The Regulation of Integrated Stress Response Signaling Pathway on Viral Infection and Viral Antagonism

The integrated stress response (ISR) is an adaptational signaling pathway induced in response to different stimuli, such as accumulation of unfolded and misfolded proteins, hypoxia, amino acid deprivation, viral infection, and ultraviolet light. It has been known that viral infection can activate th...
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Autor*in:	Yongshu Wu [verfasserIn] Zhidong Zhang [verfasserIn] Yanmin Li [verfasserIn] Yijing Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	integrated stress response eIF2α phosphorylation unfolded protein response viral replication host

Übergeordnetes Werk:	In: Frontiers in Microbiology - Frontiers Media S.A., 2011, 12(2022)
Übergeordnetes Werk:	volume:12 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmicb.2021.814635

Katalog-ID:	DOAJ013365800

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520			\|a The integrated stress response (ISR) is an adaptational signaling pathway induced in response to different stimuli, such as accumulation of unfolded and misfolded proteins, hypoxia, amino acid deprivation, viral infection, and ultraviolet light. It has been known that viral infection can activate the ISR, but the role of the ISR during viral infection is still unclear. In some cases, the ISR is a protective mechanism of host cells against viral infection, while viruses may hijack the ISR for facilitating their replication. This review highlighted recent advances on the induction of the ISR upon viral infection and the downstream responses, such as autophagy, apoptosis, formation of stress granules, and innate immunity response. We then discussed the molecular mechanism of the ISR regulating viral replication and how viruses antagonize this cellular stress response resulting from the ISR.
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allfieldsSound	10.3389/fmicb.2021.814635 doi (DE-627)DOAJ013365800 (DE-599)DOAJ94215704710b4edc842645f46b842ed7 DE-627 ger DE-627 rakwb eng QR1-502 Yongshu Wu verfasserin aut The Regulation of Integrated Stress Response Signaling Pathway on Viral Infection and Viral Antagonism 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The integrated stress response (ISR) is an adaptational signaling pathway induced in response to different stimuli, such as accumulation of unfolded and misfolded proteins, hypoxia, amino acid deprivation, viral infection, and ultraviolet light. It has been known that viral infection can activate the ISR, but the role of the ISR during viral infection is still unclear. In some cases, the ISR is a protective mechanism of host cells against viral infection, while viruses may hijack the ISR for facilitating their replication. This review highlighted recent advances on the induction of the ISR upon viral infection and the downstream responses, such as autophagy, apoptosis, formation of stress granules, and innate immunity response. We then discussed the molecular mechanism of the ISR regulating viral replication and how viruses antagonize this cellular stress response resulting from the ISR. integrated stress response eIF2α phosphorylation unfolded protein response viral replication host Microbiology Yongshu Wu verfasserin aut Zhidong Zhang verfasserin aut Yanmin Li verfasserin aut Yijing Li verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 12(2022) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:12 year:2022 https://doi.org/10.3389/fmicb.2021.814635 kostenfrei https://doaj.org/article/94215704710b4edc842645f46b842ed7 kostenfrei https://www.frontiersin.org/articles/10.3389/fmicb.2021.814635/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022
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source	In Frontiers in Microbiology 12(2022) volume:12 year:2022
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authorswithroles_txt_mv	Yongshu Wu @@aut@@ Zhidong Zhang @@aut@@ Yanmin Li @@aut@@ Yijing Li @@aut@@
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callnumber-first	Q - Science
author	Yongshu Wu
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topic_title	QR1-502 The Regulation of Integrated Stress Response Signaling Pathway on Viral Infection and Viral Antagonism integrated stress response eIF2α phosphorylation unfolded protein response viral replication host
topic	misc QR1-502 misc integrated stress response misc eIF2α phosphorylation misc unfolded protein response misc viral replication misc host misc Microbiology
topic_unstemmed	misc QR1-502 misc integrated stress response misc eIF2α phosphorylation misc unfolded protein response misc viral replication misc host misc Microbiology
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title	The Regulation of Integrated Stress Response Signaling Pathway on Viral Infection and Viral Antagonism
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title_sort	regulation of integrated stress response signaling pathway on viral infection and viral antagonism
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title_auth	The Regulation of Integrated Stress Response Signaling Pathway on Viral Infection and Viral Antagonism
abstract	The integrated stress response (ISR) is an adaptational signaling pathway induced in response to different stimuli, such as accumulation of unfolded and misfolded proteins, hypoxia, amino acid deprivation, viral infection, and ultraviolet light. It has been known that viral infection can activate the ISR, but the role of the ISR during viral infection is still unclear. In some cases, the ISR is a protective mechanism of host cells against viral infection, while viruses may hijack the ISR for facilitating their replication. This review highlighted recent advances on the induction of the ISR upon viral infection and the downstream responses, such as autophagy, apoptosis, formation of stress granules, and innate immunity response. We then discussed the molecular mechanism of the ISR regulating viral replication and how viruses antagonize this cellular stress response resulting from the ISR.
abstractGer	The integrated stress response (ISR) is an adaptational signaling pathway induced in response to different stimuli, such as accumulation of unfolded and misfolded proteins, hypoxia, amino acid deprivation, viral infection, and ultraviolet light. It has been known that viral infection can activate the ISR, but the role of the ISR during viral infection is still unclear. In some cases, the ISR is a protective mechanism of host cells against viral infection, while viruses may hijack the ISR for facilitating their replication. This review highlighted recent advances on the induction of the ISR upon viral infection and the downstream responses, such as autophagy, apoptosis, formation of stress granules, and innate immunity response. We then discussed the molecular mechanism of the ISR regulating viral replication and how viruses antagonize this cellular stress response resulting from the ISR.
abstract_unstemmed	The integrated stress response (ISR) is an adaptational signaling pathway induced in response to different stimuli, such as accumulation of unfolded and misfolded proteins, hypoxia, amino acid deprivation, viral infection, and ultraviolet light. It has been known that viral infection can activate the ISR, but the role of the ISR during viral infection is still unclear. In some cases, the ISR is a protective mechanism of host cells against viral infection, while viruses may hijack the ISR for facilitating their replication. This review highlighted recent advances on the induction of the ISR upon viral infection and the downstream responses, such as autophagy, apoptosis, formation of stress granules, and innate immunity response. We then discussed the molecular mechanism of the ISR regulating viral replication and how viruses antagonize this cellular stress response resulting from the ISR.
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title_short	The Regulation of Integrated Stress Response Signaling Pathway on Viral Infection and Viral Antagonism
url	https://doi.org/10.3389/fmicb.2021.814635 https://doaj.org/article/94215704710b4edc842645f46b842ed7 https://www.frontiersin.org/articles/10.3389/fmicb.2021.814635/full https://doaj.org/toc/1664-302X
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The Regulation of Integrated Stress Response Signaling Pathway on Viral Infection and Viral Antagonism

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Zugang & Verfügbarkeit

Vorhandene Bände

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