The Circumferential Resection Margin Is a Prognostic Predictor in Colon Cancer
Objective: This study aimed to investigate the potential value of circumferential resection margin (CRM) in colon cancer prognostics.Summary Background Data: CRM has been extensively studied as an important prognostic factor in rectal and esophageal cancer, but not in colon cancer.Methods: Data from...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Xin-Yi Tang [verfasserIn] Meng-Xi Huang [verfasserIn] Si-Qi Han [verfasserIn] Yue Chang [verfasserIn] Zhi-Ping Li [verfasserIn] Xiao-Ming Kao [verfasserIn] Yan-Yan Chen [verfasserIn] Chao Liu [verfasserIn] Ya-Di Huang [verfasserIn] Yi-Tian Chen [verfasserIn] Zeng-Jie Lei [verfasserIn] Xiao-Yuan Chu [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Frontiers in Oncology - Frontiers Media S.A., 2012, 10(2020) |
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| Übergeordnetes Werk: |
volume:10 ; year:2020 |
| Links: |
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| DOI / URN: |
10.3389/fonc.2020.00927 |
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| Katalog-ID: |
DOAJ012865214 |
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| 520 | |a Objective: This study aimed to investigate the potential value of circumferential resection margin (CRM) in colon cancer prognostics.Summary Background Data: CRM has been extensively studied as an important prognostic factor in rectal and esophageal cancer, but not in colon cancer.Methods: Data from 6,681 CRM-positive patients and 25,908 CRM-negative patients diagnosed with colon cancer in 2010–2015 were obtained from the Surveillance, Epidemiology, and End Results database. Statistical analysis methods utilized included the chi-square test, Kaplan-Meier estimates, Cox proportional, and X-tile software analyses.Results: After propensity score matching, CRM positivity was found to be negatively related with survival (P < 0.001). X-tile software identified 0 and 30 mm as optimal cutoff values (P < 0.001) for prognosis, which was applicable only in stage II–IV patients. A 20 and 33% risk decrease were observed in patients with CRM between 0 and 30 mm [95% confidence interval (CI) = 0.76–0.84], and larger than 30 mm (95% CI = 0.62–0.71), respectively. Chemotherapy strongly benefited prognosis with a hazard ratio of 0.36 (95% CI = 0.34–0.38) for overall survival (OS). Patients with a CRM value of 0–30 mm seemed to benefit most from chemotherapy compared with other groups. CRM and number of regional lymph nodes are independent risk factors, and the latter is a good substitute for CRM in AJCC stage I patients.Conclusion: CRM positivity is a strong unfavorable survival indicator for colon cancer patients. A better outcome is expected with CRM values larger than 30 mm. This cutoff value only applied to stage II–IV patients. For stage I patients, number of regional lymph nodes is a good substitute to predict survival. Chemotherapy was another favorable prognostic factor, especially for patients with a CRM value between 0 and 30 mm. | ||
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| 653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
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10.3389/fonc.2020.00927 doi (DE-627)DOAJ012865214 (DE-599)DOAJ1d473f2109ef4a18a5d3c7bd3a5d25e8 DE-627 ger DE-627 rakwb eng RC254-282 Xin-Yi Tang verfasserin aut The Circumferential Resection Margin Is a Prognostic Predictor in Colon Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This study aimed to investigate the potential value of circumferential resection margin (CRM) in colon cancer prognostics.Summary Background Data: CRM has been extensively studied as an important prognostic factor in rectal and esophageal cancer, but not in colon cancer.Methods: Data from 6,681 CRM-positive patients and 25,908 CRM-negative patients diagnosed with colon cancer in 2010–2015 were obtained from the Surveillance, Epidemiology, and End Results database. Statistical analysis methods utilized included the chi-square test, Kaplan-Meier estimates, Cox proportional, and X-tile software analyses.Results: After propensity score matching, CRM positivity was found to be negatively related with survival (P < 0.001). X-tile software identified 0 and 30 mm as optimal cutoff values (P < 0.001) for prognosis, which was applicable only in stage II–IV patients. A 20 and 33% risk decrease were observed in patients with CRM between 0 and 30 mm [95% confidence interval (CI) = 0.76–0.84], and larger than 30 mm (95% CI = 0.62–0.71), respectively. Chemotherapy strongly benefited prognosis with a hazard ratio of 0.36 (95% CI = 0.34–0.38) for overall survival (OS). Patients with a CRM value of 0–30 mm seemed to benefit most from chemotherapy compared with other groups. CRM and number of regional lymph nodes are independent risk factors, and the latter is a good substitute for CRM in AJCC stage I patients.Conclusion: CRM positivity is a strong unfavorable survival indicator for colon cancer patients. A better outcome is expected with CRM values larger than 30 mm. This cutoff value only applied to stage II–IV patients. For stage I patients, number of regional lymph nodes is a good substitute to predict survival. Chemotherapy was another favorable prognostic factor, especially for patients with a CRM value between 0 and 30 mm. circumferential resection margin cutoff colon cancer prognostic predictor SEER database Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xin-Yi Tang verfasserin aut Meng-Xi Huang verfasserin aut Si-Qi Han verfasserin aut Yue Chang verfasserin aut Zhi-Ping Li verfasserin aut Xiao-Ming Kao verfasserin aut Yan-Yan Chen verfasserin aut Chao Liu verfasserin aut Ya-Di Huang verfasserin aut Yi-Tian Chen verfasserin aut Zeng-Jie Lei verfasserin aut Zeng-Jie Lei verfasserin aut Xiao-Yuan Chu verfasserin aut Xiao-Yuan Chu verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.00927 kostenfrei https://doaj.org/article/1d473f2109ef4a18a5d3c7bd3a5d25e8 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.00927/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 |
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10.3389/fonc.2020.00927 doi (DE-627)DOAJ012865214 (DE-599)DOAJ1d473f2109ef4a18a5d3c7bd3a5d25e8 DE-627 ger DE-627 rakwb eng RC254-282 Xin-Yi Tang verfasserin aut The Circumferential Resection Margin Is a Prognostic Predictor in Colon Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This study aimed to investigate the potential value of circumferential resection margin (CRM) in colon cancer prognostics.Summary Background Data: CRM has been extensively studied as an important prognostic factor in rectal and esophageal cancer, but not in colon cancer.Methods: Data from 6,681 CRM-positive patients and 25,908 CRM-negative patients diagnosed with colon cancer in 2010–2015 were obtained from the Surveillance, Epidemiology, and End Results database. Statistical analysis methods utilized included the chi-square test, Kaplan-Meier estimates, Cox proportional, and X-tile software analyses.Results: After propensity score matching, CRM positivity was found to be negatively related with survival (P < 0.001). X-tile software identified 0 and 30 mm as optimal cutoff values (P < 0.001) for prognosis, which was applicable only in stage II–IV patients. A 20 and 33% risk decrease were observed in patients with CRM between 0 and 30 mm [95% confidence interval (CI) = 0.76–0.84], and larger than 30 mm (95% CI = 0.62–0.71), respectively. Chemotherapy strongly benefited prognosis with a hazard ratio of 0.36 (95% CI = 0.34–0.38) for overall survival (OS). Patients with a CRM value of 0–30 mm seemed to benefit most from chemotherapy compared with other groups. CRM and number of regional lymph nodes are independent risk factors, and the latter is a good substitute for CRM in AJCC stage I patients.Conclusion: CRM positivity is a strong unfavorable survival indicator for colon cancer patients. A better outcome is expected with CRM values larger than 30 mm. This cutoff value only applied to stage II–IV patients. For stage I patients, number of regional lymph nodes is a good substitute to predict survival. Chemotherapy was another favorable prognostic factor, especially for patients with a CRM value between 0 and 30 mm. circumferential resection margin cutoff colon cancer prognostic predictor SEER database Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xin-Yi Tang verfasserin aut Meng-Xi Huang verfasserin aut Si-Qi Han verfasserin aut Yue Chang verfasserin aut Zhi-Ping Li verfasserin aut Xiao-Ming Kao verfasserin aut Yan-Yan Chen verfasserin aut Chao Liu verfasserin aut Ya-Di Huang verfasserin aut Yi-Tian Chen verfasserin aut Zeng-Jie Lei verfasserin aut Zeng-Jie Lei verfasserin aut Xiao-Yuan Chu verfasserin aut Xiao-Yuan Chu verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.00927 kostenfrei https://doaj.org/article/1d473f2109ef4a18a5d3c7bd3a5d25e8 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.00927/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 |
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10.3389/fonc.2020.00927 doi (DE-627)DOAJ012865214 (DE-599)DOAJ1d473f2109ef4a18a5d3c7bd3a5d25e8 DE-627 ger DE-627 rakwb eng RC254-282 Xin-Yi Tang verfasserin aut The Circumferential Resection Margin Is a Prognostic Predictor in Colon Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This study aimed to investigate the potential value of circumferential resection margin (CRM) in colon cancer prognostics.Summary Background Data: CRM has been extensively studied as an important prognostic factor in rectal and esophageal cancer, but not in colon cancer.Methods: Data from 6,681 CRM-positive patients and 25,908 CRM-negative patients diagnosed with colon cancer in 2010–2015 were obtained from the Surveillance, Epidemiology, and End Results database. Statistical analysis methods utilized included the chi-square test, Kaplan-Meier estimates, Cox proportional, and X-tile software analyses.Results: After propensity score matching, CRM positivity was found to be negatively related with survival (P < 0.001). X-tile software identified 0 and 30 mm as optimal cutoff values (P < 0.001) for prognosis, which was applicable only in stage II–IV patients. A 20 and 33% risk decrease were observed in patients with CRM between 0 and 30 mm [95% confidence interval (CI) = 0.76–0.84], and larger than 30 mm (95% CI = 0.62–0.71), respectively. Chemotherapy strongly benefited prognosis with a hazard ratio of 0.36 (95% CI = 0.34–0.38) for overall survival (OS). Patients with a CRM value of 0–30 mm seemed to benefit most from chemotherapy compared with other groups. CRM and number of regional lymph nodes are independent risk factors, and the latter is a good substitute for CRM in AJCC stage I patients.Conclusion: CRM positivity is a strong unfavorable survival indicator for colon cancer patients. A better outcome is expected with CRM values larger than 30 mm. This cutoff value only applied to stage II–IV patients. For stage I patients, number of regional lymph nodes is a good substitute to predict survival. Chemotherapy was another favorable prognostic factor, especially for patients with a CRM value between 0 and 30 mm. circumferential resection margin cutoff colon cancer prognostic predictor SEER database Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xin-Yi Tang verfasserin aut Meng-Xi Huang verfasserin aut Si-Qi Han verfasserin aut Yue Chang verfasserin aut Zhi-Ping Li verfasserin aut Xiao-Ming Kao verfasserin aut Yan-Yan Chen verfasserin aut Chao Liu verfasserin aut Ya-Di Huang verfasserin aut Yi-Tian Chen verfasserin aut Zeng-Jie Lei verfasserin aut Zeng-Jie Lei verfasserin aut Xiao-Yuan Chu verfasserin aut Xiao-Yuan Chu verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.00927 kostenfrei https://doaj.org/article/1d473f2109ef4a18a5d3c7bd3a5d25e8 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.00927/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 |
| allfieldsGer |
10.3389/fonc.2020.00927 doi (DE-627)DOAJ012865214 (DE-599)DOAJ1d473f2109ef4a18a5d3c7bd3a5d25e8 DE-627 ger DE-627 rakwb eng RC254-282 Xin-Yi Tang verfasserin aut The Circumferential Resection Margin Is a Prognostic Predictor in Colon Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This study aimed to investigate the potential value of circumferential resection margin (CRM) in colon cancer prognostics.Summary Background Data: CRM has been extensively studied as an important prognostic factor in rectal and esophageal cancer, but not in colon cancer.Methods: Data from 6,681 CRM-positive patients and 25,908 CRM-negative patients diagnosed with colon cancer in 2010–2015 were obtained from the Surveillance, Epidemiology, and End Results database. Statistical analysis methods utilized included the chi-square test, Kaplan-Meier estimates, Cox proportional, and X-tile software analyses.Results: After propensity score matching, CRM positivity was found to be negatively related with survival (P < 0.001). X-tile software identified 0 and 30 mm as optimal cutoff values (P < 0.001) for prognosis, which was applicable only in stage II–IV patients. A 20 and 33% risk decrease were observed in patients with CRM between 0 and 30 mm [95% confidence interval (CI) = 0.76–0.84], and larger than 30 mm (95% CI = 0.62–0.71), respectively. Chemotherapy strongly benefited prognosis with a hazard ratio of 0.36 (95% CI = 0.34–0.38) for overall survival (OS). Patients with a CRM value of 0–30 mm seemed to benefit most from chemotherapy compared with other groups. CRM and number of regional lymph nodes are independent risk factors, and the latter is a good substitute for CRM in AJCC stage I patients.Conclusion: CRM positivity is a strong unfavorable survival indicator for colon cancer patients. A better outcome is expected with CRM values larger than 30 mm. This cutoff value only applied to stage II–IV patients. For stage I patients, number of regional lymph nodes is a good substitute to predict survival. Chemotherapy was another favorable prognostic factor, especially for patients with a CRM value between 0 and 30 mm. circumferential resection margin cutoff colon cancer prognostic predictor SEER database Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xin-Yi Tang verfasserin aut Meng-Xi Huang verfasserin aut Si-Qi Han verfasserin aut Yue Chang verfasserin aut Zhi-Ping Li verfasserin aut Xiao-Ming Kao verfasserin aut Yan-Yan Chen verfasserin aut Chao Liu verfasserin aut Ya-Di Huang verfasserin aut Yi-Tian Chen verfasserin aut Zeng-Jie Lei verfasserin aut Zeng-Jie Lei verfasserin aut Xiao-Yuan Chu verfasserin aut Xiao-Yuan Chu verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.00927 kostenfrei https://doaj.org/article/1d473f2109ef4a18a5d3c7bd3a5d25e8 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.00927/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 |
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10.3389/fonc.2020.00927 doi (DE-627)DOAJ012865214 (DE-599)DOAJ1d473f2109ef4a18a5d3c7bd3a5d25e8 DE-627 ger DE-627 rakwb eng RC254-282 Xin-Yi Tang verfasserin aut The Circumferential Resection Margin Is a Prognostic Predictor in Colon Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This study aimed to investigate the potential value of circumferential resection margin (CRM) in colon cancer prognostics.Summary Background Data: CRM has been extensively studied as an important prognostic factor in rectal and esophageal cancer, but not in colon cancer.Methods: Data from 6,681 CRM-positive patients and 25,908 CRM-negative patients diagnosed with colon cancer in 2010–2015 were obtained from the Surveillance, Epidemiology, and End Results database. Statistical analysis methods utilized included the chi-square test, Kaplan-Meier estimates, Cox proportional, and X-tile software analyses.Results: After propensity score matching, CRM positivity was found to be negatively related with survival (P < 0.001). X-tile software identified 0 and 30 mm as optimal cutoff values (P < 0.001) for prognosis, which was applicable only in stage II–IV patients. A 20 and 33% risk decrease were observed in patients with CRM between 0 and 30 mm [95% confidence interval (CI) = 0.76–0.84], and larger than 30 mm (95% CI = 0.62–0.71), respectively. Chemotherapy strongly benefited prognosis with a hazard ratio of 0.36 (95% CI = 0.34–0.38) for overall survival (OS). Patients with a CRM value of 0–30 mm seemed to benefit most from chemotherapy compared with other groups. CRM and number of regional lymph nodes are independent risk factors, and the latter is a good substitute for CRM in AJCC stage I patients.Conclusion: CRM positivity is a strong unfavorable survival indicator for colon cancer patients. A better outcome is expected with CRM values larger than 30 mm. This cutoff value only applied to stage II–IV patients. For stage I patients, number of regional lymph nodes is a good substitute to predict survival. Chemotherapy was another favorable prognostic factor, especially for patients with a CRM value between 0 and 30 mm. circumferential resection margin cutoff colon cancer prognostic predictor SEER database Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xin-Yi Tang verfasserin aut Meng-Xi Huang verfasserin aut Si-Qi Han verfasserin aut Yue Chang verfasserin aut Zhi-Ping Li verfasserin aut Xiao-Ming Kao verfasserin aut Yan-Yan Chen verfasserin aut Chao Liu verfasserin aut Ya-Di Huang verfasserin aut Yi-Tian Chen verfasserin aut Zeng-Jie Lei verfasserin aut Zeng-Jie Lei verfasserin aut Xiao-Yuan Chu verfasserin aut Xiao-Yuan Chu verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.00927 kostenfrei https://doaj.org/article/1d473f2109ef4a18a5d3c7bd3a5d25e8 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.00927/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 |
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10.3389/fonc.2020.00927 |
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circumferential resection margin is a prognostic predictor in colon cancer |
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The Circumferential Resection Margin Is a Prognostic Predictor in Colon Cancer |
| abstract |
Objective: This study aimed to investigate the potential value of circumferential resection margin (CRM) in colon cancer prognostics.Summary Background Data: CRM has been extensively studied as an important prognostic factor in rectal and esophageal cancer, but not in colon cancer.Methods: Data from 6,681 CRM-positive patients and 25,908 CRM-negative patients diagnosed with colon cancer in 2010–2015 were obtained from the Surveillance, Epidemiology, and End Results database. Statistical analysis methods utilized included the chi-square test, Kaplan-Meier estimates, Cox proportional, and X-tile software analyses.Results: After propensity score matching, CRM positivity was found to be negatively related with survival (P < 0.001). X-tile software identified 0 and 30 mm as optimal cutoff values (P < 0.001) for prognosis, which was applicable only in stage II–IV patients. A 20 and 33% risk decrease were observed in patients with CRM between 0 and 30 mm [95% confidence interval (CI) = 0.76–0.84], and larger than 30 mm (95% CI = 0.62–0.71), respectively. Chemotherapy strongly benefited prognosis with a hazard ratio of 0.36 (95% CI = 0.34–0.38) for overall survival (OS). Patients with a CRM value of 0–30 mm seemed to benefit most from chemotherapy compared with other groups. CRM and number of regional lymph nodes are independent risk factors, and the latter is a good substitute for CRM in AJCC stage I patients.Conclusion: CRM positivity is a strong unfavorable survival indicator for colon cancer patients. A better outcome is expected with CRM values larger than 30 mm. This cutoff value only applied to stage II–IV patients. For stage I patients, number of regional lymph nodes is a good substitute to predict survival. Chemotherapy was another favorable prognostic factor, especially for patients with a CRM value between 0 and 30 mm. |
| abstractGer |
Objective: This study aimed to investigate the potential value of circumferential resection margin (CRM) in colon cancer prognostics.Summary Background Data: CRM has been extensively studied as an important prognostic factor in rectal and esophageal cancer, but not in colon cancer.Methods: Data from 6,681 CRM-positive patients and 25,908 CRM-negative patients diagnosed with colon cancer in 2010–2015 were obtained from the Surveillance, Epidemiology, and End Results database. Statistical analysis methods utilized included the chi-square test, Kaplan-Meier estimates, Cox proportional, and X-tile software analyses.Results: After propensity score matching, CRM positivity was found to be negatively related with survival (P < 0.001). X-tile software identified 0 and 30 mm as optimal cutoff values (P < 0.001) for prognosis, which was applicable only in stage II–IV patients. A 20 and 33% risk decrease were observed in patients with CRM between 0 and 30 mm [95% confidence interval (CI) = 0.76–0.84], and larger than 30 mm (95% CI = 0.62–0.71), respectively. Chemotherapy strongly benefited prognosis with a hazard ratio of 0.36 (95% CI = 0.34–0.38) for overall survival (OS). Patients with a CRM value of 0–30 mm seemed to benefit most from chemotherapy compared with other groups. CRM and number of regional lymph nodes are independent risk factors, and the latter is a good substitute for CRM in AJCC stage I patients.Conclusion: CRM positivity is a strong unfavorable survival indicator for colon cancer patients. A better outcome is expected with CRM values larger than 30 mm. This cutoff value only applied to stage II–IV patients. For stage I patients, number of regional lymph nodes is a good substitute to predict survival. Chemotherapy was another favorable prognostic factor, especially for patients with a CRM value between 0 and 30 mm. |
| abstract_unstemmed |
Objective: This study aimed to investigate the potential value of circumferential resection margin (CRM) in colon cancer prognostics.Summary Background Data: CRM has been extensively studied as an important prognostic factor in rectal and esophageal cancer, but not in colon cancer.Methods: Data from 6,681 CRM-positive patients and 25,908 CRM-negative patients diagnosed with colon cancer in 2010–2015 were obtained from the Surveillance, Epidemiology, and End Results database. Statistical analysis methods utilized included the chi-square test, Kaplan-Meier estimates, Cox proportional, and X-tile software analyses.Results: After propensity score matching, CRM positivity was found to be negatively related with survival (P < 0.001). X-tile software identified 0 and 30 mm as optimal cutoff values (P < 0.001) for prognosis, which was applicable only in stage II–IV patients. A 20 and 33% risk decrease were observed in patients with CRM between 0 and 30 mm [95% confidence interval (CI) = 0.76–0.84], and larger than 30 mm (95% CI = 0.62–0.71), respectively. Chemotherapy strongly benefited prognosis with a hazard ratio of 0.36 (95% CI = 0.34–0.38) for overall survival (OS). Patients with a CRM value of 0–30 mm seemed to benefit most from chemotherapy compared with other groups. CRM and number of regional lymph nodes are independent risk factors, and the latter is a good substitute for CRM in AJCC stage I patients.Conclusion: CRM positivity is a strong unfavorable survival indicator for colon cancer patients. A better outcome is expected with CRM values larger than 30 mm. This cutoff value only applied to stage II–IV patients. For stage I patients, number of regional lymph nodes is a good substitute to predict survival. Chemotherapy was another favorable prognostic factor, especially for patients with a CRM value between 0 and 30 mm. |
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The Circumferential Resection Margin Is a Prognostic Predictor in Colon Cancer |
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https://doi.org/10.3389/fonc.2020.00927 https://doaj.org/article/1d473f2109ef4a18a5d3c7bd3a5d25e8 https://www.frontiersin.org/article/10.3389/fonc.2020.00927/full https://doaj.org/toc/2234-943X |
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Xin-Yi Tang Meng-Xi Huang Si-Qi Han Yue Chang Zhi-Ping Li Xiao-Ming Kao Yan-Yan Chen Chao Liu Ya-Di Huang Yi-Tian Chen Zeng-Jie Lei Xiao-Yuan Chu |
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Xin-Yi Tang Meng-Xi Huang Si-Qi Han Yue Chang Zhi-Ping Li Xiao-Ming Kao Yan-Yan Chen Chao Liu Ya-Di Huang Yi-Tian Chen Zeng-Jie Lei Xiao-Yuan Chu |
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2024-07-03T14:28:12.034Z |
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