics misc oxygen radiation misc plasma metabolomics misc ionizing radiation misc untargeted profiling misc mass spectrometry misc Microbiology
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title	Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
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title_full	Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
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title_sort	identification of plasma lipidome changes associated with low dose space-type radiation exposure in a murine model
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title_auth	Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
abstract	Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, particularly of injuries that appear weeks or months after radiation exposure. To assess the feasibility of using plasma metabolic and lipidomic profiles as biomarkers of injury from space radiation, we used a mouse model of exposure to low doses of oxygen ions (<sup<16</sup<O) and protons (<sup<1</sup<H). Plasma profiles were compared with those of mice exposed to γ-rays as a reference set. Our results demonstrate major changes in glycerophospholipid metabolism, amino acid metabolism, as well as fatty acid metabolism. We also observed dyslipidemia and lipid peroxidation, suggesting an inflammatory phenotype with possible long-term consequences to overall health upon exposure to low doses of high linear energy transfer (LET) radiation.
abstractGer	Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, particularly of injuries that appear weeks or months after radiation exposure. To assess the feasibility of using plasma metabolic and lipidomic profiles as biomarkers of injury from space radiation, we used a mouse model of exposure to low doses of oxygen ions (<sup<16</sup<O) and protons (<sup<1</sup<H). Plasma profiles were compared with those of mice exposed to γ-rays as a reference set. Our results demonstrate major changes in glycerophospholipid metabolism, amino acid metabolism, as well as fatty acid metabolism. We also observed dyslipidemia and lipid peroxidation, suggesting an inflammatory phenotype with possible long-term consequences to overall health upon exposure to low doses of high linear energy transfer (LET) radiation.
abstract_unstemmed	Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, particularly of injuries that appear weeks or months after radiation exposure. To assess the feasibility of using plasma metabolic and lipidomic profiles as biomarkers of injury from space radiation, we used a mouse model of exposure to low doses of oxygen ions (<sup<16</sup<O) and protons (<sup<1</sup<H). Plasma profiles were compared with those of mice exposed to γ-rays as a reference set. Our results demonstrate major changes in glycerophospholipid metabolism, amino acid metabolism, as well as fatty acid metabolism. We also observed dyslipidemia and lipid peroxidation, suggesting an inflammatory phenotype with possible long-term consequences to overall health upon exposure to low doses of high linear energy transfer (LET) radiation.
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title_short	Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
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