Intractable hyperkalemia due to nicorandil induced potassium channel syndrome
Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closur...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Vivek Chowdhry [verfasserIn] B B Mohanty [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Übergeordnetes Werk: |
In: Annals of Cardiac Anaesthesia - Wolters Kluwer Medknow Publications, 2004, 18(2015), 1, Seite 101-103 |
|---|---|
| Übergeordnetes Werk: |
volume:18 ; year:2015 ; number:1 ; pages:101-103 |
| Links: |
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| DOI / URN: |
10.4103/0971-9784.148331 |
|---|
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DOAJ01272288X |
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| 520 | |a Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of K ATP channel, it can expel K + ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy. | ||
| 650 | 4 | |a Atrial fibrillation; Cardiac surgery; Diastolic dysfunction; Diastolic function; Postoperative | |
| 650 | 4 | |a Postoperative pain | |
| 650 | 4 | |a presternal bupivacaine infusion | |
| 650 | 4 | |a sternotomy | |
| 650 | 4 | |a Aprotinin; Bleeding; Cardiopulmonary bypass; Paediatric open-heart surgery; Tranexamic acid | |
| 650 | 4 | |a Airway; dexmedetomidine; radiographic assessment | |
| 650 | 4 | |a Cardiac resynchronization therapy; coronary artery bypass; heart failure | |
| 650 | 4 | |a Acute kidney injury | |
| 650 | 4 | |a Cardiac surgery | |
| 650 | 4 | |a Neutrophil gelatinase-associated lipocalin | |
| 650 | 4 | |a Anti-platelet therapy; Bleeding; Coronary artery bypass grafting; Multiplate; Platelet Dysfunction; Platelet function assessment | |
| 650 | 4 | |a Developing country; outcomes; quality improvement | |
| 650 | 4 | |a Cardiac surgery; Davinci; One-lung ventilation; Totally endoscopic coronary artery bypass; Transesophageal echocardiography; Robotic surgery; Minimally invasive cardiac surgery | |
| 650 | 4 | |a Atrial septal defects | |
| 650 | 4 | |a Congenital heart disease | |
| 650 | 4 | |a Echocardiography | |
| 650 | 4 | |a Transthoracic echocardiography | |
| 650 | 4 | |a Transesophageal echocardiography | |
| 650 | 4 | |a Three- dimensional echocardiography | |
| 650 | 4 | |a Two-dimensional echocardiography | |
| 650 | 4 | |a Clinical research | |
| 650 | 4 | |a measurement types | |
| 650 | 4 | |a predictive modelling | |
| 650 | 4 | |a statistical analysis | |
| 650 | 4 | |a Aortic dissection flap | |
| 650 | 4 | |a intra-operative echocardiography | |
| 650 | 4 | |a three-dimensional transesophageal echocardiography | |
| 650 | 4 | |a type A aortic dissection | |
| 650 | 4 | |a Left ventricular rupture | |
| 650 | 4 | |a mitral valve replacement | |
| 650 | 4 | |a risk factors | |
| 650 | 4 | |a Coronary artery bypass graft; hypoxemia; patent foramen ovale; stroke | |
| 650 | 4 | |a Left ventricle; Myxoma; Thrombus | |
| 650 | 4 | |a Anesthesia; Aortic stenosis; Aortic valve replacement; Cesarean section; Pregnancy | |
| 650 | 4 | |a ATP-sensitive potassium channels; channelopathy; hyperkalemia; nicorandil | |
| 653 | 0 | |a Anesthesiology | |
| 653 | 0 | |a Diseases of the circulatory (Cardiovascular) system | |
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10.4103/0971-9784.148331 doi (DE-627)DOAJ01272288X (DE-599)DOAJcf0e5ba2fe594783b85e7668eb6f5780 DE-627 ger DE-627 rakwb eng RD78.3-87.3 RC666-701 Vivek Chowdhry verfasserin aut Intractable hyperkalemia due to nicorandil induced potassium channel syndrome 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of K ATP channel, it can expel K + ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy. Atrial fibrillation; Cardiac surgery; Diastolic dysfunction; Diastolic function; Postoperative Postoperative pain presternal bupivacaine infusion sternotomy Aprotinin; Bleeding; Cardiopulmonary bypass; Paediatric open-heart surgery; Tranexamic acid Airway; dexmedetomidine; radiographic assessment Cardiac resynchronization therapy; coronary artery bypass; heart failure Acute kidney injury Cardiac surgery Neutrophil gelatinase-associated lipocalin Anti-platelet therapy; Bleeding; Coronary artery bypass grafting; Multiplate; Platelet Dysfunction; Platelet function assessment Developing country; outcomes; quality improvement Cardiac surgery; Davinci; One-lung ventilation; Totally endoscopic coronary artery bypass; Transesophageal echocardiography; Robotic surgery; Minimally invasive cardiac surgery Atrial septal defects Congenital heart disease Echocardiography Transthoracic echocardiography Transesophageal echocardiography Three- dimensional echocardiography Two-dimensional echocardiography Clinical research measurement types predictive modelling statistical analysis Aortic dissection flap intra-operative echocardiography three-dimensional transesophageal echocardiography type A aortic dissection Left ventricular rupture mitral valve replacement risk factors Coronary artery bypass graft; hypoxemia; patent foramen ovale; stroke Left ventricle; Myxoma; Thrombus Anesthesia; Aortic stenosis; Aortic valve replacement; Cesarean section; Pregnancy ATP-sensitive potassium channels; channelopathy; hyperkalemia; nicorandil Anesthesiology Diseases of the circulatory (Cardiovascular) system B B Mohanty verfasserin aut In Annals of Cardiac Anaesthesia Wolters Kluwer Medknow Publications, 2004 18(2015), 1, Seite 101-103 (DE-627)363764232 (DE-600)2106866-5 09745181 nnns volume:18 year:2015 number:1 pages:101-103 https://doi.org/10.4103/0971-9784.148331 kostenfrei https://doaj.org/article/cf0e5ba2fe594783b85e7668eb6f5780 kostenfrei http://www.annals.in/article.asp?issn=0971-9784;year=2015;volume=18;issue=1;spage=101;epage=103;aulast=Chowdhry kostenfrei https://doaj.org/toc/0971-9784 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2015 1 101-103 |
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10.4103/0971-9784.148331 doi (DE-627)DOAJ01272288X (DE-599)DOAJcf0e5ba2fe594783b85e7668eb6f5780 DE-627 ger DE-627 rakwb eng RD78.3-87.3 RC666-701 Vivek Chowdhry verfasserin aut Intractable hyperkalemia due to nicorandil induced potassium channel syndrome 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of K ATP channel, it can expel K + ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy. Atrial fibrillation; Cardiac surgery; Diastolic dysfunction; Diastolic function; Postoperative Postoperative pain presternal bupivacaine infusion sternotomy Aprotinin; Bleeding; Cardiopulmonary bypass; Paediatric open-heart surgery; Tranexamic acid Airway; dexmedetomidine; radiographic assessment Cardiac resynchronization therapy; coronary artery bypass; heart failure Acute kidney injury Cardiac surgery Neutrophil gelatinase-associated lipocalin Anti-platelet therapy; Bleeding; Coronary artery bypass grafting; Multiplate; Platelet Dysfunction; Platelet function assessment Developing country; outcomes; quality improvement Cardiac surgery; Davinci; One-lung ventilation; Totally endoscopic coronary artery bypass; Transesophageal echocardiography; Robotic surgery; Minimally invasive cardiac surgery Atrial septal defects Congenital heart disease Echocardiography Transthoracic echocardiography Transesophageal echocardiography Three- dimensional echocardiography Two-dimensional echocardiography Clinical research measurement types predictive modelling statistical analysis Aortic dissection flap intra-operative echocardiography three-dimensional transesophageal echocardiography type A aortic dissection Left ventricular rupture mitral valve replacement risk factors Coronary artery bypass graft; hypoxemia; patent foramen ovale; stroke Left ventricle; Myxoma; Thrombus Anesthesia; Aortic stenosis; Aortic valve replacement; Cesarean section; Pregnancy ATP-sensitive potassium channels; channelopathy; hyperkalemia; nicorandil Anesthesiology Diseases of the circulatory (Cardiovascular) system B B Mohanty verfasserin aut In Annals of Cardiac Anaesthesia Wolters Kluwer Medknow Publications, 2004 18(2015), 1, Seite 101-103 (DE-627)363764232 (DE-600)2106866-5 09745181 nnns volume:18 year:2015 number:1 pages:101-103 https://doi.org/10.4103/0971-9784.148331 kostenfrei https://doaj.org/article/cf0e5ba2fe594783b85e7668eb6f5780 kostenfrei http://www.annals.in/article.asp?issn=0971-9784;year=2015;volume=18;issue=1;spage=101;epage=103;aulast=Chowdhry kostenfrei https://doaj.org/toc/0971-9784 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2015 1 101-103 |
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10.4103/0971-9784.148331 doi (DE-627)DOAJ01272288X (DE-599)DOAJcf0e5ba2fe594783b85e7668eb6f5780 DE-627 ger DE-627 rakwb eng RD78.3-87.3 RC666-701 Vivek Chowdhry verfasserin aut Intractable hyperkalemia due to nicorandil induced potassium channel syndrome 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of K ATP channel, it can expel K + ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy. Atrial fibrillation; Cardiac surgery; Diastolic dysfunction; Diastolic function; Postoperative Postoperative pain presternal bupivacaine infusion sternotomy Aprotinin; Bleeding; Cardiopulmonary bypass; Paediatric open-heart surgery; Tranexamic acid Airway; dexmedetomidine; radiographic assessment Cardiac resynchronization therapy; coronary artery bypass; heart failure Acute kidney injury Cardiac surgery Neutrophil gelatinase-associated lipocalin Anti-platelet therapy; Bleeding; Coronary artery bypass grafting; Multiplate; Platelet Dysfunction; Platelet function assessment Developing country; outcomes; quality improvement Cardiac surgery; Davinci; One-lung ventilation; Totally endoscopic coronary artery bypass; Transesophageal echocardiography; Robotic surgery; Minimally invasive cardiac surgery Atrial septal defects Congenital heart disease Echocardiography Transthoracic echocardiography Transesophageal echocardiography Three- dimensional echocardiography Two-dimensional echocardiography Clinical research measurement types predictive modelling statistical analysis Aortic dissection flap intra-operative echocardiography three-dimensional transesophageal echocardiography type A aortic dissection Left ventricular rupture mitral valve replacement risk factors Coronary artery bypass graft; hypoxemia; patent foramen ovale; stroke Left ventricle; Myxoma; Thrombus Anesthesia; Aortic stenosis; Aortic valve replacement; Cesarean section; Pregnancy ATP-sensitive potassium channels; channelopathy; hyperkalemia; nicorandil Anesthesiology Diseases of the circulatory (Cardiovascular) system B B Mohanty verfasserin aut In Annals of Cardiac Anaesthesia Wolters Kluwer Medknow Publications, 2004 18(2015), 1, Seite 101-103 (DE-627)363764232 (DE-600)2106866-5 09745181 nnns volume:18 year:2015 number:1 pages:101-103 https://doi.org/10.4103/0971-9784.148331 kostenfrei https://doaj.org/article/cf0e5ba2fe594783b85e7668eb6f5780 kostenfrei http://www.annals.in/article.asp?issn=0971-9784;year=2015;volume=18;issue=1;spage=101;epage=103;aulast=Chowdhry kostenfrei https://doaj.org/toc/0971-9784 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2015 1 101-103 |
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10.4103/0971-9784.148331 doi (DE-627)DOAJ01272288X (DE-599)DOAJcf0e5ba2fe594783b85e7668eb6f5780 DE-627 ger DE-627 rakwb eng RD78.3-87.3 RC666-701 Vivek Chowdhry verfasserin aut Intractable hyperkalemia due to nicorandil induced potassium channel syndrome 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of K ATP channel, it can expel K + ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy. Atrial fibrillation; Cardiac surgery; Diastolic dysfunction; Diastolic function; Postoperative Postoperative pain presternal bupivacaine infusion sternotomy Aprotinin; Bleeding; Cardiopulmonary bypass; Paediatric open-heart surgery; Tranexamic acid Airway; dexmedetomidine; radiographic assessment Cardiac resynchronization therapy; coronary artery bypass; heart failure Acute kidney injury Cardiac surgery Neutrophil gelatinase-associated lipocalin Anti-platelet therapy; Bleeding; Coronary artery bypass grafting; Multiplate; Platelet Dysfunction; Platelet function assessment Developing country; outcomes; quality improvement Cardiac surgery; Davinci; One-lung ventilation; Totally endoscopic coronary artery bypass; Transesophageal echocardiography; Robotic surgery; Minimally invasive cardiac surgery Atrial septal defects Congenital heart disease Echocardiography Transthoracic echocardiography Transesophageal echocardiography Three- dimensional echocardiography Two-dimensional echocardiography Clinical research measurement types predictive modelling statistical analysis Aortic dissection flap intra-operative echocardiography three-dimensional transesophageal echocardiography type A aortic dissection Left ventricular rupture mitral valve replacement risk factors Coronary artery bypass graft; hypoxemia; patent foramen ovale; stroke Left ventricle; Myxoma; Thrombus Anesthesia; Aortic stenosis; Aortic valve replacement; Cesarean section; Pregnancy ATP-sensitive potassium channels; channelopathy; hyperkalemia; nicorandil Anesthesiology Diseases of the circulatory (Cardiovascular) system B B Mohanty verfasserin aut In Annals of Cardiac Anaesthesia Wolters Kluwer Medknow Publications, 2004 18(2015), 1, Seite 101-103 (DE-627)363764232 (DE-600)2106866-5 09745181 nnns volume:18 year:2015 number:1 pages:101-103 https://doi.org/10.4103/0971-9784.148331 kostenfrei https://doaj.org/article/cf0e5ba2fe594783b85e7668eb6f5780 kostenfrei http://www.annals.in/article.asp?issn=0971-9784;year=2015;volume=18;issue=1;spage=101;epage=103;aulast=Chowdhry kostenfrei https://doaj.org/toc/0971-9784 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2015 1 101-103 |
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RD78.3-87.3 RC666-701 Intractable hyperkalemia due to nicorandil induced potassium channel syndrome Atrial fibrillation; Cardiac surgery; Diastolic dysfunction; Diastolic function; Postoperative Postoperative pain presternal bupivacaine infusion sternotomy Aprotinin; Bleeding; Cardiopulmonary bypass; Paediatric open-heart surgery; Tranexamic acid Airway; dexmedetomidine; radiographic assessment Cardiac resynchronization therapy; coronary artery bypass; heart failure Acute kidney injury Cardiac surgery Neutrophil gelatinase-associated lipocalin Anti-platelet therapy; Bleeding; Coronary artery bypass grafting; Multiplate; Platelet Dysfunction; Platelet function assessment Developing country; outcomes; quality improvement Cardiac surgery; Davinci; One-lung ventilation; Totally endoscopic coronary artery bypass; Transesophageal echocardiography; Robotic surgery; Minimally invasive cardiac surgery Atrial septal defects Congenital heart disease Echocardiography Transthoracic echocardiography Transesophageal echocardiography Three- dimensional echocardiography Two-dimensional echocardiography Clinical research measurement types predictive modelling statistical analysis Aortic dissection flap intra-operative echocardiography three-dimensional transesophageal echocardiography type A aortic dissection Left ventricular rupture mitral valve replacement risk factors Coronary artery bypass graft; hypoxemia; patent foramen ovale; stroke Left ventricle; Myxoma; Thrombus Anesthesia; Aortic stenosis; Aortic valve replacement; Cesarean section; Pregnancy ATP-sensitive potassium channels; channelopathy; hyperkalemia; nicorandil |
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misc RD78.3-87.3 misc RC666-701 misc Atrial fibrillation; Cardiac surgery; Diastolic dysfunction; Diastolic function; Postoperative misc Postoperative pain misc presternal bupivacaine infusion misc sternotomy misc Aprotinin; Bleeding; Cardiopulmonary bypass; Paediatric open-heart surgery; Tranexamic acid misc Airway; dexmedetomidine; radiographic assessment misc Cardiac resynchronization therapy; coronary artery bypass; heart failure misc Acute kidney injury misc Cardiac surgery misc Neutrophil gelatinase-associated lipocalin misc Anti-platelet therapy; Bleeding; Coronary artery bypass grafting; Multiplate; Platelet Dysfunction; Platelet function assessment misc Developing country; outcomes; quality improvement misc Cardiac surgery; Davinci; One-lung ventilation; Totally endoscopic coronary artery bypass; Transesophageal echocardiography; Robotic surgery; Minimally invasive cardiac surgery misc Atrial septal defects misc Congenital heart disease misc Echocardiography misc Transthoracic echocardiography misc Transesophageal echocardiography misc Three- dimensional echocardiography misc Two-dimensional echocardiography misc Clinical research misc measurement types misc predictive modelling misc statistical analysis misc Aortic dissection flap misc intra-operative echocardiography misc three-dimensional transesophageal echocardiography misc type A aortic dissection misc Left ventricular rupture misc mitral valve replacement misc risk factors misc Coronary artery bypass graft; hypoxemia; patent foramen ovale; stroke misc Left ventricle; Myxoma; Thrombus misc Anesthesia; Aortic stenosis; Aortic valve replacement; Cesarean section; Pregnancy misc ATP-sensitive potassium channels; channelopathy; hyperkalemia; nicorandil misc Anesthesiology misc Diseases of the circulatory (Cardiovascular) system |
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Intractable hyperkalemia due to nicorandil induced potassium channel syndrome |
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Intractable hyperkalemia due to nicorandil induced potassium channel syndrome |
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Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of K ATP channel, it can expel K + ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy. |
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Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of K ATP channel, it can expel K + ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy. |
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Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of K ATP channel, it can expel K + ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy. |
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| score |
7.400402 |