Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension

OBJECTIVE: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). METHODS: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right h...
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Autor*in:	Francisca Gavilanes [verfasserIn] José Leonidas Alves Jr [verfasserIn] Caio Fernandes [verfasserIn] Luis Felipe Lopes Prada [verfasserIn] Carlos Viana Poyares Jardim [verfasserIn] Luciana Tamie Kato Morinaga [verfasserIn] Bruno Arantes Dias [verfasserIn] Susana Hoette [verfasserIn] Rogerio Souza [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Portugiesisch

Erschienen:	2014

Schlagwörter:	Hipertensão pulmonar Cateterismo cardíaco Disfunção ventricular esquerda

Übergeordnetes Werk:	In: Jornal Brasileiro de Pneumologia - Sociedade Brasileira de Pneumologia e Tisiologia, 2005, 40(2014), 6, Seite 609-616
Übergeordnetes Werk:	volume:40 ; year:2014 ; number:6 ; pages:609-616

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1590/S1806-37132014000600004

Katalog-ID:	DOAJ012924245

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520			\|a OBJECTIVE: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). METHODS: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism-between 2008 and 2013 at our facility. RESULTS: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3%) and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant.
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allfields	10.1590/S1806-37132014000600004 doi (DE-627)DOAJ012924245 (DE-599)DOAJ01927694bf0c4beab907d72cba1e4c46 DE-627 ger DE-627 rakwb eng por RC705-779 Francisca Gavilanes verfasserin aut Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OBJECTIVE: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). METHODS: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism-between 2008 and 2013 at our facility. RESULTS: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3%) and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant. Hipertensão pulmonar Cateterismo cardíaco Disfunção ventricular esquerda Diseases of the respiratory system José Leonidas Alves Jr verfasserin aut Caio Fernandes verfasserin aut Luis Felipe Lopes Prada verfasserin aut Carlos Viana Poyares Jardim verfasserin aut Luciana Tamie Kato Morinaga verfasserin aut Bruno Arantes Dias verfasserin aut Susana Hoette verfasserin aut Rogerio Souza verfasserin aut In Jornal Brasileiro de Pneumologia Sociedade Brasileira de Pneumologia e Tisiologia, 2005 40(2014), 6, Seite 609-616 (DE-627)508330513 (DE-600)2223157-2 18063756 nnns volume:40 year:2014 number:6 pages:609-616 https://doi.org/10.1590/S1806-37132014000600004 kostenfrei https://doaj.org/article/01927694bf0c4beab907d72cba1e4c46 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132014000600609&lng=en&tlng=en kostenfrei https://doaj.org/toc/1806-3756 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 40 2014 6 609-616
spelling	10.1590/S1806-37132014000600004 doi (DE-627)DOAJ012924245 (DE-599)DOAJ01927694bf0c4beab907d72cba1e4c46 DE-627 ger DE-627 rakwb eng por RC705-779 Francisca Gavilanes verfasserin aut Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OBJECTIVE: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). METHODS: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism-between 2008 and 2013 at our facility. RESULTS: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3%) and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant. Hipertensão pulmonar Cateterismo cardíaco Disfunção ventricular esquerda Diseases of the respiratory system José Leonidas Alves Jr verfasserin aut Caio Fernandes verfasserin aut Luis Felipe Lopes Prada verfasserin aut Carlos Viana Poyares Jardim verfasserin aut Luciana Tamie Kato Morinaga verfasserin aut Bruno Arantes Dias verfasserin aut Susana Hoette verfasserin aut Rogerio Souza verfasserin aut In Jornal Brasileiro de Pneumologia Sociedade Brasileira de Pneumologia e Tisiologia, 2005 40(2014), 6, Seite 609-616 (DE-627)508330513 (DE-600)2223157-2 18063756 nnns volume:40 year:2014 number:6 pages:609-616 https://doi.org/10.1590/S1806-37132014000600004 kostenfrei https://doaj.org/article/01927694bf0c4beab907d72cba1e4c46 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132014000600609&lng=en&tlng=en kostenfrei https://doaj.org/toc/1806-3756 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 40 2014 6 609-616
allfields_unstemmed	10.1590/S1806-37132014000600004 doi (DE-627)DOAJ012924245 (DE-599)DOAJ01927694bf0c4beab907d72cba1e4c46 DE-627 ger DE-627 rakwb eng por RC705-779 Francisca Gavilanes verfasserin aut Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OBJECTIVE: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). METHODS: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism-between 2008 and 2013 at our facility. RESULTS: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3%) and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant. Hipertensão pulmonar Cateterismo cardíaco Disfunção ventricular esquerda Diseases of the respiratory system José Leonidas Alves Jr verfasserin aut Caio Fernandes verfasserin aut Luis Felipe Lopes Prada verfasserin aut Carlos Viana Poyares Jardim verfasserin aut Luciana Tamie Kato Morinaga verfasserin aut Bruno Arantes Dias verfasserin aut Susana Hoette verfasserin aut Rogerio Souza verfasserin aut In Jornal Brasileiro de Pneumologia Sociedade Brasileira de Pneumologia e Tisiologia, 2005 40(2014), 6, Seite 609-616 (DE-627)508330513 (DE-600)2223157-2 18063756 nnns volume:40 year:2014 number:6 pages:609-616 https://doi.org/10.1590/S1806-37132014000600004 kostenfrei https://doaj.org/article/01927694bf0c4beab907d72cba1e4c46 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132014000600609&lng=en&tlng=en kostenfrei https://doaj.org/toc/1806-3756 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 40 2014 6 609-616
allfieldsGer	10.1590/S1806-37132014000600004 doi (DE-627)DOAJ012924245 (DE-599)DOAJ01927694bf0c4beab907d72cba1e4c46 DE-627 ger DE-627 rakwb eng por RC705-779 Francisca Gavilanes verfasserin aut Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OBJECTIVE: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). METHODS: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism-between 2008 and 2013 at our facility. RESULTS: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3%) and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant. Hipertensão pulmonar Cateterismo cardíaco Disfunção ventricular esquerda Diseases of the respiratory system José Leonidas Alves Jr verfasserin aut Caio Fernandes verfasserin aut Luis Felipe Lopes Prada verfasserin aut Carlos Viana Poyares Jardim verfasserin aut Luciana Tamie Kato Morinaga verfasserin aut Bruno Arantes Dias verfasserin aut Susana Hoette verfasserin aut Rogerio Souza verfasserin aut In Jornal Brasileiro de Pneumologia Sociedade Brasileira de Pneumologia e Tisiologia, 2005 40(2014), 6, Seite 609-616 (DE-627)508330513 (DE-600)2223157-2 18063756 nnns volume:40 year:2014 number:6 pages:609-616 https://doi.org/10.1590/S1806-37132014000600004 kostenfrei https://doaj.org/article/01927694bf0c4beab907d72cba1e4c46 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132014000600609&lng=en&tlng=en kostenfrei https://doaj.org/toc/1806-3756 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 40 2014 6 609-616
allfieldsSound	10.1590/S1806-37132014000600004 doi (DE-627)DOAJ012924245 (DE-599)DOAJ01927694bf0c4beab907d72cba1e4c46 DE-627 ger DE-627 rakwb eng por RC705-779 Francisca Gavilanes verfasserin aut Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OBJECTIVE: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). METHODS: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism-between 2008 and 2013 at our facility. RESULTS: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3%) and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant. Hipertensão pulmonar Cateterismo cardíaco Disfunção ventricular esquerda Diseases of the respiratory system José Leonidas Alves Jr verfasserin aut Caio Fernandes verfasserin aut Luis Felipe Lopes Prada verfasserin aut Carlos Viana Poyares Jardim verfasserin aut Luciana Tamie Kato Morinaga verfasserin aut Bruno Arantes Dias verfasserin aut Susana Hoette verfasserin aut Rogerio Souza verfasserin aut In Jornal Brasileiro de Pneumologia Sociedade Brasileira de Pneumologia e Tisiologia, 2005 40(2014), 6, Seite 609-616 (DE-627)508330513 (DE-600)2223157-2 18063756 nnns volume:40 year:2014 number:6 pages:609-616 https://doi.org/10.1590/S1806-37132014000600004 kostenfrei https://doaj.org/article/01927694bf0c4beab907d72cba1e4c46 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132014000600609&lng=en&tlng=en kostenfrei https://doaj.org/toc/1806-3756 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 40 2014 6 609-616
language	English Portuguese
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author	Francisca Gavilanes
spellingShingle	Francisca Gavilanes misc RC705-779 misc Hipertensão pulmonar misc Cateterismo cardíaco misc Disfunção ventricular esquerda misc Diseases of the respiratory system Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension
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topic_title	RC705-779 Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension Hipertensão pulmonar Cateterismo cardíaco Disfunção ventricular esquerda
topic	misc RC705-779 misc Hipertensão pulmonar misc Cateterismo cardíaco misc Disfunção ventricular esquerda misc Diseases of the respiratory system
topic_unstemmed	misc RC705-779 misc Hipertensão pulmonar misc Cateterismo cardíaco misc Disfunção ventricular esquerda misc Diseases of the respiratory system
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title	Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension
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title_full	Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension
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author_browse	Francisca Gavilanes José Leonidas Alves Jr Caio Fernandes Luis Felipe Lopes Prada Carlos Viana Poyares Jardim Luciana Tamie Kato Morinaga Bruno Arantes Dias Susana Hoette Rogerio Souza
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title_sort	left ventricular dysfunction in patients with suspected pulmonary arterial hypertension
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title_auth	Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension
abstract	OBJECTIVE: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). METHODS: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism-between 2008 and 2013 at our facility. RESULTS: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3%) and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant.
abstractGer	OBJECTIVE: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). METHODS: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism-between 2008 and 2013 at our facility. RESULTS: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3%) and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant.
abstract_unstemmed	OBJECTIVE: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). METHODS: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism-between 2008 and 2013 at our facility. RESULTS: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3%) and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant.
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up_date	2024-07-03T14:47:59.734Z
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METHODS: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism-between 2008 and 2013 at our facility. RESULTS: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3%) and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. 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Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension

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