Peri-Prosthetic Infection in the Orthopedic Tumor Patient
Background: Infection complicates traditional joint reconstruction prostheses in up to 7% of cases, with even higher rates in oncologic cases. Questions / Purposes: The authors ask if prosthetic infection in bone tumor patients is associated with any epidemiologic, treatment, or outcome variables t...
Ausführliche Beschreibung
Autor*in: |
Daniel Allison MD, MBA, FACS [verfasserIn] Eddie Huang, MD [verfasserIn] Elke Ahlmann, MD [verfasserIn] Scott Carney, MD [verfasserIn] Ling Wang, PA-C [verfasserIn] Lawrence Menendez, MD, FACS [verfasserIn] |
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E-Artikel |
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Englisch |
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2014 |
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Übergeordnetes Werk: |
In: Reconstructive Review - Joint Implant Surgery & Research Foundation, 2016, 4(2014), 3 |
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Übergeordnetes Werk: |
volume:4 ; year:2014 ; number:3 |
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Link aufrufen |
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DOI / URN: |
10.15438/rr.4.3.74 |
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Katalog-ID: |
DOAJ013086642 |
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520 | |a Background: Infection complicates traditional joint reconstruction prostheses in up to 7% of cases, with even higher rates in oncologic cases. Questions / Purposes: The authors ask if prosthetic infection in bone tumor patients is associated with any epidemiologic, treatment, or outcome variables that could influence management of these difficult conditions. Patients and Methods: Authors retrospectively reviewed 329 consecutive bone tumor (malignant and benign) patients treated with hip or knee tumor resection and subsequent joint reconstruction, comparing infected and non-infected cases. Patients were followed for a mean of 34 months. Results: Of lower extremity tumor reconstructions, 13.1% developed periprosthetic infection, with the knee significantly more involved than the hip (20.5% vs 6.1%). The most common organism cultured was Staphylococcus aureus (33%). The diagnosis of sarcoma was associated with a higher infection rate, and infections were associated with a two-fold increase in number of total surgeries. Adjuvant radiation alone and chemotherapy alone (but not in combination) was associated with statistically increased infection rates. Debridement with fixed implant retention achieved a 70% infection remission rate, as opposed to 62% with two-staged treatment, and 100% with amputation. The implants tended to survive longer than the patients. Conclusions: Infection complicates lower extremity prosthetic joint reconstructions in tumor patients more frequently than in non-tumor arthroplasty cases, with eradication rates lower than that of non-tumor patients. Periprosthetic infection correlates with radiation and chemotherapy administration, as well as an overall increase in revision surgery. Single stage debridement procedures result in infection remission rates comparable to two-stage reconstructions. Level of Evidence Level III, Retrospective comparative study. | ||
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10.15438/rr.4.3.74 doi (DE-627)DOAJ013086642 (DE-599)DOAJ869195f8ff744e27a60df40081d675c8 DE-627 ger DE-627 rakwb eng RD701-811 Daniel Allison MD, MBA, FACS verfasserin aut Peri-Prosthetic Infection in the Orthopedic Tumor Patient 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Infection complicates traditional joint reconstruction prostheses in up to 7% of cases, with even higher rates in oncologic cases. Questions / Purposes: The authors ask if prosthetic infection in bone tumor patients is associated with any epidemiologic, treatment, or outcome variables that could influence management of these difficult conditions. Patients and Methods: Authors retrospectively reviewed 329 consecutive bone tumor (malignant and benign) patients treated with hip or knee tumor resection and subsequent joint reconstruction, comparing infected and non-infected cases. Patients were followed for a mean of 34 months. Results: Of lower extremity tumor reconstructions, 13.1% developed periprosthetic infection, with the knee significantly more involved than the hip (20.5% vs 6.1%). The most common organism cultured was Staphylococcus aureus (33%). The diagnosis of sarcoma was associated with a higher infection rate, and infections were associated with a two-fold increase in number of total surgeries. Adjuvant radiation alone and chemotherapy alone (but not in combination) was associated with statistically increased infection rates. Debridement with fixed implant retention achieved a 70% infection remission rate, as opposed to 62% with two-staged treatment, and 100% with amputation. The implants tended to survive longer than the patients. Conclusions: Infection complicates lower extremity prosthetic joint reconstructions in tumor patients more frequently than in non-tumor arthroplasty cases, with eradication rates lower than that of non-tumor patients. Periprosthetic infection correlates with radiation and chemotherapy administration, as well as an overall increase in revision surgery. Single stage debridement procedures result in infection remission rates comparable to two-stage reconstructions. Level of Evidence Level III, Retrospective comparative study. Orthopedic surgery Eddie Huang, MD verfasserin aut Elke Ahlmann, MD verfasserin aut Scott Carney, MD verfasserin aut Ling Wang, PA-C verfasserin aut Lawrence Menendez, MD, FACS verfasserin aut In Reconstructive Review Joint Implant Surgery & Research Foundation, 2016 4(2014), 3 (DE-627)1760633844 23312270 nnns volume:4 year:2014 number:3 https://doi.org/10.15438/rr.4.3.74 kostenfrei https://doaj.org/article/869195f8ff744e27a60df40081d675c8 kostenfrei http://reconstructivereview.org/ojs/index.php/rr/article/view/74 kostenfrei https://doaj.org/toc/2331-2262 Journal toc kostenfrei https://doaj.org/toc/2331-2270 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 4 2014 3 |
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10.15438/rr.4.3.74 doi (DE-627)DOAJ013086642 (DE-599)DOAJ869195f8ff744e27a60df40081d675c8 DE-627 ger DE-627 rakwb eng RD701-811 Daniel Allison MD, MBA, FACS verfasserin aut Peri-Prosthetic Infection in the Orthopedic Tumor Patient 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Infection complicates traditional joint reconstruction prostheses in up to 7% of cases, with even higher rates in oncologic cases. Questions / Purposes: The authors ask if prosthetic infection in bone tumor patients is associated with any epidemiologic, treatment, or outcome variables that could influence management of these difficult conditions. Patients and Methods: Authors retrospectively reviewed 329 consecutive bone tumor (malignant and benign) patients treated with hip or knee tumor resection and subsequent joint reconstruction, comparing infected and non-infected cases. Patients were followed for a mean of 34 months. Results: Of lower extremity tumor reconstructions, 13.1% developed periprosthetic infection, with the knee significantly more involved than the hip (20.5% vs 6.1%). The most common organism cultured was Staphylococcus aureus (33%). The diagnosis of sarcoma was associated with a higher infection rate, and infections were associated with a two-fold increase in number of total surgeries. Adjuvant radiation alone and chemotherapy alone (but not in combination) was associated with statistically increased infection rates. Debridement with fixed implant retention achieved a 70% infection remission rate, as opposed to 62% with two-staged treatment, and 100% with amputation. The implants tended to survive longer than the patients. Conclusions: Infection complicates lower extremity prosthetic joint reconstructions in tumor patients more frequently than in non-tumor arthroplasty cases, with eradication rates lower than that of non-tumor patients. Periprosthetic infection correlates with radiation and chemotherapy administration, as well as an overall increase in revision surgery. Single stage debridement procedures result in infection remission rates comparable to two-stage reconstructions. Level of Evidence Level III, Retrospective comparative study. Orthopedic surgery Eddie Huang, MD verfasserin aut Elke Ahlmann, MD verfasserin aut Scott Carney, MD verfasserin aut Ling Wang, PA-C verfasserin aut Lawrence Menendez, MD, FACS verfasserin aut In Reconstructive Review Joint Implant Surgery & Research Foundation, 2016 4(2014), 3 (DE-627)1760633844 23312270 nnns volume:4 year:2014 number:3 https://doi.org/10.15438/rr.4.3.74 kostenfrei https://doaj.org/article/869195f8ff744e27a60df40081d675c8 kostenfrei http://reconstructivereview.org/ojs/index.php/rr/article/view/74 kostenfrei https://doaj.org/toc/2331-2262 Journal toc kostenfrei https://doaj.org/toc/2331-2270 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 4 2014 3 |
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10.15438/rr.4.3.74 doi (DE-627)DOAJ013086642 (DE-599)DOAJ869195f8ff744e27a60df40081d675c8 DE-627 ger DE-627 rakwb eng RD701-811 Daniel Allison MD, MBA, FACS verfasserin aut Peri-Prosthetic Infection in the Orthopedic Tumor Patient 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Infection complicates traditional joint reconstruction prostheses in up to 7% of cases, with even higher rates in oncologic cases. Questions / Purposes: The authors ask if prosthetic infection in bone tumor patients is associated with any epidemiologic, treatment, or outcome variables that could influence management of these difficult conditions. Patients and Methods: Authors retrospectively reviewed 329 consecutive bone tumor (malignant and benign) patients treated with hip or knee tumor resection and subsequent joint reconstruction, comparing infected and non-infected cases. Patients were followed for a mean of 34 months. Results: Of lower extremity tumor reconstructions, 13.1% developed periprosthetic infection, with the knee significantly more involved than the hip (20.5% vs 6.1%). The most common organism cultured was Staphylococcus aureus (33%). The diagnosis of sarcoma was associated with a higher infection rate, and infections were associated with a two-fold increase in number of total surgeries. Adjuvant radiation alone and chemotherapy alone (but not in combination) was associated with statistically increased infection rates. Debridement with fixed implant retention achieved a 70% infection remission rate, as opposed to 62% with two-staged treatment, and 100% with amputation. The implants tended to survive longer than the patients. Conclusions: Infection complicates lower extremity prosthetic joint reconstructions in tumor patients more frequently than in non-tumor arthroplasty cases, with eradication rates lower than that of non-tumor patients. Periprosthetic infection correlates with radiation and chemotherapy administration, as well as an overall increase in revision surgery. Single stage debridement procedures result in infection remission rates comparable to two-stage reconstructions. Level of Evidence Level III, Retrospective comparative study. Orthopedic surgery Eddie Huang, MD verfasserin aut Elke Ahlmann, MD verfasserin aut Scott Carney, MD verfasserin aut Ling Wang, PA-C verfasserin aut Lawrence Menendez, MD, FACS verfasserin aut In Reconstructive Review Joint Implant Surgery & Research Foundation, 2016 4(2014), 3 (DE-627)1760633844 23312270 nnns volume:4 year:2014 number:3 https://doi.org/10.15438/rr.4.3.74 kostenfrei https://doaj.org/article/869195f8ff744e27a60df40081d675c8 kostenfrei http://reconstructivereview.org/ojs/index.php/rr/article/view/74 kostenfrei https://doaj.org/toc/2331-2262 Journal toc kostenfrei https://doaj.org/toc/2331-2270 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 4 2014 3 |
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10.15438/rr.4.3.74 doi (DE-627)DOAJ013086642 (DE-599)DOAJ869195f8ff744e27a60df40081d675c8 DE-627 ger DE-627 rakwb eng RD701-811 Daniel Allison MD, MBA, FACS verfasserin aut Peri-Prosthetic Infection in the Orthopedic Tumor Patient 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Infection complicates traditional joint reconstruction prostheses in up to 7% of cases, with even higher rates in oncologic cases. Questions / Purposes: The authors ask if prosthetic infection in bone tumor patients is associated with any epidemiologic, treatment, or outcome variables that could influence management of these difficult conditions. Patients and Methods: Authors retrospectively reviewed 329 consecutive bone tumor (malignant and benign) patients treated with hip or knee tumor resection and subsequent joint reconstruction, comparing infected and non-infected cases. Patients were followed for a mean of 34 months. Results: Of lower extremity tumor reconstructions, 13.1% developed periprosthetic infection, with the knee significantly more involved than the hip (20.5% vs 6.1%). The most common organism cultured was Staphylococcus aureus (33%). The diagnosis of sarcoma was associated with a higher infection rate, and infections were associated with a two-fold increase in number of total surgeries. Adjuvant radiation alone and chemotherapy alone (but not in combination) was associated with statistically increased infection rates. Debridement with fixed implant retention achieved a 70% infection remission rate, as opposed to 62% with two-staged treatment, and 100% with amputation. The implants tended to survive longer than the patients. Conclusions: Infection complicates lower extremity prosthetic joint reconstructions in tumor patients more frequently than in non-tumor arthroplasty cases, with eradication rates lower than that of non-tumor patients. Periprosthetic infection correlates with radiation and chemotherapy administration, as well as an overall increase in revision surgery. Single stage debridement procedures result in infection remission rates comparable to two-stage reconstructions. Level of Evidence Level III, Retrospective comparative study. Orthopedic surgery Eddie Huang, MD verfasserin aut Elke Ahlmann, MD verfasserin aut Scott Carney, MD verfasserin aut Ling Wang, PA-C verfasserin aut Lawrence Menendez, MD, FACS verfasserin aut In Reconstructive Review Joint Implant Surgery & Research Foundation, 2016 4(2014), 3 (DE-627)1760633844 23312270 nnns volume:4 year:2014 number:3 https://doi.org/10.15438/rr.4.3.74 kostenfrei https://doaj.org/article/869195f8ff744e27a60df40081d675c8 kostenfrei http://reconstructivereview.org/ojs/index.php/rr/article/view/74 kostenfrei https://doaj.org/toc/2331-2262 Journal toc kostenfrei https://doaj.org/toc/2331-2270 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 4 2014 3 |
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Peri-Prosthetic Infection in the Orthopedic Tumor Patient |
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Daniel Allison MD, MBA, FACS |
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Reconstructive Review |
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Reconstructive Review |
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2014 |
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Daniel Allison MD, MBA, FACS Eddie Huang, MD Elke Ahlmann, MD Scott Carney, MD Ling Wang, PA-C Lawrence Menendez, MD, FACS |
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Daniel Allison MD, MBA, FACS |
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10.15438/rr.4.3.74 |
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peri-prosthetic infection in the orthopedic tumor patient |
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RD701-811 |
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Peri-Prosthetic Infection in the Orthopedic Tumor Patient |
abstract |
Background: Infection complicates traditional joint reconstruction prostheses in up to 7% of cases, with even higher rates in oncologic cases. Questions / Purposes: The authors ask if prosthetic infection in bone tumor patients is associated with any epidemiologic, treatment, or outcome variables that could influence management of these difficult conditions. Patients and Methods: Authors retrospectively reviewed 329 consecutive bone tumor (malignant and benign) patients treated with hip or knee tumor resection and subsequent joint reconstruction, comparing infected and non-infected cases. Patients were followed for a mean of 34 months. Results: Of lower extremity tumor reconstructions, 13.1% developed periprosthetic infection, with the knee significantly more involved than the hip (20.5% vs 6.1%). The most common organism cultured was Staphylococcus aureus (33%). The diagnosis of sarcoma was associated with a higher infection rate, and infections were associated with a two-fold increase in number of total surgeries. Adjuvant radiation alone and chemotherapy alone (but not in combination) was associated with statistically increased infection rates. Debridement with fixed implant retention achieved a 70% infection remission rate, as opposed to 62% with two-staged treatment, and 100% with amputation. The implants tended to survive longer than the patients. Conclusions: Infection complicates lower extremity prosthetic joint reconstructions in tumor patients more frequently than in non-tumor arthroplasty cases, with eradication rates lower than that of non-tumor patients. Periprosthetic infection correlates with radiation and chemotherapy administration, as well as an overall increase in revision surgery. Single stage debridement procedures result in infection remission rates comparable to two-stage reconstructions. Level of Evidence Level III, Retrospective comparative study. |
abstractGer |
Background: Infection complicates traditional joint reconstruction prostheses in up to 7% of cases, with even higher rates in oncologic cases. Questions / Purposes: The authors ask if prosthetic infection in bone tumor patients is associated with any epidemiologic, treatment, or outcome variables that could influence management of these difficult conditions. Patients and Methods: Authors retrospectively reviewed 329 consecutive bone tumor (malignant and benign) patients treated with hip or knee tumor resection and subsequent joint reconstruction, comparing infected and non-infected cases. Patients were followed for a mean of 34 months. Results: Of lower extremity tumor reconstructions, 13.1% developed periprosthetic infection, with the knee significantly more involved than the hip (20.5% vs 6.1%). The most common organism cultured was Staphylococcus aureus (33%). The diagnosis of sarcoma was associated with a higher infection rate, and infections were associated with a two-fold increase in number of total surgeries. Adjuvant radiation alone and chemotherapy alone (but not in combination) was associated with statistically increased infection rates. Debridement with fixed implant retention achieved a 70% infection remission rate, as opposed to 62% with two-staged treatment, and 100% with amputation. The implants tended to survive longer than the patients. Conclusions: Infection complicates lower extremity prosthetic joint reconstructions in tumor patients more frequently than in non-tumor arthroplasty cases, with eradication rates lower than that of non-tumor patients. Periprosthetic infection correlates with radiation and chemotherapy administration, as well as an overall increase in revision surgery. Single stage debridement procedures result in infection remission rates comparable to two-stage reconstructions. Level of Evidence Level III, Retrospective comparative study. |
abstract_unstemmed |
Background: Infection complicates traditional joint reconstruction prostheses in up to 7% of cases, with even higher rates in oncologic cases. Questions / Purposes: The authors ask if prosthetic infection in bone tumor patients is associated with any epidemiologic, treatment, or outcome variables that could influence management of these difficult conditions. Patients and Methods: Authors retrospectively reviewed 329 consecutive bone tumor (malignant and benign) patients treated with hip or knee tumor resection and subsequent joint reconstruction, comparing infected and non-infected cases. Patients were followed for a mean of 34 months. Results: Of lower extremity tumor reconstructions, 13.1% developed periprosthetic infection, with the knee significantly more involved than the hip (20.5% vs 6.1%). The most common organism cultured was Staphylococcus aureus (33%). The diagnosis of sarcoma was associated with a higher infection rate, and infections were associated with a two-fold increase in number of total surgeries. Adjuvant radiation alone and chemotherapy alone (but not in combination) was associated with statistically increased infection rates. Debridement with fixed implant retention achieved a 70% infection remission rate, as opposed to 62% with two-staged treatment, and 100% with amputation. The implants tended to survive longer than the patients. Conclusions: Infection complicates lower extremity prosthetic joint reconstructions in tumor patients more frequently than in non-tumor arthroplasty cases, with eradication rates lower than that of non-tumor patients. Periprosthetic infection correlates with radiation and chemotherapy administration, as well as an overall increase in revision surgery. Single stage debridement procedures result in infection remission rates comparable to two-stage reconstructions. Level of Evidence Level III, Retrospective comparative study. |
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Peri-Prosthetic Infection in the Orthopedic Tumor Patient |
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https://doi.org/10.15438/rr.4.3.74 https://doaj.org/article/869195f8ff744e27a60df40081d675c8 http://reconstructivereview.org/ojs/index.php/rr/article/view/74 https://doaj.org/toc/2331-2262 https://doaj.org/toc/2331-2270 |
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Eddie Huang, MD Elke Ahlmann, MD Scott Carney, MD Ling Wang, PA-C Lawrence Menendez, MD, FACS |
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Eddie Huang, MD Elke Ahlmann, MD Scott Carney, MD Ling Wang, PA-C Lawrence Menendez, MD, FACS |
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2024-07-03T15:42:01.935Z |
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