Patterns of Theta Activity in Limbic Anxiety Circuit Preceding Exploratory Behavior in Approach-Avoidance Conflict

Theta oscillations within the hippocampus-amygdala-medial prefrontal cortex (HPC-AMY-mPFC(PrL)) circuit have been consistently implicated in the regulation of anxiety behaviors, including risk-assessment. To study if theta activity during risk-assessment was correlated with exploratory behavior in a...
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Autor*in:	Luis R Jacinto [verfasserIn] João J Cerqueira [verfasserIn] Nuno Sousa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Amygdala Anxiety Prefrontal Cortex stress Local Field Potentials ventral hippocampus

Übergeordnetes Werk:	In: Frontiers in Behavioral Neuroscience - Frontiers Media S.A., 2008, 10(2016)
Übergeordnetes Werk:	volume:10 ; year:2016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnbeh.2016.00171

Katalog-ID:	DOAJ012908061

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language	English
source	In Frontiers in Behavioral Neuroscience 10(2016) volume:10 year:2016
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topic_facet	Amygdala Anxiety Prefrontal Cortex stress Local Field Potentials ventral hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Behavioral Neuroscience
authorswithroles_txt_mv	Luis R Jacinto @@aut@@ João J Cerqueira @@aut@@ Nuno Sousa @@aut@@
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callnumber-first	R - Medicine
author	Luis R Jacinto
spellingShingle	Luis R Jacinto misc RC321-571 misc Amygdala misc Anxiety misc Prefrontal Cortex misc stress misc Local Field Potentials misc ventral hippocampus misc Neurosciences. Biological psychiatry. Neuropsychiatry Patterns of Theta Activity in Limbic Anxiety Circuit Preceding Exploratory Behavior in Approach-Avoidance Conflict
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topic_title	RC321-571 Patterns of Theta Activity in Limbic Anxiety Circuit Preceding Exploratory Behavior in Approach-Avoidance Conflict Amygdala Anxiety Prefrontal Cortex stress Local Field Potentials ventral hippocampus
topic	misc RC321-571 misc Amygdala misc Anxiety misc Prefrontal Cortex misc stress misc Local Field Potentials misc ventral hippocampus misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Amygdala misc Anxiety misc Prefrontal Cortex misc stress misc Local Field Potentials misc ventral hippocampus misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Patterns of Theta Activity in Limbic Anxiety Circuit Preceding Exploratory Behavior in Approach-Avoidance Conflict
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title_full	Patterns of Theta Activity in Limbic Anxiety Circuit Preceding Exploratory Behavior in Approach-Avoidance Conflict
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title_sort	patterns of theta activity in limbic anxiety circuit preceding exploratory behavior in approach-avoidance conflict
callnumber	RC321-571
title_auth	Patterns of Theta Activity in Limbic Anxiety Circuit Preceding Exploratory Behavior in Approach-Avoidance Conflict
abstract	Theta oscillations within the hippocampus-amygdala-medial prefrontal cortex (HPC-AMY-mPFC(PrL)) circuit have been consistently implicated in the regulation of anxiety behaviors, including risk-assessment. To study if theta activity during risk-assessment was correlated with exploratory behavior in an approach/avoidance paradigm we recorded simultaneous local field potentials from this circuit in rats exploring the elevated-plus maze (EPM). Opposing patterns of power variations in the ventral hippocampus (vHPC), basolateral amygdala (BLA) and prelimbic (PrL) mPFC, but not in the dorsal hippocampus (dHPC), during exploratory risk-assessment of the open arms preceded further exploration of the open arms or retreat back to the safer closed arms. The same patterns of theta power variations in the HPC-BLA-mPFC(PrL) circuit were also displayed by animals submitted to chronic unpredictable stress protocol known to induce an anxious state. Diverging patterns of vHPC-mPFC(PrL) theta coherence were also significantly correlated with forthcoming approach or avoidance behavior in the conflict situation in both controls and stressed animals; interestingly, vHPC-BLA and BLA-mPFC(PrL) theta coherence correlated with future behavior only in stressed animals, underlying the pivotal role of the amygdala on the stress response.
abstractGer	Theta oscillations within the hippocampus-amygdala-medial prefrontal cortex (HPC-AMY-mPFC(PrL)) circuit have been consistently implicated in the regulation of anxiety behaviors, including risk-assessment. To study if theta activity during risk-assessment was correlated with exploratory behavior in an approach/avoidance paradigm we recorded simultaneous local field potentials from this circuit in rats exploring the elevated-plus maze (EPM). Opposing patterns of power variations in the ventral hippocampus (vHPC), basolateral amygdala (BLA) and prelimbic (PrL) mPFC, but not in the dorsal hippocampus (dHPC), during exploratory risk-assessment of the open arms preceded further exploration of the open arms or retreat back to the safer closed arms. The same patterns of theta power variations in the HPC-BLA-mPFC(PrL) circuit were also displayed by animals submitted to chronic unpredictable stress protocol known to induce an anxious state. Diverging patterns of vHPC-mPFC(PrL) theta coherence were also significantly correlated with forthcoming approach or avoidance behavior in the conflict situation in both controls and stressed animals; interestingly, vHPC-BLA and BLA-mPFC(PrL) theta coherence correlated with future behavior only in stressed animals, underlying the pivotal role of the amygdala on the stress response.
abstract_unstemmed	Theta oscillations within the hippocampus-amygdala-medial prefrontal cortex (HPC-AMY-mPFC(PrL)) circuit have been consistently implicated in the regulation of anxiety behaviors, including risk-assessment. To study if theta activity during risk-assessment was correlated with exploratory behavior in an approach/avoidance paradigm we recorded simultaneous local field potentials from this circuit in rats exploring the elevated-plus maze (EPM). Opposing patterns of power variations in the ventral hippocampus (vHPC), basolateral amygdala (BLA) and prelimbic (PrL) mPFC, but not in the dorsal hippocampus (dHPC), during exploratory risk-assessment of the open arms preceded further exploration of the open arms or retreat back to the safer closed arms. The same patterns of theta power variations in the HPC-BLA-mPFC(PrL) circuit were also displayed by animals submitted to chronic unpredictable stress protocol known to induce an anxious state. Diverging patterns of vHPC-mPFC(PrL) theta coherence were also significantly correlated with forthcoming approach or avoidance behavior in the conflict situation in both controls and stressed animals; interestingly, vHPC-BLA and BLA-mPFC(PrL) theta coherence correlated with future behavior only in stressed animals, underlying the pivotal role of the amygdala on the stress response.
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title_short	Patterns of Theta Activity in Limbic Anxiety Circuit Preceding Exploratory Behavior in Approach-Avoidance Conflict
url	https://doi.org/10.3389/fnbeh.2016.00171 https://doaj.org/article/ffee2e1b039a48519354b553a18d51cd http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00171/full https://doaj.org/toc/1662-5153
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