Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration

Tendon disorders represent a very common pathology in today’s population, and tendinopathies that account 30% of tendon-related injuries, affect yearly millions of people which in turn cause huge socioeconomic and health repercussions worldwide. Inflammation plays a prominent role in the development of tendon pathologies, and advances in understanding the underlying mechanisms during the inflammatory state have provided additional insights into its potential role in tendon disorders. Different cell compartments, in combination with secreted immune modulators, have shown to control and modulate the inflammatory response during tendinopathies. Stromal compartment represented by tenocytes has shown to display an important role in orchestrating the inflammatory response during tendon injuries due to the interplay they exhibit with the immune-sensing and infiltrating compartments, which belong to resident and recruited immune cells. The use of stem cells or their derived secretomes within the regenerative medicine field might represent synergic new therapeutical approaches that can be used to tune the reaction of immune cells within the damaged tissues. To this end, promising opportunities are headed to the stimulation of macrophages polarization towards anti-inflammatory phenotype together with the recruitment of stem cells, that possess immunomodulatory properties, able to infiltrate within the damaged tissues and improve tendinopathies resolution. Indeed, the comprehension of the interactions between tenocytes or stem cells with the immune cells might considerably modulate the immune reaction solving hence the inflammatory response and preventing fibrotic tissue formation. The purpose of this review is to compare the roles of distinct cell compartments during tendon homeostasis and injury. Furthermore, the role of immune cells in this field, as well as their interactions with stem cells and tenocytes during tendon regeneration, will be discussed to gain insights into new ways for dealing with tendinopathies. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Valentina Russo [verfasserIn] Mohammad El Khatib [verfasserIn] Giuseppe Prencipe [verfasserIn] Maria Rita Citeroni [verfasserIn] Melisa Faydaver [verfasserIn] Annunziata Mauro [verfasserIn] Paolo Berardinelli [verfasserIn] Adrián Cerveró-Varona [verfasserIn] Arlette A. Haidar-Montes [verfasserIn] Maura Turriani [verfasserIn] Oriana Di Giacinto [verfasserIn] Marcello Raspa [verfasserIn] Ferdinando Scavizzi [verfasserIn] Fabrizio Bonaventura [verfasserIn] Johannes Stöckl [verfasserIn] Barbara Barboni [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	tendinopathies inflammation immune cells immune modulators innate immune response adaptive immune response

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 11(2022), 3, p 434
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:3, p 434

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells11030434

Katalog-ID:	DOAJ013411306

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allfields	10.3390/cells11030434 doi (DE-627)DOAJ013411306 (DE-599)DOAJd58b7784b57849fb8e648432259bc6a9 DE-627 ger DE-627 rakwb eng QH573-671 Valentina Russo verfasserin aut Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tendon disorders represent a very common pathology in today’s population, and tendinopathies that account 30% of tendon-related injuries, affect yearly millions of people which in turn cause huge socioeconomic and health repercussions worldwide. Inflammation plays a prominent role in the development of tendon pathologies, and advances in understanding the underlying mechanisms during the inflammatory state have provided additional insights into its potential role in tendon disorders. Different cell compartments, in combination with secreted immune modulators, have shown to control and modulate the inflammatory response during tendinopathies. Stromal compartment represented by tenocytes has shown to display an important role in orchestrating the inflammatory response during tendon injuries due to the interplay they exhibit with the immune-sensing and infiltrating compartments, which belong to resident and recruited immune cells. The use of stem cells or their derived secretomes within the regenerative medicine field might represent synergic new therapeutical approaches that can be used to tune the reaction of immune cells within the damaged tissues. To this end, promising opportunities are headed to the stimulation of macrophages polarization towards anti-inflammatory phenotype together with the recruitment of stem cells, that possess immunomodulatory properties, able to infiltrate within the damaged tissues and improve tendinopathies resolution. Indeed, the comprehension of the interactions between tenocytes or stem cells with the immune cells might considerably modulate the immune reaction solving hence the inflammatory response and preventing fibrotic tissue formation. The purpose of this review is to compare the roles of distinct cell compartments during tendon homeostasis and injury. Furthermore, the role of immune cells in this field, as well as their interactions with stem cells and tenocytes during tendon regeneration, will be discussed to gain insights into new ways for dealing with tendinopathies. tendinopathies inflammation immune cells immune modulators innate immune response adaptive immune response Cytology Mohammad El Khatib verfasserin aut Giuseppe Prencipe verfasserin aut Maria Rita Citeroni verfasserin aut Melisa Faydaver verfasserin aut Annunziata Mauro verfasserin aut Paolo Berardinelli verfasserin aut Adrián Cerveró-Varona verfasserin aut Arlette A. Haidar-Montes verfasserin aut Maura Turriani verfasserin aut Oriana Di Giacinto verfasserin aut Marcello Raspa verfasserin aut Ferdinando Scavizzi verfasserin aut Fabrizio Bonaventura verfasserin aut Johannes Stöckl verfasserin aut Barbara Barboni verfasserin aut In Cells MDPI AG, 2012 11(2022), 3, p 434 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2022 number:3, p 434 https://doi.org/10.3390/cells11030434 kostenfrei https://doaj.org/article/d58b7784b57849fb8e648432259bc6a9 kostenfrei https://www.mdpi.com/2073-4409/11/3/434 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 3, p 434
spelling	10.3390/cells11030434 doi (DE-627)DOAJ013411306 (DE-599)DOAJd58b7784b57849fb8e648432259bc6a9 DE-627 ger DE-627 rakwb eng QH573-671 Valentina Russo verfasserin aut Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tendon disorders represent a very common pathology in today’s population, and tendinopathies that account 30% of tendon-related injuries, affect yearly millions of people which in turn cause huge socioeconomic and health repercussions worldwide. Inflammation plays a prominent role in the development of tendon pathologies, and advances in understanding the underlying mechanisms during the inflammatory state have provided additional insights into its potential role in tendon disorders. Different cell compartments, in combination with secreted immune modulators, have shown to control and modulate the inflammatory response during tendinopathies. Stromal compartment represented by tenocytes has shown to display an important role in orchestrating the inflammatory response during tendon injuries due to the interplay they exhibit with the immune-sensing and infiltrating compartments, which belong to resident and recruited immune cells. The use of stem cells or their derived secretomes within the regenerative medicine field might represent synergic new therapeutical approaches that can be used to tune the reaction of immune cells within the damaged tissues. To this end, promising opportunities are headed to the stimulation of macrophages polarization towards anti-inflammatory phenotype together with the recruitment of stem cells, that possess immunomodulatory properties, able to infiltrate within the damaged tissues and improve tendinopathies resolution. Indeed, the comprehension of the interactions between tenocytes or stem cells with the immune cells might considerably modulate the immune reaction solving hence the inflammatory response and preventing fibrotic tissue formation. The purpose of this review is to compare the roles of distinct cell compartments during tendon homeostasis and injury. Furthermore, the role of immune cells in this field, as well as their interactions with stem cells and tenocytes during tendon regeneration, will be discussed to gain insights into new ways for dealing with tendinopathies. tendinopathies inflammation immune cells immune modulators innate immune response adaptive immune response Cytology Mohammad El Khatib verfasserin aut Giuseppe Prencipe verfasserin aut Maria Rita Citeroni verfasserin aut Melisa Faydaver verfasserin aut Annunziata Mauro verfasserin aut Paolo Berardinelli verfasserin aut Adrián Cerveró-Varona verfasserin aut Arlette A. Haidar-Montes verfasserin aut Maura Turriani verfasserin aut Oriana Di Giacinto verfasserin aut Marcello Raspa verfasserin aut Ferdinando Scavizzi verfasserin aut Fabrizio Bonaventura verfasserin aut Johannes Stöckl verfasserin aut Barbara Barboni verfasserin aut In Cells MDPI AG, 2012 11(2022), 3, p 434 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2022 number:3, p 434 https://doi.org/10.3390/cells11030434 kostenfrei https://doaj.org/article/d58b7784b57849fb8e648432259bc6a9 kostenfrei https://www.mdpi.com/2073-4409/11/3/434 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 3, p 434
allfields_unstemmed	10.3390/cells11030434 doi (DE-627)DOAJ013411306 (DE-599)DOAJd58b7784b57849fb8e648432259bc6a9 DE-627 ger DE-627 rakwb eng QH573-671 Valentina Russo verfasserin aut Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tendon disorders represent a very common pathology in today’s population, and tendinopathies that account 30% of tendon-related injuries, affect yearly millions of people which in turn cause huge socioeconomic and health repercussions worldwide. Inflammation plays a prominent role in the development of tendon pathologies, and advances in understanding the underlying mechanisms during the inflammatory state have provided additional insights into its potential role in tendon disorders. Different cell compartments, in combination with secreted immune modulators, have shown to control and modulate the inflammatory response during tendinopathies. Stromal compartment represented by tenocytes has shown to display an important role in orchestrating the inflammatory response during tendon injuries due to the interplay they exhibit with the immune-sensing and infiltrating compartments, which belong to resident and recruited immune cells. The use of stem cells or their derived secretomes within the regenerative medicine field might represent synergic new therapeutical approaches that can be used to tune the reaction of immune cells within the damaged tissues. To this end, promising opportunities are headed to the stimulation of macrophages polarization towards anti-inflammatory phenotype together with the recruitment of stem cells, that possess immunomodulatory properties, able to infiltrate within the damaged tissues and improve tendinopathies resolution. Indeed, the comprehension of the interactions between tenocytes or stem cells with the immune cells might considerably modulate the immune reaction solving hence the inflammatory response and preventing fibrotic tissue formation. The purpose of this review is to compare the roles of distinct cell compartments during tendon homeostasis and injury. Furthermore, the role of immune cells in this field, as well as their interactions with stem cells and tenocytes during tendon regeneration, will be discussed to gain insights into new ways for dealing with tendinopathies. tendinopathies inflammation immune cells immune modulators innate immune response adaptive immune response Cytology Mohammad El Khatib verfasserin aut Giuseppe Prencipe verfasserin aut Maria Rita Citeroni verfasserin aut Melisa Faydaver verfasserin aut Annunziata Mauro verfasserin aut Paolo Berardinelli verfasserin aut Adrián Cerveró-Varona verfasserin aut Arlette A. Haidar-Montes verfasserin aut Maura Turriani verfasserin aut Oriana Di Giacinto verfasserin aut Marcello Raspa verfasserin aut Ferdinando Scavizzi verfasserin aut Fabrizio Bonaventura verfasserin aut Johannes Stöckl verfasserin aut Barbara Barboni verfasserin aut In Cells MDPI AG, 2012 11(2022), 3, p 434 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2022 number:3, p 434 https://doi.org/10.3390/cells11030434 kostenfrei https://doaj.org/article/d58b7784b57849fb8e648432259bc6a9 kostenfrei https://www.mdpi.com/2073-4409/11/3/434 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 3, p 434
allfieldsGer	10.3390/cells11030434 doi (DE-627)DOAJ013411306 (DE-599)DOAJd58b7784b57849fb8e648432259bc6a9 DE-627 ger DE-627 rakwb eng QH573-671 Valentina Russo verfasserin aut Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tendon disorders represent a very common pathology in today’s population, and tendinopathies that account 30% of tendon-related injuries, affect yearly millions of people which in turn cause huge socioeconomic and health repercussions worldwide. Inflammation plays a prominent role in the development of tendon pathologies, and advances in understanding the underlying mechanisms during the inflammatory state have provided additional insights into its potential role in tendon disorders. Different cell compartments, in combination with secreted immune modulators, have shown to control and modulate the inflammatory response during tendinopathies. Stromal compartment represented by tenocytes has shown to display an important role in orchestrating the inflammatory response during tendon injuries due to the interplay they exhibit with the immune-sensing and infiltrating compartments, which belong to resident and recruited immune cells. The use of stem cells or their derived secretomes within the regenerative medicine field might represent synergic new therapeutical approaches that can be used to tune the reaction of immune cells within the damaged tissues. To this end, promising opportunities are headed to the stimulation of macrophages polarization towards anti-inflammatory phenotype together with the recruitment of stem cells, that possess immunomodulatory properties, able to infiltrate within the damaged tissues and improve tendinopathies resolution. Indeed, the comprehension of the interactions between tenocytes or stem cells with the immune cells might considerably modulate the immune reaction solving hence the inflammatory response and preventing fibrotic tissue formation. The purpose of this review is to compare the roles of distinct cell compartments during tendon homeostasis and injury. Furthermore, the role of immune cells in this field, as well as their interactions with stem cells and tenocytes during tendon regeneration, will be discussed to gain insights into new ways for dealing with tendinopathies. tendinopathies inflammation immune cells immune modulators innate immune response adaptive immune response Cytology Mohammad El Khatib verfasserin aut Giuseppe Prencipe verfasserin aut Maria Rita Citeroni verfasserin aut Melisa Faydaver verfasserin aut Annunziata Mauro verfasserin aut Paolo Berardinelli verfasserin aut Adrián Cerveró-Varona verfasserin aut Arlette A. Haidar-Montes verfasserin aut Maura Turriani verfasserin aut Oriana Di Giacinto verfasserin aut Marcello Raspa verfasserin aut Ferdinando Scavizzi verfasserin aut Fabrizio Bonaventura verfasserin aut Johannes Stöckl verfasserin aut Barbara Barboni verfasserin aut In Cells MDPI AG, 2012 11(2022), 3, p 434 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2022 number:3, p 434 https://doi.org/10.3390/cells11030434 kostenfrei https://doaj.org/article/d58b7784b57849fb8e648432259bc6a9 kostenfrei https://www.mdpi.com/2073-4409/11/3/434 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 3, p 434
allfieldsSound	10.3390/cells11030434 doi (DE-627)DOAJ013411306 (DE-599)DOAJd58b7784b57849fb8e648432259bc6a9 DE-627 ger DE-627 rakwb eng QH573-671 Valentina Russo verfasserin aut Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tendon disorders represent a very common pathology in today’s population, and tendinopathies that account 30% of tendon-related injuries, affect yearly millions of people which in turn cause huge socioeconomic and health repercussions worldwide. Inflammation plays a prominent role in the development of tendon pathologies, and advances in understanding the underlying mechanisms during the inflammatory state have provided additional insights into its potential role in tendon disorders. Different cell compartments, in combination with secreted immune modulators, have shown to control and modulate the inflammatory response during tendinopathies. Stromal compartment represented by tenocytes has shown to display an important role in orchestrating the inflammatory response during tendon injuries due to the interplay they exhibit with the immune-sensing and infiltrating compartments, which belong to resident and recruited immune cells. The use of stem cells or their derived secretomes within the regenerative medicine field might represent synergic new therapeutical approaches that can be used to tune the reaction of immune cells within the damaged tissues. To this end, promising opportunities are headed to the stimulation of macrophages polarization towards anti-inflammatory phenotype together with the recruitment of stem cells, that possess immunomodulatory properties, able to infiltrate within the damaged tissues and improve tendinopathies resolution. Indeed, the comprehension of the interactions between tenocytes or stem cells with the immune cells might considerably modulate the immune reaction solving hence the inflammatory response and preventing fibrotic tissue formation. The purpose of this review is to compare the roles of distinct cell compartments during tendon homeostasis and injury. Furthermore, the role of immune cells in this field, as well as their interactions with stem cells and tenocytes during tendon regeneration, will be discussed to gain insights into new ways for dealing with tendinopathies. tendinopathies inflammation immune cells immune modulators innate immune response adaptive immune response Cytology Mohammad El Khatib verfasserin aut Giuseppe Prencipe verfasserin aut Maria Rita Citeroni verfasserin aut Melisa Faydaver verfasserin aut Annunziata Mauro verfasserin aut Paolo Berardinelli verfasserin aut Adrián Cerveró-Varona verfasserin aut Arlette A. Haidar-Montes verfasserin aut Maura Turriani verfasserin aut Oriana Di Giacinto verfasserin aut Marcello Raspa verfasserin aut Ferdinando Scavizzi verfasserin aut Fabrizio Bonaventura verfasserin aut Johannes Stöckl verfasserin aut Barbara Barboni verfasserin aut In Cells MDPI AG, 2012 11(2022), 3, p 434 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2022 number:3, p 434 https://doi.org/10.3390/cells11030434 kostenfrei https://doaj.org/article/d58b7784b57849fb8e648432259bc6a9 kostenfrei https://www.mdpi.com/2073-4409/11/3/434 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 3, p 434
language	English
source	In Cells 11(2022), 3, p 434 volume:11 year:2022 number:3, p 434
sourceStr	In Cells 11(2022), 3, p 434 volume:11 year:2022 number:3, p 434
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	tendinopathies inflammation immune cells immune modulators innate immune response adaptive immune response Cytology
isfreeaccess_bool	true
container_title	Cells
authorswithroles_txt_mv	Valentina Russo @@aut@@ Mohammad El Khatib @@aut@@ Giuseppe Prencipe @@aut@@ Maria Rita Citeroni @@aut@@ Melisa Faydaver @@aut@@ Annunziata Mauro @@aut@@ Paolo Berardinelli @@aut@@ Adrián Cerveró-Varona @@aut@@ Arlette A. Haidar-Montes @@aut@@ Maura Turriani @@aut@@ Oriana Di Giacinto @@aut@@ Marcello Raspa @@aut@@ Ferdinando Scavizzi @@aut@@ Fabrizio Bonaventura @@aut@@ Johannes Stöckl @@aut@@ Barbara Barboni @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	718622081
id	DOAJ013411306
language_de	englisch
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author	Valentina Russo
spellingShingle	Valentina Russo misc QH573-671 misc tendinopathies misc inflammation misc immune cells misc immune modulators misc innate immune response misc adaptive immune response misc Cytology Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration
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topic_title	QH573-671 Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration tendinopathies inflammation immune cells immune modulators innate immune response adaptive immune response
topic	misc QH573-671 misc tendinopathies misc inflammation misc immune cells misc immune modulators misc innate immune response misc adaptive immune response misc Cytology
topic_unstemmed	misc QH573-671 misc tendinopathies misc inflammation misc immune cells misc immune modulators misc innate immune response misc adaptive immune response misc Cytology
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title	Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration
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author_browse	Valentina Russo Mohammad El Khatib Giuseppe Prencipe Maria Rita Citeroni Melisa Faydaver Annunziata Mauro Paolo Berardinelli Adrián Cerveró-Varona Arlette A. Haidar-Montes Maura Turriani Oriana Di Giacinto Marcello Raspa Ferdinando Scavizzi Fabrizio Bonaventura Johannes Stöckl Barbara Barboni
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title_sort	tendon immune regeneration: insights on the synergetic role of stem and immune cells during tendon regeneration
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title_auth	Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration
abstract	Tendon disorders represent a very common pathology in today’s population, and tendinopathies that account 30% of tendon-related injuries, affect yearly millions of people which in turn cause huge socioeconomic and health repercussions worldwide. Inflammation plays a prominent role in the development of tendon pathologies, and advances in understanding the underlying mechanisms during the inflammatory state have provided additional insights into its potential role in tendon disorders. Different cell compartments, in combination with secreted immune modulators, have shown to control and modulate the inflammatory response during tendinopathies. Stromal compartment represented by tenocytes has shown to display an important role in orchestrating the inflammatory response during tendon injuries due to the interplay they exhibit with the immune-sensing and infiltrating compartments, which belong to resident and recruited immune cells. The use of stem cells or their derived secretomes within the regenerative medicine field might represent synergic new therapeutical approaches that can be used to tune the reaction of immune cells within the damaged tissues. To this end, promising opportunities are headed to the stimulation of macrophages polarization towards anti-inflammatory phenotype together with the recruitment of stem cells, that possess immunomodulatory properties, able to infiltrate within the damaged tissues and improve tendinopathies resolution. Indeed, the comprehension of the interactions between tenocytes or stem cells with the immune cells might considerably modulate the immune reaction solving hence the inflammatory response and preventing fibrotic tissue formation. The purpose of this review is to compare the roles of distinct cell compartments during tendon homeostasis and injury. Furthermore, the role of immune cells in this field, as well as their interactions with stem cells and tenocytes during tendon regeneration, will be discussed to gain insights into new ways for dealing with tendinopathies.
abstractGer	Tendon disorders represent a very common pathology in today’s population, and tendinopathies that account 30% of tendon-related injuries, affect yearly millions of people which in turn cause huge socioeconomic and health repercussions worldwide. Inflammation plays a prominent role in the development of tendon pathologies, and advances in understanding the underlying mechanisms during the inflammatory state have provided additional insights into its potential role in tendon disorders. Different cell compartments, in combination with secreted immune modulators, have shown to control and modulate the inflammatory response during tendinopathies. Stromal compartment represented by tenocytes has shown to display an important role in orchestrating the inflammatory response during tendon injuries due to the interplay they exhibit with the immune-sensing and infiltrating compartments, which belong to resident and recruited immune cells. The use of stem cells or their derived secretomes within the regenerative medicine field might represent synergic new therapeutical approaches that can be used to tune the reaction of immune cells within the damaged tissues. To this end, promising opportunities are headed to the stimulation of macrophages polarization towards anti-inflammatory phenotype together with the recruitment of stem cells, that possess immunomodulatory properties, able to infiltrate within the damaged tissues and improve tendinopathies resolution. Indeed, the comprehension of the interactions between tenocytes or stem cells with the immune cells might considerably modulate the immune reaction solving hence the inflammatory response and preventing fibrotic tissue formation. The purpose of this review is to compare the roles of distinct cell compartments during tendon homeostasis and injury. Furthermore, the role of immune cells in this field, as well as their interactions with stem cells and tenocytes during tendon regeneration, will be discussed to gain insights into new ways for dealing with tendinopathies.
abstract_unstemmed	Tendon disorders represent a very common pathology in today’s population, and tendinopathies that account 30% of tendon-related injuries, affect yearly millions of people which in turn cause huge socioeconomic and health repercussions worldwide. Inflammation plays a prominent role in the development of tendon pathologies, and advances in understanding the underlying mechanisms during the inflammatory state have provided additional insights into its potential role in tendon disorders. Different cell compartments, in combination with secreted immune modulators, have shown to control and modulate the inflammatory response during tendinopathies. Stromal compartment represented by tenocytes has shown to display an important role in orchestrating the inflammatory response during tendon injuries due to the interplay they exhibit with the immune-sensing and infiltrating compartments, which belong to resident and recruited immune cells. The use of stem cells or their derived secretomes within the regenerative medicine field might represent synergic new therapeutical approaches that can be used to tune the reaction of immune cells within the damaged tissues. To this end, promising opportunities are headed to the stimulation of macrophages polarization towards anti-inflammatory phenotype together with the recruitment of stem cells, that possess immunomodulatory properties, able to infiltrate within the damaged tissues and improve tendinopathies resolution. Indeed, the comprehension of the interactions between tenocytes or stem cells with the immune cells might considerably modulate the immune reaction solving hence the inflammatory response and preventing fibrotic tissue formation. The purpose of this review is to compare the roles of distinct cell compartments during tendon homeostasis and injury. Furthermore, the role of immune cells in this field, as well as their interactions with stem cells and tenocytes during tendon regeneration, will be discussed to gain insights into new ways for dealing with tendinopathies.
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title_short	Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration
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