Small Molecule-Induced Pancreatic β-Like Cell Development: Mechanistic Approaches and Available Strategies

Diabetes is a metabolic disease which affects not only glucose metabolism but also lipid and protein metabolism. It encompasses two major types: type 1 and 2 diabetes. Despite the different etiologies of type 1 and 2 diabetes mellitus (T1DM and T2DM, respectively), the defining features of the two f...
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Autor*in:	Gitika Thakur [verfasserIn] Hyeon-Jeong Lee [verfasserIn] Ryoung-Hoon Jeon [verfasserIn] Sung-Lim Lee [verfasserIn] Gyu-Jin Rho [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	diabetes pancreatic differentiation small molecules pancreatic beta-like cells islet organoids

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 21(2020), 7, p 2388
Übergeordnetes Werk:	volume:21 ; year:2020 ; number:7, p 2388

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms21072388

Katalog-ID:	DOAJ013166433

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language	English
source	In International Journal of Molecular Sciences 21(2020), 7, p 2388 volume:21 year:2020 number:7, p 2388
sourceStr	In International Journal of Molecular Sciences 21(2020), 7, p 2388 volume:21 year:2020 number:7, p 2388
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Gitika Thakur @@aut@@ Hyeon-Jeong Lee @@aut@@ Ryoung-Hoon Jeon @@aut@@ Sung-Lim Lee @@aut@@ Gyu-Jin Rho @@aut@@
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callnumber-first	Q - Science
author	Gitika Thakur
spellingShingle	Gitika Thakur misc QH301-705.5 misc QD1-999 misc diabetes misc pancreatic differentiation misc small molecules misc pancreatic beta-like cells misc islet organoids misc Biology (General) misc Chemistry Small Molecule-Induced Pancreatic β-Like Cell Development: Mechanistic Approaches and Available Strategies
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topic_title	QH301-705.5 QD1-999 Small Molecule-Induced Pancreatic β-Like Cell Development: Mechanistic Approaches and Available Strategies diabetes pancreatic differentiation small molecules pancreatic beta-like cells islet organoids
topic	misc QH301-705.5 misc QD1-999 misc diabetes misc pancreatic differentiation misc small molecules misc pancreatic beta-like cells misc islet organoids misc Biology (General) misc Chemistry
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title	Small Molecule-Induced Pancreatic β-Like Cell Development: Mechanistic Approaches and Available Strategies
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title_sort	small molecule-induced pancreatic β-like cell development: mechanistic approaches and available strategies
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title_auth	Small Molecule-Induced Pancreatic β-Like Cell Development: Mechanistic Approaches and Available Strategies
abstract	Diabetes is a metabolic disease which affects not only glucose metabolism but also lipid and protein metabolism. It encompasses two major types: type 1 and 2 diabetes. Despite the different etiologies of type 1 and 2 diabetes mellitus (T1DM and T2DM, respectively), the defining features of the two forms are insulin deficiency and resistance, respectively. Stem cell therapy is an efficient method for the treatment of diabetes, which can be achieved by differentiating pancreatic β-like cells. The consistent generation of glucose-responsive insulin releasing cells remains challenging. In this review article, we present basic concepts of pancreatic organogenesis, which intermittently provides a basis for engineering differentiation procedures, mainly based on the use of small molecules. Small molecules are more auspicious than any other growth factors, as they have unique, valuable properties like cell-permeability, as well as a nonimmunogenic nature; furthermore, they offer immense benefits in terms of generating efficient functional beta-like cells. We also summarize advances in the generation of stem cell-derived pancreatic cell lineages, especially endocrine β-like cells or islet organoids. The successful induction of stem cells depends on the quantity and quality of available stem cells and the efficient use of small molecules.
abstractGer	Diabetes is a metabolic disease which affects not only glucose metabolism but also lipid and protein metabolism. It encompasses two major types: type 1 and 2 diabetes. Despite the different etiologies of type 1 and 2 diabetes mellitus (T1DM and T2DM, respectively), the defining features of the two forms are insulin deficiency and resistance, respectively. Stem cell therapy is an efficient method for the treatment of diabetes, which can be achieved by differentiating pancreatic β-like cells. The consistent generation of glucose-responsive insulin releasing cells remains challenging. In this review article, we present basic concepts of pancreatic organogenesis, which intermittently provides a basis for engineering differentiation procedures, mainly based on the use of small molecules. Small molecules are more auspicious than any other growth factors, as they have unique, valuable properties like cell-permeability, as well as a nonimmunogenic nature; furthermore, they offer immense benefits in terms of generating efficient functional beta-like cells. We also summarize advances in the generation of stem cell-derived pancreatic cell lineages, especially endocrine β-like cells or islet organoids. The successful induction of stem cells depends on the quantity and quality of available stem cells and the efficient use of small molecules.
abstract_unstemmed	Diabetes is a metabolic disease which affects not only glucose metabolism but also lipid and protein metabolism. It encompasses two major types: type 1 and 2 diabetes. Despite the different etiologies of type 1 and 2 diabetes mellitus (T1DM and T2DM, respectively), the defining features of the two forms are insulin deficiency and resistance, respectively. Stem cell therapy is an efficient method for the treatment of diabetes, which can be achieved by differentiating pancreatic β-like cells. The consistent generation of glucose-responsive insulin releasing cells remains challenging. In this review article, we present basic concepts of pancreatic organogenesis, which intermittently provides a basis for engineering differentiation procedures, mainly based on the use of small molecules. Small molecules are more auspicious than any other growth factors, as they have unique, valuable properties like cell-permeability, as well as a nonimmunogenic nature; furthermore, they offer immense benefits in terms of generating efficient functional beta-like cells. We also summarize advances in the generation of stem cell-derived pancreatic cell lineages, especially endocrine β-like cells or islet organoids. The successful induction of stem cells depends on the quantity and quality of available stem cells and the efficient use of small molecules.
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title_short	Small Molecule-Induced Pancreatic β-Like Cell Development: Mechanistic Approaches and Available Strategies
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up_date	2024-07-03T16:07:58.329Z
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