Transcranial direct current stimulation (tDCS) of the right inferior frontal gyrus attenuates skin conductance responses to unpredictable threat conditions

Patients with panic and post-traumatic stress disorders seem to show increased psychophysiological reactions to conditions of unpredictable threat, which has been discussed as a neurobiological marker of elevated levels of sustained fear in these disorders. Interestingly, a recent study found that t...
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Gespeichert in:

Autor*in:	Martin J. Herrmann [verfasserIn] Jennifer Beier [verfasserIn] Bibiane Simons [verfasserIn] Thomas Polak [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	transcranial direct current stimulation emotional regulation right inferior frontal gyrus NPU sustained fear

Übergeordnetes Werk:	In: Frontiers in Human Neuroscience - Frontiers Media S.A., 2008, 10(2016)
Übergeordnetes Werk:	volume:10 ; year:2016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnhum.2016.00352

Katalog-ID:	DOAJ012860239

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language	English
source	In Frontiers in Human Neuroscience 10(2016) volume:10 year:2016
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topic_facet	transcranial direct current stimulation emotional regulation right inferior frontal gyrus NPU sustained fear Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Human Neuroscience
authorswithroles_txt_mv	Martin J. Herrmann @@aut@@ Jennifer Beier @@aut@@ Bibiane Simons @@aut@@ Thomas Polak @@aut@@
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callnumber-first	R - Medicine
author	Martin J. Herrmann
spellingShingle	Martin J. Herrmann misc RC321-571 misc transcranial direct current stimulation misc emotional regulation misc right inferior frontal gyrus misc NPU misc sustained fear misc Neurosciences. Biological psychiatry. Neuropsychiatry Transcranial direct current stimulation (tDCS) of the right inferior frontal gyrus attenuates skin conductance responses to unpredictable threat conditions
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topic_title	RC321-571 Transcranial direct current stimulation (tDCS) of the right inferior frontal gyrus attenuates skin conductance responses to unpredictable threat conditions transcranial direct current stimulation emotional regulation right inferior frontal gyrus NPU sustained fear
topic	misc RC321-571 misc transcranial direct current stimulation misc emotional regulation misc right inferior frontal gyrus misc NPU misc sustained fear misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc transcranial direct current stimulation misc emotional regulation misc right inferior frontal gyrus misc NPU misc sustained fear misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Transcranial direct current stimulation (tDCS) of the right inferior frontal gyrus attenuates skin conductance responses to unpredictable threat conditions
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title_full	Transcranial direct current stimulation (tDCS) of the right inferior frontal gyrus attenuates skin conductance responses to unpredictable threat conditions
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title_sort	transcranial direct current stimulation (tdcs) of the right inferior frontal gyrus attenuates skin conductance responses to unpredictable threat conditions
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title_auth	Transcranial direct current stimulation (tDCS) of the right inferior frontal gyrus attenuates skin conductance responses to unpredictable threat conditions
abstract	Patients with panic and post-traumatic stress disorders seem to show increased psychophysiological reactions to conditions of unpredictable threat, which has been discussed as a neurobiological marker of elevated levels of sustained fear in these disorders. Interestingly, a recent study found that the right inferior frontal gyrus (rIFG) is correlated to the successful regulation of sustained fear during unpredictable threat. Therefore this study aimed to examine the potential use of non-invasive brain stimulation to foster the rIFG by means of anodal transcranial direct current stimulation (tDCS) in order to reduce psychophysiological reactions to unpredictable threat. 26 participants were randomly assigned into an anodal and sham stimulation group in a double-blinded manner. Anodal and cathodal electrodes (7*5 cm) were positioned right frontal to target the rIFG. Stimulation intensity was I = 2mA applied for 20 minutes during a task including unpredictable threat conditions (NPU-task). The effects of the NPU paradigm were measured by assessing the emotional startle modulation and the skin conductance response (SCR) at the outset of the different conditions. We found a significant interaction effect of Condition x tDCS for the SCR (F[2,48] = 6.3, p < 0.01) without main effects of Condition and tDCS. Post-hoc tests revealed that the increase in SCR from neutral to unpredictable condition was significantly reduced in verum compared to the sham tDCS group (t[24] = 3.84, p < 0.001). Our results emphasize the causal role of rIFG for emotional regulation and the potential use of tDCS to reduce apprehension during unpredictable threat conditions and therefore as a treatment for anxiety disorders.
abstractGer	Patients with panic and post-traumatic stress disorders seem to show increased psychophysiological reactions to conditions of unpredictable threat, which has been discussed as a neurobiological marker of elevated levels of sustained fear in these disorders. Interestingly, a recent study found that the right inferior frontal gyrus (rIFG) is correlated to the successful regulation of sustained fear during unpredictable threat. Therefore this study aimed to examine the potential use of non-invasive brain stimulation to foster the rIFG by means of anodal transcranial direct current stimulation (tDCS) in order to reduce psychophysiological reactions to unpredictable threat. 26 participants were randomly assigned into an anodal and sham stimulation group in a double-blinded manner. Anodal and cathodal electrodes (7*5 cm) were positioned right frontal to target the rIFG. Stimulation intensity was I = 2mA applied for 20 minutes during a task including unpredictable threat conditions (NPU-task). The effects of the NPU paradigm were measured by assessing the emotional startle modulation and the skin conductance response (SCR) at the outset of the different conditions. We found a significant interaction effect of Condition x tDCS for the SCR (F[2,48] = 6.3, p < 0.01) without main effects of Condition and tDCS. Post-hoc tests revealed that the increase in SCR from neutral to unpredictable condition was significantly reduced in verum compared to the sham tDCS group (t[24] = 3.84, p < 0.001). Our results emphasize the causal role of rIFG for emotional regulation and the potential use of tDCS to reduce apprehension during unpredictable threat conditions and therefore as a treatment for anxiety disorders.
abstract_unstemmed	Patients with panic and post-traumatic stress disorders seem to show increased psychophysiological reactions to conditions of unpredictable threat, which has been discussed as a neurobiological marker of elevated levels of sustained fear in these disorders. Interestingly, a recent study found that the right inferior frontal gyrus (rIFG) is correlated to the successful regulation of sustained fear during unpredictable threat. Therefore this study aimed to examine the potential use of non-invasive brain stimulation to foster the rIFG by means of anodal transcranial direct current stimulation (tDCS) in order to reduce psychophysiological reactions to unpredictable threat. 26 participants were randomly assigned into an anodal and sham stimulation group in a double-blinded manner. Anodal and cathodal electrodes (7*5 cm) were positioned right frontal to target the rIFG. Stimulation intensity was I = 2mA applied for 20 minutes during a task including unpredictable threat conditions (NPU-task). The effects of the NPU paradigm were measured by assessing the emotional startle modulation and the skin conductance response (SCR) at the outset of the different conditions. We found a significant interaction effect of Condition x tDCS for the SCR (F[2,48] = 6.3, p < 0.01) without main effects of Condition and tDCS. Post-hoc tests revealed that the increase in SCR from neutral to unpredictable condition was significantly reduced in verum compared to the sham tDCS group (t[24] = 3.84, p < 0.001). Our results emphasize the causal role of rIFG for emotional regulation and the potential use of tDCS to reduce apprehension during unpredictable threat conditions and therefore as a treatment for anxiety disorders.
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title_short	Transcranial direct current stimulation (tDCS) of the right inferior frontal gyrus attenuates skin conductance responses to unpredictable threat conditions
url	https://doi.org/10.3389/fnhum.2016.00352 https://doaj.org/article/8bf2c246e15141e2a9fa7381553d2767 http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00352/full https://doaj.org/toc/1662-5161
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Transcranial direct current stimulation (tDCS) of the right inferior frontal gyrus attenuates skin conductance responses to unpredictable threat conditions

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