Molecular Mechanism and Regulation of Autophagy and Its Potential Role in Epilepsy

Autophagy is an evolutionally conserved degradation mechanism for maintaining cell homeostasis whereby cytoplasmic components are wrapped in autophagosomes and subsequently delivered to lysosomes for degradation. This process requires the concerted actions of multiple autophagy-related proteins and...
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Autor*in:	Hanxiao Zhu [verfasserIn] Wei Wang [verfasserIn] Yun Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	autophagy autophagosome epilepsy synapse mTOR pathological mechanism

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 11(2022), 17, p 2621
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:17, p 2621

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells11172621

Katalog-ID:	DOAJ013267515

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language	English
source	In Cells 11(2022), 17, p 2621 volume:11 year:2022 number:17, p 2621
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format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	autophagy autophagosome epilepsy synapse mTOR pathological mechanism Cytology
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authorswithroles_txt_mv	Hanxiao Zhu @@aut@@ Wei Wang @@aut@@ Yun Li @@aut@@
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author	Hanxiao Zhu
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topic_title	QH573-671 Molecular Mechanism and Regulation of Autophagy and Its Potential Role in Epilepsy autophagy autophagosome epilepsy synapse mTOR pathological mechanism
topic	misc QH573-671 misc autophagy misc autophagosome misc epilepsy misc synapse misc mTOR misc pathological mechanism misc Cytology
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title	Molecular Mechanism and Regulation of Autophagy and Its Potential Role in Epilepsy
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title_sort	molecular mechanism and regulation of autophagy and its potential role in epilepsy
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title_auth	Molecular Mechanism and Regulation of Autophagy and Its Potential Role in Epilepsy
abstract	Autophagy is an evolutionally conserved degradation mechanism for maintaining cell homeostasis whereby cytoplasmic components are wrapped in autophagosomes and subsequently delivered to lysosomes for degradation. This process requires the concerted actions of multiple autophagy-related proteins and accessory regulators. In neurons, autophagy is dynamically regulated in different compartments including soma, axons, and dendrites. It determines the turnover of selected materials in a spatiotemporal control manner, which facilitates the formation of specialized neuronal functions. It is not surprising, therefore, that dysfunctional autophagy occurs in epilepsy, mainly caused by an imbalance between excitation and inhibition in the brain. In recent years, much attention has been focused on how autophagy may cause the development of epilepsy. In this article, we overview the historical landmarks and distinct types of autophagy, recent progress in the core machinery and regulation of autophagy, and biological roles of autophagy in homeostatic maintenance of neuronal structures and functions, with a particular focus on synaptic plasticity. We also discuss the relevance of autophagy mechanisms to the pathophysiology of epileptogenesis.
abstractGer	Autophagy is an evolutionally conserved degradation mechanism for maintaining cell homeostasis whereby cytoplasmic components are wrapped in autophagosomes and subsequently delivered to lysosomes for degradation. This process requires the concerted actions of multiple autophagy-related proteins and accessory regulators. In neurons, autophagy is dynamically regulated in different compartments including soma, axons, and dendrites. It determines the turnover of selected materials in a spatiotemporal control manner, which facilitates the formation of specialized neuronal functions. It is not surprising, therefore, that dysfunctional autophagy occurs in epilepsy, mainly caused by an imbalance between excitation and inhibition in the brain. In recent years, much attention has been focused on how autophagy may cause the development of epilepsy. In this article, we overview the historical landmarks and distinct types of autophagy, recent progress in the core machinery and regulation of autophagy, and biological roles of autophagy in homeostatic maintenance of neuronal structures and functions, with a particular focus on synaptic plasticity. We also discuss the relevance of autophagy mechanisms to the pathophysiology of epileptogenesis.
abstract_unstemmed	Autophagy is an evolutionally conserved degradation mechanism for maintaining cell homeostasis whereby cytoplasmic components are wrapped in autophagosomes and subsequently delivered to lysosomes for degradation. This process requires the concerted actions of multiple autophagy-related proteins and accessory regulators. In neurons, autophagy is dynamically regulated in different compartments including soma, axons, and dendrites. It determines the turnover of selected materials in a spatiotemporal control manner, which facilitates the formation of specialized neuronal functions. It is not surprising, therefore, that dysfunctional autophagy occurs in epilepsy, mainly caused by an imbalance between excitation and inhibition in the brain. In recent years, much attention has been focused on how autophagy may cause the development of epilepsy. In this article, we overview the historical landmarks and distinct types of autophagy, recent progress in the core machinery and regulation of autophagy, and biological roles of autophagy in homeostatic maintenance of neuronal structures and functions, with a particular focus on synaptic plasticity. We also discuss the relevance of autophagy mechanisms to the pathophysiology of epileptogenesis.
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title_short	Molecular Mechanism and Regulation of Autophagy and Its Potential Role in Epilepsy
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