Mixture of Phlorotannin and Fucoidan from <i<Ecklonia cava</i< Prevents the Aβ-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation
The anti-amnesic effect of a mixture (4:6 = phlorotannin:fucoidan from <i<Ecklonia cava</i<, P4F6) was evaluated on amyloid-beta peptide (Aβ)-induced cognitive deficit mice. The cognitive function was examined by Y-maze, passive avoidance, and Morris water maze tests, and the intake of t...
Ausführliche Beschreibung
Autor*in: |
Hye Ju Han [verfasserIn] Seon Kyeong Park [verfasserIn] Jin Yong Kang [verfasserIn] Jong Min Kim [verfasserIn] Seul Ki Yoo [verfasserIn] Dae-Ok Kim [verfasserIn] Gun-Hee Kim [verfasserIn] Ho Jin Heo [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Marine Drugs - MDPI AG, 2005, 19(2021), 8, p 434 |
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Übergeordnetes Werk: |
volume:19 ; year:2021 ; number:8, p 434 |
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DOI / URN: |
10.3390/md19080434 |
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Katalog-ID: |
DOAJ013331701 |
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10.3390/md19080434 doi (DE-627)DOAJ013331701 (DE-599)DOAJ9404971622ea4e41865436ec7ef7919a DE-627 ger DE-627 rakwb eng QH301-705.5 Hye Ju Han verfasserin aut Mixture of Phlorotannin and Fucoidan from <i<Ecklonia cava</i< Prevents the Aβ-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-amnesic effect of a mixture (4:6 = phlorotannin:fucoidan from <i<Ecklonia cava</i<, P4F6) was evaluated on amyloid-beta peptide (Aβ)-induced cognitive deficit mice. The cognitive function was examined by Y-maze, passive avoidance, and Morris water maze tests, and the intake of the mixture (P4F6) showed an ameliorating effect on Aβ-induced learning and memory impairment. After the behavioral tests, superoxide dismutase (SOD) activity and thiobarbituric acid-reactive substances (TBARS) contents were confirmed in brain tissue, and in the results, the mixture (P4F6) attenuated Aβ-induced oxidative stress. In addition, mitochondrial activity was evaluated by mitochondrial reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) content, and mitochondria-mediated apoptotic signaling pathway, and the mixture (P4F6) enhanced mitochondrial function. Furthermore, the mixture (P4F6) effectively regulated tau hyperphosphorylation by regulating the protein kinase B (Akt) pathway, and promoted brain-derived neurotrophic factor (BDNF) in brain tissue. Moreover, in the cholinergic system, the mixture (P4F6) ameliorated acetylcholine (ACh) content by regulating acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression in brain tissue. Based on these results, we suggest that this mixture of phlorotannin and fucoidan (P4F6) might be a substance for improving cognitive function by effectively regulating cognition-related molecules. <i<Ecklonia cava</i< phlorotannin fucoidan amyloid-beta cognition mitochondrial function Biology (General) Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Jong Min Kim verfasserin aut Seul Ki Yoo verfasserin aut Dae-Ok Kim verfasserin aut Gun-Hee Kim verfasserin aut Ho Jin Heo verfasserin aut In Marine Drugs MDPI AG, 2005 19(2021), 8, p 434 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:19 year:2021 number:8, p 434 https://doi.org/10.3390/md19080434 kostenfrei https://doaj.org/article/9404971622ea4e41865436ec7ef7919a kostenfrei https://www.mdpi.com/1660-3397/19/8/434 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 8, p 434 |
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10.3390/md19080434 doi (DE-627)DOAJ013331701 (DE-599)DOAJ9404971622ea4e41865436ec7ef7919a DE-627 ger DE-627 rakwb eng QH301-705.5 Hye Ju Han verfasserin aut Mixture of Phlorotannin and Fucoidan from <i<Ecklonia cava</i< Prevents the Aβ-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-amnesic effect of a mixture (4:6 = phlorotannin:fucoidan from <i<Ecklonia cava</i<, P4F6) was evaluated on amyloid-beta peptide (Aβ)-induced cognitive deficit mice. The cognitive function was examined by Y-maze, passive avoidance, and Morris water maze tests, and the intake of the mixture (P4F6) showed an ameliorating effect on Aβ-induced learning and memory impairment. After the behavioral tests, superoxide dismutase (SOD) activity and thiobarbituric acid-reactive substances (TBARS) contents were confirmed in brain tissue, and in the results, the mixture (P4F6) attenuated Aβ-induced oxidative stress. In addition, mitochondrial activity was evaluated by mitochondrial reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) content, and mitochondria-mediated apoptotic signaling pathway, and the mixture (P4F6) enhanced mitochondrial function. Furthermore, the mixture (P4F6) effectively regulated tau hyperphosphorylation by regulating the protein kinase B (Akt) pathway, and promoted brain-derived neurotrophic factor (BDNF) in brain tissue. Moreover, in the cholinergic system, the mixture (P4F6) ameliorated acetylcholine (ACh) content by regulating acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression in brain tissue. Based on these results, we suggest that this mixture of phlorotannin and fucoidan (P4F6) might be a substance for improving cognitive function by effectively regulating cognition-related molecules. <i<Ecklonia cava</i< phlorotannin fucoidan amyloid-beta cognition mitochondrial function Biology (General) Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Jong Min Kim verfasserin aut Seul Ki Yoo verfasserin aut Dae-Ok Kim verfasserin aut Gun-Hee Kim verfasserin aut Ho Jin Heo verfasserin aut In Marine Drugs MDPI AG, 2005 19(2021), 8, p 434 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:19 year:2021 number:8, p 434 https://doi.org/10.3390/md19080434 kostenfrei https://doaj.org/article/9404971622ea4e41865436ec7ef7919a kostenfrei https://www.mdpi.com/1660-3397/19/8/434 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 8, p 434 |
allfields_unstemmed |
10.3390/md19080434 doi (DE-627)DOAJ013331701 (DE-599)DOAJ9404971622ea4e41865436ec7ef7919a DE-627 ger DE-627 rakwb eng QH301-705.5 Hye Ju Han verfasserin aut Mixture of Phlorotannin and Fucoidan from <i<Ecklonia cava</i< Prevents the Aβ-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-amnesic effect of a mixture (4:6 = phlorotannin:fucoidan from <i<Ecklonia cava</i<, P4F6) was evaluated on amyloid-beta peptide (Aβ)-induced cognitive deficit mice. The cognitive function was examined by Y-maze, passive avoidance, and Morris water maze tests, and the intake of the mixture (P4F6) showed an ameliorating effect on Aβ-induced learning and memory impairment. After the behavioral tests, superoxide dismutase (SOD) activity and thiobarbituric acid-reactive substances (TBARS) contents were confirmed in brain tissue, and in the results, the mixture (P4F6) attenuated Aβ-induced oxidative stress. In addition, mitochondrial activity was evaluated by mitochondrial reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) content, and mitochondria-mediated apoptotic signaling pathway, and the mixture (P4F6) enhanced mitochondrial function. Furthermore, the mixture (P4F6) effectively regulated tau hyperphosphorylation by regulating the protein kinase B (Akt) pathway, and promoted brain-derived neurotrophic factor (BDNF) in brain tissue. Moreover, in the cholinergic system, the mixture (P4F6) ameliorated acetylcholine (ACh) content by regulating acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression in brain tissue. Based on these results, we suggest that this mixture of phlorotannin and fucoidan (P4F6) might be a substance for improving cognitive function by effectively regulating cognition-related molecules. <i<Ecklonia cava</i< phlorotannin fucoidan amyloid-beta cognition mitochondrial function Biology (General) Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Jong Min Kim verfasserin aut Seul Ki Yoo verfasserin aut Dae-Ok Kim verfasserin aut Gun-Hee Kim verfasserin aut Ho Jin Heo verfasserin aut In Marine Drugs MDPI AG, 2005 19(2021), 8, p 434 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:19 year:2021 number:8, p 434 https://doi.org/10.3390/md19080434 kostenfrei https://doaj.org/article/9404971622ea4e41865436ec7ef7919a kostenfrei https://www.mdpi.com/1660-3397/19/8/434 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 8, p 434 |
allfieldsGer |
10.3390/md19080434 doi (DE-627)DOAJ013331701 (DE-599)DOAJ9404971622ea4e41865436ec7ef7919a DE-627 ger DE-627 rakwb eng QH301-705.5 Hye Ju Han verfasserin aut Mixture of Phlorotannin and Fucoidan from <i<Ecklonia cava</i< Prevents the Aβ-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-amnesic effect of a mixture (4:6 = phlorotannin:fucoidan from <i<Ecklonia cava</i<, P4F6) was evaluated on amyloid-beta peptide (Aβ)-induced cognitive deficit mice. The cognitive function was examined by Y-maze, passive avoidance, and Morris water maze tests, and the intake of the mixture (P4F6) showed an ameliorating effect on Aβ-induced learning and memory impairment. After the behavioral tests, superoxide dismutase (SOD) activity and thiobarbituric acid-reactive substances (TBARS) contents were confirmed in brain tissue, and in the results, the mixture (P4F6) attenuated Aβ-induced oxidative stress. In addition, mitochondrial activity was evaluated by mitochondrial reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) content, and mitochondria-mediated apoptotic signaling pathway, and the mixture (P4F6) enhanced mitochondrial function. Furthermore, the mixture (P4F6) effectively regulated tau hyperphosphorylation by regulating the protein kinase B (Akt) pathway, and promoted brain-derived neurotrophic factor (BDNF) in brain tissue. Moreover, in the cholinergic system, the mixture (P4F6) ameliorated acetylcholine (ACh) content by regulating acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression in brain tissue. Based on these results, we suggest that this mixture of phlorotannin and fucoidan (P4F6) might be a substance for improving cognitive function by effectively regulating cognition-related molecules. <i<Ecklonia cava</i< phlorotannin fucoidan amyloid-beta cognition mitochondrial function Biology (General) Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Jong Min Kim verfasserin aut Seul Ki Yoo verfasserin aut Dae-Ok Kim verfasserin aut Gun-Hee Kim verfasserin aut Ho Jin Heo verfasserin aut In Marine Drugs MDPI AG, 2005 19(2021), 8, p 434 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:19 year:2021 number:8, p 434 https://doi.org/10.3390/md19080434 kostenfrei https://doaj.org/article/9404971622ea4e41865436ec7ef7919a kostenfrei https://www.mdpi.com/1660-3397/19/8/434 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 8, p 434 |
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10.3390/md19080434 doi (DE-627)DOAJ013331701 (DE-599)DOAJ9404971622ea4e41865436ec7ef7919a DE-627 ger DE-627 rakwb eng QH301-705.5 Hye Ju Han verfasserin aut Mixture of Phlorotannin and Fucoidan from <i<Ecklonia cava</i< Prevents the Aβ-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-amnesic effect of a mixture (4:6 = phlorotannin:fucoidan from <i<Ecklonia cava</i<, P4F6) was evaluated on amyloid-beta peptide (Aβ)-induced cognitive deficit mice. The cognitive function was examined by Y-maze, passive avoidance, and Morris water maze tests, and the intake of the mixture (P4F6) showed an ameliorating effect on Aβ-induced learning and memory impairment. After the behavioral tests, superoxide dismutase (SOD) activity and thiobarbituric acid-reactive substances (TBARS) contents were confirmed in brain tissue, and in the results, the mixture (P4F6) attenuated Aβ-induced oxidative stress. In addition, mitochondrial activity was evaluated by mitochondrial reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) content, and mitochondria-mediated apoptotic signaling pathway, and the mixture (P4F6) enhanced mitochondrial function. Furthermore, the mixture (P4F6) effectively regulated tau hyperphosphorylation by regulating the protein kinase B (Akt) pathway, and promoted brain-derived neurotrophic factor (BDNF) in brain tissue. Moreover, in the cholinergic system, the mixture (P4F6) ameliorated acetylcholine (ACh) content by regulating acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression in brain tissue. Based on these results, we suggest that this mixture of phlorotannin and fucoidan (P4F6) might be a substance for improving cognitive function by effectively regulating cognition-related molecules. <i<Ecklonia cava</i< phlorotannin fucoidan amyloid-beta cognition mitochondrial function Biology (General) Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Jong Min Kim verfasserin aut Seul Ki Yoo verfasserin aut Dae-Ok Kim verfasserin aut Gun-Hee Kim verfasserin aut Ho Jin Heo verfasserin aut In Marine Drugs MDPI AG, 2005 19(2021), 8, p 434 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:19 year:2021 number:8, p 434 https://doi.org/10.3390/md19080434 kostenfrei https://doaj.org/article/9404971622ea4e41865436ec7ef7919a kostenfrei https://www.mdpi.com/1660-3397/19/8/434 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 8, p 434 |
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Mixture of Phlorotannin and Fucoidan from <i<Ecklonia cava</i< Prevents the Aβ-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation |
abstract |
The anti-amnesic effect of a mixture (4:6 = phlorotannin:fucoidan from <i<Ecklonia cava</i<, P4F6) was evaluated on amyloid-beta peptide (Aβ)-induced cognitive deficit mice. The cognitive function was examined by Y-maze, passive avoidance, and Morris water maze tests, and the intake of the mixture (P4F6) showed an ameliorating effect on Aβ-induced learning and memory impairment. After the behavioral tests, superoxide dismutase (SOD) activity and thiobarbituric acid-reactive substances (TBARS) contents were confirmed in brain tissue, and in the results, the mixture (P4F6) attenuated Aβ-induced oxidative stress. In addition, mitochondrial activity was evaluated by mitochondrial reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) content, and mitochondria-mediated apoptotic signaling pathway, and the mixture (P4F6) enhanced mitochondrial function. Furthermore, the mixture (P4F6) effectively regulated tau hyperphosphorylation by regulating the protein kinase B (Akt) pathway, and promoted brain-derived neurotrophic factor (BDNF) in brain tissue. Moreover, in the cholinergic system, the mixture (P4F6) ameliorated acetylcholine (ACh) content by regulating acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression in brain tissue. Based on these results, we suggest that this mixture of phlorotannin and fucoidan (P4F6) might be a substance for improving cognitive function by effectively regulating cognition-related molecules. |
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The anti-amnesic effect of a mixture (4:6 = phlorotannin:fucoidan from <i<Ecklonia cava</i<, P4F6) was evaluated on amyloid-beta peptide (Aβ)-induced cognitive deficit mice. The cognitive function was examined by Y-maze, passive avoidance, and Morris water maze tests, and the intake of the mixture (P4F6) showed an ameliorating effect on Aβ-induced learning and memory impairment. After the behavioral tests, superoxide dismutase (SOD) activity and thiobarbituric acid-reactive substances (TBARS) contents were confirmed in brain tissue, and in the results, the mixture (P4F6) attenuated Aβ-induced oxidative stress. In addition, mitochondrial activity was evaluated by mitochondrial reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) content, and mitochondria-mediated apoptotic signaling pathway, and the mixture (P4F6) enhanced mitochondrial function. Furthermore, the mixture (P4F6) effectively regulated tau hyperphosphorylation by regulating the protein kinase B (Akt) pathway, and promoted brain-derived neurotrophic factor (BDNF) in brain tissue. Moreover, in the cholinergic system, the mixture (P4F6) ameliorated acetylcholine (ACh) content by regulating acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression in brain tissue. Based on these results, we suggest that this mixture of phlorotannin and fucoidan (P4F6) might be a substance for improving cognitive function by effectively regulating cognition-related molecules. |
abstract_unstemmed |
The anti-amnesic effect of a mixture (4:6 = phlorotannin:fucoidan from <i<Ecklonia cava</i<, P4F6) was evaluated on amyloid-beta peptide (Aβ)-induced cognitive deficit mice. The cognitive function was examined by Y-maze, passive avoidance, and Morris water maze tests, and the intake of the mixture (P4F6) showed an ameliorating effect on Aβ-induced learning and memory impairment. After the behavioral tests, superoxide dismutase (SOD) activity and thiobarbituric acid-reactive substances (TBARS) contents were confirmed in brain tissue, and in the results, the mixture (P4F6) attenuated Aβ-induced oxidative stress. In addition, mitochondrial activity was evaluated by mitochondrial reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) content, and mitochondria-mediated apoptotic signaling pathway, and the mixture (P4F6) enhanced mitochondrial function. Furthermore, the mixture (P4F6) effectively regulated tau hyperphosphorylation by regulating the protein kinase B (Akt) pathway, and promoted brain-derived neurotrophic factor (BDNF) in brain tissue. Moreover, in the cholinergic system, the mixture (P4F6) ameliorated acetylcholine (ACh) content by regulating acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression in brain tissue. Based on these results, we suggest that this mixture of phlorotannin and fucoidan (P4F6) might be a substance for improving cognitive function by effectively regulating cognition-related molecules. |
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